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The Proliferative and Apoptotic Landscape of Basal-like Breast Cancer.

Alexandrou S, George SM, Ormandy CJ, Lim E, Oakes SR, Caldon CE.

Int J Mol Sci. 2019 Feb 4;20(3). pii: E667. doi: 10.3390/ijms20030667. Review.


Single-Cell Transcriptomics in Cancer Immunobiology: The Future of Precision Oncology.

Valdes-Mora F, Handler K, Law AMK, Salomon R, Oakes SR, Ormandy CJ, Gallego-Ortega D.

Front Immunol. 2018 Nov 12;9:2582. doi: 10.3389/fimmu.2018.02582. eCollection 2018. Review.


Static droplet array for culturing single live adherent cells in an isolated chemical microenvironment.

Hassanzadeh-Barforoushi A, Law AMK, Hejri A, Asadnia M, Ormandy CJ, Gallego-Ortega D, Ebrahimi Warkiani M.

Lab Chip. 2018 Jul 24;18(15):2156-2166. doi: 10.1039/c8lc00403j.


Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion.

Young AI, Timpson P, Gallego-Ortega D, Ormandy CJ, Oakes SR.

Cell Adh Migr. 2018;12(6):513-523. doi: 10.1080/19336918.2017.1393591. Epub 2017 Dec 21. Review.


Andy's Algorithms: new automated digital image analysis pipelines for FIJI.

Law AMK, Yin JXM, Castillo L, Young AIJ, Piggin C, Rogers S, Caldon CE, Burgess A, Millar EKA, O'Toole SA, Gallego-Ortega D, Ormandy CJ, Oakes SR.

Sci Rep. 2017 Nov 16;7(1):15717. doi: 10.1038/s41598-017-15885-6.


A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.

Oakes SR, Gallego-Ortega D, Stanford PM, Junankar S, Au WWY, Kikhtyak Z, von Korff A, Sergio CM, Law AMK, Castillo LE, Allerdice SL, Young AIJ, Piggin C, Whittle B, Bertram E, Naylor MJ, Roden DL, Donovan J, Korennykh A, Goodnow CC, O'Bryan MK, Ormandy CJ.

PLoS Genet. 2017 Nov 8;13(11):e1007072. doi: 10.1371/journal.pgen.1007072. eCollection 2017 Nov.


A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

Nobis M, Herrmann D, Warren SC, Kadir S, Leung W, Killen M, Magenau A, Stevenson D, Lucas MC, Reischmann N, Vennin C, Conway JRW, Boulghourjian A, Zaratzian A, Law AM, Gallego-Ortega D, Ormandy CJ, Walters SN, Grey ST, Bailey J, Chtanova T, Quinn JMW, Baldock PA, Croucher PI, Schwarz JP, Mrowinska A, Zhang L, Herzog H, Masedunskas A, Hardeman EC, Gunning PW, Del Monte-Nieto G, Harvey RP, Samuel MS, Pajic M, McGhee EJ, Johnsson AE, Sansom OJ, Welch HCE, Morton JP, Strathdee D, Anderson KI, Timpson P.

Cell Rep. 2017 Oct 3;21(1):274-288. doi: 10.1016/j.celrep.2017.09.022.


The innate and adaptive infiltrating immune systems as targets for breast cancer immunotherapy.

Law AMK, Lim E, Ormandy CJ, Gallego-Ortega D.

Endocr Relat Cancer. 2017 Jul;24(7):X1. doi: 10.1530/ERC-16-0404e. No abstract available.


Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

Vennin C, Chin VT, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec P, Walters SN, Del Monte-Nieto G, Conway JR, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam AA, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NL, Phan T, Jain R, Weninger W, McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP, Biankin AV; Australian Pancreatic Cancer Genome Initiative (APGI), Evans TR, Anderson KI, Grey ST, Ormandy CJ, Gallego-Ortega D, Wang Y, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M, Timpson P.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaai8504. doi: 10.1126/scitranslmed.aai8504.


The innate and adaptive infiltrating immune systems as targets for breast cancer immunotherapy.

Law AM, Lim E, Ormandy CJ, Gallego-Ortega D.

Endocr Relat Cancer. 2017 Apr;24(4):R123-R144. doi: 10.1530/ERC-16-0404. Epub 2017 Feb 13. Review. Erratum in: Endocr Relat Cancer. 2017 Jul;24(7):X1.


MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib.

Young AI, Law AM, Castillo L, Chong S, Cullen HD, Koehler M, Herzog S, Brummer T, Lee EF, Fairlie WD, Lucas MC, Herrmann D, Allam A, Timpson P, Watkins DN, Millar EK, O'Toole SA, Gallego-Ortega D, Ormandy CJ, Oakes SR.

Breast Cancer Res. 2016 Dec 8;18(1):125.


ELF5 isoform expression is tissue-specific and significantly altered in cancer.

Piggin CL, Roden DL, Gallego-Ortega D, Lee HJ, Oakes SR, Ormandy CJ.

Breast Cancer Res. 2016 Jan 7;18(1):4. doi: 10.1186/s13058-015-0666-0.


Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue.

Erami Z, Herrmann D, Warren SC, Nobis M, McGhee EJ, Lucas MC, Leung W, Reischmann N, Mrowinska A, Schwarz JP, Kadir S, Conway JRW, Vennin C, Karim SA, Campbell AD, Gallego-Ortega D, Magenau A, Murphy KJ, Ridgway RA, Law AM, Walters SN, Grey ST, Croucher DR, Zhang L, Herzog H, Hardeman EC, Gunning PW, Ormandy CJ, Evans TRJ, Strathdee D, Sansom OJ, Morton JP, Anderson KI, Timpson P.

Cell Rep. 2016 Jan 5;14(1):152-167. doi: 10.1016/j.celrep.2015.12.020. Epub 2015 Dec 24.


ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.

Gallego-Ortega D, Ledger A, Roden DL, Law AM, Magenau A, Kikhtyak Z, Cho C, Allerdice SL, Lee HJ, Valdes-Mora F, Herrmann D, Salomon R, Young AI, Lee BY, Sergio CM, Kaplan W, Piggin C, Conway JR, Rabinovich B, Millar EK, Oakes SR, Chtanova T, Swarbrick A, Naylor MJ, O'Toole S, Green AR, Timpson P, Gee JM, Ellis IO, Clark SJ, Ormandy CJ.

PLoS Biol. 2015 Dec 30;13(12):e1002330. doi: 10.1371/journal.pbio.1002330. eCollection 2015 Dec.


Correction: HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.

Lim SL, Qu ZP, Kortschak RD, Lawrence DM, Geoghegan J, Hempfling AL, Bergmann M, Goodnow CC, Ormandy CJ, Wong L, Mann J, Scott HS, Jamsai D, Adelson DL, O'Bryan MK.

PLoS Genet. 2015 Dec 29;11(12):e1005782. doi: 10.1371/journal.pgen.1005782. eCollection 2015 Dec. No abstract available.


HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.

Lim SL, Qu ZP, Kortschak RD, Lawrence DM, Geoghegan J, Hempfling AL, Bergmann M, Goodnow CC, Ormandy CJ, Wong L, Mann J, Scott HS, Jamsai D, Adelson DL, O'Bryan MK.

PLoS Genet. 2015 Oct 23;11(10):e1005620. doi: 10.1371/journal.pgen.1005620. eCollection 2015 Oct. Erratum in: PLoS Genet. 2015 Dec;11(12):e1005782.


LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.

Liu Y, DeBoer K, de Kretser DM, O'Donnell L, O'Connor AE, Merriner DJ, Okuda H, Whittle B, Jans DA, Efthymiadis A, McLachlan RI, Ormandy CJ, Goodnow CC, Jamsai D, O'Bryan MK.

PLoS Genet. 2015 Mar 17;11(3):e1005090. doi: 10.1371/journal.pgen.1005090. eCollection 2015 Mar.


Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease.

Hilton HN, Doan TB, Graham JD, Oakes SR, Silvestri A, Santucci N, Kantimm S, Huschtscha LI, Ormandy CJ, Funder JW, Simpson ER, Kuczek ES, Leedman PJ, Tilley WD, Fuller PJ, Muscat GE, Clarke CL.

Oncotarget. 2014 Sep 30;5(18):8651-64.


Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways.

Ali NA, Wu J, Hochgräfe F, Chan H, Nair R, Ye S, Zhang L, Lyons RJ, Pinese M, Lee HC, Armstrong N, Ormandy CJ, Clark SJ, Swarbrick A, Daly RJ.

Breast Cancer Res. 2014 Sep 9;16(5):437. doi: 10.1186/s13058-014-0437-3.


The mammary cellular hierarchy and breast cancer.

Oakes SR, Gallego-Ortega D, Ormandy CJ.

Cell Mol Life Sci. 2014 Nov;71(22):4301-24. doi: 10.1007/s00018-014-1674-4. Epub 2014 Jul 31. Review.


Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer.

Owens TW, Rogers RL, Best S, Ledger A, Mooney AM, Ferguson A, Shore P, Swarbrick A, Ormandy CJ, Simpson PT, Carroll JS, Visvader J, Naylor MJ.

Cancer Res. 2014 Sep 15;74(18):5277-5286. doi: 10.1158/0008-5472.CAN-14-0053. Epub 2014 Jul 23.


A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse.

Jamsai D, Clark BJ, Smith SJ, Whittle B, Goodnow CC, Ormandy CJ, O'Bryan MK.

PLoS One. 2013 Oct 21;8(10):e77311. doi: 10.1371/journal.pone.0077311. eCollection 2013.


c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer.

Nair R, Roden DL, Teo WS, McFarland A, Junankar S, Ye S, Nguyen A, Yang J, Nikolic I, Hui M, Morey A, Shah J, Pfefferle AD, Usary J, Selinger C, Baker LA, Armstrong N, Cowley MJ, Naylor MJ, Ormandy CJ, Lakhani SR, Herschkowitz JI, Perou CM, Kaplan W, O'Toole SA, Swarbrick A.

Oncogene. 2014 Jul 24;33(30):3992-4002. doi: 10.1038/onc.2013.368. Epub 2013 Sep 23.


RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility.

O'Bryan MK, Clark BJ, McLaughlin EA, D'Sylva RJ, O'Donnell L, Wilce JA, Sutherland J, O'Connor AE, Whittle B, Goodnow CC, Ormandy CJ, Jamsai D.

PLoS Genet. 2013;9(7):e1003628. doi: 10.1371/journal.pgen.1003628. Epub 2013 Jul 25.


BCL-2 hypermethylation is a potential biomarker of sensitivity to antimitotic chemotherapy in endocrine-resistant breast cancer.

Stone A, Cowley MJ, Valdes-Mora F, McCloy RA, Sergio CM, Gallego-Ortega D, Caldon CE, Ormandy CJ, Biankin AV, Gee JM, Nicholson RI, Print CG, Clark SJ, Musgrove EA.

Mol Cancer Ther. 2013 Sep;12(9):1874-85. doi: 10.1158/1535-7163.MCT-13-0012. Epub 2013 Jul 16.


Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells.

Lee HJ, Gallego-Ortega D, Ledger A, Schramek D, Joshi P, Szwarc MM, Cho C, Lydon JP, Khokha R, Penninger JM, Ormandy CJ.

Development. 2013 Apr;140(7):1397-401. doi: 10.1242/dev.088948. Epub 2013 Mar 5.


RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model.

Byrne FL, Yang L, Phillips PA, Hansford LM, Fletcher JI, Ormandy CJ, McCarroll JA, Kavallaris M.

Oncogene. 2014 Feb 13;33(7):882-90. doi: 10.1038/onc.2013.11. Epub 2013 Feb 11.


ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

Kalyuga M, Gallego-Ortega D, Lee HJ, Roden DL, Cowley MJ, Caldon CE, Stone A, Allerdice SL, Valdes-Mora F, Launchbury R, Statham AL, Armstrong N, Alles MC, Young A, Egger A, Au W, Piggin CL, Evans CJ, Ledger A, Brummer T, Oakes SR, Kaplan W, Gee JM, Nicholson RI, Sutherland RL, Swarbrick A, Naylor MJ, Clark SJ, Carroll JS, Ormandy CJ.

PLoS Biol. 2012;10(12):e1001461. doi: 10.1371/journal.pbio.1001461. Epub 2012 Dec 27.


RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.

Lo JC, Jamsai D, O'Connor AE, Borg C, Clark BJ, Whisstock JC, Field MC, Adams V, Ishikawa T, Aitken RJ, Whittle B, Goodnow CC, Ormandy CJ, O'Bryan MK.

PLoS Genet. 2012;8(10):e1002969. doi: 10.1371/journal.pgen.1002969. Epub 2012 Oct 4.


Functional characterization of cancer-associated Gab1 mutations.

Ortiz-Padilla C, Gallego-Ortega D, Browne BC, Hochgräfe F, Caldon CE, Lyons RJ, Croucher DR, Rickwood D, Ormandy CJ, Brummer T, Daly RJ.

Oncogene. 2013 May 23;32(21):2696-702. doi: 10.1038/onc.2012.271. Epub 2012 Jul 2.


An essential role for katanin p80 and microtubule severing in male gamete production.

O'Donnell L, Rhodes D, Smith SJ, Merriner DJ, Clark BJ, Borg C, Whittle B, O'Connor AE, Smith LB, McNally FJ, de Kretser DM, Goodnow CC, Ormandy CJ, Jamsai D, O'Bryan MK.

PLoS Genet. 2012;8(5):e1002698. doi: 10.1371/journal.pgen.1002698. Epub 2012 May 24.


Grb10 regulates the development of fiber number in skeletal muscle.

Holt LJ, Turner N, Mokbel N, Trefely S, Kanzleiter T, Kaplan W, Ormandy CJ, Daly RJ, Cooney GJ.

FASEB J. 2012 Sep;26(9):3658-69. doi: 10.1096/fj.11-199349. Epub 2012 May 23.


Elf5, hormones and cell fate.

Lee HJ, Ormandy CJ.

Trends Endocrinol Metab. 2012 Jun;23(6):292-8. doi: 10.1016/j.tem.2012.02.006. Epub 2012 Mar 30. Review.


Interplay between progesterone and prolactin in mammary development and implications for breast cancer.

Lee HJ, Ormandy CJ.

Mol Cell Endocrinol. 2012 Jun 24;357(1-2):101-7. doi: 10.1016/j.mce.2011.09.020. Epub 2011 Sep 16. Review.


Lineage specific methylation of the Elf5 promoter in mammary epithelial cells.

Lee HJ, Hinshelwood RA, Bouras T, Gallego-Ortega D, Valdés-Mora F, Blazek K, Visvader JE, Clark SJ, Ormandy CJ.

Stem Cells. 2011 Oct;29(10):1611-9. doi: 10.1002/stem.706.


Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer.

O'Toole SA, Machalek DA, Shearer RF, Millar EK, Nair R, Schofield P, McLeod D, Cooper CL, McNeil CM, McFarland A, Nguyen A, Ormandy CJ, Qiu MR, Rabinovich B, Martelotto LG, Vu D, Hannigan GE, Musgrove EA, Christ D, Sutherland RL, Watkins DN, Swarbrick A.

Cancer Res. 2011 Jun 1;71(11):4002-14. doi: 10.1158/0008-5472.CAN-10-3738.


Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.

Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, Penninger JM.

Nature. 2010 Nov 4;468(7320):98-102. doi: 10.1038/nature09387. Epub 2010 Sep 29.


The antiproliferative effects of progestins in T47D breast cancer cells are tempered by progestin induction of the ETS transcription factor Elf5.

Hilton HN, Kalyuga M, Cowley MJ, Alles MC, Lee HJ, Caldon CE, Blazek K, Kaplan W, Musgrove EA, Daly RJ, Naylor MJ, Graham JD, Clarke CL, Ormandy CJ.

Mol Endocrinol. 2010 Jul;24(7):1380-92. doi: 10.1210/me.2009-0516. Epub 2010 Jun 2.


High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype.

Zardawi SJ, Zardawi I, McNeil CM, Millar EK, McLeod D, Morey AL, Crea P, Murphy NC, Pinese M, Lopez-Knowles E, Oakes SR, Ormandy CJ, Qiu MR, Hamilton A, Spillane A, Soon Lee C, Sutherland RL, Musgrove EA, O'Toole SA.

Histopathology. 2010 Feb;56(3):286-96. doi: 10.1111/j.1365-2559.2009.03475.x.


PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.

Chan CB, Liu X, Ensslin MA, Dillehay DL, Ormandy CJ, Sohn P, Serra R, Ye K.

EMBO J. 2010 Mar 3;29(5):956-68. doi: 10.1038/emboj.2009.406. Epub 2010 Jan 14.


Galanin mediates the pathogenesis of cerulein-induced acute pancreatitis in the mouse.

Bhandari M, Thomas AC, Hussey DJ, Li X, Jaya SP, Woods CM, Schloithe AC, Mayne GC, Carati CJ, Toouli J, Ormandy CJ, Saccone GT.

Pancreas. 2010 Mar;39(2):182-7. doi: 10.1097/MPA.0b013e3181bdc152.


Insulin, a key regulator of hormone responsive milk protein synthesis during lactogenesis in murine mammary explants.

Menzies KK, Lee HJ, Lefèvre C, Ormandy CJ, Macmillan KL, Nicholas KR.

Funct Integr Genomics. 2010 Mar;10(1):87-95. doi: 10.1007/s10142-009-0140-0. Epub 2009 Oct 15.


Meta-analysis and gene set enrichment relative to er status reveal elevated activity of MYC and E2F in the "basal" breast cancer subgroup.

Alles MC, Gardiner-Garden M, Nott DJ, Wang Y, Foekens JA, Sutherland RL, Musgrove EA, Ormandy CJ.

PLoS One. 2009;4(3):e4710. doi: 10.1371/journal.pone.0004710. Epub 2009 Mar 9.


Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer.

Musgrove EA, Sergio CM, Loi S, Inman CK, Anderson LR, Alles MC, Pinese M, Caldon CE, Schütte J, Gardiner-Garden M, Ormandy CJ, McArthur G, Butt AJ, Sutherland RL.

PLoS One. 2008 Aug 20;3(8):e2987. doi: 10.1371/journal.pone.0002987.


Identification of downstream targets of estrogen and c-myc in breast cancer cells.

Musgrove EA, Sergio CM, Anderson LR, Inman CK, McNeil CM, Alles MC, Gardiner-Garden M, Ormandy CJ, Butt AJ, Sutherland RL.

Adv Exp Med Biol. 2008;617:445-51. doi: 10.1007/978-0-387-69080-3_43.


Transcriptome analysis identifies pathways associated with enhanced maternal performance in QSi5 mice.

Ramanathan P, Martin IC, Gardiner-Garden M, Thomson PC, Taylor RM, Ormandy CJ, Moran C, Williamson P.

BMC Genomics. 2008 Apr 29;9:197. doi: 10.1186/1471-2164-9-197.


The Ets transcription factor Elf5 specifies mammary alveolar cell fate.

Oakes SR, Naylor MJ, Asselin-Labat ML, Blazek KD, Gardiner-Garden M, Hilton HN, Kazlauskas M, Pritchard MA, Chodosh LA, Pfeffer PL, Lindeman GJ, Visvader JE, Ormandy CJ.

Genes Dev. 2008 Mar 1;22(5):581-6. doi: 10.1101/gad.1614608.


Prolactin regulation of mammary gland development.

Oakes SR, Rogers RL, Naylor MJ, Ormandy CJ.

J Mammary Gland Biol Neoplasia. 2008 Mar;13(1):13-28. doi: 10.1007/s10911-008-9069-5. Epub 2008 Jan 25. Review.


KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling.

Hilton HN, Stanford PM, Harris J, Oakes SR, Kaplan W, Daly RJ, Ormandy CJ.

Biochim Biophys Acta. 2008 Mar;1783(3):383-93. doi: 10.1016/j.bbamcr.2007.12.007. Epub 2008 Jan 9.


Gata-3 and mammary cell fate.

Naylor MJ, Ormandy CJ.

Breast Cancer Res. 2007;9(2):302. Review.

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