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The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/β1 integrin complex in endothelial cell adhesion and migration.

Barbera S, Nardi F, Elia I, Realini G, Lugano R, Santucci A, Tosi GM, Dimberg A, Galvagni F, Orlandini M.

Cell Commun Signal. 2019 May 28;17(1):55. doi: 10.1186/s12964-019-0375-x.


The Controversial Role of TGF-β in Neovascular Age-Related Macular Degeneration Pathogenesis.

Tosi GM, Orlandini M, Galvagni F.

Int J Mol Sci. 2018 Oct 27;19(11). pii: E3363. doi: 10.3390/ijms19113363. Review.


Publisher Correction: TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration.

Tosi GM, Neri G, Caldi E, Fusco F, Bacci T, Tarantello A, Nuti E, Marigliani D, Baiocchi S, Traversi C, Barbarino M, Eandi CM, Parolini B, Mundo L, Santucci A, Orlandini M, Galvagni F.

Sci Rep. 2018 Jun 29;8(1):10141. doi: 10.1038/s41598-018-28203-5.


TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration.

Tosi GM, Neri G, Caldi E, Fusco F, Bacci T, Tarantello A, Nuti E, Marigliani D, Baiocchi S, Traversi C, Barbarino M, Eandi CM, Parolini B, Mundo L, Santucci A, Orlandini M, Galvagni F.

Sci Rep. 2018 May 23;8(1):8053. doi: 10.1038/s41598-018-26442-0. Erratum in: Sci Rep. 2018 Jun 29;8(1):10141.


Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.

Bernardini G, Geminiani M, Gambassi S, Orlandini M, Petricci E, Marzocchi B, Laschi M, Taddei M, Manetti F, Santucci A.

J Cell Physiol. 2018 Jun;233(6):4961-4971. doi: 10.1002/jcp.26330. Epub 2018 Jan 15.


Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium.

Galvagni F, Nardi F, Spiga O, Trezza A, Tarticchio G, Pellicani R, Andreuzzi E, Caldi E, Toti P, Tosi GM, Santucci A, Iozzo RV, Mongiat M, Orlandini M.

Matrix Biol. 2017 Dec;64:112-127. doi: 10.1016/j.matbio.2017.08.003. Epub 2017 Sep 11.


Efficacy of a hydroactive colloid gel versus historical controls for the prevention of radiotherapy-induced moist desquamation in breast cancer patients.

Censabella S, Claes S, Orlandini M, Braekers R, Bulens P.

Eur J Oncol Nurs. 2017 Aug;29:1-7. doi: 10.1016/j.ejon.2017.04.003. Epub 2017 Apr 29.


Histological and Ultrastructural Characterization of Alkaptonuric Tissues.

Millucci L, Bernardini G, Spreafico A, Orlandini M, Braconi D, Laschi M, Geminiani M, Lupetti P, Giorgetti G, Viti C, Frediani B, Marzocchi B, Santucci A.

Calcif Tissue Int. 2017 Jul;101(1):50-64. doi: 10.1007/s00223-017-0260-9. Epub 2017 Mar 7.


HTRA1 and TGF-β1 Concentrations in the Aqueous Humor of Patients With Neovascular Age-Related Macular Degeneration.

Tosi GM, Caldi E, Neri G, Nuti E, Marigliani D, Baiocchi S, Traversi C, Cevenini G, Tarantello A, Fusco F, Nardi F, Orlandini M, Galvagni F.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):162-167. doi: 10.1167/iovs.16-20922.


Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria.

Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL, Petricci E, Manetti F, Taddei M, Knight MM, Santucci A.

J Cell Physiol. 2017 Nov;232(11):3103-3111. doi: 10.1002/jcp.25761. Epub 2017 Mar 29.


CD93 as a Potential Target in Neovascular Age-Related Macular Degeneration.

Tosi GM, Caldi E, Parolini B, Toti P, Neri G, Nardi F, Traversi C, Cevenini G, Marigliani D, Nuti E, Bacci T, Galvagni F, Orlandini M.

J Cell Physiol. 2017 Jul;232(7):1767-1773. doi: 10.1002/jcp.25689. Epub 2016 Nov 30.


Angiogenesis in alkaptonuria.

Millucci L, Bernardini G, Marzocchi B, Braconi D, Geminiani M, Gambassi S, Laschi M, Frediani B, Galvagni F, Orlandini M, Santucci A.

J Inherit Metab Dis. 2016 Nov;39(6):801-806. Epub 2016 Sep 26.


Immediate stabilization of human blood for delayed quantification of endogenous thiols and disulfides.

Giustarini D, Galvagni F, Orlandini M, Fanti P, Rossi R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Apr 15;1019:51-8. doi: 10.1016/j.jchromb.2016.02.009. Epub 2016 Feb 8.


CD93 and dystroglycan cooperation in human endothelial cell adhesion and migration adhesion and migration.

Galvagni F, Nardi F, Maida M, Bernardini G, Vannuccini S, Petraglia F, Santucci A, Orlandini M.

Oncotarget. 2016 Mar 1;7(9):10090-103. doi: 10.18632/oncotarget.7136.


Diagnosis of secondary amyloidosis in alkaptonuria.

Millucci L, Ghezzi L, Bernardini G, Braconi D, Lupetti P, Perfetto F, Orlandini M, Santucci A.

Diagn Pathol. 2014 Sep 26;9:185. doi: 10.1186/s13000-014-0185-9.


Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes.

Galvagni F, Lentucci C, Neri F, Dettori D, De Clemente C, Orlandini M, Anselmi F, Rapelli S, Grillo M, Borghi S, Oliviero S.

Stem Cells. 2015 Mar;33(3):742-50. doi: 10.1002/stem.1898.


Chondroptosis in alkaptonuric cartilage.

Millucci L, Giorgetti G, Viti C, Ghezzi L, Gambassi S, Braconi D, Marzocchi B, Paffetti A, Lupetti P, Bernardini G, Orlandini M, Santucci A.

J Cell Physiol. 2015 May;230(5):1148-57. doi: 10.1002/jcp.24850.


Retrospective study of radiotherapy-induced skin reactions in breast cancer patients: reduced incidence of moist desquamation with a hydroactive colloid gel versus dexpanthenol.

Censabella S, Claes S, Orlandini M, Braekers R, Thijs H, Bulens P.

Eur J Oncol Nurs. 2014 Oct;18(5):499-504. doi: 10.1016/j.ejon.2014.04.009. Epub 2014 May 28.


Amyloidosis, inflammation, and oxidative stress in the heart of an alkaptonuric patient.

Millucci L, Ghezzi L, Paccagnini E, Giorgetti G, Viti C, Braconi D, Laschi M, Geminiani M, Soldani P, Lupetti P, Orlandini M, Benvenuti C, Perfetto F, Spreafico A, Bernardini G, Santucci A.

Mediators Inflamm. 2014;2014:258471. doi: 10.1155/2014/258471. Epub 2014 Apr 28.


The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target.

Orlandini M, Galvagni F, Bardelli M, Rocchigiani M, Lentucci C, Anselmi F, Zippo A, Bini L, Oliviero S.

Oncotarget. 2014 May 15;5(9):2750-60.


Proteomics and phosphoproteomics provide insights into the mechanism of action of a novel pyrazolo[3,4-d]pyrimidine Src inhibitor in human osteosarcoma.

Bernardini G, Laschi M, Serchi T, Spreafico A, Botta M, Schenone S, Arena S, Geminiani M, Scaloni A, Collodel G, Orlandini M, Niccolai N, Santucci A.

Mol Biosyst. 2014 Jun;10(6):1305-12. doi: 10.1039/c3mb70328b. Epub 2014 Mar 11.


Secondary amyloidosis in an alkaptonuric aortic valve.

Millucci L, Ghezzi L, Braconi D, Laschi M, Geminiani M, Amato L, Orlandini M, Benvenuti C, Bernardini G, Santucci A.

Int J Cardiol. 2014;172(1):e121-3. doi: 10.1016/j.ijcard.2013.12.117. Epub 2014 Jan 4. No abstract available.


Frequency of and factors associated with vascular complications after pediatric liver transplantation.

Orlandini M, Feier FH, Jaeger B, Kieling C, Vieira SG, Zanotelli ML.

J Pediatr (Rio J). 2014 Mar-Apr;90(2):169-75. doi: 10.1016/j.jped.2013.08.010. Epub 2013 Dec 24.


Role of the AP-1 transcription factor FOSL1 in endothelial cells adhesion and migration.

Galvagni F, Orlandini M, Oliviero S.

Cell Adh Migr. 2013 Sep-Oct;7(5):408-11. doi: 10.4161/cam.25894. Epub 2013 Jul 25. Review.


FOSL1 controls the assembly of endothelial cells into capillary tubes by direct repression of αv and β3 integrin transcription.

Evellin S, Galvagni F, Zippo A, Neri F, Orlandini M, Incarnato D, Dettori D, Neubauer S, Kessler H, Wagner EF, Oliviero S.

Mol Cell Biol. 2013 Mar;33(6):1198-209. doi: 10.1128/MCB.01054-12. Epub 2013 Jan 14.


Measured vs simulated portal images for low MU fields on three accelerator types: possible consequences for 2D portal dosimetry.

Podesta M, Nijsten SM, Snaith J, Orlandini M, Lustberg T, Emans D, Aland T, Verhaegen F.

Med Phys. 2012 Dec;39(12):7470-9. doi: 10.1118/1.4761950.


Alkaptonuria is a novel human secondary amyloidogenic disease.

Millucci L, Spreafico A, Tinti L, Braconi D, Ghezzi L, Paccagnini E, Bernardini G, Amato L, Laschi M, Selvi E, Galeazzi M, Mannoni A, Benucci M, Lupetti P, Chellini F, Orlandini M, Santucci A.

Biochim Biophys Acta. 2012 Nov;1822(11):1682-91. doi: 10.1016/j.bbadis.2012.07.011. Epub 2012 Jul 28.


An apical actin-rich domain drives the establishment of cell polarity during cell adhesion.

Galvagni F, Baldari CT, Oliviero S, Orlandini M.

Histochem Cell Biol. 2012 Sep;138(3):419-33. doi: 10.1007/s00418-012-0965-9. Epub 2012 May 29.


c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1.

Anselmi F, Orlandini M, Rocchigiani M, De Clemente C, Salameh A, Lentucci C, Oliviero S, Galvagni F.

Angiogenesis. 2012 Jun;15(2):187-97. doi: 10.1007/s10456-012-9252-6. Epub 2012 Feb 11.


Surfome analysis of a wild-type wine Saccharomyces cerevisiae strain.

Braconi D, Amato L, Bernardini G, Arena S, Orlandini M, Scaloni A, Santucci A.

Food Microbiol. 2011 Sep;28(6):1220-30. doi: 10.1016/ Epub 2011 May 4.


Growth factor stimulation induces cell survival by c-Jun. ATF2-dependent activation of Bcl-XL.

Salameh A, Galvagni F, Anselmi F, De Clemente C, Orlandini M, Oliviero S.

J Biol Chem. 2010 Jul 23;285(30):23096-104. doi: 10.1074/jbc.M109.087221. Epub 2010 May 27.


Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity.

Galvagni F, Pennacchini S, Salameh A, Rocchigiani M, Neri F, Orlandini M, Petraglia F, Gotta S, Sardone GL, Matteucci G, Terstappen GC, Oliviero S.

Circ Res. 2010 Jun 25;106(12):1839-48. doi: 10.1161/CIRCRESAHA.109.206326. Epub 2010 Apr 29.


[Severe case of male external genitalia injury in a polytraumatized patient].

Venzano F, Simonato A, Ambruosi A, Montanaro T, Orlandini M, Varca V, Carmignani G.

Urologia. 2009 Apr-Jun;76(2):153-5. Italian. No abstract available.


[Early vs delayed radical cystectomy compared in highgrade superficial bladder tumors].

Varca V, Simonato A, Esposito M, Curotto A, Orlandini M, Rikani E.

Urologia. 2009 Apr-Jun;76(2):83-6. Italian.


Morphogenesis of human endothelial cells is inhibited by DAB2 via Src.

Orlandini M, Nucciotti S, Galvagni F, Bardelli M, Rocchigiani M, Petraglia F, Oliviero S.

FEBS Lett. 2008 Jul 23;582(17):2542-8. doi: 10.1016/j.febslet.2008.06.025. Epub 2008 Jun 26.


Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells.

Spreafico A, Schenone S, Serchi T, Orlandini M, Angelucci A, Magrini D, Bernardini G, Collodel G, Di Stefano A, Tintori C, Bologna M, Manetti F, Botta M, Santucci A.

FASEB J. 2008 May;22(5):1560-71. doi: 10.1096/fj.07-9873com. Epub 2008 Jan 2.


Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice.

Manetti F, Santucci A, Locatelli GA, Maga G, Spreafico A, Serchi T, Orlandini M, Bernardini G, Caradonna NP, Spallarossa A, Brullo C, Schenone S, Bruno O, Ranise A, Bondavalli F, Hoffmann O, Bologna M, Angelucci A, Botta M.

J Med Chem. 2007 Nov 15;50(23):5579-88. Epub 2007 Oct 11.


VEGF-D is expressed in activated lymphoid cells and in tumors of hematopoietic and lymphoid tissues.

Bardelli M, Leucci E, Schürfeld K, Bellan C, Passiatore G, Rocchigiani M, Bartolommei S, Orlandini M, Zagursky J, Lazzi S, De Falco G, Tosi P, Oliviero S, Leoncini L.

Leuk Lymphoma. 2007 Oct;48(10):2014-21.


Vascular endothelial growth factor receptor-3 activity is modulated by its association with caveolin-1 on endothelial membrane.

Galvagni F, Anselmi F, Salameh A, Orlandini M, Rocchigiani M, Oliviero S.

Biochemistry. 2007 Apr 3;46(13):3998-4005. Epub 2007 Mar 10.


Vascular endothelial growth factor-D activates VEGFR-3 expressed in osteoblasts inducing their differentiation.

Orlandini M, Spreafico A, Bardelli M, Rocchigiani M, Salameh A, Nucciotti S, Capperucci C, Frediani B, Oliviero S.

J Biol Chem. 2006 Jun 30;281(26):17961-7. Epub 2006 Apr 19.


Beta-catenin inversely regulates vascular endothelial growth factor-D mRNA stability.

Orlandini M, Semboloni S, Oliviero S.

J Biol Chem. 2003 Nov 7;278(45):44650-6. Epub 2003 Aug 13.


In fibroblasts Vegf-D expression is induced by cell-cell contact mediated by cadherin-11.

Orlandini M, Oliviero S.

J Biol Chem. 2001 Mar 2;276(9):6576-81. Epub 2000 Dec 6.


Discovery of a transient absorption edge in the X-ray spectrum of GRB 990705.

Amati L, Frontera F, Vietri M, in 't Zand JJ, Soffitta P, Costa E, Del Sordo S, Pian E, Piro L, Antonelli LA, Fiume DD, Feroci M, Gandolfi G, Guidorzi C, Heise J, Kuulkers E, Masetti N, Montanari E, Nicastro L, Orlandini M, Palazzi E.

Science. 2000 Nov 3;290(5493):953-5.


BeppoSAX and Chandra Observations of SAX J0103.2-7209 = 2E 0101.5-7225: A New Persistent 345 Second X-Ray Pulsar in the Small Magellanic Cloud.

Israel GL, Campana S, Covino S, Dal Fiume D, Gaetz TJ, Mereghetti S, Oosterbroek T, Orlandini M, Parmar AN, Ricci D, Stella L.

Astrophys J. 2000 Mar 10;531(2):L131-L134.


Protein kinase CK2alpha' is induced by serum as a delayed early gene and cooperates with Ha-ras in fibroblast transformation.

Orlandini M, Semplici F, Ferruzzi R, Meggio F, Pinna LA, Oliviero S.

J Biol Chem. 1998 Aug 14;273(33):21291-7.


Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes.

Rocchigiani M, Lestingi M, Luddi A, Orlandini M, Franco B, Rossi E, Ballabio A, Zuffardi O, Oliviero S.

Genomics. 1998 Jan 15;47(2):207-16.


Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family.

Orlandini M, Marconcini L, Ferruzzi R, Oliviero S.

Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11675-80. Erratum in: Proc Natl Acad Sci U S A 1997 Feb 18;94(4):1603.


Was it infarction or haemorrhage? A clinical diagnosis by means of the Allen score.

Celani MG, Ceravolo MG, Duca E, Minciotti P, Caputo N, Orlandini M, Ricci S, Provinciali L.

J Neurol. 1992 Aug;239(7):411-3.


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