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Items: 1 to 50 of 216

1.

β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea.

Jansson L, Ebeid M, Shen JW, Mokhtari TE, Quiruz LA, Ornitz DM, Huh SH, Cheng AG.

Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21054-21060. doi: 10.1073/pnas.1910223116. Epub 2019 Sep 30.

PMID:
31570588
2.

Crouzon syndrome mouse model exhibits cartilage hyperproliferation and defective segmentation in the developing trachea.

Hines EA, Jones MN, Harvey JF, Perlyn C, Ornitz DM, Sun X, Verheyden JM.

Sci China Life Sci. 2019 Oct;62(10):1375-1380. doi: 10.1007/s11427-019-9568-x. Epub 2019 Aug 26.

PMID:
31463736
3.

FGF2-induced STAT3 activation regulates pathologic neovascularization.

Dong Z, Santeford A, Ban N, Lee TJ, Smith C, Ornitz DM, Apte RS.

Exp Eye Res. 2019 Oct;187:107775. doi: 10.1016/j.exer.2019.107775. Epub 2019 Aug 23.

PMID:
31449793
4.

Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18).

Hagan AS, Boylan M, Smith C, Perez-Santamarina E, Kowalska K, Hung IH, Lewis RM, Hajihosseini MK, Lewandoski M, Ornitz DM.

Dev Dyn. 2019 Sep;248(9):882-893. doi: 10.1002/dvdy.85. Epub 2019 Jul 22.

PMID:
31290205
5.

Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner.

Yang LM, Cheah KSE, Huh SH, Ornitz DM.

PLoS Genet. 2019 Jul 5;15(7):e1008254. doi: 10.1371/journal.pgen.1008254. eCollection 2019 Jul.

6.

Osteocyte Death and Bone Overgrowth in Mice Lacking Fibroblast Growth Factor Receptors 1 and 2 in Mature Osteoblasts and Osteocytes.

McKenzie J, Smith C, Karuppaiah K, Langberg J, Silva MJ, Ornitz DM.

J Bone Miner Res. 2019 Sep;34(9):1660-1675. doi: 10.1002/jbmr.3742. Epub 2019 Jun 17.

PMID:
31206783
7.

Characterisation of endogenous players in fibroblast growth factor-regulated functions of hypothalamic tanycytes and energy-balance nuclei.

Kaminskas B, Goodman T, Hagan A, Bellusci S, Ornitz DM, Hajihosseini MK.

J Neuroendocrinol. 2019 Aug;31(8):e12750. doi: 10.1111/jne.12750. Epub 2019 Jul 8.

8.

Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts.

Hegab AE, Ozaki M, Kameyama N, Gao J, Kagawa S, Yasuda H, Soejima K, Yin Y, Guzy RD, Nakamura Y, Ornitz DM, Betsuyaku T.

J Pathol. 2019 Oct;249(2):193-205. doi: 10.1002/path.5290. Epub 2019 Jun 24.

PMID:
31090071
9.

Diagnosis and Pathophysiological Mechanisms of Group 3 Hypoxia-Induced Pulmonary Hypertension.

Woo KV, Ornitz DM, Singh GK.

Curr Treat Options Cardiovasc Med. 2019 Mar 22;21(3):16. doi: 10.1007/s11936-019-0718-3. Review.

PMID:
30903302
10.

Fibroblast growth factors in skeletal development.

Ornitz DM, Marie PJ.

Curr Top Dev Biol. 2019;133:195-234. doi: 10.1016/bs.ctdb.2018.11.020. Epub 2019 Jan 3.

PMID:
30902253
11.

Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development.

McKey J, Bunce C, Batchvarov IS, Ornitz DM, Capel B.

Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5570-5575. doi: 10.1073/pnas.1814930116. Epub 2019 Feb 28.

12.

Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent.

Mok KW, Saxena N, Heitman N, Grisanti L, Srivastava D, Muraro MJ, Jacob T, Sennett R, Wang Z, Su Y, Yang LM, Ma'ayan A, Ornitz DM, Kasper M, Rendl M.

Dev Cell. 2019 Jan 7;48(1):32-48.e5. doi: 10.1016/j.devcel.2018.11.034. Epub 2018 Dec 27.

PMID:
30595537
13.

Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1).

Oladipupo SS, Kabir AU, Smith C, Choi K, Ornitz DM.

Sci Rep. 2018 Oct 3;8(1):14724. doi: 10.1038/s41598-018-33037-2.

14.

Sculpting the skull through neurosensory epithelial-mesenchymal signaling.

Yang LM, Ornitz DM.

Dev Dyn. 2019 Jan;248(1):88-97. doi: 10.1002/dvdy.24664. Epub 2018 Sep 24. Review.

PMID:
30117627
15.

FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area.

Yang LM, Huh SH, Ornitz DM.

Dev Cell. 2018 Sep 10;46(5):564-580.e5. doi: 10.1016/j.devcel.2018.07.010. Epub 2018 Aug 9.

16.

Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.

Koo HY, El-Baz LM, House S, Cilvik SN, Dorry SJ, Shoukry NM, Salem ML, Hafez HS, Dulin NO, Ornitz DM, Guzy RD.

J Pathol. 2018 Sep;246(1):54-66. doi: 10.1002/path.5106. Epub 2018 Jul 5.

17.

Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms.

Hegab AE, Ozaki M, Kagawa S, Hamamoto J, Yasuda H, Naoki K, Soejima K, Yin Y, Kinoshita T, Yaguchi T, Kawakami Y, Ornitz DM, Betsuyaku T.

Lung Cancer. 2018 May;119:25-35. doi: 10.1016/j.lungcan.2018.02.015. Epub 2018 Mar 2.

PMID:
29656749
18.

Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty.

Elo T, Lindfors PH, Lan Q, Voutilainen M, Trela E, Ohlsson C, Huh SH, Ornitz DM, Poutanen M, Howard BA, Mikkola ML.

Sci Rep. 2017 Jul 11;7(1):5049. doi: 10.1038/s41598-017-04637-1.

19.

Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling.

Guzy RD, Li L, Smith C, Dorry SJ, Koo HY, Chen L, Ornitz DM.

J Biol Chem. 2017 Jun 23;292(25):10364-10378. doi: 10.1074/jbc.M117.791764. Epub 2017 May 9.

20.

FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms.

BonDurant LD, Ameka M, Naber MC, Markan KR, Idiga SO, Acevedo MR, Walsh SA, Ornitz DM, Potthoff MJ.

Cell Metab. 2017 Apr 4;25(4):935-944.e4. doi: 10.1016/j.cmet.2017.03.005.

21.

Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice.

Zhang H, Kamiya N, Tsuji T, Takeda H, Scott G, Rajderkar S, Ray MK, Mochida Y, Allen B, Lefebvre V, Hung IH, Ornitz DM, Kunieda T, Mishina Y.

PLoS Genet. 2016 Dec 27;12(12):e1006510. doi: 10.1371/journal.pgen.1006510. eCollection 2016 Dec.

22.

Achondroplasia: Development, pathogenesis, and therapy.

Ornitz DM, Legeai-Mallet L.

Dev Dyn. 2017 Apr;246(4):291-309. doi: 10.1002/dvdy.24479. Epub 2017 Mar 2. Review.

23.

An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities.

Xia X, Kumru OS, Blaber SI, Middaugh CR, Li L, Ornitz DM, Suh JM, Atkins AR, Downes M, Evans RM, Tenorio CA, Bienkiewicz E, Blaber M.

J Pharm Sci. 2016 Dec;105(12):3507-3519. doi: 10.1016/j.xphs.2016.09.005. Epub 2016 Oct 20.

24.

Sulfated hydrogel matrices direct mitogenicity and maintenance of chondrocyte phenotype through activation of FGF signaling.

Öztürk E, Arlov Ø, Aksel S, Li L, Ornitz DM, Skjåk-Bræk G, Zenobi-Wong M.

Adv Funct Mater. 2016 Jun 7;26(21):3649-3662. doi: 10.1002/adfm.201600092. Epub 2016 Mar 23.

25.

Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody.

Yin Y, Ren X, Smith C, Guo Q, Malabunga M, Guernah I, Zhang Y, Shen J, Sun H, Chehab N, Loizos N, Ludwig DL, Ornitz DM.

Dis Model Mech. 2016 May 1;9(5):563-71. doi: 10.1242/dmm.024760. Epub 2016 Apr 7.

26.

FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth.

Karuppaiah K, Yu K, Lim J, Chen J, Smith C, Long F, Ornitz DM.

Development. 2016 May 15;143(10):1811-22. doi: 10.1242/dev.131722. Epub 2016 Apr 6.

27.

Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.

Xia X, Kumru OS, Blaber SI, Middaugh CR, Li L, Ornitz DM, Sutherland MA, Tenorio CA, Blaber M.

J Pharm Sci. 2016 Apr;105(4):1444-53. doi: 10.1016/j.xphs.2016.02.010.

28.

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival.

Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, Pruett-Miller SM, Ornitz DM, Allen PM, Beatty WL, Schmidt RE, DiAntonio A, Tooze SA, Virgin HW.

Sci Rep. 2016 Mar 18;6:23326. doi: 10.1038/srep23326.

29.

Proteomic analysis of native cerebellar iFGF14 complexes.

Bosch MK, Nerbonne JM, Townsend RR, Miyazaki H, Nukina N, Ornitz DM, Marionneau C.

Channels (Austin). 2016 Jul 3;10(4):297-312. doi: 10.1080/19336950.2016.1153203. Epub 2016 Feb 18.

30.

A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development.

Hung IH, Schoenwolf GC, Lewandoski M, Ornitz DM.

Dev Biol. 2016 Mar 1;411(1):72-84. doi: 10.1016/j.ydbio.2016.01.008. Epub 2016 Jan 16.

31.

Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury.

House SL, Castro AM, Lupu TS, Weinheimer C, Smith C, Kovacs A, Ornitz DM.

Am J Physiol Heart Circ Physiol. 2016 Mar 1;310(5):H559-71. doi: 10.1152/ajpheart.00758.2015. Epub 2016 Jan 8.

32.

Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development.

Luo X, Fu Y, Loza AJ, Murali B, Leahy KM, Ruhland MK, Gang M, Su X, Zamani A, Shi Y, Lavine KJ, Ornitz DM, Weilbaecher KN, Long F, Novack DV, Faccio R, Longmore GD, Stewart SA.

Cell Rep. 2016 Jan 5;14(1):82-92. doi: 10.1016/j.celrep.2015.12.016. Epub 2015 Dec 24.

33.

Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2.

Park C, Lee TJ, Bhang SH, Liu F, Nakamura R, Oladipupo SS, Pitha-Rowe I, Capoccia B, Choi HS, Kim TM, Urao N, Ushio-Fukai M, Lee DJ, Miyoshi H, Kim BS, Lim DS, Apte RS, Ornitz DM, Choi K.

Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):86-96. doi: 10.1161/ATVBAHA.115.306430. Epub 2015 Nov 19.

34.

Mesenchymal fibroblast growth factor receptor signaling regulates palatal shelf elevation during secondary palate formation.

Yu K, Karuppaiah K, Ornitz DM.

Dev Dyn. 2015 Nov;244(11):1427-38. doi: 10.1002/dvdy.24319. Epub 2015 Aug 24.

35.

Fibroblast growth factor signaling in skeletal development and disease.

Ornitz DM, Marie PJ.

Genes Dev. 2015 Jul 15;29(14):1463-86. doi: 10.1101/gad.266551.115. Review.

36.

Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma.

Yin Y, Castro AM, Hoekstra M, Yan TJ, Kanakamedala AC, Dehner LP, Hill DA, Ornitz DM.

PLoS Genet. 2015 May 15;11(5):e1005242. doi: 10.1371/journal.pgen.1005242. eCollection 2015 May.

37.

Intracellular FGF14 (iFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance.

Bosch MK, Carrasquillo Y, Ransdell JL, Kanakamedala A, Ornitz DM, Nerbonne JM.

J Neurosci. 2015 Apr 29;35(17):6752-69. doi: 10.1523/JNEUROSCI.2663-14.2015.

38.

Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling.

Huh SH, Warchol ME, Ornitz DM.

Elife. 2015 Apr 27;4. doi: 10.7554/eLife.05921.

39.

The Fibroblast Growth Factor signaling pathway.

Ornitz DM, Itoh N.

Wiley Interdiscip Rev Dev Biol. 2015 May-Jun;4(3):215-66. doi: 10.1002/wdev.176. Epub 2015 Mar 13. Review.

40.

Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development.

Okazawa M, Murashima A, Harada M, Nakagata N, Noguchi M, Morimoto M, Kimura T, Ornitz DM, Yamada G.

Dev Biol. 2015 Apr 1;400(1):139-47. doi: 10.1016/j.ydbio.2015.01.023. Epub 2015 Feb 9.

41.

Fibroblast growth factor 2 is an essential cardioprotective factor in a closed-chest model of cardiac ischemia-reperfusion injury.

House SL, Wang J, Castro AM, Weinheimer C, Kovacs A, Ornitz DM.

Physiol Rep. 2015 Jan 27;3(1). pii: e12278. doi: 10.14814/phy2.12278. Print 2015 Jan 1.

42.

Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma.

Arai D, Hegab AE, Soejima K, Kuroda A, Ishioka K, Yasuda H, Naoki K, Shizuko K, Hamamoto J, Yin Y, Ornitz DM, Betsuyaku T.

J Pathol. 2015 Mar;235(4):593-605. doi: 10.1002/path.4486. Epub 2014 Dec 17.

43.

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart.

Lavine KJ, Epelman S, Uchida K, Weber KJ, Nichols CG, Schilling JD, Ornitz DM, Randolph GJ, Mann DL.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16029-34. doi: 10.1073/pnas.1406508111. Epub 2014 Oct 27. Erratum in: Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):E1414. Dosage error in article text.

44.

OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells.

Kim JY, Lee RH, Kim TM, Kim DW, Jeon YJ, Huh SH, Oh SY, Kyba M, Kataoka H, Choi K, Ornitz DM, Chae JI, Park C.

Blood. 2014 Nov 6;124(19):2948-52. doi: 10.1182/blood-2014-03-556332. Epub 2014 Sep 29.

45.

Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis.

Oladipupo SS, Smith C, Santeford A, Park C, Sene A, Wiley LA, Osei-Owusu P, Hsu J, Zapata N, Liu F, Nakamura R, Lavine KJ, Blumer KJ, Choi K, Apte RS, Ornitz DM.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13379-84. doi: 10.1073/pnas.1324235111. Epub 2014 Aug 19.

46.

Dual transgene expression in murine cerebellar Purkinje neurons by viral transduction in vivo.

Bosch MK, Nerbonne JM, Ornitz DM.

PLoS One. 2014 Aug 5;9(8):e104062. doi: 10.1371/journal.pone.0104062. eCollection 2014.

47.

Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin.

Guzy RD, Stoilov I, Elton TJ, Mecham RP, Ornitz DM.

Am J Respir Cell Mol Biol. 2015 Jan;52(1):116-28. doi: 10.1165/rcmb.2014-0184OC.

48.

In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90.

Moreland KT, Hong M, Lu W, Rowley CW, Ornitz DM, De Yoreo JJ, Thalmann R.

PLoS One. 2014 Apr 18;9(4):e95333. doi: 10.1371/journal.pone.0095333. eCollection 2014.

49.

Osx-Cre targets multiple cell types besides osteoblast lineage in postnatal mice.

Chen J, Shi Y, Regan J, Karuppaiah K, Ornitz DM, Long F.

PLoS One. 2014 Jan 15;9(1):e85161. doi: 10.1371/journal.pone.0085161. eCollection 2014.

50.

Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy.

Cilvik SN, Wang JI, Lavine KJ, Uchida K, Castro A, Gierasch CM, Weinheimer CJ, House SL, Kovacs A, Nichols CG, Ornitz DM.

PLoS One. 2013 Dec 11;8(12):e82979. doi: 10.1371/journal.pone.0082979. eCollection 2013.

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