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p53: not just a tumor suppressor.

Oren M.

J Mol Cell Biol. 2019 Jul 10. pii: mjz070. doi: 10.1093/jmcb/mjz070. [Epub ahead of print] No abstract available.


Individual Sea Urchin Coelomocytes Undergo Somatic Immune Gene Diversification.

Oren M, Rosental B, Hawley TS, Kim GY, Agronin J, Reynolds CR, Grayfer L, Smith LC.

Front Immunol. 2019 Jun 6;10:1298. doi: 10.3389/fimmu.2019.01298. eCollection 2019.


Correction: Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides.

Tal P, Eizenberger S, Cohen E, Goldfinger N, Pietrokovski S, Oren M, Rotter V.

Oncotarget. 2019 May 7;10(34):3203-3206. doi: 10.18632/oncotarget.26921. eCollection 2019 May 7.


The relationship between common geriatric syndromes and potentially inappropriate medication use among older adults.

Kucukdagli P, Bahat G, Bay I, Kilic C, Oren MM, Turkmen BO, Karan MA.

Aging Clin Exp Res. 2019 Jun 12. doi: 10.1007/s40520-019-01239-x. [Epub ahead of print]


Postnatal diagnosis of de novo complex der(8) in a boy with prenatal diagnosis of recombinant chromosome 8 syndrome.

Oren MS, Camacho JE, Xie H, Lowe J, Cushing T, Clericuzio C, Maxwell JR.

Clin Case Rep. 2019 Mar 25;7(5):898-902. doi: 10.1002/ccr3.2109. eCollection 2019 May.


The effects of pre-operative somatostatin analogue therapy on treatment cost and remission in acromegaly.

Polat Korkmaz O, Gurcan M, Nuhoglu Kantarci FE, Haliloglu O, Ozkaya HM, Sahin S, Oren MM, Tanriover N, Gazioglu N, Kadioglu P.

Pituitary. 2019 Aug;22(4):387-396. doi: 10.1007/s11102-019-00968-6.


New insights into YAP/TAZ nucleo-cytoplasmic shuttling: new cancer therapeutic opportunities?

Shreberk-Shaked M, Oren M.

Mol Oncol. 2019 Jun;13(6):1335-1341. doi: 10.1002/1878-0261.12498. Epub 2019 May 17. Review.


Retraction: Transactivation of the EGR1 Gene Contributes to Mutant p53 Gain of Function.

Weisz L, Zalcenstein A, Stambolsky P, Cohen Y, Goldfinger N, Oren M, Rotter V.

Cancer Res. 2019 Apr 15;79(8):2085. doi: 10.1158/0008-5472.CAN-19-0560. No abstract available.


Usefulness of the 'two-step method' of digital follow-up for early-stage melanoma detection in high-risk French patients: a retrospective 4-year study.

Gasparini G, Madjlessi N, Delyon J, Carmisciano L, Brahimi N, Basset-Seguin N, Oren M, Battistella M, Lebbé C, Herms F, Baroudjian B.

Br J Dermatol. 2019 Aug;181(2):415-416. doi: 10.1111/bjd.18006. Epub 2019 May 12. No abstract available.


Does Decompressive Duraplasty Have a Neuroprotective Effect on Spinal Trauma?: An Experimental Study.

Camlar M, Turk Ç, Buhur A, Oltulu F, Oren M, Senoglu M, Ozer F.

World Neurosurg. 2019 Feb 26. pii: S1878-8750(19)30454-1. doi: 10.1016/j.wneu.2019.02.043. [Epub ahead of print]


How Safe is the Use of Intrathecal Fluorescein? An Experimental Study.

Camlar M, Turk C, Oltulu F, Oren M, Buhur A, Yigitturk G, Ozer F, Gazioglu N.

Turk Neurosurg. 2019;29(4):549-554. doi: 10.5137/1019-5149.JTN.24085-18.3.


Methods for collection, handling, and analysis of sea urchin coelomocytes.

Smith LC, Hawley TS, Henson JH, Majeske AJ, Oren M, Rosental B.

Methods Cell Biol. 2019;150:357-389. doi: 10.1016/bs.mcb.2018.11.009. Epub 2019 Jan 9. Review.


Mobile Phone-Use Habits Among Adolescents: Predictors of Intensive Use.

Hirsh-Yechezkel G, Mandelzweig L, Novikov I, Bar-Yosef N, Livneh I, Oren M, Waysberg R, Sadetzki S.

Cyberpsychol Behav Soc Netw. 2019 Mar;22(3):212-219. doi: 10.1089/cyber.2018.0177. Epub 2019 Jan 7.


Functional Repair Assay for the Diagnosis of Constitutional Mismatch Repair Deficiency From Non-Neoplastic Tissue.

Shuen AY, Lanni S, Panigrahi GB, Edwards M, Yu L, Campbell BB, Mandel A, Zhang C, Zhukova N, Alharbi M, Bernstein M, Bowers DC, Carroll S, Cole KA, Constantini S, Crooks B, Dvir R, Farah R, Hijiya N, George B, Laetsch TW, Larouche V, Lindhorst S, Luiten RC, Magimairajan V, Mason G, Mason W, Mordechai O, Mushtaq N, Nicholas G, Oren M, Palma L, Pedroza LA, Ramdas J, Samuel D, Wolfe Schneider K, Seeley A, Semotiuk K, Shamvil A, Sumerauer D, Toledano H, Tomboc P, Wierman M, Van Damme A, Lee YY, Zapotocky M, Bouffet E, Durno C, Aronson M, Gallinger S, Foulkes WD, Malkin D, Tabori U, Pearson CE.

J Clin Oncol. 2019 Feb 20;37(6):461-470. doi: 10.1200/JCO.18.00474. Epub 2019 Jan 4.


Statistical concerns about the study: "Risk factors for polypharmacy in older adults in a primary care setting: a cross-sectional study".

Aydin K, Oren MM, Aydin T.

Clin Interv Aging. 2018 Dec 14;13:2539-2542. doi: 10.2147/CIA.S192184. eCollection 2018. No abstract available.


Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer.

Hooda J, Novak M, Salomon MP, Matsuba C, Ramos RI, MacDuffie E, Song M, Hirsch MS, Lester J, Parkash V, Karlan BY, Oren M, Hoon DS, Drapkin R.

Cancer Res. 2019 Feb 15;79(4):760-772. doi: 10.1158/0008-5472.CAN-18-2297. Epub 2018 Dec 18.


Functional characterization of the p53 "mutome".

Kotler E, Segal E, Oren M.

Mol Cell Oncol. 2018 Sep 25;5(6):e1511207. doi: 10.1080/23723556.2018.1511207. eCollection 2018.


LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state.

Furth N, Pateras IS, Rotkopf R, Vlachou V, Rivkin I, Schmitt I, Bakaev D, Gershoni A, Ainbinder E, Leshkowitz D, Johnson RL, Gorgoulis VG, Oren M, Aylon Y.

Life Sci Alliance. 2018 Oct 30;1(5):e201800171. doi: 10.26508/lsa.201800171. eCollection 2018 Oct.


Reliability and validity of Turkish version of the Simplified Nutritional Appetite Questionnaire (SNAQ).

İlhan B, Bahat G, Oren MM, BKılıç C, Durmazoglu S, Karan MA.

J Nutr Health Aging. 2018;22(9):1039-1044. doi: 10.1007/s12603-018-1051-3.


Comparing SARC-F with SARC-CalF to Screen Sarcopenia in Community Living Older Adults.

Bahat G, Oren MM, Yilmaz O, Kılıç C, Aydin K, Karan MA.

J Nutr Health Aging. 2018;22(9):1034-1038. doi: 10.1007/s12603-018-1072-y.


Corrigendum: p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity.

Tovy A, Spiro A, McCarthy R, Shipony Z, Aylon Y, Allton K, Ainbinder E, Furth N, Tanay A, Barton M, Oren M.

Genes Dev. 2018 Oct 1;32(19-20):1358. doi: 10.1101/gad.319863.118. No abstract available.


Performance of SARC-F in Regard to Sarcopenia Definitions, Muscle Mass and Functional Measures.

Bahat G, Yilmaz O, Kılıç C, Oren MM, Karan MA.

J Nutr Health Aging. 2018;22(8):898-903. doi: 10.1007/s12603-018-1067-8.


A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.

Kotler E, Shani O, Goldfeld G, Lotan-Pompan M, Tarcic O, Gershoni A, Hopf TA, Marks DS, Oren M, Segal E.

Mol Cell. 2018 Sep 6;71(5):873. doi: 10.1016/j.molcel.2018.08.013. No abstract available.


Association of sociodemographic profile, dyslipidemias, and obesity in smoker, former smoker, and nonsmoker patients with coronary artery disease.

Kafadar D, Dogan FG, Oren MM, Ayca B, Okuyan E.

Niger J Clin Pract. 2018 Sep;21(9):1190-1197. doi: 10.4103/njcp.njcp_171_17.


Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.

Minzel W, Venkatachalam A, Fink A, Hung E, Brachya G, Burstain I, Shaham M, Rivlin A, Omer I, Zinger A, Elias S, Winter E, Erdman PE, Sullivan RW, Fung L, Mercurio F, Li D, Vacca J, Kaushansky N, Shlush L, Oren M, Levine R, Pikarsky E, Snir-Alkalay I, Ben-Neriah Y.

Cell. 2018 Sep 20;175(1):171-185.e25. doi: 10.1016/j.cell.2018.07.045. Epub 2018 Aug 23.


Does clinically measured ankle plantar flexor muscle strength or weakness correlate with walking performance in healthy individuals?

Akalan NE, Kuchimov S, Apti A, Temelli Y, Ören M, Nene A.

J Back Musculoskelet Rehabil. 2018;31(6):1201-1209. doi: 10.3233/BMR-171082.


Statistical concerns about the study: hypoglycemic and antioxidant effect of Tai chi exercise training in older adults with metabolic syndrome.

Aydın T, Oren MM, Bahat G.

Clin Interv Aging. 2018 Jul 11;13:1233-1235. doi: 10.2147/CIA.S171443. eCollection 2018. No abstract available.


A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.

Kotler E, Shani O, Goldfeld G, Lotan-Pompan M, Tarcic O, Gershoni A, Hopf TA, Marks DS, Oren M, Segal E.

Mol Cell. 2018 Jul 5;71(1):178-190.e8. doi: 10.1016/j.molcel.2018.06.012. Erratum in: Mol Cell. 2018 Sep 6;71(5):873.


Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features.

Arandkar S, Furth N, Elisha Y, Nataraj NB, van der Kuip H, Yarden Y, Aulitzky W, Ulitsky I, Geiger B, Oren M.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6410-6415. doi: 10.1073/pnas.1719076115. Epub 2018 Jun 4.


Explicit versus implicit evaluation to detect inappropriate medication use in geriatric outpatients.

Bahat G, Ilhan B, Bay I, Kilic C, Kucukdagli P, Oren MM, Karan MA.

Aging Male. 2018 Apr 19:1-6. doi: 10.1080/13685538.2018.1464552. [Epub ahead of print]


TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.

Jethwa A, Słabicki M, Hüllein J, Jentzsch M, Dalal V, Rabe S, Wagner L, Walther T, Klapper W; MMML Network Project, Bohnenberger H, Rettel M, Lu J, Smits AH, Stein F, Savitski MM, Huber W, Aylon Y, Oren M, Zenz T.

Blood. 2018 Jun 21;131(25):2789-2802. doi: 10.1182/blood-2017-09-806679. Epub 2018 Apr 13.


PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma.

Ghannam-Shahbari D, Jacob E, Kakun RR, Wasserman T, Korsensky L, Sternfeld O, Kagan J, Bublik DR, Aviel-Ronen S, Levanon K, Sabo E, Larisch S, Oren M, Hershkovitz D, Perets R.

Oncogene. 2018 Apr;37(17):2213-2224. doi: 10.1038/s41388-017-0040-z. Epub 2018 Jan 30.


Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.


Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

Solomon H, Dinowitz N, Pateras IS, Cooks T, Shetzer Y, Molchadsky A, Charni M, Rabani S, Koifman G, Tarcic O, Porat Z, Kogan-Sakin I, Goldfinger N, Oren M, Harris CC, Gorgoulis VG, Rotter V.

Oncogene. 2018 Mar;37(12):1669-1684. doi: 10.1038/s41388-017-0060-8. Epub 2018 Jan 18.


Coupling astogenic aging in the colonial tunicate Botryllus schlosseri with the stress protein mortalin.

Ben-Hamo O, Rosner A, Rabinowitz C, Oren M, Rinkevich B.

Dev Biol. 2018 Jan 1;433(1):33-46. doi: 10.1016/j.ydbio.2017.10.023. Epub 2017 Nov 8.


Corrigendum: The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.

Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M.

Genes Dev. 2017 Sep 15;31(18):1926. doi: 10.1101/gad.307207.117. No abstract available.


Epigenetic mechanisms underlie the crosstalk between growth factors and a steroid hormone.

Enuka Y, Feldman ME, Chowdhury A, Srivastava S, Lindzen M, Sas-Chen A, Massart R, Cheishvili D, Suderman MJ, Zaltsman Y, Mazza CA, Shukla K, Körner C, Furth N, Lauriola M, Oren M, Wiemann S, Szyf M, Yarden Y.

Nucleic Acids Res. 2017 Dec 15;45(22):12681-12699. doi: 10.1093/nar/gkx865.


Tumor Suppression by p53: Bring in the Hippo!

Aylon Y, Oren M.

Cancer Cell. 2017 Oct 9;32(4):397-399. doi: 10.1016/j.ccell.2017.09.010.


p53 shades of Hippo.

Furth N, Aylon Y, Oren M.

Cell Death Differ. 2018 Jan;25(1):81-92. doi: 10.1038/cdd.2017.163. Epub 2017 Oct 6. Review.


p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity.

Tovy A, Spiro A, McCarthy R, Shipony Z, Aylon Y, Allton K, Ainbinder E, Furth N, Tanay A, Barton M, Oren M.

Genes Dev. 2017 May 15;31(10):959-972. doi: 10.1101/gad.299198.117. Epub 2017 Jun 12. Erratum in: Genes Dev. 2018 Oct 1;32(19-20):1358.


let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery.

Spolverini A, Fuchs G, Bublik DR, Oren M.

Oncogene. 2017 Oct 19;36(42):5819-5828. doi: 10.1038/onc.2017.187. Epub 2017 Jun 12.


RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.

Tarcic O, Granit RZ, Pateras IS, Masury H, Maly B, Zwang Y, Yarden Y, Gorgoulis VG, Pikarsky E, Ben-Porath I, Oren M.

Cell Death Differ. 2017 Apr;24(4):694-704. doi: 10.1038/cdd.2016.126. Epub 2017 Feb 3.


Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival.

Bublik DR, Bursać S, Sheffer M, Oršolić I, Shalit T, Tarcic O, Kotler E, Mouhadeb O, Hoffman Y, Fuchs G, Levin Y, Volarević S, Oren M.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E496-E505. doi: 10.1073/pnas.1614876114. Epub 2016 Dec 19.


Short tandem repeats, segmental duplications, gene deletion, and genomic instability in a rapidly diversified immune gene family.

Oren M, Barela Hudgell MA, D'Allura B, Agronin J, Gross A, Podini D, Smith LC.

BMC Genomics. 2016 Nov 9;17(1):900.


The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry.

Simerzin A, Zorde-Khvalevsky E, Rivkin M, Adar R, Zucman-Rossi J, Couchy G, Roskams T, Govaere O, Oren M, Giladi H, Galun E.

Hepatology. 2016 Nov;64(5):1623-1636. doi: 10.1002/hep.28679. Epub 2016 Jul 25.


TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.

Isaac R, Goldstein I, Furth N, Zilber N, Streim S, Boura-Halfon S, Elhanany E, Rotter V, Oren M, Zick Y.

Cell Death Differ. 2017 Jan;24(1):132-143. doi: 10.1038/cdd.2016.108. Epub 2016 Oct 14.


Transradial versus Transfemoral Approach in Peripheral Arterial Interventions.

Oren O, Oren M, Turgeman Y.

Int J Angiol. 2016 Sep;25(3):148-52. doi: 10.1055/s-0035-1563607. Epub 2015 Sep 7.


On the generalizability of prostate cancer studies: why race matters.

Oren O, Oren M, Beach D.

Ann Oncol. 2016 Dec;27(12):2146-2148. doi: 10.1093/annonc/mdw409. Epub 2016 Aug 29. No abstract available.


p53 mutations promote proteasomal activity.

Oren M, Kotler E.

Nat Cell Biol. 2016 Jul 27;18(8):833-5. doi: 10.1038/ncb3392.


The Hippo pathway, p53 and cholesterol.

Aylon Y, Oren M.

Cell Cycle. 2016 Sep;15(17):2248-55. doi: 10.1080/15384101.2016.1207840. Epub 2016 Jul 15. Review.

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