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CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer.

Ferrandon S, DeVecchio J, Duraes L, Chouhan H, Karagkounis G, Davenport J, Orloff M, Liska D, Kalady MF.

Cancer Res. 2019 Nov 8. pii: canres.1161.2019. doi: 10.1158/0008-5472.CAN-19-1161. [Epub ahead of print]


A Prospective Phase II Trial of Radioembolization for Treatment of Uveal Melanoma Hepatic Metastasis.

Gonsalves CF, Eschelman DJ, Adamo RD, Anne PR, Orloff MM, Terai M, Hage AN, Yi M, Chervoneva I, Sato T.

Radiology. 2019 Oct;293(1):223-231. doi: 10.1148/radiol.2019190199. Epub 2019 Aug 27.


Using Machine Learning to Predict Progression in the Gastric Precancerous Process in a Population from a Developing Country Who Underwent a Gastroscopy for Dyspeptic Symptoms.

Thapa S, Fischbach LA, Delongchamp R, Faramawi MF, Orloff MS.

Gastroenterol Res Pract. 2019 Apr 1;2019:8321942. doi: 10.1155/2019/8321942. eCollection 2019.


The Association between Salt and Potential Mediators of the Gastric Precancerous Process.

Thapa S, Fischbach LA, Delongchamp R, Faramawi MF, Orloff M.

Cancers (Basel). 2019 Apr 15;11(4). pii: E535. doi: 10.3390/cancers11040535.


Association between Dietary Salt Intake and Progression in the Gastric Precancerous Process.

Thapa S, Fischbach LA, Delongchamp R, Faramawi MF, Orloff M.

Cancers (Basel). 2019 Apr 3;11(4). pii: E467. doi: 10.3390/cancers11040467.


Genome-wide tracts of homozygosity and exome analyses reveal repetitive elements with Barrets esophagus/esophageal adenocarcinoma risk.

Wanchai V, Jin J, Bircan E, Eng C, Orloff M.

BMC Bioinformatics. 2019 Mar 14;20(Suppl 2):98. doi: 10.1186/s12859-019-2622-y.


The meaning of confounding adjustment in the presence of multiple versions of treatment: an application to organ transplantation.

Wanis KN, Madenci AL, Dokus MK, Orloff MS, Levstik MA, Hernandez-Alejandro R, HernĂ¡n MA.

Eur J Epidemiol. 2019 Mar;34(3):225-233. doi: 10.1007/s10654-019-00484-8. Epub 2019 Jan 23.


Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma.

Chua V, Orloff M, Teh JL, Sugase T, Liao C, Purwin TJ, Lam BQ, Terai M, Ambrosini G, Carvajal RD, Schwartz G, Sato T, Aplin AE.

EMBO Mol Med. 2019 Feb;11(2). pii: e9081. doi: 10.15252/emmm.201809081.


Longterm Impact of Living Liver Donation: A Self-Report of the Donation Experience.

LaPointe Rudow D, DeLair S, Feeley T, Florman S, Guarrera J, Kinkhabwala M, Orloff M, Teperman L, Morgan G.

Liver Transpl. 2019 May;25(5):724-733. doi: 10.1002/lt.25402. Epub 2019 Mar 26.


Poly(ADP-Ribose) Polymerase Inhibition Sensitizes Colorectal Cancer-Initiating Cells to Chemotherapy.

Jarrar A, Lotti F, DeVecchio J, Ferrandon S, Gantt G, Mace A, Karagkounis G, Orloff M, Venere M, Hitomi M, Lathia J, Rich JN, Kalady MF.

Stem Cells. 2019 Jan;37(1):42-53. doi: 10.1002/stem.2929. Epub 2018 Nov 12.


PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin.

Apopa PL, Alley L, Penney RB, Arnaoutakis K, Steliga MA, Jeffus S, Bircan E, Gopalan B, Jin J, Patumcharoenpol P, Jenjaroenpun P, Wongsurawat T, Shah N, Boysen G, Ussery D, Nookaew I, Fagan P, Bebek G, Orloff MS.

Front Microbiol. 2018 Aug 6;9:1757. doi: 10.3389/fmicb.2018.01757. eCollection 2018.


CHECKPOINT INHIBITOR IMMUNE THERAPY: Systemic Indications and Ophthalmic Side Effects.

Dalvin LA, Shields CL, Orloff M, Sato T, Shields JA.

Retina. 2018 Jun;38(6):1063-1078. doi: 10.1097/IAE.0000000000002181. Review.


Melanoma Immunotherapy in the Elderly.

Orloff M.

Curr Oncol Rep. 2018 Mar 2;20(2):20. doi: 10.1007/s11912-018-0656-3. Review.


Accuracy of vascular invasion reporting in hepatocellular carcinoma before and after implementation of subspecialty surgical pathology sign-out.

Huber AR, Gonzalez RS, Orloff MS, Barry CT, Whitney-Miller CL.

Indian J Pathol Microbiol. 2017 Oct-Dec;60(4):501-504. doi: 10.4103/IJPM.IJPM_827_16.


Survey of Living Organ Donors' Experience and Directions for Process Improvement.

Li T, Dokus MK, Kelly KN, Ugoeke N, Rogers JR, Asham G, Sharma VA, Cirillo DJ, Robinson MK, Venniro EK, Taylor JG, Orloff MS, McIntosh S, Kashyap R.

Prog Transplant. 2017 Sep;27(3):232-239. doi: 10.1177/1526924817715467. Epub 2017 Jul 4.


PD-L1 expression in tumor metastasis is different between uveal melanoma and cutaneous melanoma.

Javed A, Arguello D, Johnston C, Gatalica Z, Terai M, Weight RM, Orloff M, Mastrangelo MJ, Sato T.

Immunotherapy. 2017 Dec;9(16):1323-1330. doi: 10.2217/imt-2017-0066.


Adjuvant Sunitinib in High-Risk Patients with Uveal Melanoma: Comparison with Institutional Controls.

Valsecchi ME, Orloff M, Sato R, Chervoneva I, Shields CL, Shields JA, Mastrangelo MJ, Sato T.

Ophthalmology. 2018 Feb;125(2):210-217. doi: 10.1016/j.ophtha.2017.08.017. Epub 2017 Sep 19.


Tobacco Use is a Modifiable Risk Factor for Post-Transplant Biliary Complications.

Dulaney DT, Dokus KM, McIntosh S, Al-Judaibi B, Ramaraju GA, Tomiyama K, Levstik M, Hernandez-Alejandro R, Orloff MS, Kashyap R.

J Gastrointest Surg. 2017 Oct;21(10):1643-1649. doi: 10.1007/s11605-017-3519-6. Epub 2017 Aug 7.


Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients.

Makhoul I, Todorova VK, Siegel ER, Erickson SW, Dhakal I, Raj VR, Lee JY, Orloff MS, Griffin RJ, Henry-Tillman RS, Klimberg S, Hutchins LF, Kadlubar SA.

PLoS One. 2017 Jan 3;12(1):e0168550. doi: 10.1371/journal.pone.0168550. eCollection 2017.


Case Report Demonstrating the Safe and Effective Means of Expanding the Donor Pool With Livers Recovered From Brain-Dead Donors After Ethylene Glycol Toxicity.

Fujii MH, Gierlach J, Alami S, Ericksen C, Kashyap R, Orloff MS, Marroquin CE.

Transplant Proc. 2016 Nov;48(9):3064-3066. doi: 10.1016/j.transproceed.2016.04.003.


2-amino-1-methyl-6-phenylimidazo(4,5-b) pyridine (PhIP) induces gene expression changes in JAK/STAT and MAPK pathways related to inflammation, diabetes and cancer.

Rogers LJ, Basnakian AG, Orloff MS, Ning B, Yao-Borengasser A, Raj V, Kadlubar S.

Nutr Metab (Lond). 2016 Aug 20;13:54. doi: 10.1186/s12986-016-0111-0. eCollection 2016.


Tuberculosis and leprosy infections in the Marshallese population of Arkansas, USA.

Cardenas VM, Orloff MS, Kaminaga J, Cardenas IC, Brown J, Hainline-Williams S, Duthie MS, Gonzalez-Puche AC, Mukasa L, Patil N, Mcelfish PA, Bates JH.

Lepr Rev. 2016 Mar;87(1):109-12.


Immune Check Point Inhibitors Combination in Melanoma: Worth the Toxicity?

Orloff M, Weight R, Valsecchi ME, Sato T.

Rev Recent Clin Trials. 2016;11(2):81-6.


Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells.

Terai M, Mu Z, Eschelman DJ, Gonsalves CF, Kageyama K, Chervoneva I, Orloff M, Weight R, Mastrangelo MJ, Cristofanilli M, Sato T.

EBioMedicine. 2015 Sep 18;2(11):1821-6. doi: 10.1016/j.ebiom.2015.09.019. eCollection 2015 Nov.


Comparison of outcomes between SBRT, yttrium-90 radioembolization, transarterial chemoembolization, and radiofrequency ablation as bridge to transplant for hepatocellular carcinoma.

Mohamed M, Katz AW, Tejani MA, Sharma AK, Kashyap R, Noel MS, Qiu H, Hezel AF, Ramaraju GA, Dokus MK, Orloff MS.

Adv Radiat Oncol. 2015 Dec 29;1(1):35-42. doi: 10.1016/j.adro.2015.12.003. eCollection 2016 Jan-Mar.


Parathyroid Hormone-Related Peptide-Linked Hypercalcemia in a Melanoma Patient Treated With Ipilimumab: Hormone Source and Clinical and Metabolic Correlates.

Mills TA, Orloff M, Domingo-Vidal M, Cotzia P, Birbe RC, Draganova-Tacheva R, Martinez Cantarin MP, Tuluc M, Martinez-Outschoorn U.

Semin Oncol. 2015 Dec;42(6):909-14. doi: 10.1053/j.seminoncol.2015.09.006. Epub 2015 Sep 8.


Successes and setbacks of early investigational drugs for melanoma.

Orloff M, Valsecchi ME, Sato T.

Expert Opin Investig Drugs. 2015;24(8):993-7. doi: 10.1517/13543784.2015.1051618. Epub 2015 Jun 12.


Association of specific PTEN/10q haplotypes with endometrial cancer phenotypes in African-American and European American women.

Sutton J, Orloff MS, Michener C, Chiesa-Vottero A, Prayson R, Nowacki AS, Eng C.

Gynecol Oncol. 2015 Aug;138(2):434-40. doi: 10.1016/j.ygyno.2015.05.024. Epub 2015 May 28.


Randomized trials of endoscopic therapy and transjugular intrahepatic portosystemic shunt versus portacaval shunt for emergency and elective treatment of bleeding gastric varices in cirrhosis.

Orloff MJ, Hye RJ, Wheeler HO, Isenberg JI, Haynes KS, Vaida F, Girard B, Orloff KJ.

Surgery. 2015 Jun;157(6):1028-45. doi: 10.1016/j.surg.2014.12.003.


A man in his 50s with a giant abdominal mass.

Tchantchaleishvili V, Kashyap R, Orloff MS.

JAMA Surg. 2015 Apr;150(4):363-4. doi: 10.1001/jamasurg.2014.871. No abstract available.


Genotypic and allelic variability in CYP19A1 among populations of African and European ancestry.

Starlard-Davenport A, Orloff MS, Dhakal I, Penney RB, Kadlubar SA.

PLoS One. 2015 Feb 3;10(2):e0117347. doi: 10.1371/journal.pone.0117347. eCollection 2015.


Unshuntable extrahepatic portal hypertension revisited: 43 years' experience with radical esophagogastrectomy treatment of bleeding esophagogastric varices.

Orloff MJ, Orloff MS, Orloff SL, Orloff LA, Daily PO, Girard B, Isenberg JI, Wheeler HO.

Am J Surg. 2014 Jan;207(1):46-52. doi: 10.1016/j.amjsurg.2013.06.001. Epub 2013 Sep 24.


It is more than just size: obesity and transplantation.

Orloff MS, Dokus MK.

Liver Transpl. 2013 Aug;19(8):790-5. doi: 10.1002/lt.23705. No abstract available.


Somatic hypermutations confer rheumatoid factor activity in hepatitis C virus-associated mixed cryoglobulinemia.

Charles ED, Orloff MI, Nishiuchi E, Marukian S, Rice CM, Dustin LB.

Arthritis Rheum. 2013 Sep;65(9):2430-40. doi: 10.1002/art.38041.


cgaTOH: extended approach for identifying tracts of homozygosity.

Zhang L, Orloff MS, Reber S, Li S, Zhao Y, Eng C.

PLoS One. 2013;8(3):e57772. doi: 10.1371/journal.pone.0057772. Epub 2013 Mar 1.


Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps.

Ngeow J, Heald B, Rybicki LA, Orloff MS, Chen JL, Liu X, Yerian L, Willis J, Lehtonen HJ, Lehtonen R, Mester JL, Moline J, Burke CA, Church J, Aaltonen LA, Eng C.

Gastroenterology. 2013 Jun;144(7):1402-9, 1409.e1-5. doi: 10.1053/j.gastro.2013.02.001. Epub 2013 Feb 8.


Diabetes mellitus impacts risk of macrovascular invasion in patients undergoing transplantation for hepatocellular carcinoma.

Connolly GC, Safadjou S, Kashyap R, Chen R, Orloff MS, Hezel AF.

BMC Gastroenterol. 2013 Jan 14;13:9. doi: 10.1186/1471-230X-13-9.


Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.

Orloff MS, He X, Peterson C, Chen F, Chen JL, Mester JL, Eng C.

Am J Hum Genet. 2013 Jan 10;92(1):76-80. doi: 10.1016/j.ajhg.2012.10.021. Epub 2012 Dec 13.


Utility of PTEN protein dosage in predicting for underlying germline PTEN mutations among patients presenting with thyroid cancer and Cowden-like phenotypes.

Ngeow J, He X, Mester JL, Lei J, Romigh T, Orloff MS, Milas M, Eng C.

J Clin Endocrinol Metab. 2012 Dec;97(12):E2320-7. doi: 10.1210/jc.2012-2944. Epub 2012 Oct 12.


Randomized controlled trial of emergency transjugular intrahepatic portosystemic shunt versus emergency portacaval shunt treatment of acute bleeding esophageal varices in cirrhosis.

Orloff MJ, Vaida F, Haynes KS, Hye RJ, Isenberg JI, Jinich-Brook H.

J Gastrointest Surg. 2012 Nov;16(11):2094-111. doi: 10.1007/s11605-012-2003-6. Epub 2012 Sep 25.


Analysis of cell viability using time-dependent increase in fluorescence intensity.

Hamalainen-Laanaya HK, Orloff MS.

Anal Biochem. 2012 Oct 1;429(1):32-8. doi: 10.1016/j.ab.2012.07.006. Epub 2012 Jul 14.


Invasive fungal infections following liver transplantation: incidence, risk factors, survival, and impact of fluconazole-resistant Candida parapsilosis (2003-2007).

Raghuram A, Restrepo A, Safadjou S, Cooley J, Orloff M, Hardy D, Butler S, Koval CE.

Liver Transpl. 2012 Sep;18(9):1100-9. doi: 10.1002/lt.23467.


Disability index in a randomized controlled trial of emergency sclerotherapy versus portacaval shunt for bleeding varices in cirrhosis.

Orloff MJ, Isenberg JI, Wheeler HO, Haynes KS, Jinich-Brook H, Rapier R, Vaida F, Hye RJ, Orloff SL.

Am J Surg. 2012 Aug;204(2):157-66. doi: 10.1016/j.amjsurg.2011.09.034. Epub 2012 May 9.


Extensive abdominal aortitis in a patient with Crohn's disease.

Lebude B, Orloff M, Coben R.

J Cardiovasc Med (Hagerstown). 2012 Sep;13(9):587-9. doi: 10.2459/JCM.0b013e3283536b12.


Child-Turcotte score versus MELD for prognosis in a randomized controlled trial of emergency treatment of bleeding esophageal varices in cirrhosis.

Orloff MJ, Vaida F, Isenberg JI, Wheeler HO, Haynes KS, Jinich-Brook H, Rapier R, Hye RJ, Orloff SL.

J Surg Res. 2012 Nov;178(1):139-46. doi: 10.1016/j.jss.2012.01.004. Epub 2012 Mar 10.


Integrative genomic analysis reveals extended germline homozygosity with lung cancer risk in the PLCO cohort.

Orloff MS, Zhang L, Bebek G, Eng C.

PLoS One. 2012;7(2):e31975. doi: 10.1371/journal.pone.0031975. Epub 2012 Feb 27.


Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes.

Ashida S, Orloff MS, Bebek G, Zhang L, Zheng P, Peehl DM, Eng C.

Clin Cancer Res. 2012 Mar 15;18(6):1578-87. doi: 10.1158/1078-0432.CCR-11-2535. Epub 2012 Jan 24.


Lifetime cancer risks in individuals with germline PTEN mutations.

Tan MH, Mester JL, Ngeow J, Rybicki LA, Orloff MS, Eng C.

Clin Cancer Res. 2012 Jan 15;18(2):400-7. doi: 10.1158/1078-0432.CCR-11-2283.

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