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Items: 8

1.

RNA-Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO Cells.

Orellana CA, Marcellin E, Palfreyman RW, Munro TP, Gray PP, Nielsen LK.

Biotechnol J. 2018 Mar;13(3):e1700231. doi: 10.1002/biot.201700231. Epub 2018 Feb 1.

PMID:
29316330
2.

Overexpression of the regulatory subunit of glutamate-cysteine ligase enhances monoclonal antibody production in CHO cells.

Orellana CA, Marcellin E, Gray PP, Nielsen LK.

Biotechnol Bioeng. 2017 Aug;114(8):1825-1836. doi: 10.1002/bit.26316. Epub 2017 May 8.

PMID:
28436007
3.

A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.

Hefzi H, Ang KS, Hanscho M, Bordbar A, Ruckerbauer D, Lakshmanan M, Orellana CA, Baycin-Hizal D, Huang Y, Ley D, Martinez VS, Kyriakopoulos S, Jiménez NE, Zielinski DC, Quek LE, Wulff T, Arnsdorf J, Li S, Lee JS, Paglia G, Loira N, Spahn PN, Pedersen LE, Gutierrez JM, King ZA, Lund AM, Nagarajan H, Thomas A, Abdel-Haleem AM, Zanghellini J, Kildegaard HF, Voldborg BG, Gerdtzen ZP, Betenbaugh MJ, Palsson BO, Andersen MR, Nielsen LK, Borth N, Lee DY, Lewis NE.

Cell Syst. 2016 Nov 23;3(5):434-443.e8. doi: 10.1016/j.cels.2016.10.020.

4.

Recon 2.2: from reconstruction to model of human metabolism.

Swainston N, Smallbone K, Hefzi H, Dobson PD, Brewer J, Hanscho M, Zielinski DC, Ang KS, Gardiner NJ, Gutierrez JM, Kyriakopoulos S, Lakshmanan M, Li S, Liu JK, Martínez VS, Orellana CA, Quek LE, Thomas A, Zanghellini J, Borth N, Lee DY, Nielsen LK, Kell DB, Lewis NE, Mendes P.

Metabolomics. 2016;12:109. Epub 2016 Jun 7.

5.

High-antibody-producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis.

Orellana CA, Marcellin E, Schulz BL, Nouwens AS, Gray PP, Nielsen LK.

J Proteome Res. 2015 Feb 6;14(2):609-18. doi: 10.1021/pr501027c. Epub 2015 Jan 14.

PMID:
25495469
6.

Mathematical modeling of elution curves for a protein mixture in ion exchange chromatography applied to high protein concentration.

Orellana CA, Shene C, Asenjo JA.

Biotechnol Bioeng. 2009 Oct 15;104(3):572-81. doi: 10.1002/bit.22422.

PMID:
19593757
7.

Factors leading to hip subluxation and dislocation in femoral lengthening of unilateral congenital short femur.

Bowen JR, Kumar SJ, Orellana CA, Andreacchio A, Cardona JI.

J Pediatr Orthop. 2001 May-Jun;21(3):354-9.

PMID:
11371820
8.

Lateral column lengthening as treatment for planovalgus foot deformity in ambulatory children with spastic cerebral palsy.

Andreacchio A, Orellana CA, Miller F, Bowen TR.

J Pediatr Orthop. 2000 Jul-Aug;20(4):501-5.

PMID:
10912608

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