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Items: 1 to 50 of 64

1.

Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state.

Mizukoshi K, Okazawa Y, Haeno H, Koyama Y, Sulidan K, Komiyama H, Saeki H, Ohtsuji N, Ito Y, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K, Orimo A.

Int J Cancer. 2019 Sep 10. doi: 10.1002/ijc.32672. [Epub ahead of print]

PMID:
31506938
2.

Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity.

Matsumura Y, Ito Y, Mezawa Y, Sulidan K, Daigo Y, Hiraga T, Mogushi K, Wali N, Suzuki H, Itoh T, Miyagi Y, Yokose T, Shimizu S, Takano A, Terao Y, Saeki H, Ozawa M, Abe M, Takeda S, Okumura K, Habu S, Hino O, Takeda K, Hamada M, Orimo A.

Life Sci Alliance. 2019 Jul 22;2(4). pii: e201900425. doi: 10.26508/lsa.201900425. Print 2019 Aug.

3.

CD26 expression is attenuated by TGF-β and SDF-1 autocrine signaling on stromal myofibroblasts in human breast cancers.

Mezawa Y, Daigo Y, Takano A, Miyagi Y, Yokose T, Yamashita T, Morimoto C, Hino O, Orimo A.

Cancer Med. 2019 Jul;8(8):3936-3948. doi: 10.1002/cam4.2249. Epub 2019 May 29.

4.

Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies.

Yoshida GJ, Azuma A, Miura Y, Orimo A.

Int J Mol Sci. 2019 May 7;20(9). pii: E2256. doi: 10.3390/ijms20092256. Review.

5.

High-sensitivity Detection of Micrometastases Generated by GFP Lentivirus-transduced Organoids Cultured from a Patient-derived Colon Tumor.

Okazawa Y, Mizukoshi K, Koyama Y, Okubo S, Komiyama H, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K, Orimo A.

J Vis Exp. 2018 Jun 14;(136). doi: 10.3791/57374.

PMID:
29985333
6.

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.

Roswall P, Bocci M, Bartoschek M, Li H, Kristiansen G, Jansson S, Lehn S, Sjölund J, Reid S, Larsson C, Eriksson P, Anderberg C, Cortez E, Saal LH, Orsmark-Pietras C, Cordero E, Haller BK, Häkkinen J, Burvenich IJG, Lim E, Orimo A, Höglund M, Rydén L, Moch H, Scott AM, Eriksson U, Pietras K.

Nat Med. 2018 May;24(4):463-473. doi: 10.1038/nm.4494. Epub 2018 Mar 12.

7.

The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.

Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.

Oncogene. 2018 Mar;37(9):1205-1219. doi: 10.1038/s41388-017-0033-y. Epub 2017 Dec 15.

PMID:
29242607
8.

Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth.

Nakaoka HJ, Tanei Z, Hara T, Weng JS, Kanamori A, Hayashi T, Sato H, Orimo A, Otsuji K, Tada K, Morikawa T, Sasaki T, Fukayama M, Seiki M, Murakami Y, Sakamoto T.

Oncogenesis. 2017 May 15;6(5):e334. doi: 10.1038/oncsis.2017.27.

9.

Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes.

Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama KY, Taka H, Kaga N, Orimo A, Liu X, Takahashi K.

Respir Res. 2017 Mar 11;18(1):46. doi: 10.1186/s12931-017-0529-6.

10.

Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer.

Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirström K, Pietras K, Blom AM.

Oncogene. 2016 Oct 27;35(43):5585-5596. doi: 10.1038/onc.2016.98. Epub 2016 Apr 11.

PMID:
27065333
11.

Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer.

Escudero-Esparza A, Bartoschek M, Gialeli C, Okroj M, Owen S, Jirström K, Orimo A, Jiang WG, Pietras K, Blom AM.

Oncotarget. 2016 Nov 22;7(47):76920-76933. doi: 10.18632/oncotarget.12729.

12.

The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas.

Mezawa Y, Orimo A.

Cell Tissue Res. 2016 Sep;365(3):675-89. doi: 10.1007/s00441-016-2471-1. Epub 2016 Aug 10. Review.

PMID:
27506216
13.

The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and infiltrating T cells is associated with better prognosis of breast cancer patients.

Englund E, Reitsma B, King BC, Escudero-Esparza A, Owen S, Orimo A, Okroj M, Anagnostaki L, Jiang WG, Jirström K, Blom AM.

BMC Cancer. 2015 Oct 19;15:737. doi: 10.1186/s12885-015-1734-7.

14.

Carcinoma-associated fibroblasts are a promising therapeutic target.

Togo S, Polanska UM, Horimoto Y, Orimo A.

Cancers (Basel). 2013 Jan 31;5(1):149-69. doi: 10.3390/cancers5010149.

15.

Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells.

Polanska UM, Orimo A.

J Cell Physiol. 2013 Aug;228(8):1651-7. doi: 10.1002/jcp.24347. Review.

PMID:
23460038
16.

Transforming growth factor-β: guardian of catabolic metabolism in carcinoma-associated fibroblasts.

Khan HY, Orimo A.

Cell Cycle. 2012 Dec 1;11(23):4302-3. doi: 10.4161/cc.22811. Epub 2012 Nov 16. No abstract available.

17.

Emerging roles of the tumor-associated stroma in promoting tumor metastasis.

Horimoto Y, Polanska UM, Takahashi Y, Orimo A.

Cell Adh Migr. 2012 May-Jun;6(3):193-202. doi: 10.4161/cam.20631. Epub 2012 May 1. Review.

18.

Experimental generation of carcinoma-associated fibroblasts (CAFs) from human mammary fibroblasts.

Polanska UM, Acar A, Orimo A.

J Vis Exp. 2011 Oct 25;(56):e3201. doi: 10.3791/3201.

19.

Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts.

Kojima Y, Acar A, Eaton EN, Mellody KT, Scheel C, Ben-Porath I, Onder TT, Wang ZC, Richardson AL, Weinberg RA, Orimo A.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20009-14. doi: 10.1073/pnas.1013805107. Epub 2010 Nov 1.

20.

Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression.

Shimoda M, Mellody KT, Orimo A.

Semin Cell Dev Biol. 2010 Feb;21(1):19-25. doi: 10.1016/j.semcdb.2009.10.002. Epub 2009 Oct 24. Review.

21.

Heterogeneity of stromal fibroblasts in tumors.

Orimo A, Weinberg RA.

Cancer Biol Ther. 2007 Apr;6(4):618-9. No abstract available.

PMID:
18027438
22.

Stromal fibroblasts in cancer: a novel tumor-promoting cell type.

Orimo A, Weinberg RA.

Cell Cycle. 2006 Aug;5(15):1597-601. Epub 2006 Aug 1. Review.

PMID:
16880743
23.

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion.

Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA.

Cell. 2005 May 6;121(3):335-48.

24.

Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression.

Orimo A, Tomioka Y, Shimizu Y, Sato M, Oigawa S, Kamata K, Nogi Y, Inoue S, Takahashi M, Hata T, Muramatsu M.

Clin Cancer Res. 2001 Oct;7(10):3097-105.

25.

Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem.

Orimo A, Tominaga N, Yoshimura K, Yamauchi Y, Nomura M, Sato M, Nogi Y, Suzuki M, Suzuki H, Ikeda K, Inoue S, Muramatsu M.

Genomics. 2000 Oct 1;69(1):143-9.

PMID:
11013086
26.

Molecular cloning of testis-abundant finger Protein/Ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC.

Orimo A, Yamagishi T, Tominaga N, Yamauchi Y, Hishinuma T, Okada K, Suzuki M, Sato M, Nogi Y, Suzuki H, Inoue S, Yoshimura K, Shimizu Y, Muramatsu M.

Biochem Biophys Res Commun. 2000 Sep 16;276(1):45-51.

PMID:
11006080
27.

Chromosome mapping of RNF16 and rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family.

Ogawa S, Saito T, Matsuda Y, Seki N, Hayashi A, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, Hori T, Inoue S.

Cytogenet Cell Genet. 2000;89(1-2):56-8.

PMID:
10894938
28.

Impaired estrogen sensitivity in bone by inhibiting both estrogen receptor alpha and beta pathways.

Ogawa S, Fujita M, Ishii Y, Tsurukami H, Hirabayashi M, Ikeda K, Orimo A, Hosoi T, Ueda M, Nakamura T, Ouchi Y, Muramatsu M, Inoue S.

J Biol Chem. 2000 Jul 14;275(28):21372-9.

29.

Efp as a primary estrogen-responsive gene in human breast cancer.

Ikeda K, Orimo A, Higashi Y, Muramatsu M, Inoue S.

FEBS Lett. 2000 Apr 21;472(1):9-13.

30.

Estrogen activates telomerase.

Kyo S, Takakura M, Kanaya T, Zhuo W, Fujimoto K, Nishio Y, Orimo A, Inoue M.

Cancer Res. 1999 Dec 1;59(23):5917-21.

31.

Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor alpha.

Orimo A, Inoue S, Minowa O, Tominaga N, Tomioka Y, Sato M, Kuno J, Hiroi H, Shimizu Y, Suzuki M, Noda T, Muramatsu M.

Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12027-32.

32.

Molecular cloning of rat efp: expression and regulation in primary osteoblasts.

Inoue S, Urano T, Ogawa S, Saito T, Orimo A, Hosoi T, Ouchi Y, Muramatsu M.

Biochem Biophys Res Commun. 1999 Aug 2;261(2):412-8.

PMID:
10425199
33.

[The molecular mechanisms of estrogen action against senile disease].

Orimo A, Inoue S, Muramatsu M, Noda T.

Nihon Ronen Igakkai Zasshi. 1999 Feb;36(2):95-8. Japanese. No abstract available.

34.

Successful germ-line transmission of chimeras generated by coculture aggregation with J1 ES cells and eight-cell embryos.

Orimo A, Tominaga N, Suzuki M, Kawakami T, Kuno J, Sato M, Minowa O, Inoue S, Kato S, Noda T, Muramatsu M.

Anal Biochem. 1999 Apr 10;269(1):204-7. No abstract available.

PMID:
10094797
35.

Differential immunolocalization of estrogen receptor alpha and beta in rat ovary and uterus.

Hiroi H, Inoue S, Watanabe T, Goto W, Orimo A, Momoeda M, Tsutsumi O, Taketani Y, Muramatsu M.

J Mol Endocrinol. 1999 Feb;22(1):37-44.

PMID:
9924178
36.

NMDA receptor type 2D gene as target for estrogen receptor in the brain.

Watanabe T, Inoue S, Hiroi H, Orimo A, Muramatsu M.

Brain Res Mol Brain Res. 1999 Jan 8;63(2):375-9.

PMID:
9878838
37.

Molecular cloning, localization, and developmental expression of mouse brain finger protein (Bfp)/ZNF179: distribution of bfp mRNA partially coincides with the affected areas of Smith-Magenis syndrome.

Orimo A, Inoue S, Ikeda K, Sato M, Kato A, Tominaga N, Suzuki M, Noda T, Watanabe M, Muramatsu M.

Genomics. 1998 Nov 15;54(1):59-69.

PMID:
9806830
38.

Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis.

Ogawa S, Goto W, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, Inoue S.

Biochem Biophys Res Commun. 1998 Oct 20;251(2):515-9.

PMID:
9792805
39.
40.

Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human.

Ogawa S, Inoue S, Watanabe T, Orimo A, Hosoi T, Ouchi Y, Muramatsu M.

Nucleic Acids Res. 1998 Aug 1;26(15):3505-12.

41.

UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells.

Okuda A, Fukushima A, Nishimoto M, Orimo A, Yamagishi T, Nabeshima Y, Kuro-o M, Nabeshima Yi, Boon K, Keaveney M, Stunnenberg HG, Muramatsu M.

EMBO J. 1998 Apr 1;17(7):2019-32.

42.

Cross-inhibition of both estrogen receptor alpha and beta pathways by each dominant negative mutant.

Ogawa S, Inoue S, Orimo A, Hosoi T, Ouchi Y, Muramatsu M.

FEBS Lett. 1998 Feb 20;423(2):129-32.

43.

[New medicinal action of native hormone].

Orimo A, Inoue S, Minowa O, Ikeda K, Hiroi H, Ogawa S, Watanabe T, Kuno J, Noda T, Muramatsu M.

Nihon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:44P-49P. Review. Japanese.

PMID:
9503404
44.

The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro.

Ogawa S, Inoue S, Watanabe T, Hiroi H, Orimo A, Hosoi T, Ouchi Y, Muramatsu M.

Biochem Biophys Res Commun. 1998 Feb 4;243(1):122-6.

PMID:
9473491
45.

Isolation of estrogen-responsive genes with a CpG island library.

Watanabe T, Inoue S, Hiroi H, Orimo A, Kawashima H, Muramatsu M.

Mol Cell Biol. 1998 Jan;18(1):442-9.

46.

A novel RING finger protein, BFP, predominantly expressed in the brain.

Inoue S, Orimo A, Saito T, Ikeda K, Sakata K, Hosoi T, Orimo H, Ouchi Y, Muramatsu M.

Biochem Biophys Res Commun. 1997 Nov 7;240(1):8-14.

PMID:
9367872
47.

Multiple regulatory elements and binding proteins of the 5'-flanking region of the human estrogen-responsive finger protein (efp) gene.

Ikeda K, Inoue S, Orimo A, Sano M, Watanabe T, Tsutsumi K, Muramatsu M.

Biochem Biophys Res Commun. 1997 Jul 30;236(3):765-71.

PMID:
9245730
48.

Agonistic effect of tamoxifen is dependent on cell type, ERE-promoter context, and estrogen receptor subtype: functional difference between estrogen receptors alpha and beta.

Watanabe T, Inoue S, Ogawa S, Ishii Y, Hiroi H, Ikeda K, Orimo A, Muramatsu M.

Biochem Biophys Res Commun. 1997 Jul 9;236(1):140-5.

PMID:
9223441
49.

The brain finger protein gene (ZNF179), a member of the RING finger family, maps within the Smith-Magenis syndrome region at 17p11.2.

Kimura T, Arakawa Y, Inoue S, Fukushima Y, Kondo I, Koyama K, Hosoi T, Orimo A, Muramatsu M, Nakamura Y, Abe T, Inazawa J.

Am J Med Genet. 1997 Mar 31;69(3):320-4.

PMID:
9096764
50.

[Reconsideration of evaluation criteria for physical fitness tests of a working population--comparing conventional and new evaluation criteria].

Kono K, Orimo A, Takeda S, Haraguchi T, Kurotani I, Mitsuhashi A.

Sangyo Eiseigaku Zasshi. 1997 Jan;39(1):27-37. Japanese.

PMID:
9138775

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