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Skin platinum deposition in colorectal cancer patients following oxaliplatin-based therapy.

Cao Y, Chang Q, Zhang W, Ornatsky O, Hedley D, Chen EX.

Cancer Chemother Pharmacol. 2019 Sep 13. doi: 10.1007/s00280-019-03956-6. [Epub ahead of print]


Highly stable and inert complexation of Indium(III) by reinforced cyclam dipicolinate and a bifunctional derivative for bead encoding in mass cytometry.

Grenier L, Beyler M, Platas-Iglesias C, Closson T, Gómez DE, Seferos DS, Liu P, Ornatsky OI, Baranov V, Tripier R.

Chemistry. 2019 Sep 3. doi: 10.1002/chem.201903969. [Epub ahead of print]


Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry.

Ramaglia V, Sheikh-Mohamed S, Legg K, Park C, Rojas OL, Zandee S, Fu F, Ornatsky O, Swanson EC, Pitt D, Prat A, McKee TD, Gommerman JL.

Elife. 2019 Aug 1;8. pii: e48051. doi: 10.7554/eLife.48051.


Multidimensional profiling of drug-treated cells by Imaging Mass Cytometry.

Bouzekri A, Esch A, Ornatsky O.

FEBS Open Bio. 2019 Sep;9(9):1652-1669. doi: 10.1002/2211-5463.12692. Epub 2019 Jul 21.


Human lymphoid organ cDC2 and macrophages play complementary roles in T follicular helper responses.

Durand M, Walter T, Pirnay T, Naessens T, Gueguen P, Goudot C, Lameiras S, Chang Q, Talaei N, Ornatsky O, Vassilevskaia T, Baulande S, Amigorena S, Segura E.

J Exp Med. 2019 Jul 1;216(7):1561-1581. doi: 10.1084/jem.20181994. Epub 2019 May 9.


Lanthanide nanoparticles for high sensitivity multiparameter single cell analysis.

Pichaandi J, Zhao G, Bouzekri A, Lu E, Ornatsky O, Baranov V, Nitz M, Winnik MA.

Chem Sci. 2019 Jan 23;10(10):2965-2974. doi: 10.1039/c8sc04407d. eCollection 2019 Mar 14.


Tumor Platinum Concentrations and Pathological Responses Following Cisplatin-Containing Chemotherapy in Gastric Cancer Patients.

Cao Y, Chang Q, Cabanero M, Zhang W, Hafezi-Bakhtiari S, Hedley D, Darling G, Quereshy F, Jang R, Elimova E, Knox J, Ornatsky O, Serra S, Chen E.

J Gastrointest Cancer. 2018 Aug 16. doi: 10.1007/s12029-018-0153-9. [Epub ahead of print]


Clickable and High-Sensitivity Metal-Containing Tags for Mass Cytometry.

Allo B, Lou X, Bouzekri A, Ornatsky O.

Bioconjug Chem. 2018 Jun 20;29(6):2028-2038. doi: 10.1021/acs.bioconjchem.8b00239. Epub 2018 May 17.


Aptamer-facilitated mass cytometry.

Mironov GG, Bouzekri A, Watson J, Loboda O, Ornatsky O, Berezovski MV.

Anal Bioanal Chem. 2018 May;410(13):3047-3051. doi: 10.1007/s00216-018-1011-0. Epub 2018 Mar 20.


Opposing Roles of Dendritic Cell Subsets in Experimental GN.

Brähler S, Zinselmeyer BH, Raju S, Nitschke M, Suleiman H, Saunders BT, Johnson MW, Böhner AMC, Viehmann SF, Theisen DJ, Kretzer NM, Briseño CG, Zaitsev K, Ornatsky O, Chang Q, Carrero JA, Kopp JB, Artyomov MN, Kurts C, Murphy KM, Miner JH, Shaw AS.

J Am Soc Nephrol. 2018 Jan;29(1):138-154. doi: 10.1681/ASN.2017030270. Epub 2017 Dec 7.


Simultaneous Detection of Protein and mRNA in Jurkat and KG-1a Cells by Mass Cytometry.

Mavropoulos A, Allo B, He M, Park E, Majonis D, Ornatsky O.

Cytometry A. 2017 Dec;91(12):1200-1208. doi: 10.1002/cyto.a.23281. Epub 2017 Nov 30.


Staining of Frozen and Formalin-Fixed, Paraffin-Embedded Tissues with Metal-Labeled Antibodies for Imaging Mass Cytometry Analysis.

Chang Q, Ornatsky O, Hedley D.

Curr Protoc Cytom. 2017 Oct 2;82:12.47.1-12.47.8. doi: 10.1002/cpcy.29.


Imaging Mass Cytometry.

Chang Q, Ornatsky OI, Siddiqui I, Loboda A, Baranov VI, Hedley DW.

Cytometry A. 2017 Feb;91(2):160-169. doi: 10.1002/cyto.a.23053. Epub 2017 Feb 3.


Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues.

Chang Q, Ornatsky OI, Siddiqui I, Straus R, Baranov VI, Hedley DW.

Sci Rep. 2016 Nov 4;6:36641. doi: 10.1038/srep36641.


Single-cell measurement of the uptake, intratumoral distribution and cell cycle effects of cisplatin using mass cytometry.

Chang Q, Ornatsky OI, Koch CJ, Chaudary N, Marie-Egyptienne DT, Hill RP, Tanner SD, Hedley DW.

Int J Cancer. 2015 Mar 1;136(5):1202-9. doi: 10.1002/ijc.29074. Epub 2014 Jul 16.


Dual-purpose polymer labels for fluorescent and mass cytometric affinity bioassays.

Majonis D, Ornatsky O, Weinrich D, Winnik MA.

Biomacromolecules. 2013 May 13;14(5):1503-13. doi: 10.1021/bm4001662. Epub 2013 Apr 10.


An introduction to mass cytometry: fundamentals and applications.

Tanner SD, Baranov VI, Ornatsky OI, Bandura DR, George TC.

Cancer Immunol Immunother. 2013 May;62(5):955-65. doi: 10.1007/s00262-013-1416-8. Epub 2013 Apr 7. Review.


Metal-chelating polymers by anionic ring-opening polymerization and their use in quantitative mass cytometry.

Illy N, Majonis D, Herrera I, Ornatsky O, Winnik MA.

Biomacromolecules. 2012 Aug 13;13(8):2359-69. doi: 10.1021/bm300613x. Epub 2012 Jul 19.


Human CD4+ lymphocytes for antigen quantification: characterization using conventional flow cytometry and mass cytometry.

Wang L, Abbasi F, Ornatsky O, Cole KD, Misakian M, Gaigalas AK, He HJ, Marti GE, Tanner S, Stebbings R.

Cytometry A. 2012 Jul;81(7):567-75. doi: 10.1002/cyto.a.22060. Epub 2012 Apr 26.


Curious results with palladium- and platinum-carrying polymers in mass cytometry bioassays and an unexpected application as a dead cell stain.

Majonis D, Ornatsky O, Kinach R, Winnik MA.

Biomacromolecules. 2011 Nov 14;12(11):3997-4010. doi: 10.1021/bm201011t. Epub 2011 Sep 28.


Development of mass cytometry methods for bacterial discrimination.

Leipold MD, Ornatsky O, Baranov V, Whitfield C, Nitz M.

Anal Biochem. 2011 Dec 1;419(1):1-8. doi: 10.1016/j.ab.2011.07.035. Epub 2011 Aug 5.


Surface Functionalization Methods to Enhance Bioconjugation in Metal-Labeled Polystyrene Particles.

Abdelrahman AI, Thickett SC, Liang Y, Ornatsky O, Baranov V, Winnik MA.

Macromolecules. 2011 Jun 28;44(12):4801-4813.


Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum.

Bendall SC, Simonds EF, Qiu P, Amir el-AD, Krutzik PO, Finck R, Bruggner RV, Melamed R, Trejo A, Ornatsky OI, Balderas RS, Plevritis SK, Sachs K, Pe'er D, Tanner SD, Nolan GP.

Science. 2011 May 6;332(6030):687-96. doi: 10.1126/science.1198704.


Synthesis of a functional metal-chelating polymer and steps toward quantitative mass cytometry bioassays.

Majonis D, Herrera I, Ornatsky O, Schulze M, Lou X, Soleimani M, Nitz M, Winnik MA.

Anal Chem. 2010 Nov 1;82(21):8961-9. doi: 10.1021/ac101901x. Epub 2010 Oct 12.


Multiplexed protease assays using element-tagged substrates.

Lathia US, Ornatsky O, Baranov V, Nitz M.

Anal Biochem. 2011 Jan 1;408(1):157-9. doi: 10.1016/j.ab.2010.09.008. Epub 2010 Sep 16.


Highly multiparametric analysis by mass cytometry.

Ornatsky O, Bandura D, Baranov V, Nitz M, Winnik MA, Tanner S.

J Immunol Methods. 2010 Sep 30;361(1-2):1-20. doi: 10.1016/j.jim.2010.07.002. Epub 2010 Jul 21. Review.


A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.

Milyavsky M, Gan OI, Trottier M, Komosa M, Tabach O, Notta F, Lechman E, Hermans KG, Eppert K, Konovalova Z, Ornatsky O, Domany E, Meyn MS, Dick JE.

Cell Stem Cell. 2010 Aug 6;7(2):186-97. doi: 10.1016/j.stem.2010.05.016. Epub 2010 Jul 8.


Bio-Functional, Lanthanide-Labeled Polymer Particles by Seeded Emulsion Polymerization and their Characterization by Novel ICP-MS Detection.

Thickett SC, Abdelrahman AI, Ornatsky O, Bandura D, Baranov V, Winnik MA.

J Anal At Spectrom. 2010;25(3):269-281.


Metal-Containing Polystyrene Beads as Standards for Mass Cytometry.

Abdelrahman AI, Ornatsky O, Bandura D, Baranov V, Kinach R, Dai S, Thickett SC, Tanner S, Winnik MA.

J Anal At Spectrom. 2010;25(3):260-268.


Development of inductively coupled plasma-mass spectrometry-based protease assays.

Lathia US, Ornatsky O, Baranov V, Nitz M.

Anal Biochem. 2010 Mar 1;398(1):93-8. doi: 10.1016/j.ab.2009.11.010. Epub 2009 Nov 11.


Lanthanide-containing polymer microspheres by multiple-stage dispersion polymerization for highly multiplexed bioassays.

Abdelrahman AI, Dai S, Thickett SC, Ornatsky O, Bandura D, Baranov V, Winnik MA.

J Am Chem Soc. 2009 Oct 28;131(42):15276-83. doi: 10.1021/ja9052009. Erratum in: J Am Chem Soc. 2010 Feb 24;132(7):2465.


Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry.

Bandura DR, Baranov VI, Ornatsky OI, Antonov A, Kinach R, Lou X, Pavlov S, Vorobiev S, Dick JE, Tanner SD.

Anal Chem. 2009 Aug 15;81(16):6813-22. doi: 10.1021/ac901049w.


Development of analytical methods for multiplex bio-assay with inductively coupled plasma mass spectrometry.

Ornatsky OI, Kinach R, Bandura DR, Lou X, Tanner SD, Baranov VI, Nitz M, Winnik MA.

J Anal At Spectrom. 2008;23(4):463-469.


ICP-MS-based multiplex profiling of glycoproteins using lectins conjugated to lanthanide-chelating polymers.

Leipold MD, Herrera I, Ornatsky O, Baranov V, Nitz M.

J Proteome Res. 2009 Feb;8(2):443-9. doi: 10.1021/pr800645r.


Biocompatible hybrid nanogels.

Pich A, Zhang F, Shen L, Berger S, Ornatsky O, Baranov V, Winnik MA.

Small. 2008 Dec;4(12):2171-5. doi: 10.1002/smll.200801159. No abstract available.


Element-tagged immunoassay with ICP-MS detection: evaluation and comparison to conventional immunoassays.

Razumienko E, Ornatsky O, Kinach R, Milyavsky M, Lechman E, Baranov V, Winnik MA, Tanner SD.

J Immunol Methods. 2008 Jul 20;336(1):56-63. doi: 10.1016/j.jim.2008.03.011. Epub 2008 Apr 22.


Study of cell antigens and intracellular DNA by identification of element-containing labels and metallointercalators using inductively coupled plasma mass spectrometry.

Ornatsky OI, Lou X, Nitz M, Schäfer S, Sheldrick WS, Baranov VI, Bandura DR, Tanner SD.

Anal Chem. 2008 Apr 1;80(7):2539-47. doi: 10.1021/ac702128m. Epub 2008 Mar 5.


Lanthanide-containing polymer nanoparticles for biological tagging applications: nonspecific endocytosis and cell adhesion.

Vancaeyzeele C, Ornatsky O, Baranov V, Shen L, Abdelrahman A, Winnik MA.

J Am Chem Soc. 2007 Nov 7;129(44):13653-60. Epub 2007 Oct 12.


Polymer-based elemental tags for sensitive bioassays.

Lou X, Zhang G, Herrera I, Kinach R, Ornatsky O, Baranov V, Nitz M, Winnik MA.

Angew Chem Int Ed Engl. 2007;46(32):6111-4. No abstract available.


Large-scale mapping of human protein-protein interactions by mass spectrometry.

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D.

Mol Syst Biol. 2007;3:89. Epub 2007 Mar 13.


Messenger RNA Detection in Leukemia Cell lines by Novel Metal-Tagged in situ Hybridization using Inductively Coupled Plasma Mass Spectrometry.

Ornatsky OI, Baranov VI, Bandura DR, Tanner SD, Dick J.

Transl Oncogenomics. 2006 Sep 14;1:1-9. Print 2006.


Multiple cellular antigen detection by ICP-MS.

Ornatsky O, Baranov VI, Bandura DR, Tanner SD, Dick J.

J Immunol Methods. 2006 Jan 20;308(1-2):68-76. Epub 2005 Nov 21.


The reproducible acquisition of comparative liquid chromatography/tandem mass spectrometry data from complex biological samples.

Stewart II, Zhao L, Le Bihan T, Larsen B, Scozzaro S, Figeys D, Mao GD, Ornatsky O, Dharsee M, Orsi C, Ewing R, Goh T.

Rapid Commun Mass Spectrom. 2004;18(15):1697-710.


Administration of exogenous endothelin-1 following vascular balloon injury: early and late effects on intimal hyperplasia.

Barolet AW, Babaei S, Robinson R, Picard P, Tsui W, Nili N, Mohamed F, Ornatsky O, Sparkes JD, Stewart DJ, Strauss BH.

Cardiovasc Res. 2001 Dec;52(3):468-76.


Effects of estrogen replacement on infarct size, cardiac remodeling, and the endothelin system after myocardial infarction in ovariectomized rats.

Smith PJ, Ornatsky O, Stewart DJ, Picard P, Dawood F, Wen WH, Liu PP, Webb DJ, Monge JC.

Circulation. 2000 Dec 12;102(24):2983-9.


Post-translational control of the MEF2A transcriptional regulatory protein.

Ornatsky OI, Cox DM, Tangirala P, Andreucci JJ, Quinn ZA, Wrana JL, Prywes R, Yu YT, McDermott JC.

Nucleic Acids Res. 1999 Jul 1;27(13):2646-54.


Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1.

Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA.

Nucleic Acids Res. 1998 Oct 15;26(20):4771-7.


A dominant-negative form of transcription factor MEF2 inhibits myogenesis.

Ornatsky OI, Andreucci JJ, McDermott JC.

J Biol Chem. 1997 Dec 26;272(52):33271-8.

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