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Items: 37


Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis.

Leete P, Oram RA, McDonald TJ, Shields BM, Ziller C; TIGI study team, Hattersley AT, Richardson SJ, Morgan NG.

Diabetologia. 2020 Mar 15. doi: 10.1007/s00125-020-05115-6. [Epub ahead of print]


Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M.

Diabetes Care. 2020 Jan;43(1):5-12. doi: 10.2337/dc19-0880. Epub 2019 Nov 21.


Methods for quick, accurate and cost-effective determination of the type 1 diabetes genetic risk score (T1D-GRS).

Locke JM, Latten MJ, Datta RY, Wood AR, Crockard MA, Lamont JV, Weedon MN, Oram RA.

Clin Chem Lab Med. 2020 Mar 26;58(4):e102-e104. doi: 10.1515/cclm-2019-0787. No abstract available.


New insights on the genetics of type 1 diabetes.

Oram RA, Redondo MJ.

Curr Opin Endocrinol Diabetes Obes. 2019 Aug;26(4):181-187. doi: 10.1097/MED.0000000000000489.


Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes.

Thomas NJ, Lynam AL, Hill AV, Weedon MN, Shields BM, Oram RA, McDonald TJ, Hattersley AT, Jones AG.

Diabetologia. 2019 Jul;62(7):1167-1172. doi: 10.1007/s00125-019-4863-8. Epub 2019 Apr 10.


Persistent C-peptide is associated with reduced hypoglycaemia but not HbA1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice?

Marren SM, Hammersley S, McDonald TJ, Shields BM, Knight BA, Hill A, Bolt R, Tree TI, Roep BO, Hattersley AT, Jones AG, Oram RA; TIGI consortium.

Diabet Med. 2019 Sep;36(9):1092-1099. doi: 10.1111/dme.13960. Epub 2019 Jun 27.


Beta cells in type 1 diabetes: mass and function; sleeping or dead?

Oram RA, Sims EK, Evans-Molina C.

Diabetologia. 2019 Apr;62(4):567-577. doi: 10.1007/s00125-019-4822-4. Epub 2019 Feb 14. Review.


Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis.

Sharp SA, Rich SS, Wood AR, Jones SE, Beaumont RN, Harrison JW, Schneider DA, Locke JM, Tyrrell J, Weedon MN, Hagopian WA, Oram RA.

Diabetes Care. 2019 Feb;42(2):200-207. doi: 10.2337/dc18-1785.


Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes.

Ocaña GJ, Sims EK, Watkins RA, Ragg S, Mather KJ, Oram RA, Mirmira RG, DiMeglio LA, Blum JS, Evans-Molina C.

PLoS One. 2019 Jan 10;14(1):e0208456. doi: 10.1371/journal.pone.0208456. eCollection 2019.


A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy.

Grubb AL, McDonald TJ, Rutters F, Donnelly LA, Hattersley AT, Oram RA, Palmer CNA, van der Heijden AA, Carr F, Elders PJM, Weedon MN, Slieker RC, 't Hart LM, Pearson ER, Shields BM, Jones AG.

Diabetes Care. 2019 Feb;42(2):208-214. doi: 10.2337/dc18-0431. Epub 2018 Oct 23.


A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.

Redondo MJ, Geyer S, Steck AK, Sharp S, Wentworth JM, Weedon MN, Antinozzi P, Sosenko J, Atkinson M, Pugliese A, Oram RA; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2018 Sep;41(9):1887-1894. doi: 10.2337/dc18-0087. Epub 2018 Jul 12.


Type 1 diabetes.

DiMeglio LA, Evans-Molina C, Oram RA.

Lancet. 2018 Jun 16;391(10138):2449-2462. doi: 10.1016/S0140-6736(18)31320-5. Review.


Clinical and research uses of genetic risk scores in type 1 diabetes.

Sharp SA, Weedon MN, Hagopian WA, Oram RA.

Curr Opin Genet Dev. 2018 Jun;50:96-102. doi: 10.1016/j.gde.2018.03.009. Epub 2018 Apr 24. Review.


Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.

Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, Weedon MN, Laimighofer M, Hattersley AT, Krumsiek J, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Oram RA, Rich SS, Ziegler AG; TEDDY Study Group.

PLoS Med. 2018 Apr 3;15(4):e1002548. doi: 10.1371/journal.pmed.1002548. eCollection 2018 Apr.


Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.

Perry DJ, Wasserfall CH, Oram RA, Williams MD, Posgai A, Muir AB, Haller MJ, Schatz DA, Wallet MA, Mathews CE, Atkinson MA, Brusko TM.

Sci Rep. 2018 Mar 14;8(1):4529. doi: 10.1038/s41598-018-22574-5.


Genetic risk scores in adult-onset type 1 diabetes - Authors' reply.

Thomas NJ, Jones SE, Weedon MN, Shields BM, Hattersley AT, Oram RA.

Lancet Diabetes Endocrinol. 2018 Mar;6(3):169. doi: 10.1016/S2213-8587(18)30046-9. No abstract available.


Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes.

Roshandel D, Gubitosi-Klug R, Bull SB, Canty AJ, Pezzolesi MG, King GL, Keenan HA, Snell-Bergeon JK, Maahs DM, Klein R, Klein BEK, Orchard TJ, Costacou T, Weedon MN; DCCT/EDIC Research Group, Oram RA, Paterson AD.

Diabetologia. 2018 May;61(5):1098-1111. doi: 10.1007/s00125-018-4555-9. Epub 2018 Feb 5.


Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank.

Thomas NJ, Jones SE, Weedon MN, Shields BM, Oram RA, Hattersley AT.

Lancet Diabetes Endocrinol. 2018 Feb;6(2):122-129. doi: 10.1016/S2213-8587(17)30362-5. Epub 2017 Nov 30.


Genetic Risk Scores for Type 1 Diabetes Prediction and Diagnosis.

Redondo MJ, Oram RA, Steck AK.

Curr Diab Rep. 2017 Oct 28;17(12):129. doi: 10.1007/s11892-017-0961-5. Review.


Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes.

Shepherd M, Shields B, Hammersley S, Hudson M, McDonald TJ, Colclough K, Oram RA, Knight B, Hyde C, Cox J, Mallam K, Moudiotis C, Smith R, Fraser B, Robertson S, Greene S, Ellard S, Pearson ER, Hattersley AT; UNITED Team.

Diabetes Care. 2016 Nov;39(11):1879-1888. Epub 2016 Jun 6.


Type 1 Diabetes Genetic Risk Score: A Novel Tool to Discriminate Monogenic and Type 1 Diabetes.

Patel KA, Oram RA, Flanagan SE, De Franco E, Colclough K, Shepherd M, Ellard S, Weedon MN, Hattersley AT.

Diabetes. 2016 Jul;65(7):2094-2099. doi: 10.2337/db15-1690. Epub 2016 Apr 5.


Practical Classification Guidelines for Diabetes in patients treated with insulin: a cross-sectional study of the accuracy of diabetes diagnosis.

Hope SV, Wienand-Barnett S, Shepherd M, King SM, Fox C, Khunti K, Oram RA, Knight BA, Hattersley AT, Jones AG, Shields BM.

Br J Gen Pract. 2016 May;66(646):e315-22. doi: 10.3399/bjgp16X684961. Epub 2016 Apr 14.


Validation of the BETA-2 Score: An Improved Tool to Estimate Beta Cell Function After Clinical Islet Transplantation Using a Single Fasting Blood Sample.

Forbes S, Oram RA, Smith A, Lam A, Olateju T, Imes S, Malcolm AJ, Shapiro AM, Senior PA.

Am J Transplant. 2016 Sep;16(9):2704-13. doi: 10.1111/ajt.13807. Epub 2016 Apr 21.


A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults.

Oram RA, Patel K, Hill A, Shields B, McDonald TJ, Jones A, Hattersley AT, Weedon MN.

Diabetes Care. 2016 Mar;39(3):337-44. doi: 10.2337/dc15-1111. Epub 2015 Nov 17.


Investigating hyperkalaemia in adults.

McDonald TJ, Oram RA, Vaidya B.

BMJ. 2015 Oct 20;351:h4762. doi: 10.1136/bmj.h4762. Review. No abstract available.


Most people with long-duration type 1 diabetes in a large population-based study are insulin microsecretors.

Oram RA, McDonald TJ, Shields BM, Hudson MM, Shepherd MH, Hammersley S, Pearson ER, Hattersley AT; UNITED Team.

Diabetes Care. 2015 Feb;38(2):323-8. doi: 10.2337/dc14-0871. Epub 2014 Dec 17.


Home urine C-peptide creatinine ratio can be used to monitor islet transplant function.

Oram RA, Brooks AM, Forbes S, Eckoldt S, Smith RM, Choudhary P, Rosenthal MJ, Johnson P, Rutter MK, Burling KA, McDonald TJ, Shaw JA, Hattersley AT.

Diabetes Care. 2014 Jun;37(6):1737-40. doi: 10.2337/dc13-1266. Epub 2014 Mar 12.


Urine C-peptide creatinine ratio can be used to assess insulin resistance and insulin production in people without diabetes: an observational study.

Oram RA, Rawlingson A, Shields BM, Bingham C, Besser RE, McDonald TJ, Knight BA, Hattersley AT.

BMJ Open. 2013 Dec 18;3(12):e003193. doi: 10.1136/bmjopen-2013-003193.


The HNF4A R76W mutation causes atypical dominant Fanconi syndrome in addition to a β cell phenotype.

Hamilton AJ, Bingham C, McDonald TJ, Cook PR, Caswell RC, Weedon MN, Oram RA, Shields BM, Shepherd M, Inward CD, Hamilton-Shield JP, Kohlhase J, Ellard S, Hattersley AT.

J Med Genet. 2014 Mar;51(3):165-9. doi: 10.1136/jmedgenet-2013-102066. Epub 2013 Nov 27.


The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells.

Oram RA, Jones AG, Besser RE, Knight BA, Shields BM, Brown RJ, Hattersley AT, McDonald TJ.

Diabetologia. 2014 Jan;57(1):187-91. Erratum in: Diabetologia. 2014 Jan;57(1):262.


Investigating hypokalaemia.

Oram RA, McDonald TJ, Vaidya B.

BMJ. 2013 Sep 24;347:f5137. doi: 10.1136/bmj.f5137. No abstract available.


HNF1B deletions in patients with young-onset diabetes but no known renal disease.

Edghill EL, Stals K, Oram RA, Shepherd MH, Hattersley AT, Ellard S.

Diabet Med. 2013 Jan;30(1):114-7. doi: 10.1111/j.1464-5491.2012.03709.x.


Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes.

Jones AG, Besser RE, McDonald TJ, Shields BM, Hope SV, Bowman P, Oram RA, Knight BA, Hattersley AT.

Diabet Med. 2011 Sep;28(9):1034-8. doi: 10.1111/j.1464-5491.2011.03272.x.


Mutations in the hepatocyte nuclear factor-1β (HNF1B) gene are common with combined uterine and renal malformations but are not found with isolated uterine malformations.

Oram RA, Edghill EL, Blackman J, Taylor MJ, Kay T, Flanagan SE, Ismail-Pratt I, Creighton SM, Ellard S, Hattersley AT, Bingham C.

Am J Obstet Gynecol. 2010 Oct;203(4):364.e1-5. doi: 10.1016/j.ajog.2010.05.022. Epub 2010 Jul 15.


RET gene mutations are not a common cause of congenital solitary functioning kidney in adults.

Oram RA, Edghill EL, Woolf AS, Hennekam RC, Ellard S, Hattersley AT, Bingham C.

NDT Plus. 2009 Apr;2(2):183-4. doi: 10.1093/ndtplus/sfn204. No abstract available.


Manual assessment of the initial fall in blood pressure after orthostatic challenge at high altitude.

Mytton OT, Simpson A, Thompson AA, Oram RA, Darowski A, Yu LM, Collier DJ, Pollard AJ.

Wilderness Environ Med. 2008 Winter;19(4):225-32. doi: 10.1580/07-WEME-OR-097.1.


Hepatocyte nuclear factor-1beta gene deletions--a common cause of renal disease.

Edghill EL, Oram RA, Owens M, Stals KL, Harries LW, Hattersley AT, Ellard S, Bingham C.

Nephrol Dial Transplant. 2008 Feb;23(2):627-35. Epub 2007 Oct 30.


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