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Items: 1 to 50 of 70

1.

Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis.

Volpi C, Orabona C, Macchiarulo A, Bianchi R, Puccetti P, Grohmann U.

Expert Opin Drug Discov. 2019 Aug 7:1-14. doi: 10.1080/17460441.2019.1646244. [Epub ahead of print]

PMID:
31389262
2.

Wolfram syndrome, a rare neurodegenerative disease: from pathogenesis to future treatment perspectives.

Pallotta MT, Tascini G, Crispoldi R, Orabona C, Mondanelli G, Grohmann U, Esposito S.

J Transl Med. 2019 Jul 23;17(1):238. doi: 10.1186/s12967-019-1993-1. Review.

3.

Effects of probiotic administration on immune responses of children and adolescents with type 1 diabetes to a quadrivalent inactivated influenza vaccine.

Bianchini S, Orabona C, Camilloni B, Berioli MG, Argentiero A, Matino D, Alunno A, Albini E, Vacca C, Pallotta MT, Mancini G, Tascini G, Toni G, Mondanelli G, Silvestri E, Grohmann U, Esposito S.

Hum Vaccin Immunother. 2019 Aug 15:1-9. doi: 10.1080/21645515.2019.1633877. [Epub ahead of print]

PMID:
31210557
4.

Amino acid metabolism as drug target in autoimmune diseases.

Mondanelli G, Iacono A, Carvalho A, Orabona C, Volpi C, Pallotta MT, Matino D, Esposito S, Grohmann U.

Autoimmun Rev. 2019 Apr;18(4):334-348. doi: 10.1016/j.autrev.2019.02.004. Epub 2019 Feb 22. Review.

5.

IL-35Ig-expressing dendritic cells induce tolerance via Arginase 1.

Panfili E, Mondanelli G, Orabona C, Bianchi R, Gargaro M, Fallarino F, Puccetti P, Grohmann U, Volpi C, Belladonna ML.

J Cell Mol Med. 2019 May;23(5):3757-3761. doi: 10.1111/jcmm.14215. Epub 2019 Feb 22.

6.

Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1.

Albini E, Coletti A, Greco F, Pallotta MT, Mondanelli G, Gargaro M, Belladonna ML, Volpi C, Bianchi R, Grohmann U, Macchiarulo A, Orabona C.

Biochem Pharmacol. 2018 Dec;158:286-297. doi: 10.1016/j.bcp.2018.10.033. Epub 2018 Nov 1.

7.

Is It Time to Use Probiotics to Prevent or Treat Obesity?

Brusaferro A, Cozzali R, Orabona C, Biscarini A, Farinelli E, Cavalli E, Grohmann U, Principi N, Esposito S.

Nutrients. 2018 Nov 1;10(11). pii: E1613. doi: 10.3390/nu10111613. Review.

8.

Immune Checkpoint Molecules, Personalized Immunotherapy, and Autoimmune Diabetes.

Orabona C, Mondanelli G, Puccetti P, Grohmann U.

Trends Mol Med. 2018 Nov;24(11):931-941. doi: 10.1016/j.molmed.2018.08.005. Epub 2018 Sep 17. Review.

PMID:
30236470
9.

Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes.

Anquetil F, Mondanelli G, Gonzalez N, Rodriguez Calvo T, Zapardiel Gonzalo J, Krogvold L, Dahl-Jørgensen K, Van den Eynde B, Orabona C, Grohmann U, von Herrath MG.

Diabetes. 2018 Sep;67(9):1858-1866. doi: 10.2337/db17-1281. Epub 2018 Jun 26.

10.

Urinary l-kynurenine quantification and selective extraction through a molecularly imprinted solid-phase extraction device.

Mergola L, Orabona C, Albini E, Vasapollo G, Scorrano S, Del Sole R.

J Sep Sci. 2018 Aug;41(16):3204-3212. doi: 10.1002/jssc.201800458. Epub 2018 Jul 11.

PMID:
29935056
11.

Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.

Orabona C, Mondanelli G, Pallotta MT, Carvalho A, Albini E, Fallarino F, Vacca C, Volpi C, Belladonna ML, Berioli MG, Ceccarini G, Esposito SM, Scattoni R, Verrotti A, Ferretti A, De Giorgi G, Toni S, Cappa M, Matteoli MC, Bianchi R, Matino D, Iacono A, Puccetti M, Cunha C, Bicciato S, Antognelli C, Talesa VN, Chatenoud L, Fuchs D, Pilotte L, Van den Eynde B, Lemos MC, Romani L, Puccetti P, Grohmann U.

JCI Insight. 2018 Mar 22;3(6). pii: 96244. doi: 10.1172/jci.insight.96244.

12.

Fragment-based approach to identify IDO1 inhibitor building blocks.

Coletti A, Camponeschi F, Albini E, Greco FA, Maione V, Custodi C, Ianni F, Grohmann U, Orabona C, Cantini F, Macchiarulo A.

Eur J Med Chem. 2017 Dec 1;141:169-177. doi: 10.1016/j.ejmech.2017.09.044. Epub 2017 Oct 3.

13.

Challenges in the design of reliable immuno-oncology mouse models to inform drug development.

Mondanelli G, Volpi C, Orabona C, Grohmann U.

Future Med Chem. 2017 Aug;9(12):1313-1317. doi: 10.4155/fmc-2017-0027. Epub 2017 Aug 3. No abstract available.

PMID:
28771031
14.

Modulation of natriuretic peptide receptors in human adipose tissue: molecular mechanisms behind the "natriuretic handicap" in morbidly obese patients.

Gentili A, Frangione MR, Albini E, Vacca C, Ricci MA, De Vuono S, Boni M, Rondelli F, Rotelli L, Lupattelli G, Orabona C.

Transl Res. 2017 Aug;186:52-61. doi: 10.1016/j.trsl.2017.06.001. Epub 2017 Jun 10.

PMID:
28651075
15.

Amino-acid sensing and degrading pathways in immune regulation.

Grohmann U, Mondanelli G, Belladonna ML, Orabona C, Pallotta MT, Iacono A, Puccetti P, Volpi C.

Cytokine Growth Factor Rev. 2017 Jun;35:37-45. doi: 10.1016/j.cytogfr.2017.05.004. Epub 2017 May 18. Review.

16.

Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry.

Coletti A, Greco FA, Dolciami D, Camaioni E, Sardella R, Pallotta MT, Volpi C, Orabona C, Grohmann U, Macchiarulo A.

Medchemcomm. 2017 May 16;8(7):1378-1392. doi: 10.1039/c7md00109f. eCollection 2017 Jul 1. Review.

17.

The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes.

Mondanelli G, Albini E, Pallotta MT, Volpi C, Chatenoud L, Kuhn C, Fallarino F, Matino D, Belladonna ML, Bianchi R, Vacca C, Bicciato S, Boon L, Ricci G, Grohmann U, Puccetti P, Orabona C.

Front Immunol. 2017 Apr 13;8:428. doi: 10.3389/fimmu.2017.00428. eCollection 2017.

18.

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells.

Mondanelli G, Bianchi R, Pallotta MT, Orabona C, Albini E, Iacono A, Belladonna ML, Vacca C, Fallarino F, Macchiarulo A, Ugel S, Bronte V, Gevi F, Zolla L, Verhaar A, Peppelenbosch M, Mazza EMC, Bicciato S, Laouar Y, Santambrogio L, Puccetti P, Volpi C, Grohmann U.

Immunity. 2017 Feb 21;46(2):233-244. doi: 10.1016/j.immuni.2017.01.005. Epub 2017 Feb 14.

19.

Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1.

Albini E, Rosini V, Gargaro M, Mondanelli G, Belladonna ML, Pallotta MT, Volpi C, Fallarino F, Macchiarulo A, Antognelli C, Bianchi R, Vacca C, Puccetti P, Grohmann U, Orabona C.

J Cell Mol Med. 2017 Jan;21(1):165-176. doi: 10.1111/jcmm.12954. Epub 2016 Sep 30.

20.

Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.

Volpi C, Mondanelli G, Pallotta MT, Vacca C, Iacono A, Gargaro M, Albini E, Bianchi R, Belladonna ML, Celanire S, Mordant C, Heroux M, Royer-Urios I, Schneider M, Vitte PA, Cacquevel M, Galibert L, Poli SM, Solari A, Bicciato S, Calvitti M, Antognelli C, Puccetti P, Orabona C, Fallarino F, Grohmann U.

Neuropharmacology. 2016 Mar;102:59-71. doi: 10.1016/j.neuropharm.2015.10.036. Epub 2015 Oct 30.

21.

IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.

Matino D, Gargaro M, Santagostino E, Di Minno MN, Castaman G, Morfini M, Rocino A, Mancuso ME, Di Minno G, Coppola A, Talesa VN, Volpi C, Vacca C, Orabona C, Iannitti R, Mazzucconi MG, Santoro C, Tosti A, Chiappalupi S, Sorci G, Tagariello G, Belvini D, Radossi P, Landolfi R, Fuchs D, Boon L, Pirro M, Marchesini E, Grohmann U, Puccetti P, Iorio A, Fallarino F.

J Clin Invest. 2015 Oct 1;125(10):3766-81. doi: 10.1172/JCI81859. Epub 2015 Aug 31.

22.

Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy.

Holtzhausen A, Zhao F, Evans KS, Tsutsui M, Orabona C, Tyler DS, Hanks BA.

Cancer Immunol Res. 2015 Sep;3(9):1082-95. doi: 10.1158/2326-6066.CIR-14-0167. Epub 2015 Jun 3.

23.

Stem cells from human amniotic fluid exert immunoregulatory function via secreted indoleamine 2,3-dioxygenase1.

Romani R, Pirisinu I, Calvitti M, Pallotta MT, Gargaro M, Bistoni G, Vacca C, Di Michele A, Orabona C, Rosati J, Pirro M, Giovagnoli S, Matino D, Prontera P, Rosi G, Grohmann U, Talesa VN, Donti E, Puccetti P, Fallarino F.

J Cell Mol Med. 2015 Jul;19(7):1593-605. doi: 10.1111/jcmm.12534. Epub 2015 Mar 17.

24.

Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-γ.

Put K, Avau A, Brisse E, Mitera T, Put S, Proost P, Bader-Meunier B, Westhovens R, Van den Eynde BJ, Orabona C, Fallarino F, De Somer L, Tousseyn T, Quartier P, Wouters C, Matthys P.

Rheumatology (Oxford). 2015 Aug;54(8):1507-17. doi: 10.1093/rheumatology/keu524. Epub 2015 Mar 12.

PMID:
25767156
25.

Vertebral carcinomatosis eleven years after advanced gastric cancer resection: A case report.

Iovino F, Orditura M, Auriemma PP, Ciorra FR, Giordano G, Orabona C, Bara F, Sergio R, Savastano B, Fabozzi A, Laterza MM, Ventriglia J, Petrillo A, Della Corte CM, DE Vita F.

Oncol Lett. 2015 Mar;9(3):1403-1405. Epub 2014 Dec 23.

26.

AhR-Mediated, Non-Genomic Modulation of IDO1 Function.

Pallotta MT, Fallarino F, Matino D, Macchiarulo A, Orabona C.

Front Immunol. 2014 Oct 15;5:497. doi: 10.3389/fimmu.2014.00497. eCollection 2014. Review.

27.

LPS-conditioned dendritic cells confer endotoxin tolerance contingent on tryptophan catabolism.

Fallarino F, Pallotta MT, Matino D, Gargaro M, Orabona C, Vacca C, Mondanelli G, Allegrucci M, Boon L, Romani R, Talesa VN, Puccetti P, Grohmann U.

Immunobiology. 2015 Feb;220(2):315-21. doi: 10.1016/j.imbio.2014.09.017. Epub 2014 Sep 28.

PMID:
25278421
28.

Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes.

Pallotta MT, Orabona C, Bianchi R, Vacca C, Fallarino F, Belladonna ML, Volpi C, Mondanelli G, Gargaro M, Allegrucci M, Talesa VN, Puccetti P, Grohmann U.

J Cell Mol Med. 2014 Oct;18(10):2082-91. doi: 10.1111/jcmm.12360. Epub 2014 Sep 12.

29.

Aryl hydrocarbon receptor control of a disease tolerance defence pathway.

Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz TV, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison MS, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F, Puccetti P.

Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323.

30.

Indoleamine 2,3-dioxygenase 1 (IDO1) is up-regulated in thyroid carcinoma and drives the development of an immunosuppressant tumor microenvironment.

Moretti S, Menicali E, Voce P, Morelli S, Cantarelli S, Sponziello M, Colella R, Fallarino F, Orabona C, Alunno A, de Biase D, Bini V, Mameli MG, Filetti S, Gerli R, Macchiarulo A, Melillo RM, Tallini G, Santoro M, Puccetti P, Avenia N, Puxeddu E.

J Clin Endocrinol Metab. 2014 May;99(5):E832-40. doi: 10.1210/jc.2013-3351. Epub 2014 Feb 11.

PMID:
24517146
31.

Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease.

Marino G, Moraci M, Armenia E, Orabona C, Sergio R, De Sena G, Capuozzo V, Barbarisi M, Rosso F, Giordano G, Iovino F, Barbarisi A.

J Surg Res. 2013 Nov;185(1):36-44. doi: 10.1016/j.jss.2013.05.024. Epub 2013 May 28.

PMID:
23773718
32.

High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9-TRIF pathway.

Volpi C, Fallarino F, Pallotta MT, Bianchi R, Vacca C, Belladonna ML, Orabona C, De Luca A, Boon L, Romani L, Grohmann U, Puccetti P.

Nat Commun. 2013;4:1852. doi: 10.1038/ncomms2874.

PMID:
23673637
33.

The p50 subunit of NF-κB orchestrates dendritic cell lifespan and activation of adaptive immunity.

Larghi P, Porta C, Riboldi E, Totaro MG, Carraro L, Orabona C, Sica A.

PLoS One. 2012;7(9):e45279. doi: 10.1371/journal.pone.0045279. Epub 2012 Sep 25.

34.

A GpC-rich oligonucleotide acts on plasmacytoid dendritic cells to promote immune suppression.

Volpi C, Fallarino F, Bianchi R, Orabona C, De Luca A, Vacca C, Romani L, Gran B, Grohmann U, Puccetti P, Belladonna ML.

J Immunol. 2012 Sep 1;189(5):2283-9. doi: 10.4049/jimmunol.1200497. Epub 2012 Jul 27.

35.

Different partners, opposite outcomes: a new perspective of the immunobiology of indoleamine 2,3-dioxygenase.

Orabona C, Pallotta MT, Grohmann U.

Mol Med. 2012 Jul 18;18:834-42. doi: 10.2119/molmed.2012.00029. Review.

36.

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells.

Pallotta MT, Orabona C, Volpi C, Vacca C, Belladonna ML, Bianchi R, Servillo G, Brunacci C, Calvitti M, Bicciato S, Mazza EM, Boon L, Grassi F, Fioretti MC, Fallarino F, Puccetti P, Grohmann U.

Nat Immunol. 2011 Jul 31;12(9):870-8. doi: 10.1038/ni.2077.

PMID:
21804557
37.

IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality.

Dumoutier L, de Heusch M, Orabona C, Satoh-Takayama N, Eberl G, Sirard JC, Di Santo JP, Renauld JC.

Eur J Immunol. 2011 Apr;41(4):1075-85. doi: 10.1002/eji.201040878. Epub 2011 Mar 14.

38.

Indoleamine 2,3-dioxygenase and regulatory function: tryptophan starvation and beyond.

Orabona C, Grohmann U.

Methods Mol Biol. 2011;677:269-80. doi: 10.1007/978-1-60761-869-0_19.

PMID:
20941617
39.

Proteasomal Degradation of Indoleamine 2,3-Dioxygenase in CD8 Dendritic Cells is Mediated by Suppressor of Cytokine Signaling 3 (SOCS3).

Pallotta MT, Orabona C, Volpi C, Grohmann U, Puccetti P, Fallarino F.

Int J Tryptophan Res. 2010;3:91-7. Epub 2010 Jun 10.

40.

TGF-beta and kynurenines as the key to infectious tolerance.

Belladonna ML, Orabona C, Grohmann U, Puccetti P.

Trends Mol Med. 2009 Feb;15(2):41-9. doi: 10.1016/j.molmed.2008.11.006. Epub 2009 Jan 21.

PMID:
19162548
41.

SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis.

Orabona C, Pallotta MT, Volpi C, Fallarino F, Vacca C, Bianchi R, Belladonna ML, Fioretti MC, Grohmann U, Puccetti P.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20828-33. doi: 10.1073/pnas.0810278105. Epub 2008 Dec 16.

42.

Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells.

Belladonna ML, Volpi C, Bianchi R, Vacca C, Orabona C, Pallotta MT, Boon L, Gizzi S, Fioretti MC, Grohmann U, Puccetti P.

J Immunol. 2008 Oct 15;181(8):5194-8.

43.

Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes.

Belladonna ML, Puccetti P, Orabona C, Fallarino F, Vacca C, Volpi C, Gizzi S, Pallotta MT, Fioretti MC, Grohmann U.

Transplantation. 2007 Jul 15;84(1 Suppl):S17-20.

PMID:
17632406
44.

Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy.

Grohmann U, Volpi C, Fallarino F, Bozza S, Bianchi R, Vacca C, Orabona C, Belladonna ML, Ayroldi E, Nocentini G, Boon L, Bistoni F, Fioretti MC, Romani L, Riccardi C, Puccetti P.

Nat Med. 2007 May;13(5):579-86. Epub 2007 Apr 8.

PMID:
17417651
45.

IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells.

Steenwinckel V, Louahed J, Orabona C, Huaux F, Warnier G, McKenzie A, Lison D, Levitt R, Renauld JC.

J Immunol. 2007 Mar 1;178(5):3244-51.

46.

Tryptophan catabolism generates autoimmune-preventive regulatory T cells.

Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Fioretti MC, Puccetti P.

Transpl Immunol. 2006 Dec;17(1):58-60. Epub 2006 Oct 10.

PMID:
17157218
47.

The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells.

Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Santamaria P, Fioretti MC, Puccetti P.

J Immunol. 2006 Jun 1;176(11):6752-61.

48.

Toward the identification of a tolerogenic signature in IDO-competent dendritic cells.

Orabona C, Puccetti P, Vacca C, Bicciato S, Luchini A, Fallarino F, Bianchi R, Velardi E, Perruccio K, Velardi A, Bronte V, Fioretti MC, Grohmann U.

Blood. 2006 Apr 1;107(7):2846-54. Epub 2005 Dec 8. Erratum in: Blood. 2006 May 1;107(9):3441.

49.

Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12.

Orabona C, Tomasello E, Fallarino F, Bianchi R, Volpi C, Bellocchio S, Romani L, Fioretti MC, Vivier E, Puccetti P, Grohmann U.

Eur J Immunol. 2005 Nov;35(11):3111-8.

50.

Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells.

Fallarino F, Orabona C, Vacca C, Bianchi R, Gizzi S, Asselin-Paturel C, Fioretti MC, Trinchieri G, Grohmann U, Puccetti P.

Int Immunol. 2005 Nov;17(11):1429-38. Epub 2005 Sep 19.

PMID:
16172135

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