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Platelet-Rich Plasma counteracts detrimental effect of high glucose concentrations on Mesenchymal Stem Cells from Bichat fat pad.

D'Esposito V, Lecce M, Marenzi G, Cabaro S, Ambrosio MR, Sammartino G, Misso S, Migliaccio T, Liguoro P, Oriente F, Fortunato L, Beguinot F, Sammartino JC, Formisano P, Gasparro R.

J Tissue Eng Regen Med. 2020 Mar 15. doi: 10.1002/term.3032. [Epub ahead of print]


Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains.

De Biase D, Piegari G, Prisco F, Cimmino I, Pirozzi C, Mattace Raso G, Oriente F, Grieco E, Papparella S, Paciello O.

J Cell Physiol. 2020 Jun;235(6):5394-5403. doi: 10.1002/jcp.29426. Epub 2020 Jan 5.


Prep1 regulates angiogenesis through a PGC-1α-mediated mechanism.

Cimmino I, Margheri F, Prisco F, Perruolo G, D'Esposito V, Laurenzana A, Fibbi G, Paciello O, Doti N, Ruvo M, Miele C, Beguinot F, Formisano P, Oriente F.

FASEB J. 2019 Dec;33(12):13893-13904. doi: 10.1096/fj.201901230RR. Epub 2019 Oct 15.


Low-dose Bisphenol-A regulates inflammatory cytokines through GPR30 in mammary adipose cells.

Cimmino I, Oriente F, D'Esposito V, Liguoro D, Liguoro P, Ambrosio MR, Cabaro S, D'Andrea F, Beguinot F, Formisano P, Valentino R.

J Mol Endocrinol. 2019 Nov;63(4):273-283. doi: 10.1530/JME-18-0265.


The Relevance of Insulin Action in the Dopaminergic System.

Fiory F, Perruolo G, Cimmino I, Cabaro S, Pignalosa FC, Miele C, Beguinot F, Formisano P, Oriente F.

Front Neurosci. 2019 Aug 16;13:868. doi: 10.3389/fnins.2019.00868. eCollection 2019. Review.


The meningococcal vaccine antigen GNA2091 is an analogue of YraP and plays key roles in outer membrane stability and virulence.

Seib KL, Haag AF, Oriente F, Fantappiè L, Borghi S, Semchenko EA, Schulz BL, Ferlicca F, Taddei AR, Giuliani MM, Pizza M, Delany I.

FASEB J. 2019 Nov;33(11):12324-12335. doi: 10.1096/fj.201900669R. Epub 2019 Aug 23.


Prep1, A Homeodomain Transcription Factor Involved in Glucose and Lipid Metabolism.

Oriente F, Perruolo G, Cimmino I, Cabaro S, Liotti A, Longo M, Miele C, Formisano P, Beguinot F.

Front Endocrinol (Lausanne). 2018 Jun 28;9:346. doi: 10.3389/fendo.2018.00346. eCollection 2018. Review.


Prep1 deficiency improves metabolic response in white adipose tissue.

Liotti A, Cabaro S, Cimmino I, Ricci S, Procaccini C, Paciello O, Raciti GA, Spinelli R, Iossa S, Matarese G, Miele C, Formisano P, Beguinot F, Oriente F.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 May;1863(5):515-525. doi: 10.1016/j.bbalip.2018.02.005. Epub 2018 Feb 21.


miR-214-Dependent Increase of PHLPP2 Levels Mediates the Impairment of Insulin-Stimulated Akt Activation in Mouse Aortic Endothelial Cells Exposed to Methylglyoxal.

Nigro C, Mirra P, Prevenzano I, Leone A, Fiory F, Longo M, Cabaro S, Oriente F, Beguinot F, Miele C.

Int J Mol Sci. 2018 Feb 9;19(2). pii: E522. doi: 10.3390/ijms19020522.


Prep1 Deficiency Affects Olfactory Perception and Feeding Behavior by Impairing BDNF-TrkB Mediated Neurotrophic Signaling.

Ricci S, Viggiano D, Cimmino I, Perruolo G, Cabaro S, Liotti A, Fiory F, Spinelli R, Di Carlo A, Beguinot F, Formisano P, Oriente F.

Mol Neurobiol. 2018 Aug;55(8):6801-6815. doi: 10.1007/s12035-018-0873-7. Epub 2018 Jan 18.


Expression of Concern. Protein Kinase C (PKC)-α Activation Inhibits PKC-ζ and Mediates the Action of PED/PEA-15 on Glucose Transport in the L6 Skeletal Muscle Cells. Diabetes 2001;50:1244-1252. DOI: PMID: 11375323.

Condorelli G, Vigliotta G, Trencia A, Maitan MA, Caruso M, Miele C, Oriente F, Santopietro S, Formisano P, Beguinot F.

Diabetes. 2017 Nov 6. pii: db17ec2017b. doi: 10.2337/db17-ec2017b. [Epub ahead of print] No abstract available.


Expression of Concern. Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase. Diabetes 2011;60:138-147. DOI: 10.2337/db10-0860. PMID: 20864515.

Oriente F, Iovino S, Cabaro S, Cassese A, Longobardi E, Miele C, Ungaro P, Formisano P, Blasi F, Beguinot F.

Diabetes. 2018 Feb;67(2):346-347. doi: 10.2337/db17-ec2017c. Epub 2017 Nov 6. No abstract available.


Expression of Concern. The IR1152 Mutant Insulin Receptor Selectively Impairs Insulin Action in Skeletal Muscle but Not in Liver. Diabetes 2000;49:1194-1202. DOI: PMID: 10909978.

Caruso M, Miele C, Oliva A, Condorelli G, Oriente F, Riccardi G, Capaldo B, Fiory F, Accili D, Formisano P, Beguinot F.

Diabetes. 2017 Nov 6. pii: db17ec2017a. doi: 10.2337/db17-ec2017a. [Epub ahead of print] No abstract available.


A peptide antagonist of Prep1-p160 interaction improves ceramide-induced insulin resistance in skeletal muscle cells.

Cimmino I, Lorenzo V, Fiory F, Doti N, Ricci S, Cabaro S, Liotti A, Vitagliano L, Longo M, Miele C, Formisano P, Beguinot F, Ruvo M, Oriente F.

Oncotarget. 2017 May 30;8(42):71845-71858. doi: 10.18632/oncotarget.18286. eCollection 2017 Sep 22.


Low-Dose Bisphenol-A Impairs Adipogenesis and Generates Dysfunctional 3T3-L1 Adipocytes.

Ariemma F, D'Esposito V, Liguoro D, Oriente F, Cabaro S, Liotti A, Cimmino I, Longo M, Beguinot F, Formisano P, Valentino R.

PLoS One. 2016 Mar 4;11(3):e0150762. doi: 10.1371/journal.pone.0150762. eCollection 2016.


Substrate-zymography: a still worthwhile method for gelatinases analysis in biological samples.

Ricci S, D'Esposito V, Oriente F, Formisano P, Di Carlo A.

Clin Chem Lab Med. 2016 Aug 1;54(8):1281-90. doi: 10.1515/cclm-2015-0668. Review.


Glucose-induced expression of the homeotic transcription factor Prep1 is associated with histone post-translational modifications in skeletal muscle.

Ciccarelli M, Vastolo V, Albano L, Lecce M, Cabaro S, Liotti A, Longo M, Oriente F, Russo GL, Macchia PE, Formisano P, Beguinot F, Ungaro P.

Diabetologia. 2016 Jan;59(1):176-186. doi: 10.1007/s00125-015-3774-6. Epub 2015 Oct 9.


Platelet-Rich Plasma Increases Growth and Motility of Adipose Tissue-Derived Mesenchymal Stem Cells and Controls Adipocyte Secretory Function.

D'Esposito V, Passaretti F, Perruolo G, Ambrosio MR, Valentino R, Oriente F, Raciti GA, Nigro C, Miele C, Sammartino G, Beguinot F, Formisano P.

J Cell Biochem. 2015 Oct;116(10):2408-18. doi: 10.1002/jcb.25235.


Bisphenol-A impairs insulin action and up-regulates inflammatory pathways in human subcutaneous adipocytes and 3T3-L1 cells.

Valentino R, D'Esposito V, Passaretti F, Liotti A, Cabaro S, Longo M, Perruolo G, Oriente F, Beguinot F, Formisano P.

PLoS One. 2013 Dec 9;8(12):e82099. doi: 10.1371/journal.pone.0082099. eCollection 2013.


PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice.

Oriente F, Cabaro S, Liotti A, Longo M, Parrillo L, Pagano TB, Raciti GA, Penkov D, Paciello O, Miele C, Formisano P, Blasi F, Beguinot F.

Diabetologia. 2013 Dec;56(12):2713-22. doi: 10.1007/s00125-013-3053-3. Epub 2013 Sep 20.


Peroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1.

Ungaro P, Mirra P, Oriente F, Nigro C, Ciccarelli M, Vastolo V, Longo M, Perruolo G, Spinelli R, Formisano P, Miele C, Beguinot F.

J Biol Chem. 2012 Dec 14;287(51):42951-61. doi: 10.1074/jbc.M112.406637. Epub 2012 Oct 26.


PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation.

Iovino S, Oriente F, Botta G, Cabaro S, Iovane V, Paciello O, Viggiano D, Perruolo G, Formisano P, Beguinot F.

Cell Death Differ. 2012 Jul;19(7):1127-38. doi: 10.1038/cdd.2011.201. Epub 2012 Jan 27.


PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms.

Buonomo R, Giacco F, Vasaturo A, Caserta S, Guido S, Pagliara V, Garbi C, Mansueto G, Cassese A, Perruolo G, Oriente F, Miele C, Beguinot F, Formisano P.

J Cell Physiol. 2012 May;227(5):2106-16. doi: 10.1002/jcp.22944.


A novel Hfq-dependent sRNA that is under FNR control and is synthesized in oxygen limitation in Neisseria meningitidis.

Fantappiè L, Oriente F, Muzzi A, Serruto D, Scarlato V, Delany I.

Mol Microbiol. 2011 Apr;80(2):507-23. doi: 10.1111/j.1365-2958.2011.07592.x. Epub 2011 Mar 7.


Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase.

Oriente F, Iovino S, Cabaro S, Cassese A, Longobardi E, Miele C, Ungaro P, Formisano P, Blasi F, Beguinot F.

Diabetes. 2011 Jan;60(1):138-47. doi: 10.2337/db10-0860. Epub 2010 Sep 23. Retraction in: Diabetes. 2019 Feb;68(2):465-466.


Influence of serogroup B meningococcal vaccine antigens on growth and survival of the meningococcus in vitro and in ex vivo and in vivo models of infection.

Seib KL, Oriente F, Adu-Bobie J, Montanari P, Ferlicca F, Giuliani MM, Rappuoli R, Pizza M, Delany I.

Vaccine. 2010 Mar 11;28(12):2416-27. doi: 10.1016/j.vaccine.2009.12.082. Epub 2010 Jan 10.


Expression of factor H binding protein of meningococcus responds to oxygen limitation through a dedicated FNR-regulated promoter.

Oriente F, Scarlato V, Delany I.

J Bacteriol. 2010 Feb;192(3):691-701. doi: 10.1128/JB.01308-09. Epub 2009 Nov 30.


Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.

Oriente F, Iovino S, Cassese A, Romano C, Miele C, Troncone G, Balletta M, Perfetti A, Santulli G, Iaccarino G, Valentino R, Beguinot F, Formisano P.

Diabetologia. 2009 Dec;52(12):2642-52. doi: 10.1007/s00125-009-1528-z. Epub 2009 Sep 30.


The RNA chaperone Hfq is involved in stress response and virulence in Neisseria meningitidis and is a pleiotropic regulator of protein expression.

Fantappiè L, Metruccio MM, Seib KL, Oriente F, Cartocci E, Ferlicca F, Giuliani MM, Scarlato V, Delany I.

Infect Immun. 2009 May;77(5):1842-53. doi: 10.1128/IAI.01216-08. Epub 2009 Feb 17.


In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.

Cassese A, Esposito I, Fiory F, Barbagallo AP, Paturzo F, Mirra P, Ulianich L, Giacco F, Iadicicco C, Lombardi A, Oriente F, Van Obberghen E, Beguinot F, Formisano P, Miele C.

J Biol Chem. 2008 Dec 26;283(52):36088-99. doi: 10.1074/jbc.M801698200. Epub 2008 Oct 27.


Factor H-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide LL-37.

Seib KL, Serruto D, Oriente F, Delany I, Adu-Bobie J, Veggi D, Aricò B, Rappuoli R, Pizza M.

Infect Immun. 2009 Jan;77(1):292-9. doi: 10.1128/IAI.01071-08. Epub 2008 Oct 13.


Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.

Oriente F, Fernandez Diaz LC, Miele C, Iovino S, Mori S, Diaz VM, Troncone G, Cassese A, Formisano P, Blasi F, Beguinot F.

Mol Cell Biol. 2008 Sep;28(18):5634-45. doi: 10.1128/MCB.00117-08. Epub 2008 Jul 21.


Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization.

Miele C, Paturzo F, Teperino R, Sakane F, Fiory F, Oriente F, Ungaro P, Valentino R, Beguinot F, Formisano P.

J Biol Chem. 2007 Nov 2;282(44):31835-43. Epub 2007 Aug 3.


PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells.

Miele C, Raciti GA, Cassese A, Romano C, Giacco F, Oriente F, Paturzo F, Andreozzi F, Zabatta A, Troncone G, Bosch F, Pujol A, Chneiweiss H, Formisano P, Beguinot F.

Diabetes. 2007 Mar;56(3):622-33.


Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

Perfetti A, Oriente F, Iovino S, Alberobello AT, Barbagallo AP, Esposito I, Fiory F, Teperino R, Ungaro P, Miele C, Formisano P, Beguinot F.

J Biol Chem. 2007 Mar 23;282(12):8648-57. Epub 2007 Jan 16.


The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes.

Valentino R, Lupoli GA, Raciti GA, Oriente F, Farinaro E, Della Valle E, Salomone M, Riccardi G, Vaccaro O, Donnarumma G, Sesti G, Hribal ML, Cardellini M, Miele C, Formisano P, Beguinot F.

Diabetologia. 2006 Dec;49(12):3058-66. Epub 2006 Oct 5.


Thrombin-activated platelets induce proliferation of human skin fibroblasts by stimulating autocrine production of insulin-like growth factor-1.

Giacco F, Perruolo G, D'Agostino E, Fratellanza G, Perna E, Misso S, Saldalamacchia G, Oriente F, Fiory F, Miele C, Formisano S, Beguinot F, Formisano P.

FASEB J. 2006 Nov;20(13):2402-4. Epub 2006 Oct 2.


Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.

Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F.

Mol Cell Biol. 2005 Dec;25(24):10803-14.


Protein kinase C-alpha regulates insulin action and degradation by interacting with insulin receptor substrate-1 and 14-3-3 epsilon.

Oriente F, Andreozzi F, Romano C, Perruolo G, Perfetti A, Fiory F, Miele C, Beguinot F, Formisano P.

J Biol Chem. 2005 Dec 9;280(49):40642-9. Epub 2005 Oct 10.


Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.

Formisano P, Perruolo G, Libertini S, Santopietro S, Troncone G, Raciti GA, Oriente F, Portella G, Miele C, Beguinot F.

Oncogene. 2005 Oct 27;24(47):7012-21.


Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15.

Trencia A, Fiory F, Maitan MA, Vito P, Barbagallo AP, Perfetti A, Miele C, Ungaro P, Oriente F, Cilenti L, Zervos AS, Formisano P, Beguinot F.

J Biol Chem. 2004 Nov 5;279(45):46566-72. Epub 2004 Aug 24.


Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action.

Vigliotta G, Miele C, Santopietro S, Portella G, Perfetti A, Maitan MA, Cassese A, Oriente F, Trencia A, Fiory F, Romano C, Tiveron C, Tatangelo L, Troncone G, Formisano P, Beguinot F.

Mol Cell Biol. 2004 Jun;24(11):5005-15.


Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting.

Fiory F, Oriente F, Miele C, Romano C, Trencia A, Alberobello AT, Esposito I, Valentino R, Beguinot F, Formisano P.

J Biol Chem. 2004 Mar 19;279(12):11137-45. Epub 2004 Jan 6.


Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.

Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E.

J Biol Chem. 2003 Nov 28;278(48):47376-87. Epub 2003 Sep 11.


Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action.

Trencia A, Perfetti A, Cassese A, Vigliotta G, Miele C, Oriente F, Santopietro S, Giacco F, Condorelli G, Formisano P, Beguinot F.

Mol Cell Biol. 2003 Jul;23(13):4511-21.


Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase.

Andreozzi F, Melillo RM, Carlomagno F, Oriente F, Miele C, Fiory F, Santopietro S, Castellone MD, Beguinot F, Santoro M, Formisano P.

Oncogene. 2003 May 15;22(19):2942-9.


Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.

Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM.

Nature. 2003 May 29;423(6939):550-5. Epub 2003 May 18.


Glucose regulates insulin mitogenic effect by modulating SHP-2 activation and localization in JAr cells.

Bifulco G, Di Carlo C, Caruso M, Oriente F, Di Spiezio Sardo A, Formisano P, Beguinot F, Nappi C.

J Biol Chem. 2002 Jul 5;277(27):24306-14. Epub 2002 Apr 30.


Mouse models of insulin resistance.

Hribal ML, Oriente F, Accili D.

Am J Physiol Endocrinol Metab. 2002 May;282(5):E977-81. Review.

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