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Items: 9


X-ray and cryo-EM structures of the mitochondrial calcium uniporter.

Fan C, Fan M, Orlando BJ, Fastman NM, Zhang J, Xu Y, Chambers MG, Xu X, Perry K, Liao M, Feng L.

Nature. 2018 Jul;559(7715):575-579. doi: 10.1038/s41586-018-0330-9. Epub 2018 Jul 11.


Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.

Dong L, Yuan C, Orlando BJ, Malkowski MG, Smith WL.

J Biol Chem. 2016 Dec 2;291(49):25641-25655. Epub 2016 Oct 18.


Crystal structure of rofecoxib bound to human cyclooxygenase-2.

Orlando BJ, Malkowski MG.

Acta Crystallogr F Struct Biol Commun. 2016 Oct 1;72(Pt 10):772-776. Epub 2016 Sep 22.


Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone.

Orlando BJ, Malkowski MG.

J Biol Chem. 2016 Jul 15;291(29):15069-81. doi: 10.1074/jbc.M116.725713. Epub 2016 May 20.


Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.

Lucido MJ, Orlando BJ, Vecchio AJ, Malkowski MG.

Biochemistry. 2016 Mar 1;55(8):1226-38. doi: 10.1021/acs.biochem.5b01378. Epub 2016 Feb 19.


Pulsed Dipolar Spectroscopy Reveals That Tyrosyl Radicals Are Generated in Both Monomers of the Cyclooxygenase-2 Dimer.

Orlando BJ, Borbat PP, Georgieva ER, Freed JH, Malkowski MG.

Biochemistry. 2015 Dec 22;54(50):7309-12. doi: 10.1021/acs.biochem.5b00979. Epub 2015 Dec 7.


The structure of ibuprofen bound to cyclooxygenase-2.

Orlando BJ, Lucido MJ, Malkowski MG.

J Struct Biol. 2015 Jan;189(1):62-6. doi: 10.1016/j.jsb.2014.11.005. Epub 2014 Nov 25.


Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs.

Orlando BJ, McDougle DR, Lucido MJ, Eng ET, Graham LA, Schneider C, Stokes DL, Das A, Malkowski MG.

Arch Biochem Biophys. 2014 Mar 15;546:33-40. doi: 10.1016/ Epub 2014 Feb 3.


Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove.

Vecchio AJ, Orlando BJ, Nandagiri R, Malkowski MG.

J Biol Chem. 2012 Jul 13;287(29):24619-30. doi: 10.1074/jbc.M112.372243. Epub 2012 May 25.

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