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Items: 1 to 50 of 69

1.

Direct Evidence of an Enzyme-Generated LPP Intermediate in (+)-Limonene Synthase Using a Fluorinated GPP Substrate Analog.

Morehouse BR, Kumar RP, Matos JO, Yu Q, Bannister A, Malik K, Temme JS, Krauss IJ, Oprian DD.

ACS Chem Biol. 2019 Sep 20;14(9):2035-2043. doi: 10.1021/acschembio.9b00514. Epub 2019 Sep 4.

PMID:
31433159
2.

Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor.

Ozdeslik RN, Olinski LE, Trieu MM, Oprian DD, Oancea E.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11508-11517. doi: 10.1073/pnas.1902825116. Epub 2019 May 16.

PMID:
31097585
3.

Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC.

Kumar RP, Morehouse BR, Fofana J, Trieu MM, Zhou DH, Lorenz MO, Oprian DD.

J Biol Chem. 2017 Dec 29;292(52):21578-21589. doi: 10.1074/jbc.M117.812685. Epub 2017 Nov 8.

4.

Purification and Characterization of RhoPDE, a Retinylidene/Phosphodiesterase Fusion Protein and Potential Optogenetic Tool from the Choanoflagellate Salpingoeca rosetta.

Lamarche LB, Kumar RP, Trieu MM, Devine EL, Cohen-Abeles LE, Theobald DL, Oprian DD.

Biochemistry. 2017 Oct 31;56(43):5812-5822. doi: 10.1021/acs.biochem.7b00519. Epub 2017 Oct 18.

5.

Expression, purification, and spectral tuning of RhoGC, a retinylidene/guanylyl cyclase fusion protein and optogenetics tool from the aquatic fungus Blastocladiella emersonii.

Trieu MM, Devine EL, Lamarche LB, Ammerman AE, Greco JA, Birge RR, Theobald DL, Oprian DD.

J Biol Chem. 2017 Jun 23;292(25):10379-10389. doi: 10.1074/jbc.M117.789636. Epub 2017 May 4.

6.

Structural Characterization of Early Michaelis Complexes in the Reaction Catalyzed by (+)-Limonene Synthase from Citrus sinensis Using Fluorinated Substrate Analogues.

Kumar RP, Morehouse BR, Matos JO, Malik K, Lin H, Krauss IJ, Oprian DD.

Biochemistry. 2017 Mar 28;56(12):1716-1725. doi: 10.1021/acs.biochem.7b00144. Epub 2017 Mar 15.

7.

Functional and Structural Characterization of a (+)-Limonene Synthase from Citrus sinensis.

Morehouse BR, Kumar RP, Matos JO, Olsen SN, Entova S, Oprian DD.

Biochemistry. 2017 Mar 28;56(12):1706-1715. doi: 10.1021/acs.biochem.7b00143. Epub 2017 Mar 15.

8.

Relocating the Active-Site Lysine in Rhodopsin: 2. Evolutionary Intermediates.

Devine EL, Theobald DL, Oprian DD.

Biochemistry. 2016 Aug 30;55(34):4864-70. doi: 10.1021/acs.biochem.6b00478. Epub 2016 Aug 12.

9.

Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis.

Chakrabarti KS, Agafonov RV, Pontiggia F, Otten R, Higgins MK, Schertler GFX, Oprian DD, Kern D.

Cell Rep. 2016 Jan 5;14(1):32-42. doi: 10.1016/j.celrep.2015.12.010. Epub 2015 Dec 24.

10.

Crystal Structure of Recoverin with Calcium Ions Bound to Both Functional EF Hands.

Kumar RP, Ranaghan MJ, Ganjei AY, Oprian DD.

Biochemistry. 2015 Dec 15;54(49):7222-8. doi: 10.1021/acs.biochem.5b01160. Epub 2015 Dec 3.

11.

Assembly of an activated rhodopsin-transducin complex in nanoscale lipid bilayers.

D'Antona AM, Xie G, Sligar SG, Oprian DD.

Biochemistry. 2014 Jan 14;53(1):127-34. doi: 10.1021/bi4012995. Epub 2013 Dec 20.

12.

A highly conserved cysteine of neuronal calcium-sensing proteins controls cooperative binding of Ca2+ to recoverin.

Ranaghan MJ, Kumar RP, Chakrabarti KS, Buosi V, Kern D, Oprian DD.

J Biol Chem. 2013 Dec 13;288(50):36160-7. doi: 10.1074/jbc.M113.524355. Epub 2013 Nov 4.

13.

Relocating the active-site lysine in rhodopsin and implications for evolution of retinylidene proteins.

Devine EL, Oprian DD, Theobald DL.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13351-5. doi: 10.1073/pnas.1306826110. Epub 2013 Jul 31.

14.

Preparation of an activated rhodopsin/transducin complex using a constitutively active mutant of rhodopsin.

Xie G, D'Antona AM, Edwards PC, Fransen M, Standfuss J, Schertler GF, Oprian DD.

Biochemistry. 2011 Nov 29;50(47):10399-407. doi: 10.1021/bi201126r. Epub 2011 Nov 2.

15.

The structural basis of agonist-induced activation in constitutively active rhodopsin.

Standfuss J, Edwards PC, D'Antona A, Fransen M, Xie G, Oprian DD, Schertler GF.

Nature. 2011 Mar 31;471(7340):656-60. doi: 10.1038/nature09795. Epub 2011 Mar 9.

16.

Crystal structure of a thermally stable rhodopsin mutant.

Standfuss J, Xie G, Edwards PC, Burghammer M, Oprian DD, Schertler GF.

J Mol Biol. 2007 Oct 5;372(5):1179-88. Epub 2007 Mar 12.

17.

Transducin activation by nanoscale lipid bilayers containing one and two rhodopsins.

Bayburt TH, Leitz AJ, Xie G, Oprian DD, Sligar SG.

J Biol Chem. 2007 May 18;282(20):14875-81. Epub 2007 Mar 29.

19.
20.

A dark and constitutively active mutant of the tiger salamander UV pigment.

Kono M, Crouch RK, Oprian DD.

Biochemistry. 2005 Jan 18;44(2):799-804.

PMID:
15641808
21.

Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge.

Kim JM, Altenbach C, Kono M, Oprian DD, Hubbell WL, Khorana HG.

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12508-13. Epub 2004 Aug 11.

22.

Role of the 9-methyl group of retinal in cone visual pigments.

Das J, Crouch RK, Ma JX, Oprian DD, Kono M.

Biochemistry. 2004 May 11;43(18):5532-8.

PMID:
15122919
23.

Opsin activation as a cause of congenital night blindness.

Jin S, Cornwall MC, Oprian DD.

Nat Neurosci. 2003 Jul;6(7):731-5.

PMID:
12778053
24.
25.

Phototaxis, chemotaxis and the missing link.

Oprian DD.

Trends Biochem Sci. 2003 Apr;28(4):167-9.

PMID:
12713898
26.

Characterization of rhodopsin congenital night blindness mutant T94I.

Gross AK, Rao VR, Oprian DD.

Biochemistry. 2003 Feb 25;42(7):2009-15.

PMID:
12590588
27.

Slow binding of retinal to rhodopsin mutants G90D and T94D.

Gross AK, Xie G, Oprian DD.

Biochemistry. 2003 Feb 25;42(7):2002-8.

PMID:
12590587
28.

An opsin mutant with increased thermal stability.

Xie G, Gross AK, Oprian DD.

Biochemistry. 2003 Feb 25;42(7):1995-2001.

PMID:
12590586
29.

Spectral tuning in the mammalian short-wavelength sensitive cone pigments.

Fasick JI, Applebury ML, Oprian DD.

Biochemistry. 2002 May 28;41(21):6860-5.

PMID:
12022891
30.

Grafting segments from the extracellular surface of CCR5 onto a bacteriorhodopsin transmembrane scaffold confers HIV-1 coreceptor activity.

Abdulaev NG, Strassmaier TT, Ngo T, Chen R, Luecke H, Oprian DD, Ridge KD.

Structure. 2002 Apr;10(4):515-25.

31.

A visual pigment expressed in both rod and cone photoreceptors.

Ma J, Znoiko S, Othersen KL, Ryan JC, Das J, Isayama T, Kono M, Oprian DD, Corson DW, Cornwall MC, Cameron DA, Harosi FI, Makino CL, Crouch RK.

Neuron. 2001 Nov 8;32(3):451-61.

32.

Salamander UV cone pigment: sequence, expression, and spectral properties.

Ma JX, Kono M, Xu L, Das J, Ryan JC, Hazard ES 3rd, Oprian DD, Crouch RK.

Vis Neurosci. 2001 May-Jun;18(3):393-9.

PMID:
11497415
33.

G protein-coupled receptor activation: analysis of a highly constrained, "straitjacketed" rhodopsin.

Struthers M, Yu H, Oprian DD.

Biochemistry. 2000 Jul 11;39(27):7938-42.

PMID:
10891074
34.

Mapping tertiary contacts between amino acid residues within rhodopsin.

Struthers M, Oprian DD.

Methods Enzymol. 2000;315:130-43. No abstract available.

PMID:
10736699
35.

Spectral tuning in the human blue cone pigment.

Fasick JI, Lee N, Oprian DD.

Biochemistry. 1999 Sep 7;38(36):11593-6.

PMID:
10512613
36.
37.

State-dependent disulfide cross-linking in rhodopsin.

Yu H, Kono M, Oprian DD.

Biochemistry. 1999 Sep 14;38(37):12028-32.

PMID:
10508406
38.

Tertiary interactions between the fifth and sixth transmembrane segments of rhodopsin.

Struthers M, Yu H, Kono M, Oprian DD.

Biochemistry. 1999 May 18;38(20):6597-603.

PMID:
10350478
39.

Disulfide bond exchange in rhodopsin.

Kono M, Yu H, Oprian DD.

Biochemistry. 1998 Feb 3;37(5):1302-5.

PMID:
9477956
41.

In vitro assay for trans-phosphorylation of rhodopsin by rhodopsin kinase.

Rim J, Faurobert E, Hurley JB, Oprian DD.

Biochemistry. 1997 Jun 10;36(23):7064-70.

PMID:
9188705
42.

Resonance Raman examination of the wavelength regulation mechanism in human visual pigments.

Kochendoerfer GG, Wang Z, Oprian DD, Mathies RA.

Biochemistry. 1997 Jun 3;36(22):6577-87.

PMID:
9184137
43.

Activating mutations of rhodopsin and other G protein-coupled receptors.

Rao VR, Oprian DD.

Annu Rev Biophys Biomol Struct. 1996;25:287-314. Review.

PMID:
8800472
44.

A general method for mapping tertiary contacts between amino acid residues in membrane-embedded proteins.

Yu H, Kono M, McKee TD, Oprian DD.

Biochemistry. 1995 Nov 21;34(46):14963-9.

PMID:
7578109
45.

Constitutive activation of opsin: interaction of mutants with rhodopsin kinase and arrestin.

Rim J, Oprian DD.

Biochemistry. 1995 Sep 19;34(37):11938-45.

PMID:
7547930
46.

Molecular determinants of human red/green color discrimination.

Asenjo AB, Rim J, Oprian DD.

Neuron. 1994 May;12(5):1131-8.

PMID:
8185948
47.

Active site-directed inactivation of constitutively active mutants of rhodopsin.

Govardhan CP, Oprian DD.

J Biol Chem. 1994 Mar 4;269(9):6524-7.

48.

Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness.

Rao VR, Cohen GB, Oprian DD.

Nature. 1994 Feb 17;367(6464):639-42.

PMID:
8107847
49.

Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness.

Dryja TP, Berson EL, Rao VR, Oprian DD.

Nat Genet. 1993 Jul;4(3):280-3.

PMID:
8358437
50.

Constitutive activation of opsin: influence of charge at position 134 and size at position 296.

Cohen GB, Yang T, Robinson PR, Oprian DD.

Biochemistry. 1993 Jun 15;32(23):6111-5.

PMID:
8099498

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