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Sodium and potassium excretion predict increased depression in urban adolescents.

Mrug S, Orihuela C, Mrug M, Sanders PW.

Physiol Rep. 2019 Aug;7(16):e14213. doi: 10.14814/phy2.14213.


Interaction between Streptococcus pneumoniae and Staphylococcus aureus generates OH radicals that rapidly kills Staphylococcus aureus strains.

Wu X, Gordon O, Jiang W, Antezana BS, Angulo-Zamudio U, Del Rio C, Moller A, Brissac T, Tierney ARP, Warncke K, Orihuela CJ, Read TD, Vidal JE.

J Bacteriol. 2019 Aug 12. pii: JB.00474-19. doi: 10.1128/JB.00474-19. [Epub ahead of print]


Necroptotic Cell Death Promotes Adaptive Immunity Against Colonizing Pneumococci.

Riegler AN, Brissac T, Gonzalez-Juarbe N, Orihuela CJ.

Front Immunol. 2019 Apr 4;10:615. doi: 10.3389/fimmu.2019.00615. eCollection 2019.


In Vitro Adhesion, Invasion, and Transcytosis of Streptococcus pneumoniae with Host Cells.

Brissac T, Orihuela CJ.

Methods Mol Biol. 2019;1968:137-146. doi: 10.1007/978-1-4939-9199-0_12.


Streptococcus pneumoniae: Invasion and Inflammation.

Loughran AJ, Orihuela CJ, Tuomanen EI.

Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.GPP3-0004-2018. Review.


Severity and properties of cardiac damage caused by Streptococcus pneumoniae are strain dependent.

Shenoy AT, Beno SM, Brissac T, Bell JW, Novak L, Orihuela CJ.

PLoS One. 2018 Sep 14;13(9):e0204032. doi: 10.1371/journal.pone.0204032. eCollection 2018.


NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis.

Pajuelo D, Gonzalez-Juarbe N, Tak U, Sun J, Orihuela CJ, Niederweis M.

Cell Rep. 2018 Jul 10;24(2):429-440. doi: 10.1016/j.celrep.2018.06.042.


Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia.

Gonzalez-Juarbe N, Bradley KM, Riegler AN, Reyes LF, Brissac T, Park SS, Restrepo MI, Orihuela CJ.

Sci Rep. 2018 Apr 11;8(1):5846. doi: 10.1038/s41598-018-24210-8.


Future Research Directions in Pneumonia. NHLBI Working Group Report.

Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):256-263. doi: 10.1164/rccm.201801-0139WS.


Bacterial-Host Interactions: Physiology and Pathophysiology of Respiratory Infection.

Hakansson AP, Orihuela CJ, Bogaert D.

Physiol Rev. 2018 Apr 1;98(2):781-811. doi: 10.1152/physrev.00040.2016. Review.


Abnormal Cardiovascular Findings in Acute Pancreatitis: Are They Associated with Disease Severity?

Chacón-Portillo MA, Payró-Ramírez G, Peláez-Luna MC, Uscanga-Domínguez LF, Vasquéz-Ortiz Z, Orihuela C, Martínez-Vázquez SE, Hernández-Calleros J.

Rev Invest Clin. 2017 Nov-Dec;69(6):314-318. doi: 10.24875/RIC.17002361.


Cell Invasion and Pyruvate Oxidase-Derived H2O2 Are Critical for Streptococcus pneumoniae-Mediated Cardiomyocyte Killing.

Brissac T, Shenoy AT, Patterson LA, Orihuela CJ.

Infect Immun. 2017 Dec 19;86(1). pii: e00569-17. doi: 10.1128/IAI.00569-17. Print 2018 Jan.


Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing.

Shenoy AT, Brissac T, Gilley RP, Kumar N, Wang Y, Gonzalez-Juarbe N, Hinkle WS, Daugherty SC, Shetty AC, Ott S, Tallon LJ, Deshane J, Tettelin H, Orihuela CJ.

PLoS Pathog. 2017 Aug 25;13(8):e1006582. doi: 10.1371/journal.ppat.1006582. eCollection 2017 Aug.


Reciprocal relationships between emotion regulation and motives for eating palatable foods in African American adolescents.

Orihuela CA, Mrug S, Boggiano MM.

Appetite. 2017 Oct 1;117:303-309. doi: 10.1016/j.appet.2017.07.008. Epub 2017 Jul 11.


High endocan levels are associated with the need for mechanical ventilation among patients with severe sepsis.

Mangat M, Amalakuhan B, Habib S, Reyes LF, Hinojosa CA, Rodriguez AH, Soni NJ, Anzueto A, Levine SM, Peters JI, Aliberti S, Sibila O, Rello J, Witzenrath M, Waterer GW, Martin-Loeches I, Blanquer J, Sanz F, Marcos PJ, Solé-Violán J, Chalmers JD, Feldman C, Wunderink RG, Cruz CSD, Orihuela CJ, Restrepo MI.

Eur Respir J. 2017 Jul 5;50(1). pii: 1700013. doi: 10.1183/13993003.00013-2017. Print 2017 Jul. No abstract available.


The Pneumococcal Serotype 15C Capsule Is Partially O-Acetylated and Allows for Limited Evasion of 23-Valent Pneumococcal Polysaccharide Vaccine-Elicited Anti-Serotype 15B Antibodies.

Spencer BL, Shenoy AT, Orihuela CJ, Nahm MH.

Clin Vaccine Immunol. 2017 Aug 4;24(8). pii: e00099-17. doi: 10.1128/CVI.00099-17. Print 2017 Aug.


Severe Pneumococcal Pneumonia Causes Acute Cardiac Toxicity and Subsequent Cardiac Remodeling.

Reyes LF, Restrepo MI, Hinojosa CA, Soni NJ, Anzueto A, Babu BL, Gonzalez-Juarbe N, Rodriguez AH, Jimenez A, Chalmers JD, Aliberti S, Sibila O, Winter VT, Coalson JJ, Giavedoni LD, Dela Cruz CS, Waterer GW, Witzenrath M, Suttorp N, Dube PH, Orihuela CJ.

Am J Respir Crit Care Med. 2017 Sep 1;196(5):609-620. doi: 10.1164/rccm.201701-0104OC.


Position of O-Acetylation within the Capsular Repeat Unit Impacts the Biological Properties of Pneumococcal Serotypes 33A and 33F.

Spencer BL, Saad JS, Shenoy AT, Orihuela CJ, Nahm MH.

Infect Immun. 2017 Jun 20;85(7). pii: e00132-17. doi: 10.1128/IAI.00132-17. Print 2017 Jul.


Transcriptional organization of pneumococcal psrP-secY2A2 and impact of GtfA and GtfB deletion on PsrP-associated virulence properties.

Lizcano A, Akula Suresh Babu R, Shenoy AT, Saville AM, Kumar N, D'Mello A, Hinojosa CA, Gilley RP, Segovia J, Mitchell TJ, Tettelin H, Orihuela CJ.

Microbes Infect. 2017 Jun;19(6):323-333. doi: 10.1016/j.micinf.2017.04.001. Epub 2017 Apr 10.


Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia.

González-Juarbe N, Bradley KM, Shenoy AT, Gilley RP, Reyes LF, Hinojosa CA, Restrepo MI, Dube PH, Bergman MA, Orihuela CJ.

Cell Death Differ. 2017 May;24(5):917-928. doi: 10.1038/cdd.2017.49. Epub 2017 Apr 7.


Killing of Serratia marcescens biofilms with chloramphenicol.

Ray C, Shenoy AT, Orihuela CJ, González-Juarbe N.

Ann Clin Microbiol Antimicrob. 2017 Mar 29;16(1):19. doi: 10.1186/s12941-017-0192-2.


YopE specific CD8+ T cells provide protection against systemic and mucosal Yersinia pseudotuberculosis infection.

González-Juarbe N, Shen H, Bergman MA, Orihuela CJ, Dube PH.

PLoS One. 2017 Feb 16;12(2):e0172314. doi: 10.1371/journal.pone.0172314. eCollection 2017.


A Non-Human Primate Model of Severe Pneumococcal Pneumonia.

Reyes LF, Restrepo MI, Hinojosa CA, Soni NJ, Shenoy AT, Gilley RP, Gonzalez-Juarbe N, Noda JR, Winter VT, de la Garza MA, Shade RE, Coalson JJ, Giavedoni LD, Anzueto A, Orihuela CJ.

PLoS One. 2016 Nov 17;11(11):e0166092. doi: 10.1371/journal.pone.0166092. eCollection 2016.


Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis.

Amalakuhan B, Habib SA, Mangat M, Reyes LF, Rodriguez AH, Hinojosa CA, Soni NJ, Gilley RP, Bustamante CA, Anzueto A, Levine SM, Peters JI, Aliberti S, Sibila O, Chalmers JD, Torres A, Waterer GW, Martin-Loeches I, Bordon J, Blanquer J, Sanz F, Marcos PJ, Rello J, Ramirez J, Solé-Violán J, Luna CM, Feldman C, Witzenrath M, Wunderink RG, Stolz D, Wiemken TL, Shindo Y, Dela Cruz CS, Orihuela CJ, Restrepo MI.

Cytokine. 2016 Dec;88:267-273. doi: 10.1016/j.cyto.2016.08.028. Epub 2016 Oct 1.


Anatomical site-specific contributions of pneumococcal virulence determinants.

Shenoy AT, Orihuela CJ.

Pneumonia (Nathan). 2016;8. pii: 7. Epub 2016 Jun 3.


Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization.

Blanchette KA, Shenoy AT, Milner J 2nd, Gilley RP, McClure E, Hinojosa CA, Kumar N, Daugherty SC, Tallon LJ, Ott S, King SJ, Ferreira DM, Gordon SB, Tettelin H, Orihuela CJ.

Infect Immun. 2016 Sep 19;84(10):2922-32. doi: 10.1128/IAI.00277-16. Print 2016 Oct.


CD8(+) T cells specific to a single Yersinia pseudotuberculosis epitope restrict bacterial replication in the liver but fail to provide sterilizing immunity.

Shen H, Gonzalez-Juarbe N, Blanchette K, Crimmins G, Bergman MA, Isberg RR, Orihuela CJ, Dube PH.

Infect Genet Evol. 2016 Sep;43:289-96. doi: 10.1016/j.meegid.2016.06.008. Epub 2016 Jun 4.


Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis following Pneumococcal Myocardial Invasion.

Gilley RP, González-Juarbe N, Shenoy AT, Reyes LF, Dube PH, Restrepo MI, Orihuela CJ.

Infect Immun. 2016 Apr 22;84(5):1457-69. doi: 10.1128/IAI.00007-16. Print 2016 May.


Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.

González-Juarbe N, Gilley RP, Hinojosa CA, Bradley KM, Kamei A, Gao G, Dube PH, Bergman MA, Orihuela CJ.

PLoS Pathog. 2015 Dec 11;11(12):e1005337. doi: 10.1371/journal.ppat.1005337. eCollection 2015 Dec.


Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.

Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, Bergman M, Orihuela CJ, Galvan V, Padrón Á, Drerup J, Liu Y, Hasty P, Sharp ZD, Curiel TJ.

Aging Cell. 2015 Dec;14(6):945-56. doi: 10.1111/acel.12380. Epub 2015 Aug 28.


Chromogranin A levels and mortality in patients with severe sepsis.

Hsu CH, Reyes LF, Orihuela CJ, Buitrago R, Anzueto A, Soni NJ, Levine S, Peters J, Hinojosa CA, Aliberti S, Sibila O, Rodriguez A, Chalmers JD, Martin-Loeches I, Bordon J, Blanquer J, Sanz F, Marcos PJ, Rello J, Solé-Violán J, Restrepo MI.

Biomarkers. 2015;20(3):171-6. doi: 10.3109/1354750X.2015.1046932. Epub 2015 Jul 8.


Cardiotoxicity during invasive pneumococcal disease.

Brown AO, Millett ER, Quint JK, Orihuela CJ.

Am J Respir Crit Care Med. 2015 Apr 1;191(7):739-45. doi: 10.1164/rccm.201411-1951PP. Review.


Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs.

Calhoun C, Shivshankar P, Saker M, Sloane LB, Livi CB, Sharp ZD, Orihuela CJ, Adnot S, White ES, Richardson A, Le Saux CJ.

J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):153-60. doi: 10.1093/gerona/glu241. Epub 2015 Jan 7.


Requirement for Serratia marcescens cytolysin in a murine model of hemorrhagic pneumonia.

González-Juarbe N, Mares CA, Hinojosa CA, Medina JL, Cantwell A, Dube PH, Orihuela CJ, Bergman MA.

Infect Immun. 2015 Feb;83(2):614-24. doi: 10.1128/IAI.01822-14. Epub 2014 Nov 24.


Pneumococci in biofilms are non-invasive: implications on nasopharyngeal colonization.

Gilley RP, Orihuela CJ.

Front Cell Infect Microbiol. 2014 Nov 6;4:163. doi: 10.3389/fcimb.2014.00163. eCollection 2014. Review.


Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function.

Brown AO, Mann B, Gao G, Hankins JS, Humann J, Giardina J, Faverio P, Restrepo MI, Halade GV, Mortensen EM, Lindsey ML, Hanes M, Happel KI, Nelson S, Bagby GJ, Lorent JA, Cardinal P, Granados R, Esteban A, LeSaux CJ, Tuomanen EI, Orihuela CJ.

PLoS Pathog. 2014 Sep 18;10(9):e1004383. doi: 10.1371/journal.ppat.1004383. eCollection 2014 Sep.


Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs.

Hinojosa CA, Akula Suresh Babu R, Rahman MM, Fernandes G, Boyd AR, Orihuela CJ.

Exp Gerontol. 2014 Jun;54:58-66. doi: 10.1016/j.exger.2014.01.007. Epub 2014 Jan 17.


Streptococcus pneumoniae biofilm formation is strain dependent, multifactorial, and associated with reduced invasiveness and immunoreactivity during colonization.

Blanchette-Cain K, Hinojosa CA, Akula Suresh Babu R, Lizcano A, Gonzalez-Juarbe N, Munoz-Almagro C, Sanchez CJ, Bergman MA, Orihuela CJ.

MBio. 2013 Oct 15;4(5):e00745-13. doi: 10.1128/mBio.00745-13.


Medium-term effects of septal and apical pacing in pacemaker-dependent patients: a double-blind prospective randomized study.

Molina L, Sutton R, Gandoy W, Reyes N, Lara S, Limón F, Gómez S, Orihuela C, Salame L, Moreno G.

Pacing Clin Electrophysiol. 2014 Feb;37(2):207-14. doi: 10.1111/pace.12257. Epub 2013 Sep 2.


Interactions between blood-borne Streptococcus pneumoniae and the blood-brain barrier preceding meningitis.

Iovino F, Orihuela CJ, Moorlag HE, Molema G, Bijlsma JJ.

PLoS One. 2013 Jul 16;8(7):e68408. doi: 10.1371/journal.pone.0068408. Print 2013.


5-SPICE: the application of an original framework for community health worker program design, quality improvement and research agenda setting.

Palazuelos D, Ellis K, Im DD, Peckarsky M, Schwarz D, Farmer DB, Dhillon R, Johnson A, Orihuela C, Hackett J, Bazile J, Berman L, Ballard M, Panjabi R, Ternier R, Slavin S, Lee S, Selinsky S, Mitnick CD.

Glob Health Action. 2013 Apr 3;6:19658. doi: 10.3402/gha.v6i0.19658.


Prospective memory in the ICU: the effect of visual cues on task execution in a representative simulation.

Grundgeiger T, Sanderson PM, Orihuela CB, Thompson A, MacDougall HG, Nunnink L, Venkatesh B.

Ergonomics. 2013;56(4):579-89. doi: 10.1080/00140139.2013.765604. Epub 2013 Mar 21.


Testing the prospective evaluation of a new healthcare system.

Planitz B, Sanderson P, Freeman C, Xiao T, Botea A, Orihuela CB.

AMIA Annu Symp Proc. 2012;2012:734-43. Epub 2012 Nov 3.


Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence.

Hinojosa CA, Mgbemena V, Van Roekel S, Austad SN, Miller RA, Bose S, Orihuela CJ.

Exp Gerontol. 2012 Dec;47(12):958-65. doi: 10.1016/j.exger.2012.08.013. Epub 2012 Sep 7.


Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae.

Selva L, Ciruela P, Blanchette K, del Amo E, Pallares R, Orihuela CJ, Muñoz-Almagro C.

PLoS One. 2012;7(7):e41587. doi: 10.1371/journal.pone.0041587. Epub 2012 Jul 25.


A role for glycosylated serine-rich repeat proteins in gram-positive bacterial pathogenesis.

Lizcano A, Sanchez CJ, Orihuela CJ.

Mol Oral Microbiol. 2012 Aug;27(4):257-69. doi: 10.1111/j.2041-1014.2012.00653.x. Epub 2012 Jun 11. Review.


Impact of oral simvastatin therapy on acute lung injury in mice during pneumococcal pneumonia.

Boyd AR, Hinojosa CA, Rodriguez PJ, Orihuela CJ.

BMC Microbiol. 2012 May 15;12:73. doi: 10.1186/1471-2180-12-73.


Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia.

Boyd AR, Shivshankar P, Jiang S, Berton MT, Orihuela CJ.

Exp Gerontol. 2012 Jul;47(7):507-18. doi: 10.1016/j.exger.2012.04.004. Epub 2012 Apr 23.


Future perspective on host-pathogen interactions during bacterial biofilm formation within the nasopharynx.

Blanchette KA, Orihuela CJ.

Future Microbiol. 2012 Feb;7(2):227-39. doi: 10.2217/fmb.11.160. Review.

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