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Items: 26


An integrated transport mechanism of the maltose ABC importer.

Mächtel R, Narducci A, Griffith DA, Cordes T, Orelle C.

Res Microbiol. 2019 Sep 24. pii: S0923-2508(19)30098-1. doi: 10.1016/j.resmic.2019.09.004. [Epub ahead of print]


Multidrug ABC transporters in bacteria.

Orelle C, Mathieu K, Jault JM.

Res Microbiol. 2019 Jun 25. pii: S0923-2508(19)30058-0. doi: 10.1016/j.resmic.2019.06.001. [Epub ahead of print]


Flexible-to-rigid transition is central for substrate transport in the ABC transporter BmrA from Bacillus subtilis.

Lacabanne D, Orelle C, Lecoq L, Kunert B, Chuilon C, Wiegand T, Ravaud S, Jault JM, Meier BH, Böckmann A.

Commun Biol. 2019 Apr 29;2:149. doi: 10.1038/s42003-019-0390-x. eCollection 2019.


Functionality of membrane proteins overexpressed and purified from E. coli is highly dependent upon the strain.

Mathieu K, Javed W, Vallet S, Lesterlin C, Candusso MP, Ding F, Xu XN, Ebel C, Jault JM, Orelle C.

Sci Rep. 2019 Feb 25;9(1):2654. doi: 10.1038/s41598-019-39382-0.


Assemblies of lauryl maltose neopentyl glycol (LMNG) and LMNG-solubilized membrane proteins.

Breyton C, Javed W, Vermot A, Arnaud CA, Hajjar C, Dupuy J, Petit-Hartlein I, Le Roy A, Martel A, Thépaut M, Orelle C, Jault JM, Fieschi F, Porcar L, Ebel C.

Biochim Biophys Acta Biomembr. 2019 May 1;1861(5):939-957. doi: 10.1016/j.bbamem.2019.02.003. Epub 2019 Feb 15.


A multidrug ABC transporter with a taste for GTP.

Orelle C, Durmort C, Mathieu K, Duchêne B, Aros S, Fenaille F, André F, Junot C, Vernet T, Jault JM.

Sci Rep. 2018 Feb 2;8(1):2309. doi: 10.1038/s41598-018-20558-z.


Gradient reconstitution of membrane proteins for solid-state NMR studies.

Lacabanne D, Lends A, Danis C, Kunert B, Fogeron ML, Jirasko V, Chuilon C, Lecoq L, Orelle C, Chaptal V, Falson P, Jault JM, Meier BH, Böckmann A.

J Biomol NMR. 2017 Oct;69(2):81-91. doi: 10.1007/s10858-017-0135-4. Epub 2017 Sep 12.


Expanding the Kinome World: A New Protein Kinase Family Widely Conserved in Bacteria.

Nguyen HA, El Khoury T, Guiral S, Laaberki MH, Candusso MP, Galisson F, Foucher AE, Kesraoui S, Ballut L, Vallet S, Orelle C, Zucchini L, Martin J, Page A, Attieh J, Aghajari N, Grangeasse C, Jault JM.

J Mol Biol. 2017 Oct 13;429(20):3056-3074. doi: 10.1016/j.jmb.2017.08.016. Epub 2017 Sep 7.


Quantification of Detergents Complexed with Membrane Proteins.

Chaptal V, Delolme F, Kilburg A, Magnard S, Montigny C, Picard M, Prier C, Monticelli L, Bornert O, Agez M, Ravaud S, Orelle C, Wagner R, Jawhari A, Broutin I, Pebay-Peyroula E, Jault JM, Kaback HR, le Maire M, Falson P.

Sci Rep. 2017 Feb 8;7:41751. doi: 10.1038/srep41751.


Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center.

Marks J, Kannan K, Roncase EJ, Klepacki D, Kefi A, Orelle C, Vázquez-Laslop N, Mankin AS.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12150-12155. Epub 2016 Oct 10.


Full engagement of liganded maltose-binding protein stabilizes a semi-open ATP-binding cassette dimer in the maltose transporter.

Alvarez FJ, Orelle C, Huang Y, Bajaj R, Everly RM, Klug CS, Davidson AL.

Mol Microbiol. 2015 Dec;98(5):878-94. doi: 10.1111/mmi.13165. Epub 2015 Sep 10.


Protein synthesis by ribosomes with tethered subunits.

Orelle C, Carlson ED, Szal T, Florin T, Jewett MC, Mankin AS.

Nature. 2015 Aug 6;524(7563):119-24. doi: 10.1038/nature14862. Epub 2015 Jul 29.


Tools for characterizing bacterial protein synthesis inhibitors.

Orelle C, Carlson S, Kaushal B, Almutairi MM, Liu H, Ochabowicz A, Quan S, Pham VC, Squires CL, Murphy BT, Mankin AS.

Antimicrob Agents Chemother. 2013 Dec;57(12):5994-6004. doi: 10.1128/AAC.01673-13. Epub 2013 Sep 16.


Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition.

Orelle C, Szal T, Klepacki D, Shaw KJ, Vázquez-Laslop N, Mankin AS.

Nucleic Acids Res. 2013 Aug;41(14):e144. doi: 10.1093/nar/gkt526. Epub 2013 Jun 12.


Dynamics of alpha-helical subdomain rotation in the intact maltose ATP-binding cassette transporter.

Orelle C, Alvarez FJ, Oldham ML, Orelle A, Wiley TE, Chen J, Davidson AL.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20293-8. doi: 10.1073/pnas.1006544107. Epub 2010 Nov 8.


Functional reconstitution of an ABC transporter in nanodiscs for use in electron paramagnetic resonance spectroscopy.

Alvarez FJ, Orelle C, Davidson AL.

J Am Chem Soc. 2010 Jul 21;132(28):9513-5. doi: 10.1021/ja104047c.


Alternating access in maltose transporter mediated by rigid-body rotations.

Khare D, Oldham ML, Orelle C, Davidson AL, Chen J.

Mol Cell. 2009 Feb 27;33(4):528-36. doi: 10.1016/j.molcel.2009.01.035.


Both maltose-binding protein and ATP are required for nucleotide-binding domain closure in the intact maltose ABC transporter.

Orelle C, Ayvaz T, Everly RM, Klug CS, Davidson AL.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12837-42. doi: 10.1073/pnas.0803799105. Epub 2008 Aug 25.


Structure, function, and evolution of bacterial ATP-binding cassette systems.

Davidson AL, Dassa E, Orelle C, Chen J.

Microbiol Mol Biol Rev. 2008 Jun;72(2):317-64, table of contents. doi: 10.1128/MMBR.00031-07. Review.


Conformational change induced by ATP binding in the multidrug ATP-binding cassette transporter BmrA.

Orelle C, Gubellini F, Durand A, Marco S, Lévy D, Gros P, Di Pietro A, Jault JM.

Biochemistry. 2008 Feb 26;47(8):2404-12. doi: 10.1021/bi702303s. Epub 2008 Jan 24.


The Q-loop disengages from the first intracellular loop during the catalytic cycle of the multidrug ABC transporter BmrA.

Dalmas O, Orelle C, Foucher AE, Geourjon C, Crouzy S, Di Pietro A, Jault JM.

J Biol Chem. 2005 Nov 4;280(44):36857-64. Epub 2005 Aug 17.


Characterization of YvcC (BmrA), a multidrug ABC transporter constitutively expressed in Bacillus subtilis.

Steinfels E, Orelle C, Fantino JR, Dalmas O, Rigaud JL, Denizot F, Di Pietro A, Jault JM.

Biochemistry. 2004 Jun 15;43(23):7491-502.


The conserved glutamate residue adjacent to the Walker-B motif is the catalytic base for ATP hydrolysis in the ATP-binding cassette transporter BmrA.

Orelle C, Dalmas O, Gros P, Di Pietro A, Jault JM.

J Biol Chem. 2003 Nov 21;278(47):47002-8. Epub 2003 Sep 10.


Highly efficient over-production in E. coli of YvcC, a multidrug-like ATP-binding cassette transporter from Bacillus subtilis.

Steinfels E, Orelle C, Dalmas O, Penin F, Miroux B, Di Pietro A, Jault JM.

Biochim Biophys Acta. 2002 Sep 20;1565(1):1-5.


Three-dimensional structure by cryo-electron microscopy of YvcC, an homodimeric ATP-binding cassette transporter from Bacillus subtilis.

Chami M, Steinfels E, Orelle C, Jault JM, Di Pietro A, Rigaud JL, Marco S.

J Mol Biol. 2002 Feb 1;315(5):1075-85.


A common mechanism for ATP hydrolysis in ABC transporter and helicase superfamilies.

Geourjon C, Orelle C, Steinfels E, Blanchet C, Deléage G, Di Pietro A, Jault JM.

Trends Biochem Sci. 2001 Sep;26(9):539-44. Review.


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