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Electronic Structure of Tetracyanonickelate(II).

Oppenheim JJ, McNicholas BJ, Miller J, Gray HB.

Inorg Chem. 2019 Nov 18;58(22):15202-15206. doi: 10.1021/acs.inorgchem.9b02135. Epub 2019 Nov 7.


Accurate non-bonded potentials based on periodic quantum mechanics calculations for use in molecular simulations of materials and systems.

Naserifar S, Oppenheim JJ, Yang H, Zhou T, Zybin S, Rizk M, Goddard WA 3rd.

J Chem Phys. 2019 Oct 21;151(15):154111. doi: 10.1063/1.5113811.


Inhibition of murine hepatoma tumor growth by cryptotanshinone involves TLR7-dependent activation of macrophages and induction of adaptive antitumor immune defenses.

Han Z, Liu S, Lin H, Trivett AL, Hannifin S, Yang, Oppenheim JJ.

Cancer Immunol Immunother. 2019 Jul;68(7):1073-1085. doi: 10.1007/s00262-019-02338-4. Epub 2019 Jun 3.


Cryptotanshinone has curative dual anti-proliferative and immunotherapeutic effects on mouse Lewis lung carcinoma.

Liu S, Han Z, Trivett AL, Lin H, Hannifin S, Yang, Oppenheim JJ.

Cancer Immunol Immunother. 2019 Jul;68(7):1059-1071. doi: 10.1007/s00262-019-02326-8. Epub 2019 Apr 10.


Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice.

Chen CY, Ueha S, Ishiwata Y, Yokochi S, Yang, Oppenheim JJ, Ogiwara H, Shichino S, Deshimaru S, Shand FHW, Shibayama S, Matsushima K.

J Immunother Cancer. 2019 Jan 29;7(1):21. doi: 10.1186/s40425-019-0503-6.


HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways.

Alam MM, Yang, Trivett A, Meyer TJ, Oppenheim JJ.

Front Immunol. 2018 Dec 18;9:2982. doi: 10.3389/fimmu.2018.02982. eCollection 2018.


Pillars Article: Purification of a Human Monocyte-Derived Neutrophil Chemotactic Factor That Has Peptide Sequence Similarity to Other Host Defense Cytokines. Proc. Natl. Acad. Sci. USA 1987. 84: 9233-9237.

Yoshimura T, Matsushima K, Tanaka S, Robinson EA, Appella E, Oppenheim JJ, Leonard EJ.

J Immunol. 2019 Jan 1;202(1):5-9. No abstract available.


First-principles-based reaction kinetics from reactive molecular dynamics simulations: Application to hydrogen peroxide decomposition.

Ilyin DV, Goddard WA 3rd, Oppenheim JJ, Cheng T.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18202-18208. doi: 10.1073/pnas.1701383115. Epub 2018 Sep 21.


High-Mobility Group Nucleosome-Binding Protein 1 as Endogenous Ligand Induces Innate Immune Tolerance in a TLR4-Sirtuin-1 Dependent Manner in Human Blood Peripheral Mononuclear Cells.

Arts RJW, Huang PK, Yang, Joosten LAB, van der Meer JWM, Oppenheim JJ, Netea MG, Cheng SC.

Front Immunol. 2018 Mar 14;9:526. doi: 10.3389/fimmu.2018.00526. eCollection 2018.


High-mobility group nucleosome binding domain 1 (HMGN1) functions as a Th1-polarizing alarmin.

Yang, Han Z, Alam MM, Oppenheim JJ.

Semin Immunol. 2018 Aug;38:49-53. doi: 10.1016/j.smim.2018.02.012. Epub 2018 Aug 16. Review.


Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer.

Nie Y, He J, Shirota H, Trivett AL, Yang, Klinman DM, Oppenheim JJ, Chen X.

Sci Signal. 2018 Jan 2;11(511). pii: eaan0790. doi: 10.1126/scisignal.aan0790.


Extension of the Polarizable Charge Equilibration Model to Higher Oxidation States with Applications to Ge, As, Se, Br, Sn, Sb, Te, I, Pb, Bi, Po, and At Elements.

Oppenheim JJ, Naserifar S, Goddard WA III.

J Phys Chem A. 2018 Jan 18;122(2):639-645. doi: 10.1021/acs.jpca.7b06612. Epub 2018 Jan 8.


Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors.

Nie Y, Yang, Trivett A, Han Z, Xin H, Chen X, Oppenheim JJ.

Sci Rep. 2017 Oct 27;7(1):14186. doi: 10.1038/s41598-017-14655-8.


Alarmins and immunity.

Yang, Han Z, Oppenheim JJ.

Immunol Rev. 2017 Nov;280(1):41-56. doi: 10.1111/imr.12577. Review.


Therapeutic vaccine to cure large mouse hepatocellular carcinomas.

Han Z, Yang, Trivett A, Oppenheim JJ.

Oncotarget. 2017 Jul 18;8(32):52061-52071. doi: 10.18632/oncotarget.19367. eCollection 2017 Aug 8.


The Future of the Cytokine Discipline.

Oppenheim JJ.

Cold Spring Harb Perspect Biol. 2018 Sep 4;10(9). pii: a028498. doi: 10.1101/cshperspect.a028498.


A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity.

Stolzenberg E, Berry D, Yang, Lee EY, Kroemer A, Kaufman S, Wong GCL, Oppenheim JJ, Sen S, Fishbein T, Bax A, Harris B, Barbut D, Zasloff MA.

J Innate Immun. 2017;9(5):456-463. doi: 10.1159/000477990. Epub 2017 Jun 27. Erratum in: J Innate Immun. 2018;10(1):82.


Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer.

Chen X, Oppenheim JJ.

Sci Signal. 2017 Jan 17;10(462). pii: eaal2328. doi: 10.1126/scisignal.aal2328. Review.


Therapy: Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity.

Chen X, Oppenheim JJ.

Nat Rev Rheumatol. 2016 Nov;12(11):625-626. doi: 10.1038/nrrheum.2016.145. Epub 2016 Sep 2. No abstract available.


Corrigendum: TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis.

Chen X, Nie Y, Xiao H, Bian Z, Scarzello AJ, Song NY, Trivett AL, Yang, Oppenheim JJ.

Sci Rep. 2016 Oct 13;6:34680. doi: 10.1038/srep34680. No abstract available.


TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis.

Chen X, Nie Y, Xiao H, Bian Z, Scarzello AJ, Song NY, Trivett AL, Yang, Oppenheim JJ.

Sci Rep. 2016 Sep 7;6:32834. doi: 10.1038/srep32834. Erratum in: Sci Rep. 2016 Oct 13;6:34680.


IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.

Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS.

J Exp Med. 2016 Sep 19;213(10):2147-66. doi: 10.1084/jem.20150376. Epub 2016 Aug 22.


Alarmins and Antitumor Immunity.

Nie Y, Yang D, Oppenheim JJ.

Clin Ther. 2016 May;38(5):1042-53. doi: 10.1016/j.clinthera.2016.03.021. Epub 2016 Apr 22. Review.


Alarmin human α defensin HNP1 activates plasmacytoid dendritic cells by triggering NF-κB and IRF1 signaling pathways.

Wang F, Qiao L, Lv X, Trivett A, Yang R, Oppenheim JJ, Yang, Zhang N.

Cytokine. 2016 Jul;83:53-60. doi: 10.1016/j.cyto.2016.03.015. Epub 2016 Mar 28.


Suppressive activity of human regulatory T cells is maintained in the presence of TNF.

Zaragoza B, Chen X, Oppenheim JJ, Baeyens A, Gregoire S, Chader D, Gorochov G, Miyara M, Salomon BL.

Nat Med. 2016 Jan;22(1):16-7. doi: 10.1038/nm.4019. No abstract available.


Harnessing the alarmin HMGN1 for anticancer therapy.

Yang D, Bustin M, Oppenheim JJ.

Immunotherapy. 2015;7(11):1129-31. doi: 10.2217/imt.15.76. Epub 2015 Nov 16. Review. No abstract available.


Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels.

Medina SH, Li S, Howard OM, Dunlap M, Trivett A, Schneider JP, Oppenheim JJ.

Biomaterials. 2015;53:545-53. doi: 10.1016/j.biomaterials.2015.02.125. Epub 2015 Mar 23.


Characterization of MT-2 cells as a human regulatory T cell-like cell line.

Hamano R, Wu X, Wang Y, Oppenheim JJ, Chen X.

Cell Mol Immunol. 2015 Nov;12(6):780-2. doi: 10.1038/cmi.2014.123. Epub 2014 Dec 29. No abstract available.


Evolution of the serendipitous discovery of macrophage-lymphocyte interactions.

Oppenheim JJ.

Front Immunol. 2014 Oct 27;5:530. doi: 10.3389/fimmu.2014.00530. eCollection 2014. No abstract available.


IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells.

Chen X, Willette-Brown J, Wu X, Hu Y, Howard OM, Hu Y, Oppenheim JJ.

FASEB J. 2015 Feb;29(2):443-54. doi: 10.1096/fj.14-259564. Epub 2014 Nov 5.


Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways.

Zhao Z, Fan H, Higgins T, Qi J, Haines D, Trivett A, Oppenheim JJ, Wei H, Li J, Lin H, Howard OM.

Cancer Lett. 2014 Dec 28;355(2):232-41. doi: 10.1016/j.canlet.2014.08.037. Epub 2014 Sep 19.


The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant.

Wei F, Yang D, Tewary P, Li Y, Li S, Chen X, Howard OM, Bustin M, Oppenheim JJ.

Cancer Res. 2014 Nov 1;74(21):5989-98. doi: 10.1158/0008-5472.CAN-13-2042. Epub 2014 Sep 9.


Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide.

Chen X, Wakefield LM, Oppenheim JJ.

Oncoimmunology. 2014 Apr 16;3:e28247. eCollection 2014.


Exposure to Bacillus anthracis capsule results in suppression of human monocyte-derived dendritic cells.

Jelacic TM, Chabot DJ, Bozue JA, Tobery SA, West MW, Moody K, Yang D, Oppenheim JJ, Friedlander AM.

Infect Immun. 2014 Aug;82(8):3405-16. doi: 10.1128/IAI.01857-14. Epub 2014 Jun 2. Erratum in: Infect Immun. 2014 Dec;82(12):5347.


Th17 cells and Tregs: unlikely allies.

Chen X, Oppenheim JJ.

J Leukoc Biol. 2014 May;95(5):723-731. Epub 2014 Feb 21. Review.


Effective chemoimmunotherapy with anti-TGFβ antibody and cyclophosphamide in a mouse model of breast cancer.

Chen X, Yang Y, Zhou Q, Weiss JM, Howard OZ, McPherson JM, Wakefield LM, Oppenheim JJ.

PLoS One. 2014 Jan 9;9(1):e85398. doi: 10.1371/journal.pone.0085398. eCollection 2014.


Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4⁺ Foxp3⁺ regulatory T cells.

Hu Y, Xiao H, Shi T, Oppenheim JJ, Chen X.

Immunology. 2014 Jun;142(2):193-201. doi: 10.1111/imm.12241.


In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo.

Zhou Q, Hu Y, Howard OM, Oppenheim JJ, Chen X.

Cytokine. 2014 Jan;65(1):56-64. doi: 10.1016/j.cyto.2013.09.008. Epub 2013 Sep 27.


β-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-α production by human plasmacytoid dendritic cells, and promote inflammation.

Tewary P, de la Rosa G, Sharma N, Rodriguez LG, Tarasov SG, Howard OM, Shirota H, Steinhagen F, Klinman DM, Yang D, Oppenheim JJ.

J Immunol. 2013 Jul 15;191(2):865-74. doi: 10.4049/jimmunol.1201648. Epub 2013 Jun 17.


Alarmin-induced cell migration.

Yang D, Wei F, Tewary P, Howard OM, Oppenheim JJ.

Eur J Immunol. 2013 Jun;43(6):1412-8. doi: 10.1002/eji.201243138. Epub 2013 May 18.


Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells.

Yoshimura T, Howard OM, Ito T, Kuwabara M, Matsukawa A, Chen K, Liu Y, Liu M, Oppenheim JJ, Wang JM.

PLoS One. 2013;8(3):e58791. doi: 10.1371/journal.pone.0058791. Epub 2013 Mar 18.


DEXterity of tolerogenic APCs.

Stagliano KE, Oppenheim JJ.

Eur J Immunol. 2013 Jan;43(1):38-41. doi: 10.1002/eji.201243184.


TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.

Chen X, Wu X, Zhou Q, Howard OM, Netea MG, Oppenheim JJ.

J Immunol. 2013 Feb 1;190(3):1076-84. doi: 10.4049/jimmunol.1202659. Epub 2012 Dec 31.


Alarmins: awaiting a clinical response.

Chan JK, Roth J, Oppenheim JJ, Tracey KJ, Vogl T, Feldmann M, Horwood N, Nanchahal J.

J Clin Invest. 2012 Aug;122(8):2711-9. doi: 10.1172/JCI62423. Epub 2012 Aug 1. Review.


High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.

Yang D, Postnikov YV, Li Y, Tewary P, de la Rosa G, Wei F, Klinman D, Gioannini T, Weiss JP, Furusawa T, Bustin M, Oppenheim JJ.

J Exp Med. 2012 Jan 16;209(1):157-71. doi: 10.1084/jem.20101354. Epub 2011 Dec 19.


Comment on "Interplay between TNF and regulatory T cells in a TNF-driven murine model of arthritis".

Chen X, Oppenheim JJ.

J Immunol. 2011 Aug 15;187(4):1527; author reply 1527-8. doi: 10.4049/jimmunol.1190029. No abstract available.


Myeloid cells migrate in response to IL-24.

Buzas K, Oppenheim JJ, Zack Howard OM.

Cytokine. 2011 Sep;55(3):429-34. doi: 10.1016/j.cyto.2011.05.018. Epub 2011 Jun 23.


Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells.

Chen X, Oppenheim JJ.

Int Immunopharmacol. 2011 Oct;11(10):1489-96. doi: 10.1016/j.intimp.2011.05.018. Epub 2011 May 31. Review.


The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells.

Chen X, Oppenheim JJ.

Immunology. 2011 Aug;133(4):426-33. doi: 10.1111/j.1365-2567.2011.03460.x. Epub 2011 Jun 2. Review.


Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles.

Tarasov SG, Gaponenko V, Howard OM, Chen Y, Oppenheim JJ, Dyba MA, Subramaniam S, Lee Y, Michejda C, Tarasova NI.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9798-803. doi: 10.1073/pnas.1014598108. Epub 2011 May 31.

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