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Items: 1 to 50 of 82


Genetic Mutations Underlying Phenotypic Plasticity in Basosquamous Carcinoma.

Chiang A, Tan CZ, Kuonen F, Hodgkinson LM, Chiang F, Cho RJ, South AP, Tang JY, Chang ALS, Rieger KE, Oro AE, Sarin KY.

J Invest Dermatol. 2019 Nov;139(11):2263-2271.e5. doi: 10.1016/j.jid.2019.03.1163. Epub 2019 Jun 15.


Loss of Primary Cilia Drives Switching from Hedgehog to Ras/MAPK Pathway in Resistant Basal Cell Carcinoma.

Kuonen F, Huskey NE, Shankar G, Jaju P, Whitson RJ, Rieger KE, Atwood SX, Sarin KY, Oro AE.

J Invest Dermatol. 2019 Jul;139(7):1439-1448. doi: 10.1016/j.jid.2018.11.035. Epub 2019 Jan 29.


TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment.

Li L, Wang Y, Torkelson JL, Shankar G, Pattison JM, Zhen HH, Fang F, Duren Z, Xin J, Gaddam S, Melo SP, Piekos SN, Li J, Liaw EJ, Chen L, Li R, Wernig M, Wong WH, Chang HY, Oro AE.

Cell Stem Cell. 2019 Feb 7;24(2):271-284.e8. doi: 10.1016/j.stem.2018.12.012. Epub 2019 Jan 24.


MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias.

Brown AS, Meera P, Altindag B, Chopra R, Perkins EM, Paul S, Scoles DR, Tarapore E, Magri J, Huang H, Jackson M, Shakkottai VG, Otis TS, Pulst SM, Atwood SX, Oro AE.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12407-E12416. doi: 10.1073/pnas.1816177115. Epub 2018 Dec 7.


LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription.

Mirza AN, McKellar SA, Urman NM, Brown AS, Hollmig T, Aasi SZ, Oro AE.

Cell. 2019 Jan 10;176(1-2):198-212.e15. doi: 10.1016/j.cell.2018.10.054. Epub 2018 Nov 29.


Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment.

Pattison JM, Melo SP, Piekos SN, Torkelson JL, Bashkirova E, Mumbach MR, Rajasingh C, Zhen HH, Li L, Liaw E, Alber D, Rubin AJ, Shankar G, Bao X, Chang HY, Khavari PA, Oro AE.

Nat Genet. 2018 Dec;50(12):1658-1665. doi: 10.1038/s41588-018-0263-0. Epub 2018 Nov 5.


Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility.

Cho HG, Kuo KY, Li S, Bailey I, Aasi S, Chang ALS, Oro AE, Tang JY, Sarin KY.

JCI Insight. 2018 Aug 9;3(15). pii: 122744. doi: 10.1172/jci.insight.122744. eCollection 2018 Aug 9.


Actin polymerization controls cilia-mediated signaling.

Drummond ML, Li M, Tarapore E, Nguyen TTL, Barouni BJ, Cruz S, Tan KC, Oro AE, Atwood SX.

J Cell Biol. 2018 Sep 3;217(9):3255-3266. doi: 10.1083/jcb.201703196. Epub 2018 Jun 26.


TGFβ, Fibronectin and Integrin α5β1 Promote Invasion in Basal Cell Carcinoma.

Kuonen F, Surbeck I, Sarin KY, Dontenwill M, Rüegg C, Gilliet M, Oro AE, Gaide O.

J Invest Dermatol. 2018 Nov;138(11):2432-2442. doi: 10.1016/j.jid.2018.04.029. Epub 2018 Jul 14.


Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas.

Whitson RJ, Lee A, Urman NM, Mirza A, Yao CY, Brown AS, Li JR, Shankar G, Fry MA, Atwood SX, Lee EY, Hollmig ST, Aasi SZ, Sarin KY, Scott MP, Epstein EH Jr, Tang JY, Oro AE.

Nat Med. 2018 Mar;24(3):271-281. doi: 10.1038/nm.4476. Epub 2018 Feb 5.


Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment.

Mirza AN, Fry MA, Urman NM, Atwood SX, Roffey J, Ott GR, Chen B, Lee A, Brown AS, Aasi SZ, Hollmig T, Ator MA, Dorsey BD, Ruggeri BR, Zificsak CA, Sirota M, Tang JY, Butte A, Epstein E, Sarin KY, Oro AE.

JCI Insight. 2017 Nov 2;2(21). pii: 97071. doi: 10.1172/jci.insight.97071.


Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior.

Whitson RJ, Oro AE.

Cell Stem Cell. 2017 Feb 2;20(2):149-150. doi: 10.1016/j.stem.2017.01.007.


Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions.

Urman NM, Mirza A, Atwood SX, Whitson RJ, Sarin KY, Tang JY, Oro AE.

PLoS One. 2016 Dec 28;11(12):e0168031. doi: 10.1371/journal.pone.0168031. eCollection 2016.


Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata.

Kennedy Crispin M, Ko JM, Craiglow BG, Li S, Shankar G, Urban JR, Chen JC, Cerise JE, Jabbari A, Winge MC, Marinkovich MP, Christiano AM, Oro AE, King BA.

JCI Insight. 2016 Sep 22;1(15):e89776. doi: 10.1172/jci.insight.89776.


Factors That May Promote an Effective Local Research Environment.

Wang K, Lee CS, Marinkovich MP, Chang HY, Oro AE, Khavari PA.

J Invest Dermatol. 2016 Aug;136(8):1529-1531. doi: 10.1016/j.jid.2016.04.015. No abstract available.


Update to an open-label clinical trial of vismodegib as neoadjuvant before surgery for high-risk basal cell carcinoma (BCC).

Kwon GP, Ally MS, Bailey-Healy I, Oro AE, Kim J, Chang AL, Aasi S, Tang JY.

J Am Acad Dermatol. 2016 Jul;75(1):213-5. doi: 10.1016/j.jaad.2016.02.1235. No abstract available.


An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib.

Danial C, Sarin KY, Oro AE, Chang AL.

Clin Cancer Res. 2016 Mar 15;22(6):1325-9. doi: 10.1158/1078-0432.CCR-15-1588. Epub 2015 Nov 6.


Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma.

Jaju PD, Nguyen CB, Mah AM, Atwood SX, Li J, Zia A, Chang ALS, Oro AE, Tang JY, Lee CS, Sarin KY.

J Invest Dermatol. 2015 Dec;135(12):3197-3200. doi: 10.1038/jid.2015.339. Epub 2015 Sep 8. No abstract available. Erratum in: J Invest Dermatol. 2016 Apr;136(4):882. Nguyen, Christine B [corrected to Nguyen, Christie B].


RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.

Zhao X, Ponomaryov T, Ornell KJ, Zhou P, Dabral SK, Pak E, Li W, Atwood SX, Whitson RJ, Chang AL, Li J, Oro AE, Chan JA, Kelleher JF, Segal RA.

Cancer Res. 2015 Sep 1;75(17):3623-35. doi: 10.1158/0008-5472.CAN-14-2999-T. Epub 2015 Jun 30.


Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma.

Atwood SX, Sarin KY, Li JR, Yao CY, Urman NM, Chang ALS, Tang JY, Oro AE.

J Invest Dermatol. 2015 Aug;135(8):2138-2141. doi: 10.1038/jid.2015.115. Epub 2015 Mar 24. No abstract available.


Smoothened variants explain the majority of drug resistance in basal cell carcinoma.

Atwood SX, Sarin KY, Whitson RJ, Li JR, Kim G, Rezaee M, Ally MS, Kim J, Yao C, Chang AL, Oro AE, Tang JY.

Cancer Cell. 2015 Mar 9;27(3):342-53. doi: 10.1016/j.ccell.2015.02.002.


Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa.

Sebastiano V, Zhen HH, Haddad B, Bashkirova E, Melo SP, Wang P, Leung TL, Siprashvili Z, Tichy A, Li J, Ameen M, Hawkins J, Lee S, Li L, Schwertschkow A, Bauer G, Lisowski L, Kay MA, Kim SK, Lane AT, Wernig M, Oro AE.

Sci Transl Med. 2014 Nov 26;6(264):264ra163. doi: 10.1126/scitranslmed.3009540. Erratum in: Sci Transl Med. 2014 Dec 17;6(267):267er8. Derafshi, Bahareh Haddad [corrected to Haddad, Bahareh].


Advanced treatment for basal cell carcinomas.

Atwood SX, Whitson RJ, Oro AE.

Cold Spring Harb Perspect Med. 2014 Jul 1;4(7):a013581. doi: 10.1101/cshperspect.a013581. Review.


Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.

Tang Y, Gholamin S, Schubert S, Willardson MI, Lee A, Bandopadhayay P, Bergthold G, Masoud S, Nguyen B, Vue N, Balansay B, Yu F, Oh S, Woo P, Chen S, Ponnuswami A, Monje M, Atwood SX, Whitson RJ, Mitra S, Cheshier SH, Qi J, Beroukhim R, Tang JY, Wechsler-Reya R, Oro AE, Link BA, Bradner JE, Cho YJ.

Nat Med. 2014 Jul;20(7):732-40. doi: 10.1038/nm.3613. Epub 2014 Jun 29.


"Atypical" regulation of Hedgehog-dependent cancers.

Atwood SX, Oro AE.

Cancer Cell. 2014 Feb 10;25(2):133-4. doi: 10.1016/j.ccr.2014.01.027.


Somatic correction of junctional epidermolysis bullosa by a highly recombinogenic AAV variant.

Melo SP, Lisowski L, Bashkirova E, Zhen HH, Chu K, Keene DR, Marinkovich MP, Kay MA, Oro AE.

Mol Ther. 2014 Apr;22(4):725-33. doi: 10.1038/mt.2013.290. Epub 2014 Jan 6.


Augmenting endogenous Wnt signaling improves skin wound healing.

Whyte JL, Smith AA, Liu B, Manzano WR, Evans ND, Dhamdhere GR, Fang MY, Chang HY, Oro AE, Helms JA.

PLoS One. 2013 Oct 18;8(10):e76883. doi: 10.1371/journal.pone.0076883. eCollection 2013.


Partial proteasome inhibitors induce hair follicle growth by stabilizing β-catenin.

Yucel G, Van Arnam J, Means PC, Huntzicker E, Altindag B, Lara MF, Yuan J, Kuo C, Oro AE.

Stem Cells. 2014 Jan;32(1):85-92. doi: 10.1002/stem.1525.


State-dependent signaling by Cav1.2 regulates hair follicle stem cell function.

Yucel G, Altindag B, Gomez-Ospina N, Rana A, Panagiotakos G, Lara MF, Dolmetsch R, Oro AE.

Genes Dev. 2013 Jun 1;27(11):1217-22. doi: 10.1101/gad.216556.113.


Surgical excision after neoadjuvant therapy with vismodegib for a locally advanced basal cell carcinoma and resistant basal carcinomas in Gorlin syndrome.

Chang AL, Atwood SX, Tartar DM, Oro AE.

JAMA Dermatol. 2013 May;149(5):639-41. doi: 10.1001/jamadermatol.2013.30. No abstract available.


"Patch"ing up our tumor signaling knowledge.

Atwood SX, Whitson RJ, Oro AE.

J Invest Dermatol. 2013 May;133(5):1131-3. doi: 10.1038/jid.2012.506.


Perivascular hair follicle stem cells associate with a venule annulus.

Xiao Y, Woo WM, Nagao K, Li W, Terunuma A, Mukouyama YS, Oro AE, Vogel JC, Brownell I.

J Invest Dermatol. 2013 Oct;133(10):2324-2331. doi: 10.1038/jid.2013.167. Epub 2013 Apr 4.


Markedly improved overall survival in 10 consecutive patients with metastatic basal cell carcinoma.

Danial C, Lingala B, Balise R, Oro AE, Reddy S, Colevas A, Chang AL.

Br J Dermatol. 2013 Sep;169(3):673-6. doi: 10.1111/bjd.12333.


Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration.

Woo WM, Atwood SX, Zhen HH, Oro AE.

J Vis Exp. 2013 Feb 28;(72):e4344. doi: 10.3791/4344.


GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

Atwood SX, Li M, Lee A, Tang JY, Oro AE.

Nature. 2013 Feb 28;494(7438):484-8. doi: 10.1038/nature11889.


New onset of keratoacanthomas after vismodegib treatment for locally advanced basal cell carcinomas: a report of 2 cases.

Aasi S, Silkiss R, Tang JY, Wysong A, Liu A, Epstein E, Oro AE, Chang AL.

JAMA Dermatol. 2013 Feb;149(2):242-3. doi: 10.1001/jamadermatol.2013.1798. No abstract available.


Hedgehog pathway inhibition and the race against tumor evolution.

Atwood SX, Chang AL, Oro AE.

J Cell Biol. 2012 Oct 15;199(2):193-7. doi: 10.1083/jcb.201207140.


Initial assessment of tumor regrowth after vismodegib in advanced Basal cell carcinoma.

Chang AL, Oro AE.

Arch Dermatol. 2012 Nov;148(11):1324-5. doi: 10.1001/archdermatol.2012.2354. No abstract available.


Translocation affecting sonic hedgehog genes in basal-cell carcinoma.

Gomez-Ospina N, Chang AL, Qu K, Oro AE.

N Engl J Med. 2012 Jun 7;366(23):2233-4. doi: 10.1056/NEJMc1115123. No abstract available.


Efficacy and safety of vismodegib in advanced basal-cell carcinoma.

Sekulic A, Migden MR, Oro AE, Dirix L, Lewis KD, Hainsworth JD, Solomon JA, Yoo S, Arron ST, Friedlander PA, Marmur E, Rudin CM, Chang AL, Low JA, Mackey HM, Yauch RL, Graham RA, Reddy JC, Hauschild A.

N Engl J Med. 2012 Jun 7;366(23):2171-9. doi: 10.1056/NEJMoa1113713.


Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop.

Woo WM, Zhen HH, Oro AE.

Genes Dev. 2012 Jun 1;26(11):1235-46. doi: 10.1101/gad.187401.112.


Neuropilins are positive regulators of Hedgehog signal transduction.

Hillman RT, Feng BY, Ni J, Woo WM, Milenkovic L, Hayden Gephart MG, Teruel MN, Oro AE, Chen JK, Scott MP.

Genes Dev. 2011 Nov 15;25(22):2333-46. doi: 10.1101/gad.173054.111. Epub 2011 Nov 3. Erratum in: Genes Dev. 2012 Mar 15;26(6):630.


SnapShot: hair follicle stem cells.

Woo WM, Oro AE.

Cell. 2011 Jul 22;146(2):334-334.e2. doi: 10.1016/j.cell.2011.07.001. No abstract available.


Cell migration: GSK3β steers the cytoskeleton's tip.

Yucel G, Oro AE.

Cell. 2011 Feb 4;144(3):319-21. doi: 10.1016/j.cell.2011.01.023.


Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation.

DeRouen MC, Zhen H, Tan SH, Williams S, Marinkovich MP, Oro AE.

BMC Dev Biol. 2010 Nov 10;10:112. doi: 10.1186/1471-213X-10-112.


MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling.

Bershteyn M, Atwood SX, Woo WM, Li M, Oro AE.

Dev Cell. 2010 Aug 17;19(2):270-83. doi: 10.1016/j.devcel.2010.07.009.


BAR domain competition during directional cellular migration.

Quiñones GA, Oro AE.

Cell Cycle. 2010 Jul 1;9(13):2522-8. doi: 10.4161/cc.9.13.12123. Review.


I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration.

Quinones GA, Jin J, Oro AE.

J Cell Biol. 2010 Apr 19;189(2):353-67. doi: 10.1083/jcb.200910136. Epub 2010 Apr 12.


The primary cilium: a small yet mighty organelle.

DeRouen MC, Oro AE.

J Invest Dermatol. 2009 Feb;129(2):264-5. doi: 10.1038/jid.2008.404. Review.


Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.

Gao J, DeRouen MC, Chen CH, Nguyen M, Nguyen NT, Ido H, Harada K, Sekiguchi K, Morgan BA, Miner JH, Oro AE, Marinkovich MP.

Genes Dev. 2008 Aug 1;22(15):2111-24. doi: 10.1101/gad.1689908.

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