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Items: 1 to 50 of 59


Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites.

Guo Y, Crnkovic CM, Won KJ, Yang X, Lee JR, Orjala J, Lee H, Jeong H.

Drug Metab Dispos. 2019 Mar;47(3):194-202. doi: 10.1124/dmd.118.084772. Epub 2018 Dec 31.


The impact of culture conditions on growth and metabolomic profiles of freshwater cyanobacteria.

Crnkovic CM, May DS, Orjala J.

J Appl Phycol. 2018 Feb;30(1):375-384. doi: 10.1007/s10811-017-1275-3. Epub 2017 Sep 14.


Calothrixamides A and B from the Cultured Cyanobacterium Calothrix sp. UIC 10520.

Crnkovic CM, Krunic A, May DS, Wilson TA, Kao D, Burdette JE, Fuchs JR, Oberlies NH, Orjala J.

J Nat Prod. 2018 Sep 28;81(9):2083-2090. doi: 10.1021/acs.jnatprod.8b00432. Epub 2018 Sep 7.


Complete Genome of Micromonospora sp. Strain B006 Reveals Biosynthetic Potential of a Lake Michigan Actinomycete.

Braesel J, Crnkovic CM, Kunstman KJ, Green SJ, Maienschein-Cline M, Orjala J, Murphy BT, Eustáquio AS.

J Nat Prod. 2018 Sep 28;81(9):2057-2068. doi: 10.1021/acs.jnatprod.8b00394. Epub 2018 Aug 15.


Hapalindole H Induces Apoptosis as an Inhibitor of NF-ĸB and Affects the Intrinsic Mitochondrial Pathway in PC-3 Androgen-insensitive Prostate Cancer Cells.

Acuña UM, Mo S, Zi J, Orjala J, DE Blanco EJC.

Anticancer Res. 2018 Jun;38(6):3299-3307. doi: 10.21873/anticanres.12595.


Total Synthesis of Scytonemide A Employing Weinreb AM Solid-Phase Resin.

Wilson TA, Tokarski RJ 2nd, Sullivan P, Demoret RM, Orjala J, Rakotondraibe LH, Fuchs JR.

J Nat Prod. 2018 Mar 23;81(3):534-542. doi: 10.1021/acs.jnatprod.7b00912. Epub 2018 Feb 5.


Ribocyclophanes A-E, Glycosylated Cyclophanes with Antiproliferative Activity from Two Cultured Terrestrial Cyanobacteria.

May DS, Kang HS, Santarsiero BD, Krunic A, Shen Q, Burdette JE, Swanson SM, Orjala J.

J Nat Prod. 2018 Mar 23;81(3):572-578. doi: 10.1021/acs.jnatprod.7b00954. Epub 2018 Jan 30.


Merocyclophanes C and D from the Cultured Freshwater Cyanobacterium Nostoc sp. (UIC 10110).

May DS, Chen WL, Lantvit DD, Zhang X, Krunic A, Burdette JE, Eustaquio A, Orjala J.

J Nat Prod. 2017 Apr 28;80(4):1073-1080. doi: 10.1021/acs.jnatprod.6b01175. Epub 2017 Mar 2.


Discovery of Anticancer Agents of Diverse Natural Origin.

Kinghorn AD, DE Blanco EJ, Lucas DM, Rakotondraibe HL, Orjala J, Soejarto DD, Oberlies NH, Pearce CJ, Wani MC, Stockwell BR, Burdette JE, Swanson SM, Fuchs JR, Phelps MA, Xu L, Zhang X, Shen YY.

Anticancer Res. 2016 Nov;36(11):5623-5637. Review.


Antimicrobial Activity of Croton macrostachyus Stem Bark Extracts against Several Human Pathogenic Bacteria.

Obey JK, von Wright A, Orjala J, Kauhanen J, Tikkanen-Kaukanen C.

J Pathog. 2016;2016:1453428. doi: 10.1155/2016/1453428. Epub 2016 May 11.


Ambiguine I Isonitrile from Fischerella ambigua Induces Caspase-Independent Cell Death in MCF-7 Hormone Dependent Breast Cancer Cells.

Acuña UM, Zi J, Orjala J, Carcache de Blanco EJ.

Int J Cancer Res (Tortola). 2015 Mar;49(1):1655-1662.


Application of high-field NMR spectroscopy for characterization and quantitation of submilligram quantities of isolated natural products.

Krunić A, Orjala J.

Magn Reson Chem. 2015 Dec;53(12):1043-50. doi: 10.1002/mrc.4304. Epub 2015 Aug 20.


Microseiramide from the Freshwater Cyanobacterium Microseira sp. UIC 10445.

Luo S, Krunic A, Chlipala GE, Orjala J.

Phytochem Lett. 2015 Sep 1;13:47-52.


Trichormamides C and D, antiproliferative cyclic lipopeptides from the cultured freshwater cyanobacterium cf. Oscillatoria sp. UIC 10045.

Luo S, Kang HS, Krunic A, Chen WL, Yang J, Woodard JL, Fuchs JR, Hyun Cho S, Franzblau SG, Swanson SM, Orjala J.

Bioorg Med Chem. 2015 Jul 1;23(13):3153-62. doi: 10.1016/j.bmc.2015.04.073. Epub 2015 May 1.


Carbamidocyclophanes F and G with Anti-Mycobacterium tuberculosis Activity from the Cultured Freshwater Cyanobacterium Nostoc sp.

Luo S, Kang HS, Krunic A, Chlipala GE, Cai G, Chen WL, Franzblau SG, Swanson SM, Orjala J.

Tetrahedron Lett. 2014 Jan 15;55(3):686-689.


Trichormamides A and B with Antiproliferative Activity from the Cultured Freshwater Cyanobacterium Trichormus sp. UIC 10339.

Luo S, Krunic A, Kang HS, Chen WL, Woodard JL, Fuchs JR, Swanson SM, Orjala J.

J Nat Prod. 2014 Aug 22;77(8):1871-80. doi: 10.1021/np5003548. Epub 2014 Aug 4.


Essential parameters for structural analysis and dereplication by (1)H NMR spectroscopy.

Pauli GF, Chen SN, Lankin DC, Bisson J, Case RJ, Chadwick LR, Gödecke T, Inui T, Krunic A, Jaki BU, McAlpine JB, Mo S, Napolitano JG, Orjala J, Lehtivarjo J, Korhonen SP, Niemitz M.

J Nat Prod. 2014 Jun 27;77(6):1473-87. doi: 10.1021/np5002384. Epub 2014 Jun 4.


Special issue in honor of Professor Otto Sticher.

Orjala J, Hamburger M, Tasdemir D, Kinghorn AD.

J Nat Prod. 2014 Mar 28;77(3):439-40. doi: 10.1021/np5001076. Epub 2014 Feb 24. No abstract available.


Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi.

Pearce CJ, Lantvit DD, Shen Q, Jarjoura D, Zhang X, Oberlies NH, Kroll DJ, Wani MC, Orjala J, Soejarto DD, Farnsworth NR, de Blanco EJ, Fuchs JR, Kinghorn AD, Swanson SM.

Methods Mol Biol. 2012;944:267-77. doi: 10.1007/978-1-62703-122-6_20.


Chemical Diversity of Metabolites from Fungi, Cyanobacteria, and Plants Relative to FDA-Approved Anticancer Agents.

El-Elimat T, Zhang X, Jarjoura D, Moy FJ, Orjala J, Kinghorn AD, Pearce CJ, Oberlies NH.

ACS Med Chem Lett. 2012 Jul 12;3(8):645-649.


Minutissamides E-L, antiproliferative cyclic lipodecapeptides from the cultured freshwater cyanobacterium cf. Anabaena sp.

Kang HS, Sturdy M, Krunic A, Kim H, Shen Q, Swanson SM, Orjala J.

Bioorg Med Chem. 2012 Oct 15;20(20):6134-43. doi: 10.1016/j.bmc.2012.08.017. Epub 2012 Aug 22.


Indole alkaloids from two cultured cyanobacteria, Westiellopsis sp. and Fischerella muscicola.

Kim H, Lantvit D, Hwang CH, Kroll DJ, Swanson SM, Franzblau SG, Orjala J.

Bioorg Med Chem. 2012 Sep 1;20(17):5290-5. doi: 10.1016/j.bmc.2012.06.030. Epub 2012 Jul 5.


Sanctolide A, a 14-membered PK-NRP hybrid macrolide from the cultured cyanobacterium Oscillatoria sancta (SAG 74.79).

Kang HS, Krunic A, Orjala J.

Tetrahedron Lett. 2012 Jul 11;53(28):3563-3567. Epub 2012 May 3.


Merocyclophanes A and B, antiproliferative cyclophanes from the cultured terrestrial Cyanobacterium Nostoc sp.

Kang HS, Santarsiero BD, Kim H, Krunic A, Shen Q, Swanson SM, Chai H, Kinghorn AD, Orjala J.

Phytochemistry. 2012 Jul;79:109-15. doi: 10.1016/j.phytochem.2012.03.005. Epub 2012 May 7.


Stigonemapeptin, an Ahp-containing depsipeptide with elastase inhibitory activity from the bloom-forming freshwater cyanobacterium Stigonema sp.

Kang HS, Krunic A, Orjala J.

J Nat Prod. 2012 Apr 27;75(4):807-11. doi: 10.1021/np300150h. Epub 2012 Apr 6.


Nitrile-Containing Fischerindoles from the Cultured Cyanobacterium Fischerella sp.

Kim H, Krunic A, Lantvit D, Shen Q, Kroll DJ, Swanson SM, Orjala J.

Tetrahedron. 2012 Apr 15;68(15):3205-3209.


Lyngbyaureidamides A and B, two anabaenopeptins from the cultured freshwater cyanobacterium Lyngbya sp. (SAG 36.91).

Zi J, Lantvit DD, Swanson SM, Orjala J.

Phytochemistry. 2012 Feb;74:173-7. doi: 10.1016/j.phytochem.2011.09.017. Epub 2011 Dec 5.


Minutissamides A-D, antiproliferative cyclic decapeptides from the cultured cyanobacterium Anabaena minutissima.

Kang HS, Krunic A, Shen Q, Swanson SM, Orjala J.

J Nat Prod. 2011 Jul 22;74(7):1597-605. doi: 10.1021/np2002226. Epub 2011 Jun 23.


Chemodiversity in freshwater and terrestrial cyanobacteria - a source for drug discovery.

Chlipala GE, Mo S, Orjala J.

Curr Drug Targets. 2011 Oct;12(11):1654-73. Review.


CYANOS: a data management system for natural product drug discovery efforts using cultured microorganisms.

Chlipala GE, Krunic A, Mo S, Sturdy M, Orjala J.

J Chem Inf Model. 2011 Jan 24;51(1):171-80. doi: 10.1021/ci100280a. Epub 2010 Dec 16.


Scytonemides A and B, cyclic peptides with 20S proteasome inhibitory activity from the cultured cyanobacterium Scytonema hofmanii.

Krunic A, Vallat A, Mo S, Lantvit DD, Swanson SM, Orjala J.

J Nat Prod. 2010 Nov 29;73(11):1927-32. doi: 10.1021/np100600z. Epub 2010 Nov 8.


Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua.

Mo S, Krunic A, Santarsiero BD, Franzblau SG, Orjala J.

Phytochemistry. 2010 Dec;71(17-18):2116-23. doi: 10.1016/j.phytochem.2010.09.004. Epub 2010 Oct 19.


Cylindrocyclophanes with proteasome inhibitory activity from the Cyanobacterium Nostoc sp.

Chlipala GE, Sturdy M, Krunic A, Lantvit DD, Shen Q, Porter K, Swanson SM, Orjala J.

J Nat Prod. 2010 Sep 24;73(9):1529-37. doi: 10.1021/np100352e.


Eucapsitrione, an anti-Mycobacterium tuberculosis anthraquinone derivative from the cultured freshwater cyanobacterium Eucapsis sp.

Sturdy M, Krunic A, Cho S, Franzblau S, Orjala J.

J Nat Prod. 2010 Aug 27;73(8):1441-3. doi: 10.1021/np100299v.


Antimalarial activity of Aspilia pruliseta, a medicinal plant from Uganda.

Sebisubi FM, Odyek O, Anokbonggo WW, Ogwal-Okeng J, Carcache-Blanco EJ, Ma C, Orjala J, Tan GT.

Planta Med. 2010 Nov;76(16):1870-3. doi: 10.1055/s-0030-1250028. Epub 2010 Jun 10.


Nhatrangins A and B, aplysiatoxin-related metabolites from the marine cyanobacterium Lyngbya majuscula from Vietnam.

Chlipala GE, Pham HT, Nguyen VH, Krunic A, Shim SH, Soejarto DD, Orjala J.

J Nat Prod. 2010 Apr 23;73(4):784-7. doi: 10.1021/np100002q.


Estrogenic and serotonergic butenolides from the leaves of Piper hispidum Swingle (Piperaceae).

Michel JL, Chen Y, Zhang H, Huang Y, Krunic A, Orjala J, Veliz M, Soni KK, Soejarto DD, Caceres A, Perez A, Mahady GB.

J Ethnopharmacol. 2010 May 27;129(2):220-6. doi: 10.1016/j.jep.2010.03.008. Epub 2010 Mar 19. Erratum in: J Ethnopharmacol. 2012 Jun 26;142(1):316-7.


Discovery of anticancer agents of diverse natural origin.

Kinghorn AD, Carcache de Blanco EJ, Chai HB, Orjala J, Farnsworth NR, Soejarto DD, Oberlies NH, Wani MC, Kroll DJ, Pearce CJ, Swanson SM, Kramer RA, Rose WC, Fairchild CR, Vite GD, Emanuel S, Jarjoura D, Cope FO.

Pure Appl Chem. 2009 Jan 1;81(6):1051-1063.


An antimicrobial guanidine-bearing sesterterpene from the cultured cyanobacterium Scytonema sp.

Mo S, Krunic A, Pegan SD, Franzblau SG, Orjala J.

J Nat Prod. 2009 Nov;72(11):2043-5. doi: 10.1021/np900288x.


Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents.

Guo S, Tipparaju SK, Pegan SD, Wan B, Mo S, Orjala J, Mesecar AD, Franzblau SG, Kozikowski AP.

Bioorg Med Chem. 2009 Oct 15;17(20):7126-30. doi: 10.1016/j.bmc.2009.08.061. Epub 2009 Sep 4.


Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua.

Mo S, Krunic A, Chlipala G, Orjala J.

J Nat Prod. 2009 May 22;72(5):894-9. doi: 10.1021/np800751j.


Investigation of antimicrobial and protease-inhibitory activity from cultured cyanobacteria.

Chlipala G, Mo S, Carcache de Blanco EJ, Ito A, Bazarek S, Orjala J.

Pharm Biol. 2009 Jan;47(1):53-60.


Isolation and structure determination of a proteasome inhibitory metabolite from a culture of Scytonema hofmanni.

Shim SH, Chlipala G, Orjala J.

J Microbiol Biotechnol. 2008 Oct;18(10):1655-8. Erratum in: J Microbiol Biotechnol. 2009 Feb;19(2):215.


Microscale LC-MS-NMR platform applied to the identification of active cyanobacterial metabolites.

Lin Y, Schiavo S, Orjala J, Vouros P, Kautz R.

Anal Chem. 2008 Nov 1;80(21):8045-54. doi: 10.1021/ac801049k. Epub 2008 Oct 4.


Short peptide induces an "uncultivable" microorganism to grow in vitro.

Nichols D, Lewis K, Orjala J, Mo S, Ortenberg R, O'Connor P, Zhao C, Vouros P, Kaeberlein T, Epstein SS.

Appl Environ Microbiol. 2008 Aug;74(15):4889-97. doi: 10.1128/AEM.00393-08. Epub 2008 May 30.


Phytochemical and biological investigation of Begonia heracleifolia.

Frei B, Heinrich M, Herrmann D, Orjala JE, Schmitt J, Sticher O.

Planta Med. 1998 May;64(4):385-6.


Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.

Fang L, Ito A, Chai HB, Mi Q, Jones WP, Madulid DR, Oliveros MB, Gao Q, Orjala J, Farnsworth NR, Soejarto DD, Cordell GA, Swanson SM, Pezzuto JM, Kinghorn AD.

J Nat Prod. 2006 Mar;69(3):332-7.


Novel extracellular diterpenoids with biological activity from the cyanobacterium Nostoc commune.

Jaki B, Orjala J, Heilmann J, Linden A, Vogler B, Sticher O.

J Nat Prod. 2000 Mar;63(3):339-43.


Acylated flavonol glycosides from leaves of Stenochlaena palustris.

Liu H, Orjala J, Sticher O, Rali T.

J Nat Prod. 1999 Jan;62(1):70-5.


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