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The SPOSIB SB2 Sicilian Cohort: Safety and Effectiveness of Infliximab Biosimilar SB2 in Inflammatory Bowel Diseases, Including Multiple Switches.

Macaluso FS, Fries W, Viola A, Centritto A, Cappello M, Giuffrida E, Privitera AC, Piccillo G, Magnano A, Vinci E, Vassallo R, Trovatello A, Belluardo N, Giangreco E, Camilleri S, Garufi S, Bertolami C, Ventimiglia M, Renna S, Orlando R, Rizzuto G, Orlando A.

Inflamm Bowel Dis. 2020 Feb 21. pii: izaa036. doi: 10.1093/ibd/izaa036. [Epub ahead of print]


Cellulose cone tip as a sorbent material for multiphase electrical field-assisted extraction of cocaine from saliva and determination by LC-MS/MS.

Sousa DVM, Pereira FV, Nascentes CC, Moreira JS, Boratto VHM, Orlando RM.

Talanta. 2020 Feb 1;208:120353. doi: 10.1016/j.talanta.2019.120353. Epub 2019 Sep 16.


Highly aggressive undifferentiated small round blue cell tumor of foot with unique SMARCA1, KAT6A and NAV3 mutations.

Parsa C, Orlando R, Marcus M, Guo J, Rupani R.

J Surg Case Rep. 2019 Sep 7;2019(9):rjz245. doi: 10.1093/jscr/rjz245. eCollection 2019 Sep.


N-linked Glycan Release Efficiency: A Quantitative Comparison between NaOCl and PNGase F Release Protocols.

Fischler DA, Orlando R.

J Biomol Tech. 2019 Dec;30(4):58-63. doi: 10.7171/jbt.19-3004-001.


Letter: psoriasiform eruption during vedolizumab therapy.

Garbo GM, Renna S, Caputo V, Orlando E, Macaluso FS, Orlando R, Bongiorno MR, Orlando A.

Aliment Pharmacol Ther. 2019 Aug;50(3):342-343. doi: 10.1111/apt.15389. No abstract available.


Compensated Hydroxyl Radical Protein Footprinting Measures Buffer and Excipient Effects on Conformation and Aggregation in an Adalimumab Biosimilar.

Misra SK, Orlando R, Weinberger SR, Sharp JS.

AAPS J. 2019 Jul 11;21(5):87. doi: 10.1208/s12248-019-0358-2.


Public reporting and transparency: a primer on public outcomes reporting.

Romanelli JR, Fuchshuber PR, Stulberg JJ, Kowalski RB, Sinha P, Aloia TA, Orlando R 3rd.

Surg Endosc. 2019 Jul;33(7):2043-2049. doi: 10.1007/s00464-019-06756-4. Epub 2019 Jun 3.


Development and Evaluation of a 66-Well Plate Using a Porous Sorbent in a Four-Phase Extraction Assisted by Electric Field Approach.

Orlando RM, Nascentes CC, Botelho BG, Moreira JS, Costa KA, de Miranda Boratto VH.

Anal Chem. 2019 May 21;91(10):6471-6478. doi: 10.1021/acs.analchem.8b04943. Epub 2019 May 10.


Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia.

Nicoletti F, Orlando R, Di Menna L, Cannella M, Notartomaso S, Mascio G, Iacovelli L, Matrisciano F, Fazio F, Caraci F, Copani A, Battaglia G, Bruno V.

Front Psychiatry. 2019 Feb 14;10:49. doi: 10.3389/fpsyt.2019.00049. eCollection 2019. Review.


Letter: SPOSIB SB2-a Sicilian prospective observational study of IBD patients treated with infliximab biosimilar SB2.

Macaluso FS, Cappello M, Giuffrida E, Fries W, Centritto A, Privitera AC, Inserra G, Vassallo R, Magnano A, Vinci E, Garufi S, Ventimiglia M, Renna S, Orlando R, Rizzuto G, Cottone M, Orlando A; Sicilian Network for Inflammatory Bowel Disease (SN-IBD).

Aliment Pharmacol Ther. 2019 Jan;49(2):234-236. doi: 10.1111/apt.15071. No abstract available.


Predicting the HILIC Retention Behavior of the N-Linked Glycopeptides Produced by Trypsin Digestion of Immunoglobulin Gs (IgGs).

Badgett MJ, Mize E, Fletcher T, Boyes B, Orlando R.

J Biomol Tech. 2018 Dec;29(4):98-104. doi: 10.7171/jbt.18-2904-002.


A Propensity Score-matched Comparison of Infliximab and Adalimumab in Tumour Necrosis Factor-α Inhibitor-naïve and Non-naïve Patients With Crohn's Disease: Real-Life Data From the Sicilian Network for Inflammatory Bowel Disease.

Macaluso FS, Fries W, Privitera AC, Cappello M, Siringo S, Inserra G, Magnano A, Di Mitri R, Mocciaro F, Belluardo N, Scarpulla G, Magrì G, Trovatello A, Carroccio A, Genova S, Bertolami C, Vassallo R, Romano C, Citrano M, Accomando S, Ventimiglia M, Renna S, Orlando R, Rizzuto G, Porcari S, Ferracane C, Cottone M, Orlando A; Sicilian Network for Inflammatory Bowel Diseases [SN-IBD].

J Crohns Colitis. 2019 Feb 1;13(2):209-217. doi: 10.1093/ecco-jcc/jjy156.


Proteomics reveals localization of cuticular proteins in Anopheles gambiae.

Zhou Y, Badgett MJ, Orlando R, Willis JH.

Insect Biochem Mol Biol. 2019 Jan;104:91-105. doi: 10.1016/j.ibmb.2018.09.011. Epub 2018 Sep 29.


In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator.

Zuena AR, Iacovelli L, Orlando R, Di Menna L, Casolini P, Alemà GS, Di Cicco G, Battaglia G, Nicoletti F.

Front Pharmacol. 2018 Jul 31;9:804. doi: 10.3389/fphar.2018.00804. eCollection 2018.


Can trained volunteers improve the mealtime care of older hospital patients? An implementation study in one English hospital.

Howson FFA, Robinson SM, Lin SX, Orlando R, Cooper C, Sayer AAP, Roberts HC.

BMJ Open. 2018 Aug 5;8(8):e022285. doi: 10.1136/bmjopen-2018-022285.


A real life comparison of the effectiveness of adalimumab and golimumab in moderate-to-severe ulcerative colitis, supported by propensity score analysis.

Renna S, Mocciaro F, Ventimiglia M, Orlando R, Macaluso FS, Cappello M, Fries W, Mendolaro M, Privitera AC, Ferracane C, Pisana V, Magnano A, Pluchino D, Inserra G, Scarpulla G, Garufi S, Carroccio A, Siringo S, Di Mitri R, Cottone M, Orlando A.

Dig Liver Dis. 2018 Dec;50(12):1292-1298. doi: 10.1016/j.dld.2018.06.008. Epub 2018 Jun 22.


Invited Commentary.

Orlando R 3rd.

J Am Coll Surg. 2018 Jun;226(6):976-977. doi: 10.1016/j.jamcollsurg.2018.03.016. No abstract available.


Adaptation, Acceptance and Adaptive Preferences in Health and Capability Well-Being Measurement Amongst Those Approaching End of Life.

Coast J, Bailey C, Orlando R, Armour K, Perry R, Jones L, Kinghorn P.

Patient. 2018 Oct;11(5):539-546. doi: 10.1007/s40271-018-0310-z.


Stress as risk factor for Alzheimer's disease.

Caruso A, Nicoletti F, Mango D, Saidi A, Orlando R, Scaccianoce S.

Pharmacol Res. 2018 Jun;132:130-134. doi: 10.1016/j.phrs.2018.04.017. Epub 2018 Apr 22. Review.


Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria.

Nardecchia F, Orlando R, Iacovelli L, Colamartino M, Fiori E, Leuzzi V, Piccinin S, Nistico R, Puglisi-Allegra S, Di Menna L, Battaglia G, Nicoletti F, Pascucci T.

Front Neurosci. 2018 Mar 16;12:154. doi: 10.3389/fnins.2018.00154. eCollection 2018.


The real-world effectiveness of vedolizumab on intestinal and articular outcomes in inflammatory bowel diseases.

Macaluso FS, Orlando R, Fries W, Scolaro M, Magnano A, Pluchino D, Cappello M, Morreale GC, Siringo S, Privitera AC, Ferracane C, Belluardo N, Alberghina N, Ventimiglia M, Rizzuto G, Renna S, Cottone M, Orlando A.

Dig Liver Dis. 2018 Jul;50(7):675-681. doi: 10.1016/j.dld.2018.02.013. Epub 2018 Mar 1.


Targeting metabotropic glutamate receptors in the treatment of primary brain tumors.

Iacovelli L, Orlando R, Rossi A, Spinsanti P, Melchiorri D, Nicoletti F.

Curr Opin Pharmacol. 2018 Feb;38:59-64. doi: 10.1016/j.coph.2018.02.005. Epub 2018 Mar 8. Review.


Letter: the addition of an immunosuppressant in patients with unsatisfactory response to vedolizumab.

Macaluso FS, Orlando R, Renna S, Sapienza C, Ventimiglia M, Rizzuto G, Cottone M, Orlando A.

Aliment Pharmacol Ther. 2018 Apr;47(7):1040-1041. doi: 10.1111/apt.14541. No abstract available.


The Addition of an Immunosuppressant After Loss of Response to Anti-TNFα Monotherapy in Inflammatory Bowel Disease: A 2-Year Study.

Macaluso FS, Sapienza C, Ventimiglia M, Renna S, Rizzuto G, Orlando R, Di Pisa M, Affronti M, Orlando E, Cottone M, Orlando A.

Inflamm Bowel Dis. 2018 Jan 18;24(2):394-401. doi: 10.1093/ibd/izx010.


Peptide retention prediction using hydrophilic interaction liquid chromatography coupled to mass spectrometry.

Badgett MJ, Boyes B, Orlando R.

J Chromatogr A. 2018 Feb 16;1537:58-65. doi: 10.1016/j.chroma.2017.12.055. Epub 2018 Jan 11.


Gene-nutrient interactions and susceptibility to human obesity.

Castillo JJ, Orlando RA, Garver WS.

Genes Nutr. 2017 Oct 30;12:29. doi: 10.1186/s12263-017-0581-3. eCollection 2017. Review.


Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.

Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F.

Neuropharmacology. 2018 Jan;128:301-313. doi: 10.1016/j.neuropharm.2017.10.026. Epub 2017 Oct 25.


Fragments of e-Cadherin as Biomarkers of Non-erosive Reflux Disease.

Jovov B, Reed CC, Shaheen NJ, Pruitt A, Ferrell K, Orlando GS, Djukic Z, Orlando RC.

Dig Dis Sci. 2018 Mar;63(3):628-635. doi: 10.1007/s10620-017-4815-4. Epub 2017 Oct 25.


Kinetics of N-Glycan Release from Human Immunoglobulin G (IgG) by PNGase F: All Glycans Are Not Created Equal.

Huang Y, Orlando R.

J Biomol Tech. 2017 Dec;28(4):150-157. doi: 10.7171/jbt.17-2804-002. Epub 2017 Oct 9.


Epidemiology and pathogenesis of fulminant viral hepatitis in pregnant women.

Tosone G, Simeone D, Spera AM, Viceconte G, Bianco V, Orlando R.

Minerva Ginecol. 2018 Aug;70(4):480-486. doi: 10.23736/S0026-4784.17.04107-7. Epub 2017 Oct 9. Review.


Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain.

Fonseca FC, Orlando RM, Turchetti-Maia RM, de Francischi JN.

J Inflamm Res. 2017 Aug 29;10:119-133. doi: 10.2147/JIR.S142424. eCollection 2017.


Topically Applied Carvedilol Attenuates Solar Ultraviolet Radiation Induced Skin Carcinogenesis.

Huang KM, Liang S, Yeung S, Oiyemhonlan E, Cleveland KH, Parsa C, Orlando R, Meyskens FL Jr, Andresen BT, Huang Y.

Cancer Prev Res (Phila). 2017 Oct;10(10):598-606. doi: 10.1158/1940-6207.CAPR-17-0132. Epub 2017 Aug 15.


Large-Scale Condensed Matter DFT Simulations: Performance and Capabilities of the CRYSTAL Code.

Erba A, Baima J, Bush I, Orlando R, Dovesi R.

J Chem Theory Comput. 2017 Oct 10;13(10):5019-5027. doi: 10.1021/acs.jctc.7b00687. Epub 2017 Sep 19.


Outstanding Scientific Poster Awards for the ABRF 2017 Organized by the Education Committee and Sponsored by Waters Corporation.

Orlando R.

J Biomol Tech. 2017 Sep;28(3):135-136. doi: 10.7171/jbt.17-2803-004. Epub 2017 Aug 4. No abstract available.


Predicting the Retention Behavior of Specific O-Linked Glycopeptides.

Badgett MJ, Boyes B, Orlando R.

J Biomol Tech. 2017 Sep;28(3):122-126. doi: 10.7171/jbt.17-2803-003. Epub 2017 Aug 4.


An update on epidemiology of congenital rubella syndrome: how far from the World Health Organization goals?

Bianco V, Spera AM, Simeone D, Tosone G, Orlando R.

Minerva Med. 2017 Oct;108(5):483-485. doi: 10.23736/S0026-4806.17.05103-5. Review. No abstract available.


Reversible Hypokalemia and Bartter-Like Syndrome during Prolonged Systemic Therapy with Colistimethate Sodium in an Adult Patient.

Kamal Eldin T, Tosone G, Capuano A, Orlando R.

Drug Saf Case Rep. 2017 Dec;4(1):10. doi: 10.1007/s40800-017-0052-1.


A global evolutionary and metabolic analysis of human obesity gene risk variants.

Castillo JJ, Hazlett ZS, Orlando RA, Garver WS.

Gene. 2017 Sep 5;627:412-419. doi: 10.1016/j.gene.2017.07.002. Epub 2017 Jul 4.


SAGES quality initiative: an introduction.

Lidor A, Telem D, Bower C, Sinha P, Orlando R 3rd, Romanelli J.

Surg Endosc. 2017 Aug;31(8):3072-3077. doi: 10.1007/s00464-017-5627-5. Epub 2017 Jun 29.


Tolerability profile of thiopurines in inflammatory bowel disease: a prospective experience.

Macaluso FS, Renna S, Maida M, Dimarco M, Sapienza C, Affronti M, Orlando E, Rizzuto G, Orlando R, Ventimiglia M, Cottone M, Orlando A.

Scand J Gastroenterol. 2017 Sep;52(9):981-987. doi: 10.1080/00365521.2017.1333626. Epub 2017 May 29.


Simultaneous determination of fumonisins B1 and B2 in different types of maize by matrix solid phase dispersion and HPLC-MS/MS.

de Oliveira GB, de Castro Gomes Vieira CM, Orlando RM, Faria AF.

Food Chem. 2017 Oct 15;233:11-19. doi: 10.1016/j.foodchem.2017.04.091. Epub 2017 Apr 18.


The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways.

Castillo JJ, Jelinek D, Wei H, Gannon NP, Vaughan RA, Horwood LJ, Meaney FJ, Garcia-Smith R, Trujillo KA, Heidenreich RA, Meyre D, Orlando RA, LeBoeuf RC, Garver WS.

Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E183-E194. doi: 10.1152/ajpendo.00369.2016. Epub 2017 May 9.


Properties of the cuticular proteins of Anopheles gambiae as revealed by serial extraction of adults.

Zhou Y, Badgett MJ, Billard L, Bowen JH, Orlando R, Willis JH.

PLoS One. 2017 Apr 18;12(4):e0175423. doi: 10.1371/journal.pone.0175423. eCollection 2017.


Inhibition of Neoplastic Transformation and Chemically-Induced Skin Hyperplasia in Mice by Traditional Chinese Medicinal Formula Si-Wu-Tang.

Liu MM, Huang KM, Yeung S, Chang A, Zhang S, Mei N, Parsa C, Orlando R, Huang Y.

Nutrients. 2017 Mar 18;9(3). pii: E300. doi: 10.3390/nu9030300.


Ethological principles predict the neuropeptides co-opted to influence parenting.

Cunningham CB, Badgett MJ, Meagher RB, Orlando R, Moore AJ.

Nat Commun. 2017 Feb 1;8:14225. doi: 10.1038/ncomms14225.


Clinical benefit of vedolizumab on articular manifestations in patients with active spondyloarthritis associated with inflammatory bowel disease.

Orlando A, Orlando R, Ciccia F, Renna S, Rizzo A, Cottone M, Macaluso FS.

Ann Rheum Dis. 2017 Sep;76(9):e31. doi: 10.1136/annrheumdis-2016-211011. Epub 2017 Jan 17. No abstract available.


Managing complex respiratory patients in the community: an evaluation of a pilot integrated respiratory care service.

Gillett K, Lippiett K, Astles C, Longstaff J, Orlando R, Lin SX, Powell A, Roberts C, Chauhan AJ, Thomas M, Wilkinson TM.

BMJ Open Respir Res. 2016 Dec 5;3(1):e000145. doi: 10.1136/bmjresp-2016-000145. eCollection 2016.


A Multivariate Mixture Model to Estimate the Accuracy of Glycosaminoglycan Identifications Made by Tandem Mass Spectrometry (MS/MS) and Database Search.

Chiu Y, Schliekelman P, Orlando R, Sharp JS.

Mol Cell Proteomics. 2017 Feb;16(2):255-264. doi: 10.1074/mcp.M116.062588. Epub 2016 Dec 9.

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