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Items: 40

1.

The transcription factor Hey and nuclear lamins specify and maintain cell identity.

Flint Brodsly N, Bitman-Lotan E, Boico O, Shafat A, Monastirioti M, Gessler M, Delidakis C, Rincon-Arano H, Orian A.

Elife. 2019 Jul 16;8. pii: e44745. doi: 10.7554/eLife.44745.

2.

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice.

Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, Sahu A, Zarecki R, Marie K, Feng Y, Khateb A, Frederick DT, Ashkenazi SK, Kim H, Perez EG, Day CP, Segura Muñoz RS, Schmaltz R, Yooseph S, Tam MA, Zhang T, Avitan-Hersh E, Tzur L, Roizman S, Boyango I, Bar-Sela G, Orian A, Kaufman RJ, Bosenberg M, Goding CR, Baaten B, Levesque MP, Dummer R, Brown K, Merlino G, Ruppin E, Flaherty K, Ramer-Tait A, Long T, Peterson SN, Bradley LM, Ronai ZA.

Nat Commun. 2019 Apr 2;10(1):1492. doi: 10.1038/s41467-019-09525-y.

3.

Drosophila HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development.

Yanku Y, Bitman-Lotan E, Zohar Y, Kurant E, Zilke N, Eilers M, Orian A.

Cells. 2018 Sep 26;7(10). pii: E151. doi: 10.3390/cells7100151.

4.

The Biology of SUMO-Targeted Ubiquitin Ligases in Drosophila Development, Immunity, and Cancer.

Abed M, Bitman-Lotan E, Orian A.

J Dev Biol. 2018 Jan 1;6(1). pii: E2. doi: 10.3390/jdb6010002. Review.

5.

The SUMO-targeted ubiquitin ligase, Dgrn, is essential for Drosophila innate immunity.

Koltun B, Shackelford E, Bonnay F, Matt N, Reichhart JM, Orian A.

Int J Dev Biol. 2017;61(3-4-5):319-327. doi: 10.1387/ijdb.160250ao.

6.

Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancer.

Diefenbacher M, Orian A.

Mol Cell Oncol. 2016 Nov 18;4(1):e1260671. doi: 10.1080/23723556.2016.1260671. eCollection 2017.

7.

RNF4-Dependent Oncogene Activation by Protein Stabilization.

Thomas JJ, Abed M, Heuberger J, Novak R, Zohar Y, Beltran Lopez AP, Trausch-Azar JS, Ilagan MXG, Benhamou D, Dittmar G, Kopan R, Birchmeier W, Schwartz AL, Orian A.

Cell Rep. 2016 Sep 20;16(12):3388-3400. doi: 10.1016/j.celrep.2016.08.024.

8.

SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.

Wang M, Sang J, Ren Y, Liu K, Liu X, Zhang J, Wang H, Wang J, Orian A, Yang J, Yi J.

Protein Cell. 2016 Jan;7(1):63-77. doi: 10.1007/s13238-015-0216-7. Epub 2015 Oct 28.

9.

Isoform-specific SCF(Fbw7) ubiquitination mediates differential regulation of PGC-1α.

Trausch-Azar JS, Abed M, Orian A, Schwartz AL.

J Cell Physiol. 2015 Apr;230(4):842-52. doi: 10.1002/jcp.24812.

10.

Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development.

Singer R, Atar S, Atias O, Oron E, Segal D, Hirsch JA, Tuller T, Orian A, Chamovitz DA.

Nucleic Acids Res. 2014 Sep;42(15):9761-70. doi: 10.1093/nar/gku723. Epub 2014 Aug 8.

11.

Sef is an inhibitor of proinflammatory cytokine signaling, acting by cytoplasmic sequestration of NF-κB.

Fuchs Y, Brunwasser M, Haif S, Haddad J, Shneyer B, Goldshmidt-Tran O, Korsensky L, Abed M, Zisman-Rozen S, Koren L, Carmi Y, Apte R, Yang RB, Orian A, Bejar J, Ron D.

Dev Cell. 2012 Sep 11;23(3):611-23. doi: 10.1016/j.devcel.2012.07.013.

12.

A fly view of a SUMO-targeted ubiquitin ligase.

Abed M, Bitman-Lotan E, Orian A.

Fly (Austin). 2011 Oct-Dec;5(4):340-4. doi: 10.4161/fly.5.4.17608. Epub 2011 Aug 22.

PMID:
21857164
13.

Phosphorylation of Groucho mediates RTK feedback inhibition and prolonged pathway target gene expression.

Helman A, Cinnamon E, Mezuman S, Hayouka Z, Von Ohlen T, Orian A, Jiménez G, Paroush Z.

Curr Biol. 2011 Jul 12;21(13):1102-10. doi: 10.1016/j.cub.2011.05.043. Epub 2011 Jun 16.

14.

The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis.

Barry KC, Abed M, Kenyagin D, Werwie TR, Boico O, Orian A, Parkhurst SM.

Development. 2011 May;138(9):1759-69. doi: 10.1242/dev.058420.

15.

Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression.

Abed M, Barry KC, Kenyagin D, Koltun B, Phippen TM, Delrow JJ, Parkhurst SM, Orian A.

EMBO J. 2011 Apr 6;30(7):1289-301. doi: 10.1038/emboj.2011.42. Epub 2011 Feb 22.

16.

The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis.

Herkert B, Dwertmann A, Herold S, Abed M, Naud JF, Finkernagel F, Harms GS, Orian A, Wanzel M, Eilers M.

J Cell Biol. 2010 Mar 22;188(6):905-18. doi: 10.1083/jcb.200908103.

17.

DamID: a methylation-based chromatin profiling approach.

Orian A, Abed M, Kenyagin-Karsenti D, Boico O.

Methods Mol Biol. 2009;567:155-69. doi: 10.1007/978-1-60327-414-2_11. Review.

PMID:
19588092
18.

Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis.

Cinnamon E, Helman A, Ben-Haroush Schyr R, Orian A, Jiménez G, Paroush Z.

Development. 2008 Mar;135(5):829-37. doi: 10.1242/dev.015206. Epub 2008 Jan 23.

19.

A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development.

Orian A, Delrow JJ, Rosales Nieves AE, Abed M, Metzger D, Paroush Z, Eisenman RN, Parkhurst SM.

Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15771-6. Epub 2007 Sep 26.

20.

Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors.

Orian A, Grewal SS, Knoepfler PS, Edgar BA, Parkhurst SM, Eisenman RN.

Cold Spring Harb Symp Quant Biol. 2005;70:299-307.

PMID:
16869766
21.

Chromatin profiling, DamID and the emerging landscape of gene expression.

Orian A.

Curr Opin Genet Dev. 2006 Apr;16(2):157-64. Epub 2006 Feb 28. Review.

PMID:
16503134
22.

Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development.

Grewal SS, Li L, Orian A, Eisenman RN, Edgar BA.

Nat Cell Biol. 2005 Mar;7(3):295-302. Epub 2005 Feb 20.

PMID:
15723055
23.

A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size.

Welcker M, Orian A, Grim JE, Eisenman RN, Clurman BE.

Curr Biol. 2004 Oct 26;14(20):1852-7. Erratum in: Curr Biol. 2005 Dec;15(24):2285. Grim, Jonathan A [corrected to Grim, Jonathan E].

24.

Hairy transcriptional repression targets and cofactor recruitment in Drosophila.

Bianchi-Frias D, Orian A, Delrow JJ, Vazquez J, Rosales-Nieves AE, Parkhurst SM.

PLoS Biol. 2004 Jul;2(7):E178. Epub 2004 Jul 13.

25.

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation.

Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, Clurman BE.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9085-90. Epub 2004 May 18. Erratum in: Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):504. Grim, Jonathan A [corrected to Grim, Jonathan E].

26.

Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network.

Orian A, van Steensel B, Delrow J, Bussemaker HJ, Li L, Sawado T, Williams E, Loo LW, Cowley SM, Yost C, Pierce S, Edgar BA, Parkhurst SM, Eisenman RN.

Genes Dev. 2003 May 1;17(9):1101-14. Epub 2003 Apr 14.

27.

Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.

Hook SS, Orian A, Cowley SM, Eisenman RN.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13425-30. Epub 2002 Sep 27.

28.

TGF-beta flips the Myc switch.

Orian A, Eisenman RN.

Sci STKE. 2001 Jun 26;2001(88):pe1. Review.

PMID:
11752658
30.

Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105.

Ciechanover A, Gonen H, Bercovich B, Cohen S, Fajerman I, Israël A, Mercurio F, Kahana C, Schwartz AL, Iwai K, Orian A.

Biochimie. 2001 Mar-Apr;83(3-4):341-9.

PMID:
11295495
31.

SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase.

Orian A, Gonen H, Bercovich B, Fajerman I, Eytan E, Israël A, Mercurio F, Iwai K, Schwartz AL, Ciechanover A.

EMBO J. 2000 Jun 1;19(11):2580-91.

32.

Ubiquitin-mediated proteolysis: biological regulation via destruction.

Ciechanover A, Orian A, Schwartz AL.

Bioessays. 2000 May;22(5):442-51. Review.

PMID:
10797484
33.

The ubiquitin-mediated proteolytic pathway: mode of action and clinical implications.

Ciechanover A, Orian A, Schwartz AL.

J Cell Biochem Suppl. 2000;34:40-51. Review.

PMID:
10762014
34.

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.

Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A.

J Biol Chem. 1999 May 21;274(21):14823-30.

35.
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37.

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

Alkalay I, Yaron A, Hatzubai A, Orian A, Ciechanover A, Ben-Neriah Y.

Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10599-603.

39.

The ubiquitin-mediated proteolytic system: involvement of molecular chaperones, degradation of oncoproteins, and activation of transcriptional regulators.

Ciechanover A, Laszlo A, Bercovich B, Stancovski I, Alkalay I, Ben-Neriah Y, Orian A.

Cold Spring Harb Symp Quant Biol. 1995;60:491-501. No abstract available.

PMID:
8824422
40.

Degradation of nuclear oncoproteins by the ubiquitin system in vitro.

Ciechanover A, DiGiuseppe JA, Bercovich B, Orian A, Richter JD, Schwartz AL, Brodeur GM.

Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):139-43.

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