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Whole Genome Sequence, Variant Discovery and Annotation in Mapuche-Huilliche Native South Americans.

Vidal EA, Moyano TC, Bustos BI, Pérez-Palma E, Moraga C, Riveras E, Montecinos A, Azócar L, Soto DC, Vidal M, Di Genova A, Puschel K, Nürnberg P, Buch S, Hampe J, Allende ML, Cambiazo V, González M, Hodar C, Montecino M, Muñoz-Espinoza C, Orellana A, Reyes-Jara A, Travisany D, Vizoso P, Moraga M, Eyheramendy S, Maass A, De Ferrari GV, Miquel JF, Gutiérrez RA.

Sci Rep. 2019 Feb 14;9(1):2132. doi: 10.1038/s41598-019-39391-z.


Comparative Transcriptome Profiling in a Segregating Peach Population with Contrasting Juiciness Phenotypes.

Del Pozo T, Miranda S, Latorre M, Olivares F, Pavez L, Gutiérrez R, Maldonado J, Hinrichsen P, Defilippi BG, Orellana A, González M.

J Agric Food Chem. 2019 Feb 6;67(5):1598-1607. doi: 10.1021/acs.jafc.8b05177. Epub 2019 Jan 24.


Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI).

de Rojas I, Romero J, Rodríguez-Gomez O, Pesini P, Sanabria A, Pérez-Cordon A, Abdelnour C, Hernández I, Rosende-Roca M, Mauleón A, Vargas L, Alegret M, Espinosa A, Ortega G, Gil S, Guitart M, Gailhajanet A, Santos-Santos MA, Moreno-Grau S, Sotolongo-Grau O, Ruiz S, Montrreal L, Martín E, Pelejà E, Lomeña F, Campos F, Vivas A, Gómez-Chiari M, Tejero MA, Giménez J, Pérez-Grijalba V, Marquié GM, Monté-Rubio G, Valero S, Orellana A, Tárraga L, Sarasa M, Ruiz A, Boada M; FACEHBI study.

Alzheimers Res Ther. 2018 Nov 29;10(1):119. doi: 10.1186/s13195-018-0444-1.


Exploring Genetic Associations of Alzheimer's Disease Loci With Mild Cognitive Impairment Neurocognitive Endophenotypes.

Espinosa A, Hernández-Olasagarre B, Moreno-Grau S, Kleineidam L, Heilmann-Heimbach S, Hernández I, Wolfsgruber S, Wagner H, Rosende-Roca M, Mauleón A, Vargas L, Lafuente A, Rodríguez-Gómez O, Abdelnour C, Gil S, Marquié M, Santos-Santos MA, Sanabria Á, Ortega G, Monté-Rubio G, Pérez A, Ibarria M, Ruiz S, Kornhuber J, Peters O, Frölich L, Hüll M, Wiltfang J, Luck T, Riedel-Heller S, Montrreal L, Cañabate P, Moreno M, Preckler S, Aguilera N, de Rojas I, Orellana A, Alegret M, Valero S, Nöthen MM, Wagner M, Jessen F, Tárraga L, Boada M, Ramírez A, Ruiz A.

Front Aging Neurosci. 2018 Oct 30;10:340. doi: 10.3389/fnagi.2018.00340. eCollection 2018.


A Prunus persica genome-wide RNA-seq approach uncovers major differences in the transcriptome among chilling injury sensitive and non-sensitive varieties.

Nilo-Poyanco R, Vizoso P, Sanhueza D, Balic I, Meneses C, Orellana A, Campos-Vargas R.

Physiol Plant. 2018 Sep 11. doi: 10.1111/ppl.12831. [Epub ahead of print]


Ouabain increases neuronal branching in hippocampus and improves spatial memory.

Orellana AM, Leite JA, Kinoshita PF, Vasconcelos AR, Andreotti DZ, de Sá Lima L, Xavier GF, Kawamoto EM, Scavone C.

Neuropharmacology. 2018 Sep 15;140:260-274. doi: 10.1016/j.neuropharm.2018.08.008. Epub 2018 Aug 9.


bZIP17 regulates the expression of genes related to seed storage and germination, reducing seed susceptibility to osmotic stress.

Cifuentes-Esquivel N, Celiz-Balboa J, Henriquez-Valencia C, Mitina I, Arraño-Salinas P, Moreno AA, Meneses C, Blanco-Herrera F, Orellana A.

J Cell Biochem. 2018 Aug;119(8):6857-6868. doi: 10.1002/jcb.26882. Epub 2018 Apr 25.


Speeding up Monte Carlo simulation of patchy hard cylinders.

Orellana AG, Romani E, De Michele C.

Eur Phys J E Soft Matter. 2018 Apr 16;41(4):51. doi: 10.1140/epje/i2018-11657-0.


The Acid-Free Cyclopropanol-Minisci Reaction Reveals the Catalytic Role of Silver-Pyridine Complexes.

Nikolaev A, Legault CY, Zhang M, Orellana A.

Org Lett. 2018 Feb 2;20(3):796-799. doi: 10.1021/acs.orglett.7b03938. Epub 2018 Jan 19.


Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells.

Orellana A, García-González V, López R, Pascual-Guiral S, Lozoya E, Díaz J, Casals D, Barrena A, Paris S, Andrés M, Segarra V, Vilella D, Malhotra R, Eastwood P, Planagumà A, Miralpeix M, Nueda A.

PLoS One. 2018 Jan 10;13(1):e0189247. doi: 10.1371/journal.pone.0189247. eCollection 2018.


Statistically Enhanced Model of In Situ Oil Sands Extraction Operations: An Evaluation of Variability in Greenhouse Gas Emissions.

Orellana A, Laurenzi IJ, MacLean HL, Bergerson JA.

Environ Sci Technol. 2018 Feb 6;52(3):947-954. doi: 10.1021/acs.est.7b04498. Epub 2018 Jan 18.


Exploring APOE genotype effects on Alzheimer's disease risk and amyloid β burden in individuals with subjective cognitive decline: The FundacioACE Healthy Brain Initiative (FACEHBI) study baseline results.

Moreno-Grau S, Rodríguez-Gómez O, Sanabria Á, Pérez-Cordón A, Sánchez-Ruiz D, Abdelnour C, Valero S, Hernández I, Rosende-Roca M, Mauleón A, Vargas L, Lafuente A, Gil S, Santos-Santos MÁ, Alegret M, Espinosa A, Ortega G, Guitart M, Gailhajanet A, de Rojas I, Sotolongo-Grau Ó, Ruiz S, Aguilera N, Papasey J, Martín E, Peleja E; Alzheimer's Disease Neuroimaging Initiative, Lomeña F, Campos F, Vivas A, Gómez-Chiari M, Tejero MÁ, Giménez J, Serrano-Ríos M, Orellana A, Tárraga L, Ruiz A, Boada M; FACEHBI study group.

Alzheimers Dement. 2018 May;14(5):634-643. doi: 10.1016/j.jalz.2017.10.005. Epub 2017 Nov 20.


Effects of Static Correlation between Spin Centers in Multicenter Transition Metal Complexes.

Chu S, Bovi D, Cappelluti F, Orellana AG, Martin H, Guidoni L.

J Chem Theory Comput. 2017 Oct 10;13(10):4675-4683. doi: 10.1021/acs.jctc.7b00316. Epub 2017 Sep 8.


Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells.

Kinoshita PF, Yshii LM, Orellana AMM, Paixão AG, Vasconcelos AR, Lima LS, Kawamoto EM, Scavone C.

Sci Rep. 2017 Jul 7;7(1):4894. doi: 10.1038/s41598-017-05075-9.


Convenient Access to meta-Substituted Phenols by Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling and Oxidation.

Wang Z, Orellana A.

Chemistry. 2017 Aug 22;23(47):11445-11449. doi: 10.1002/chem.201702651. Epub 2017 Aug 1.


Global gene expression analysis provides insight into local adaptation to geothermal streams in tadpoles of the Andean toad Rhinella spinulosa.

Pastenes L, Valdivieso C, Di Genova A, Travisany D, Hart A, Montecino M, Orellana A, Gonzalez M, Gutiérrez RA, Allende ML, Maass A, Méndez MA.

Sci Rep. 2017 May 16;7(1):1966. doi: 10.1038/s41598-017-01982-z.


The elaborate route for UDP-arabinose delivery into the Golgi of plants.

Rautengarten C, Birdseye D, Pattathil S, McFarlane HE, Saez-Aguayo S, Orellana A, Persson S, Hahn MG, Scheller HV, Heazlewood JL, Ebert B.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4261-4266. doi: 10.1073/pnas.1701894114. Epub 2017 Apr 3.


Separating the Anti-Inflammatory and Diabetogenic Effects of Glucocorticoids Through LXRβ Antagonism.

Patel R, Magomedova L, Tsai R, Angers S, Orellana A, Cummins CL.

Endocrinology. 2017 Apr 1;158(4):1034-1047. doi: 10.1210/en.2017-00094.


UUAT1 Is a Golgi-Localized UDP-Uronic Acid Transporter That Modulates the Polysaccharide Composition of Arabidopsis Seed Mucilage.

Saez-Aguayo S, Rautengarten C, Temple H, Sanhueza D, Ejsmentewicz T, Sandoval-Ibañez O, Doñas D, Parra-Rojas JP, Ebert B, Lehner A, Mollet JC, Dupree P, Scheller HV, Heazlewood JL, Reyes FC, Orellana A.

Plant Cell. 2017 Jan;29(1):129-143. doi: 10.1105/tpc.16.00465. Epub 2017 Jan 6.


The Root Hair Specific SYP123 Regulates the Localization of Cell Wall Components and Contributes to Rizhobacterial Priming of Induced Systemic Resistance.

Rodriguez-Furlán C, Salinas-Grenet H, Sandoval O, Recabarren C, Arraño-Salinas P, Soto-Alvear S, Orellana A, Blanco-Herrera F.

Front Plant Sci. 2016 Jul 26;7:1081. doi: 10.3389/fpls.2016.01081. eCollection 2016.


The inside and outside: topological issues in plant cell wall biosynthesis and the roles of nucleotide sugar transporters.

Temple H, Saez-Aguayo S, Reyes FC, Orellana A.

Glycobiology. 2016 Sep;26(9):913-925. Epub 2016 Aug 9. Review.


The Arabidopsis Golgi-localized GDP-L-fucose transporter is required for plant development.

Rautengarten C, Ebert B, Liu L, Stonebloom S, Smith-Moritz AM, Pauly M, Orellana A, Scheller HV, Heazlewood JL.

Nat Commun. 2016 Jul 6;7:12119. doi: 10.1038/ncomms12119.


The Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence.

Kinoshita PF, Leite JA, Orellana AM, Vasconcelos AR, Quintas LE, Kawamoto EM, Scavone C.

Front Physiol. 2016 Jun 2;7:195. doi: 10.3389/fphys.2016.00195. eCollection 2016. Review.


Overview of Nucleotide Sugar Transporter Gene Family Functions Across Multiple Species.

Orellana A, Moraga C, Araya M, Moreno A.

J Mol Biol. 2016 Aug 14;428(16):3150-3165. doi: 10.1016/j.jmb.2016.05.021. Epub 2016 May 31. Review.


Identification of Novel Components of the Unfolded Protein Response in Arabidopsis.

Hossain MA, Henríquez-Valencia C, Gómez-Páez M, Medina J, Orellana A, Vicente-Carbajosa J, Zouhar J.

Front Plant Sci. 2016 May 12;7:650. doi: 10.3389/fpls.2016.00650. eCollection 2016.


PIN6 auxin transporter at endoplasmic reticulum and plasma membrane mediates auxin homeostasis and organogenesis in Arabidopsis.

Simon S, Skůpa P, Viaene T, Zwiewka M, Tejos R, Klíma P, Čarná M, Rolčík J, De Rycke R, Moreno I, Dobrev PI, Orellana A, Zažímalová E, Friml J.

New Phytol. 2016 Jul;211(1):65-74. doi: 10.1111/nph.14019.


Detection of Helicobacter pylori by Real-Time PCR for 16s rRNA in Stools of NonInfected Healthy Children, Using ELISA Antigen Stool Test as the Gold Standard.

George S, Mamani N, Lucero Y, Torres JP, Farfán M, Lagomarcino AJ, Orellana A, O'Ryan M.

Helicobacter. 2016 Dec;21(6):606-612. doi: 10.1111/hel.12318. Epub 2016 May 23.


Transcriptome profiling of grapevine seedless segregants during berry development reveals candidate genes associated with berry weight.

Muñoz-Espinoza C, Di Genova A, Correa J, Silva R, Maass A, González-Agüero M, Orellana A, Hinrichsen P.

BMC Plant Biol. 2016 Apr 26;16:104. doi: 10.1186/s12870-016-0789-1.


Cardiotonic Steroids as Modulators of Neuroinflammation.

Orellana AM, Kinoshita PF, Leite JA, Kawamoto EM, Scavone C.

Front Endocrinol (Lausanne). 2016 Feb 16;7:10. doi: 10.3389/fendo.2016.00010. eCollection 2016. Review.


Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus.

Orellana AM, Vasconcelos AR, Leite JA, de Sá Lima L, Andreotti DZ, Munhoz CD, Kawamoto EM, Scavone C.

Aging (Albany NY). 2015 Dec;7(12):1094-111.


Synthesis of α,β-Unsaturated Acylsilanes via Perrhenate-Catalyzed Meyer-Schuster Rearrangement of 1-Silylalkyn-3-ols.

Nikolaev A, Orellana A.

Org Lett. 2015 Dec 4;17(23):5796-9. doi: 10.1021/acs.orglett.5b02909. Epub 2015 Nov 18.


Proteomic analysis of a segregant population reveals candidate proteins linked to mealiness in peach.

Almeida AM, Urra C, Moraga C, Jego M, Flores A, Meisel L, González M, Infante R, Defilippi BG, Campos-Vargas R, Orellana A.

J Proteomics. 2016 Jan 10;131:71-81. doi: 10.1016/j.jprot.2015.10.011. Epub 2015 Oct 13.


Posttraumatic stress disorder symptoms in close relatives of intensive care unit patients: Prevalence data resemble that of earthquake survivors in Chile.

Andresen M, Guic E, Orellana A, Diaz MJ, Castro R.

J Crit Care. 2015 Oct;30(5):1152.e7-11. doi: 10.1016/j.jcrc.2015.06.009. Epub 2015 Jun 26.


A novel inhaled Syk inhibitor blocks mast cell degranulation and early asthmatic response.

Ramis I, Otal R, Carreño C, Domènech A, Eichhorn P, Orellana A, Maldonado M, De Alba J, Prats N, Fernández JC, Vidal B, Miralpeix M.

Pharmacol Res. 2015 Sep;99:116-24. doi: 10.1016/j.phrs.2015.05.011. Epub 2015 Jun 4.


The UDP-glucose: glycoprotein glucosyltransferase (UGGT), a key enzyme in ER quality control, plays a significant role in plant growth as well as biotic and abiotic stress in Arabidopsis thaliana.

Blanco-Herrera F, Moreno AA, Tapia R, Reyes F, Araya M, D'Alessio C, Parodi A, Orellana A.

BMC Plant Biol. 2015 May 28;15:127. doi: 10.1186/s12870-015-0525-2.


Altered KLOTHO and NF-κB-TNF-α Signaling Are Correlated with Nephrectomy-Induced Cognitive Impairment in Rats.

Degaspari S, Tzanno-Martins CB, Fujihara CK, Zatz R, Branco-Martins JP, Viel TA, Buck Hde S, Orellana AM, Böhmer AE, Lima Lde S, Andreotti DZ, Munhoz CD, Scavone C, Kawamoto EM.

PLoS One. 2015 May 11;10(5):e0125271. doi: 10.1371/journal.pone.0125271. eCollection 2015.


The dynamic of the splicing of bZIP60 and the proteins encoded by the spliced and unspliced mRNAs reveals some unique features during the activation of UPR in Arabidopsis thaliana.

Parra-Rojas J, Moreno AA, Mitina I, Orellana A.

PLoS One. 2015 Apr 10;10(4):e0122936. doi: 10.1371/journal.pone.0122936. eCollection 2015.


Persistent and transient Helicobacter pylori infections in early childhood.

O'Ryan ML, Lucero Y, Rabello M, Mamani N, Salinas AM, Peña A, Torres-Torreti JP, Mejías A, Ramilo O, Suarez N, Reynolds HE, Orellana A, Lagomarcino AJ.

Clin Infect Dis. 2015 Jul 15;61(2):211-8. doi: 10.1093/cid/civ256. Epub 2015 Apr 2.


Comparative study of two table grape varieties with contrasting texture during cold storage.

Ejsmentewicz T, Balic I, Sanhueza D, Barria R, Meneses C, Orellana A, Prieto H, Defilippi BG, Campos-Vargas R.

Molecules. 2015 Feb 23;20(3):3667-80. doi: 10.3390/molecules20033667.


bZIP17 and bZIP60 Regulate the Expression of BiP3 and Other Salt Stress Responsive Genes in an UPR-Independent Manner in Arabidopsis thaliana.

Henriquez-Valencia C, Moreno AA, Sandoval-Ibañez O, Mitina I, Blanco-Herrera F, Cifuentes-Esquivel N, Orellana A.

J Cell Biochem. 2015 Aug;116(8):1638-45. doi: 10.1002/jcb.25121.


Signaling function of Na,K-ATPase induced by ouabain against LPS as an inflammation model in hippocampus.

Kinoshita PF, Yshii LM, Vasconcelos AR, Orellana AM, Lima Lde S, Davel AP, Rossoni LV, Kawamoto EM, Scavone C.

J Neuroinflammation. 2014 Dec 31;11:218. doi: 10.1186/s12974-014-0218-z.


Susceptibility to deltamethrin of wild and domestic populations of Triatoma infestans of the Gran Chaco and the Inter-Andean Valleys of Bolivia.

Gomez MB, D'Avila GC, Orellana AL, Cortez MR, Rosa AC, Noireau F, Diotaiuti LG.

Parasit Vectors. 2014 Nov 14;7:497. doi: 10.1186/s13071-014-0497-3.


Palladium-catalyzed cross-coupling of benzyl chlorides with cyclopropanol-derived ketone homoenolates.

Nithiy N, Orellana A.

Org Lett. 2014 Nov 21;16(22):5854-7. doi: 10.1021/ol5027188. Epub 2014 Oct 30.


[Art, health and prevention: initial collaborations].

Avila N, Orellana A, Cano MG, Antúnez N, Claver D.

Gac Sanit. 2014 Nov-Dec;28(6):501-4. doi: 10.1016/j.gaceta.2014.07.002. Epub 2014 Aug 23. Spanish.


The Golgi localized bifunctional UDP-rhamnose/UDP-galactose transporter family of Arabidopsis.

Rautengarten C, Ebert B, Moreno I, Temple H, Herter T, Link B, Doñas-Cofré D, Moreno A, Saéz-Aguayo S, Blanco F, Mortimer JC, Schultink A, Reiter WD, Dupree P, Pauly M, Heazlewood JL, Scheller HV, Orellana A.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11563-8. doi: 10.1073/pnas.1406073111. Epub 2014 Jul 22.


Using genomics to improve fruit quality.

Meneses C, Orellana A.

Biol Res. 2013;46(4):347-52. doi: 10.4067/S0716-97602013000400006. Review.


Whole genome comparison between table and wine grapes reveals a comprehensive catalog of structural variants.

Di Genova A, Almeida AM, Muñoz-Espinoza C, Vizoso P, Travisany D, Moraga C, Pinto M, Hinrichsen P, Orellana A, Maass A.

BMC Plant Biol. 2014 Jan 7;14:7. doi: 10.1186/1471-2229-14-7.


Identification of two putative reference genes from grapevine suitable for gene expression analysis in berry and related tissues derived from RNA-Seq data.

González-Agüero M, García-Rojas M, Di Genova A, Correa J, Maass A, Orellana A, Hinrichsen P.

BMC Genomics. 2013 Dec 13;14:878. doi: 10.1186/1471-2164-14-878.


Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice.

Patel M, Wang XX, Magomedova L, John R, Rasheed A, Santamaria H, Wang W, Tsai R, Qiu L, Orellana A, Advani A, Levi M, Cummins CL.

Diabetologia. 2014 Feb;57(2):435-46. doi: 10.1007/s00125-013-3095-6. Epub 2013 Nov 8.


Proteomic analysis of grapevine (Vitis vinifera L.) leaf changes induced by transition to autotrophy and exposure to high light irradiance.

Nilo-Poyanco R, Olivares D, Orellana A, Hinrichsen P, Pinto M.

J Proteomics. 2013 Oct 8;91:309-30. doi: 10.1016/j.jprot.2013.07.004. Epub 2013 Aug 7.


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