Sort by
Items per page

Send to

Choose Destination

Search results

Items: 27


Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock.

Orvedahl A, McAllaster MR, Sansone A, Dunlap BF, Desai C, Wang YT, Balce DR, Luke CJ, Lee S, Orchard RC, Artyomov MN, Handley SA, Doench JG, Silverman GA, Virgin HW.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16497-16506. doi: 10.1073/pnas.1822157116. Epub 2019 Jul 25.


A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis.

Lee S, Liu H, Wilen CB, Sychev ZE, Desai C, Hykes BL Jr, Orchard RC, McCune BT, Kim KW, Nice TJ, Handley SA, Baldridge MT, Amarasinghe GK, Virgin HW.

Cell Host Microbe. 2019 Jun 12;25(6):845-857.e5. doi: 10.1016/j.chom.2019.04.005. Epub 2019 May 23.


Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening.

Orchard RC, Sullender ME, Dunlap BF, Balce DR, Doench JG, Virgin HW.

J Virol. 2018 Dec 10;93(1). pii: e01324-18. doi: 10.1128/JVI.01324-18. Print 2019 Jan 1.


Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor.

Nelson CA, Wilen CB, Dai YN, Orchard RC, Kim AS, Stegeman RA, Hsieh LL, Smith TJ, Virgin HW, Fremont DH.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9201-E9210. doi: 10.1073/pnas.1805797115. Epub 2018 Sep 7.


Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection.

Orchard RC, Wilen CB, Virgin HW.

Nat Microbiol. 2018 Oct;3(10):1109-1114. doi: 10.1038/s41564-018-0221-8. Epub 2018 Aug 20.


Tropism for tuft cells determines immune promotion of norovirus pathogenesis.

Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW.

Science. 2018 Apr 13;360(6385):204-208. doi: 10.1126/science.aar3799.


Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine.

Lee S, Wilen CB, Orvedahl A, McCune BT, Kim KW, Orchard RC, Peterson ST, Nice TJ, Baldridge MT, Virgin HW.

Cell Host Microbe. 2017 Oct 11;22(4):449-459.e4. doi: 10.1016/j.chom.2017.08.021. Epub 2017 Sep 28.


A systematic exploration of the interactions between bacterial effector proteins and host cell membranes.

Weigele BA, Orchard RC, Jimenez A, Cox GW, Alto NM.

Nat Commun. 2017 Sep 14;8(1):532. doi: 10.1038/s41467-017-00700-7.


Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.

Biering SB, Choi J, Halstrom RA, Brown HM, Beatty WL, Lee S, McCune BT, Dominici E, Williams LE, Orchard RC, Wilen CB, Yamamoto M, Coers J, Taylor GA, Hwang S.

Cell Host Microbe. 2017 Jul 12;22(1):74-85.e7. doi: 10.1016/j.chom.2017.06.005. Epub 2017 Jun 29.


Discovery of a proteinaceous cellular receptor for a norovirus.

Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW.

Science. 2016 Aug 26;353(6302):933-6. doi: 10.1126/science.aaf1220. Epub 2016 Aug 18.


Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival.

Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, Pruett-Miller SM, Ornitz DM, Allen PM, Beatty WL, Schmidt RE, DiAntonio A, Tooze SA, Virgin HW.

Sci Rep. 2016 Mar 18;6:23326. doi: 10.1038/srep23326.


A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.

Selleck EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B, Virgin HW, Sibley LD.

MBio. 2015 Sep 8;6(5):e01157-15. doi: 10.1128/mBio.01157-15.


Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit.

Orchard RC, Kittisopikul M, Altschuler SJ, Wu LF, Süel GM, Alto NM.

Cell. 2012 Feb 17;148(4):803-15. doi: 10.1016/j.cell.2011.11.063.


Mimicking GEFs: a common theme for bacterial pathogens.

Orchard RC, Alto NM.

Cell Microbiol. 2012 Jan;14(1):10-8. doi: 10.1111/j.1462-5822.2011.01703.x. Epub 2011 Dec 1. Review.


The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.

Selyunin AS, Sutton SE, Weigele BA, Reddick LE, Orchard RC, Bresson SM, Tomchick DR, Alto NM.

Nature. 2011 Jan 6;469(7328):107-11. doi: 10.1038/nature09593. Epub 2010 Dec 19.


Genomic and functional analyses of Rhodococcus equi phages ReqiPepy6, ReqiPoco6, ReqiPine5, and ReqiDocB7.

Summer EJ, Liu M, Gill JJ, Grant M, Chan-Cortes TN, Ferguson L, Janes C, Lange K, Bertoli M, Moore C, Orchard RC, Cohen ND, Young R.

Appl Environ Microbiol. 2011 Jan;77(2):669-83. doi: 10.1128/AEM.01952-10. Epub 2010 Nov 19.


Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics.

Huang Z, Sutton SE, Wallenfang AJ, Orchard RC, Wu X, Feng Y, Chai J, Alto NM.

Nat Struct Mol Biol. 2009 Aug;16(8):853-60. doi: 10.1038/nsmb.1647. Epub 2009 Jul 20.


Angiotensin-converting enzyme inhibition in myocardial infarction--Part 2: Clinical issues and controversies.

Huckell VF, Bernstein V, Crowell R, Dagenais GR, Higginson LA, Isserow S, Laramée P, Liu P, McCans JL, Orchard RC, Prewitt R, Quinn BP, Samson M, Turazza F, Warnica JW, Wielgosz A.

Can J Cardiol. 1997 Feb;13(2):173-82. Review.


Angiotensin-converting enzyme inhibition in myocardial infarction--Part 1: Clinical data.

Huckell VF, Bernstein V, Cairns JA, Crowell R, Dagenais GR, Higginson LA, Isserow S, Laramée P, Liu P, McCans JL, Orchard RC, Prewitt R, Quinn BP, Samson M, Turazza F, Warnica JW, Wielgosz A.

Can J Cardiol. 1997 Feb;13(2):161-9. Review.


The prevalence of anxiety disorders among patients with mitral valve prolapse syndrome and chest pain.

Bowen RC, D'Arcy C, Orchard RC.

Psychosomatics. 1991 Fall;32(4):400-6.


Transesophageal echocardiography in the diagnosis of left atrial appendage aneurysm.

Cujec B, Bharadwaj B, Orchard RC, Lopez JF.

J Am Soc Echocardiogr. 1990 Sep-Oct;3(5):408-11.


The response of plasma fibronectin to acute myocardial infarction in humans.

Dyck RF, Orchard RC, Senger DL.

Clin Invest Med. 1990 Jun;13(3):107-10.


Mitral valve prolapse and psychiatric disorders.

Bowen RC, Orchard RC, Keegan DL, D'Arcy C.

Psychosomatics. 1985 Dec;26(12):926-32. No abstract available.


Effects of verapamil on the extracellular K+ rise during myocardial ischaemia in dogs.

Lopez JF, Orchard RC.

Cardiovasc Res. 1985 Jun;19(6):363-9.


Quantification of mitral valvular incompetence.

Lopez JF, Hanson S, Orchard RC, Tan L.

Cathet Cardiovasc Diagn. 1985;11(2):139-52.


Dicrotic pulse after open heart surgery.

Orchard RC, Craige E.

Circulation. 1980 Nov;62(5):1107-14.


Separate pools for endogenous and exogenous cholesterol in rat intestines.

Sodhi HS, Orchard RC, Agnish ND, Varughese PV, Kudchodkar BJ.

Atherosclerosis. 1973 Mar-Apr;17(2):197-210. No abstract available.


Supplemental Content

Loading ...
Support Center