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Items: 1 to 50 of 253

1.

Questioning the accuracy of currently available pneumococcal antibody testing.

Hajjar J, Al-Kaabi A, Kutac C, Dunn J, Shearer WT, Orange JS.

J Allergy Clin Immunol. 2018 Jun 21. pii: S0091-6749(18)30900-X. doi: 10.1016/j.jaci.2018.06.013. [Epub ahead of print]

PMID:
29936105
2.

The International Alliance of Primary Immune Deficiency Societies.

Gennery AR, Abraham RS, Torgerson TR, Etzioni A, Cant AJ, Meyts I, Chipeta J, Bousfiha AA, Dieye TD, Condino-Neto A, Espinosa F, Besrodnik L, Lau YL, Singh S, Chan GCF, Orange JS; European Society for Immunodeficiencies; Clinical Immunology Society; African Society for Immunodeficiencies; Latin American Society for Immunodeficiencies; Asia Pacific Society for Immunodeficiencies.

J Clin Immunol. 2018 Jun 5. doi: 10.1007/s10875-018-0517-8. [Epub ahead of print] No abstract available.

PMID:
29872941
3.

Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome.

Poli MC, Ebstein F, Nicholas SK, de Guzman MM, Forbes LR, Chinn IK, Mace EM, Vogel TP, Carisey AF, Benavides F, Coban-Akdemir ZH, Gibbs RA, Jhangiani SN, Muzny DM, Carvalho CMB, Schady DA, Jain M, Rosenfeld JA, Emrick L, Lewis RA, Lee B; Undiagnosed Diseases Network members, Zieba BA, Küry S, Krüger E, Lupski JR, Bostwick BL, Orange JS.

Am J Hum Genet. 2018 Jun 7;102(6):1126-1142. doi: 10.1016/j.ajhg.2018.04.010. Epub 2018 May 24.

4.

Discovering the Cause of Wiskott-Aldrich Syndrome and Laying the Foundation for Understanding Immune Cell Structuring.

Mace EM, Orange JS.

J Immunol. 2018 Jun 1;200(11):3667-3670. doi: 10.4049/jimmunol.1800518. No abstract available.

PMID:
29784762
5.

Correction to: Use of Genetic Testing for Primary Immunodeficiency Patients.

Heimall JR, Hagin D, Hajjar J, Henrickson SE, Hernandez-Trujillo HS, Itan Y, Kobrynski L, Paris K, Torgerson TR, Verbsky JW, Wasserman RL, Hsieh EWY, Bleesing JJ, Chou JS, Lawrence MG, Marsh RA, Rosenzweig SD, Orange JS, Abraham RS.

J Clin Immunol. 2018 May;38(4):540-541. doi: 10.1007/s10875-018-0510-2.

PMID:
29781065
6.

Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes.

DiNardo AR, Nishiguchi T, Mace EM, Rajapakshe K, Mtetwa G, Kay A, Maphalala G, Secor WE, Mejia R, Orange JS, Coarfa C, Bhalla KN, Graviss EA, Mandalakas AM, Makedonas G.

J Immunol. 2018 Jul 1;201(1):124-133. doi: 10.4049/jimmunol.1800101. Epub 2018 May 11.

PMID:
29752313
7.
8.

Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING.

Konno H, Chinn IK, Hong D, Orange JS, Lupski JR, Mendoza A, Pedroza LA, Barber GN.

Cell Rep. 2018 Apr 24;23(4):1112-1123. doi: 10.1016/j.celrep.2018.03.115.

9.

Latent therapeutic demand model for the immunoglobulin replacement therapy of primary immune deficiency disorders in the USA.

Stonebraker JS, Hajjar J, Orange JS.

Vox Sang. 2018 Apr 20. doi: 10.1111/vox.12651. [Epub ahead of print]

PMID:
29675923
10.

Use of Genetic Testing for Primary Immunodeficiency Patients.

Heimall JR, Hagin D, Hajjar J, Henrickson SE, Hernandez-Trujillo HS, Tan Y, Kobrynski L, Paris K, Torgerson TR, Verbsky JW, Wasserman RL, Hsieh EWY, Blessing JJ, Chou JS, Lawrence MG, Marsh RA, Rosenzweig SD, Orange JS, Abraham RS.

J Clin Immunol. 2018 Apr;38(3):320-329. doi: 10.1007/s10875-018-0489-8. Epub 2018 Apr 19. Erratum in: J Clin Immunol. 2018 May 21;:.

PMID:
29675737
11.

The Role of AIRE in the Immunity Against Candida Albicans in a Model of Human Macrophages.

de Albuquerque JAT, Banerjee PP, Castoldi A, Ma R, Zurro NB, Ynoue LH, Arslanian C, Barbosa-Carvalho MUW, Correia-Deur JEM, Weiler FG, Dias-da-Silva MR, Lazaretti-Castro M, Pedroza LA, Câmara NOS, Mace E, Orange JS, Condino-Neto A.

Front Immunol. 2018 Mar 21;9:567. doi: 10.3389/fimmu.2018.00567. eCollection 2018.

12.

Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis.

Chinn IK, Eckstein OS, Peckham-Gregory EC, Goldberg BR, Forbes LR, Nicholas SK, Mace EM, Vogel TP, Abhyankar HA, Diaz MI, Heslop HE, Krance RA, Martinez CA, Nguyen TC, Bashir DA, Goldman JR, Stray-Pedersen A, Pedroza LA, Poli MC, Aldave-Becerra JC, McGhee SA, Al-Herz W, Chamdin A, Coban-Akdemir ZH, Jhangiani SN, Muzny DM, Cao TN, Hong DN, Gibbs RA, Lupski JR, Orange JS, McClain KL, Allen CE.

Blood. 2018 Jul 5;132(1):89-100. doi: 10.1182/blood-2017-11-814244. Epub 2018 Apr 9.

PMID:
29632024
13.

High Incidence of Autoimmune Disease after Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease.

Yanir AD, Hanson IC, Shearer WT, Noroski LM, Forbes LR, Seeborg FO, Nicholas S, Chinn I, Orange JS, Rider NL, Leung KS, Naik S, Carrum G, Sasa G, Hegde M, Omer BA, Ahmed N, Allen CE, Khaled Y, Wu MF, Liu H, Gottschalk SM, Heslop HE, Brenner MK, Krance RA, Martinez CA.

Biol Blood Marrow Transplant. 2018 Apr 6. pii: S1083-8791(18)30163-0. doi: 10.1016/j.bbmt.2018.03.029. [Epub ahead of print]

PMID:
29630926
14.

Single Degranulations in NK Cells Can Mediate Target Cell Killing.

Gwalani LA, Orange JS.

J Immunol. 2018 May 1;200(9):3231-3243. doi: 10.4049/jimmunol.1701500. Epub 2018 Mar 28.

PMID:
29592963
15.

Corrigendum: Specific Antibody Deficiency: Controversies in Diagnosis and Management.

Perez E, Bonilla FA, Orange JS, Ballow M.

Front Immunol. 2018 Mar 15;9:450. doi: 10.3389/fimmu.2018.00450. eCollection 2018.

16.

The Value of Food Allergy Prevention in Clinical Practice in Pediatrics: Targeting Early Life.

Anagnostou K, Orange JS.

Children (Basel). 2018 Jan 23;5(2). pii: E14. doi: 10.3390/children5020014.

17.

Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells.

Carisey AF, Mace EM, Saeed MB, Davis DM, Orange JS.

Curr Biol. 2018 Feb 19;28(4):489-502.e9. doi: 10.1016/j.cub.2017.12.044. Epub 2018 Feb 1.

18.

Mutations in PI3K110δ cause impaired natural killer cell function partially rescued by rapamycin treatment.

Ruiz-García R, Vargas-Hernández A, Chinn IK, Angelo LS, Cao TN, Coban-Akdemir Z, Jhangiani SN, Meng Q, Forbes LR, Muzny DM, Allende LM, Ehlayel MS, Gibbs RA, Lupski JR, Uzel G, Orange JS, Mace EM.

J Allergy Clin Immunol. 2018 Jan 10. pii: S0091-6749(18)30026-5. doi: 10.1016/j.jaci.2017.11.042. [Epub ahead of print]

PMID:
29330011
19.

Clinical and economic outcomes of a "high-touch" clinical management program for intravenous immunoglobulin therapy.

Zhu J, Kirkham HS, Ayer G, Chen CC, Wade RL, Karkare SU, Robson CH, Orange JS.

Clinicoecon Outcomes Res. 2017 Dec 19;10:1-12. doi: 10.2147/CEOR.S142239. eCollection 2018.

20.

Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations.

Vargas-Hernández A, Mace EM, Zimmerman O, Zerbe CS, Freeman AF, Rosenzweig S, Leiding JW, Torgerson T, Altman MC, Schussler E, Cunningham-Rundles C, Chinn IK, Carisey AF, Hanson IC, Rider NL, Holland SM, Orange JS, Forbes LR.

J Allergy Clin Immunol. 2018 Jun;141(6):2142-2155.e5. doi: 10.1016/j.jaci.2017.08.040. Epub 2017 Oct 27.

PMID:
29111217
21.

Editorial: NK Cell Subsets in Health and Disease: New Developments.

Marcenaro E, Notarangelo LD, Orange JS, Vivier E.

Front Immunol. 2017 Oct 18;8:1363. doi: 10.3389/fimmu.2017.01363. eCollection 2017. No abstract available.

22.

Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-cell Malignancies.

Mamonkin M, Mukherjee M, Srinivasan M, Sharma S, Gomes-Silva D, Mo F, Krenciute G, Orange JS, Brenner MK.

Cancer Immunol Res. 2018 Jan;6(1):47-58. doi: 10.1158/2326-6066.CIR-17-0126. Epub 2017 Oct 27.

23.

c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals.

Nishimura CD, Brenner DA, Mukherjee M, Hirsch RA, Ott L, Wu MF, Liu H, Dakhova O, Orange JS, Brenner MK, Lin CY, Arber C.

Blood. 2017 Dec 21;130(25):2739-2749. doi: 10.1182/blood-2017-02-769463. Epub 2017 Oct 27.

PMID:
29079582
24.

Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma.

Bielamowicz K, Fousek K, Byrd TT, Samaha H, Mukherjee M, Aware N, Wu MF, Orange JS, Sumazin P, Man TK, Joseph SK, Hegde M, Ahmed N.

Neuro Oncol. 2018 Mar 27;20(4):506-518. doi: 10.1093/neuonc/nox182.

PMID:
29016929
25.

Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent.

Gomes-Silva D, Mukherjee M, Srinivasan M, Krenciute G, Dakhova O, Zheng Y, Cabral JMS, Rooney CM, Orange JS, Brenner MK, Mamonkin M.

Cell Rep. 2017 Oct 3;21(1):17-26. doi: 10.1016/j.celrep.2017.09.015.

26.

Immunologic Profiling of Human Metapneumovirus for the Development of Targeted Immunotherapy.

Tzannou I, Nicholas SK, Lulla P, Aguayo-Hiraldo PI, Misra A, Martinez CA, Machado AA, Orange JS, Piedra PA, Vera JF, Leen AM.

J Infect Dis. 2017 Sep 15;216(6):678-687. doi: 10.1093/infdis/jix358.

PMID:
28934427
27.

T-Cell Lymphopenia Detected by Newborn Screening in Two Siblings with an Xq13.1 Duplication.

Rios X, Chinn IK, Orange JS, Hanson CI, Rider NL.

Front Pediatr. 2017 Jul 18;5:156. doi: 10.3389/fped.2017.00156. eCollection 2017.

28.

High-resolution phenotyping identifies NK cell subsets that distinguish healthy children from adults.

Mahapatra S, Mace EM, Minard CG, Forbes LR, Vargas-Hernandez A, Duryea TK, Makedonas G, Banerjee PP, Shearer WT, Orange JS.

PLoS One. 2017 Aug 2;12(8):e0181134. doi: 10.1371/journal.pone.0181134. eCollection 2017.

29.

FiloQuant reveals increased filopodia density during breast cancer progression.

Jacquemet G, Paatero I, Carisey AF, Padzik A, Orange JS, Hamidi H, Ivaska J.

J Cell Biol. 2017 Oct 2;216(10):3387-3403. doi: 10.1083/jcb.201704045. Epub 2017 Aug 1.

30.

Tumor-priming converts NK cells to memory-like NK cells.

Pal M, Schwab L, Yermakova A, Mace EM, Claus R, Krahl AC, Woiterski J, Hartwig UF, Orange JS, Handgretinger R, André MC.

Oncoimmunology. 2017 Apr 18;6(6):e1317411. doi: 10.1080/2162402X.2017.1317411. eCollection 2017.

31.

Hematopoietic stem cell transplantation in 29 patients hemizygous for hypomorphic IKBKG/NEMO mutations.

Miot C, Imai K, Imai C, Mancini AJ, Kucuk ZY, Kawai T, Nishikomori R, Ito E, Pellier I, Dupuis Girod S, Rosain J, Sasaki S, Chandrakasan S, Pachlopnik Schmid J, Okano T, Colin E, Olaya-Vargas A, Yamazaki-Nakashimada M, Qasim W, Espinosa Padilla S, Jones A, Krol A, Cole N, Jolles S, Bleesing J, Vraetz T, Gennery AR, Abinun M, Güngör T, Costa-Carvalho B, Condino-Neto A, Veys P, Holland SM, Uzel G, Moshous D, Neven B, Blanche S, Ehl S, Döffinger R, Patel SY, Puel A, Bustamante J, Gelfand EW, Casanova JL, Orange JS, Picard C.

Blood. 2017 Sep 21;130(12):1456-1467. doi: 10.1182/blood-2017-03-771600. Epub 2017 Jul 5.

PMID:
28679735
32.

Quantitative Imaging Approaches to Study the CAR Immunological Synapse.

Mukherjee M, Mace EM, Carisey AF, Ahmed N, Orange JS.

Mol Ther. 2017 Aug 2;25(8):1757-1768. doi: 10.1016/j.ymthe.2017.06.003. Epub 2017 Jun 26. Review.

PMID:
28663103
33.

Multispecialty Rating of Evidence-Based Conditions for Intravenous Immunoglobulin Therapy Using a 3-Axis Prioritization Algorithm.

Orange JS, Johnson M, Lennert B, Shields K, Eaddy M.

Am Health Drug Benefits. 2017 May;10(3):134-142.

34.

Novel Combined Immune Deficiency and Radiation Sensitivity Blended Phenotype in an Adult with Biallelic Variations in ZAP70 and RNF168.

Chinn IK, Sanders RP, Stray-Pedersen A, Coban-Akdemir ZH, Kim VH, Dadi H, Roifman CM, Quigg T, Lupski JR, Orange JS, Hanson IC.

Front Immunol. 2017 May 26;8:576. doi: 10.3389/fimmu.2017.00576. eCollection 2017.

35.

Specific Antibody Deficiency: Controversies in Diagnosis and Management.

Perez E, Bonilla FA, Orange JS, Ballow M.

Front Immunol. 2017 May 22;8:586. doi: 10.3389/fimmu.2017.00586. eCollection 2017. Review. Erratum in: Front Immunol. 2018 Mar 15;9:450.

36.

Overview: NK-cell-based Immunotherapies: Toward & Into Clinical Trials.

Exley MA, Orange JS.

Clin Immunol. 2017 Apr;177:1-2. doi: 10.1016/j.clim.2017.05.004. No abstract available.

PMID:
28583665
37.

Changes in Frequency and Activation Status of Major CD4+ T-Cell Subsets after Initiation of Immunosuppressive Therapy in a Patient with New Diagnosis Childhood-Onset Systemic Lupus Erythematosus.

Singla S, Wenderfer SE, Muscal E, Sagcal-Gironella ACP, Orange JS, Makedonas G.

Front Pediatr. 2017 May 15;5:104. doi: 10.3389/fped.2017.00104. eCollection 2017.

38.

Health-Related Quality of Life in Adult Patients with Common Variable Immunodeficiency Disorders and Impact of Treatment.

Rider NL, Kutac C, Hajjar J, Scalchunes C, Seeborg FO, Boyle M, Orange JS.

J Clin Immunol. 2017 Jul;37(5):461-475. doi: 10.1007/s10875-017-0404-8. Epub 2017 May 23.

39.

The coordinating role of IQGAP1 in the regulation of local, endosome-specific actin networks.

Samson EB, Tsao DS, Zimak J, McLaughlin RT, Trenton NJ, Mace EM, Orange JS, Schweikhard V, Diehl MR.

Biol Open. 2017 Jun 15;6(6):785-799. doi: 10.1242/bio.022624.

40.

Linking newborn severe combined immunodeficiency screening with targeted exome sequencing: A case report.

Patel DR, Yu H, Wong LC, Lupski JR, Seeborg FO, Rider NL, Martinez CA, Orange JS, Hanson C.

J Allergy Clin Immunol Pract. 2017 Sep - Oct;5(5):1442-1444. doi: 10.1016/j.jaip.2017.03.004. Epub 2017 Apr 21. No abstract available.

PMID:
28438538
41.

Lessons learned from additional research analyses of unsolved clinical exome cases.

Eldomery MK, Coban-Akdemir Z, Harel T, Rosenfeld JA, Gambin T, Stray-Pedersen A, Küry S, Mercier S, Lessel D, Denecke J, Wiszniewski W, Penney S, Liu P, Bi W, Lalani SR, Schaaf CP, Wangler MF, Bacino CA, Lewis RA, Potocki L, Graham BH, Belmont JW, Scaglia F, Orange JS, Jhangiani SN, Chiang T, Doddapaneni H, Hu J, Muzny DM, Xia F, Beaudet AL, Boerwinkle E, Eng CM, Plon SE, Sutton VR, Gibbs RA, Posey JE, Yang Y, Lupski JR.

Genome Med. 2017 Mar 21;9(1):26. doi: 10.1186/s13073-017-0412-6.

42.

Measurement of Lytic Granule Convergence After Formation of an NK Cell Immunological Synapse.

Hsu HT, Carisey AF, Orange JS.

Methods Mol Biol. 2017;1584:497-515. doi: 10.1007/978-1-4939-6881-7_31.

43.

First Case of CD40LG Deficiency in Ecuador, Diagnosed after Whole Exome Sequencing in a Patient with Severe Cutaneous Histoplasmosis.

Pedroza LA, Guerrero N, Stray-Pedersen A, Tafur C, Macias R, Muñoz G, Akdemir ZC, Jhangiani SN, Watkin LB, Chinn IK, Lupski JR, Orange JS.

Front Pediatr. 2017 Feb 10;5:17. doi: 10.3389/fped.2017.00017. eCollection 2017.

44.

Phase I trial of low-dose interleukin 2 therapy in patients with Wiskott-Aldrich syndrome.

Jyonouchi S, Gwafila B, Gwalani LA, Ahmad M, Moertel C, Holbert C, Kim JY, Kobrinsky N, Roy-Ghanta S, Orange JS.

Clin Immunol. 2017 Jun;179:47-53. doi: 10.1016/j.clim.2017.02.001. Epub 2017 Feb 14.

PMID:
28232030
45.

Increased Incidence of Fatigue in Patients with Primary Immunodeficiency Disorders: Prevalence and Associations Within the US Immunodeficiency Network Registry.

Hajjar J, Guffey D, Minard CG, Orange JS.

J Clin Immunol. 2017 Feb;37(2):153-165. doi: 10.1007/s10875-016-0367-1. Epub 2017 Jan 26.

46.

Update on the use of immunoglobulin in human disease: A review of evidence.

Perez EE, Orange JS, Bonilla F, Chinen J, Chinn IK, Dorsey M, El-Gamal Y, Harville TO, Hossny E, Mazer B, Nelson R, Secord E, Jordan SC, Stiehm ER, Vo AA, Ballow M.

J Allergy Clin Immunol. 2017 Mar;139(3S):S1-S46. doi: 10.1016/j.jaci.2016.09.023. Epub 2016 Dec 29. Review.

PMID:
28041678
47.

Genetic Causes of Human NK Cell Deficiency and Their Effect on NK Cell Subsets.

Mace EM, Orange JS.

Front Immunol. 2016 Dec 2;7:545. eCollection 2016. Review.

48.

Pulmonologist perspectives regarding diagnosis and management of primary immunodeficiency diseases.

Orange JS, Akhter J, Seeborg FO, Boyle M, Scalchunes C, Hernandez-Trujillo V.

Allergy Asthma Proc. 2016 Nov;37(6):162-168.

PMID:
27931293
49.

NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing.

Hsu HT, Mace EM, Carisey AF, Viswanath DI, Christakou AE, Wiklund M, Önfelt B, Orange JS.

J Cell Biol. 2016 Dec 19;215(6):875-889. Epub 2016 Nov 30.

50.

Biallelic mutations in IRF8 impair human NK cell maturation and function.

Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, Maisuria S, Keller MD, Togi S, Watkin LB, LaRosa DF, Jhangiani SN, Muzny DM, Stray-Pedersen A, Coban Akdemir Z, Smith JB, Hernández-Sanabria M, Le DT, Hogg GD, Cao TN, Freud AG, Szymanski EP, Savic S, Collin M, Cant AJ, Gibbs RA, Holland SM, Caligiuri MA, Ozato K, Paust S, Doody GM, Lupski JR, Orange JS.

J Clin Invest. 2017 Jan 3;127(1):306-320. doi: 10.1172/JCI86276. Epub 2016 Nov 28.

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