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Items: 1 to 50 of 94

1.

Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial.

Maitland K, Olupot-Olupot P, Kiguli S, Chagaluka G, Alaroker F, Opoka RO, Mpoya A, Walsh K, Engoru C, Nteziyaremye J, Mallewa M, Kennedy N, Nakuya M, Namayanja C, Kayaga J, Nabawanuka E, Sennyondo T, Aromut D, Kumwenda F, Musika CW, Thomason MJ, Bates I, von Hensbroek MB, Evans JA, Uyoga S, Williams TN, Frost G, George EC, Gibb DM, Walker AS; TRACT trial group.

Lancet Glob Health. 2019 Oct;7(10):e1435-e1447. doi: 10.1016/S2214-109X(19)30345-6.

PMID:
31537373
2.

Transfusion Volume for Children with Severe Anemia in Africa.

Maitland K, Olupot-Olupot P, Kiguli S, Chagaluka G, Alaroker F, Opoka RO, Mpoya A, Engoru C, Nteziyaremye J, Mallewa M, Kennedy N, Nakuya M, Namayanja C, Kayaga J, Uyoga S, Kyeyune Byabazaire D, M'baya B, Wabwire B, Frost G, Bates I, Evans JA, Williams TN, Saramago Goncalves P, George EC, Gibb DM, Walker AS; TRACT Group.

N Engl J Med. 2019 Aug 1;381(5):420-431. doi: 10.1056/NEJMoa1900100.

PMID:
31365800
3.

Immediate Transfusion in African Children with Uncomplicated Severe Anemia.

Maitland K, Kiguli S, Olupot-Olupot P, Engoru C, Mallewa M, Saramago Goncalves P, Opoka RO, Mpoya A, Alaroker F, Nteziyaremye J, Chagaluka G, Kennedy N, Nabawanuka E, Nakuya M, Namayanja C, Uyoga S, Kyeyune Byabazaire D, M'baya B, Wabwire B, Frost G, Bates I, Evans JA, Williams TN, George EC, Gibb DM, Walker AS; TRACT Group.

N Engl J Med. 2019 Aug 1;381(5):407-419. doi: 10.1056/NEJMoa1900105.

PMID:
31365799
4.

Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia.

Datta D, Namazzi R, Conroy AL, Cusick SE, Hume HA, Tagoola A, Ware RE, Opoka RO, John CC.

Trials. 2019 Jul 26;20(1):460. doi: 10.1186/s13063-019-3569-z.

5.

Biomarkers of Systemic Inflammation in Ugandan Infants and Children Hospitalized With Respiratory Syncytial Virus Infection.

Sawatzky J, Soo J, Conroy AL, Bhargava R, Namasopo S, Opoka RO, Hawkes MT.

Pediatr Infect Dis J. 2019 Aug;38(8):854-859. doi: 10.1097/INF.0000000000002343.

PMID:
31306398
6.

Blackwater fever in Ugandan children with severe anemia is associated with poor post-discharge outcomes. A prospective cohort study.

Opoka RO, Waiswa A, Harriet N, John CC, Tumwine JK, Karamagi C.

Clin Infect Dis. 2019 Jul 12. pii: ciz648. doi: 10.1093/cid/ciz648. [Epub ahead of print]

PMID:
31300826
7.

Evaluating Immunopathogenic Biomarkers During Severe Malaria Illness as Modifiers of the Neuropsychologic Benefits of Computer Cognitive Games Rehabilitation in Ugandan Children.

Boivin MJ, Sikorskii A, Nakasujja N, Ruiseñor-Escudero H, Familiar-Lopez I, Opoka RO, Giordani B.

Pediatr Infect Dis J. 2019 Aug;38(8):840-848. doi: 10.1097/INF.0000000000002367.

PMID:
31232898
8.

Perceived benefits and risks of participation in a clinical trial for Ugandan children with sickle cell anemia.

Carman AS, Sautter C, Anyanwu JN, Ssemata AS, Opoka RO, Ware RE, Rujumba J, John CC.

Pediatr Blood Cancer. 2019 May 28:e27830. doi: 10.1002/pbc.27830. [Epub ahead of print]

PMID:
31135090
9.

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria.

Conroy AL, Opoka RO, Bangirana P, Idro R, Ssenkusu JM, Datta D, Hodges JS, Morgan C, John CC.

BMC Med. 2019 May 21;17(1):98. doi: 10.1186/s12916-019-1332-7.

10.

Elevated cerebrospinal fluid tau protein concentrations on admission are associated with long-term neurologic and cognitive impairment in Ugandan children with cerebral malaria.

Datta D, Conroy AL, Castelluccio PF, Ssenkusu JM, Park GS, Opoka RO, Bangirana P, Idro R, Saykin AJ, John CC.

Clin Infect Dis. 2019 May 2. pii: ciz325. doi: 10.1093/cid/ciz325. [Epub ahead of print]

PMID:
31044219
11.

Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub-Saharan Africa.

Uyoga S, Mpoya A, Olupot-Olupot P, Kiguli S, Opoka RO, Engoru C, Mallewa M, Kennedy N, M'baya B, Kyeyune D, Wabwire B, Bates I, Gibb DM, Walker AS, George EC, Williams TN, Maitland K.

Vox Sang. 2019 May;114(4):340-348. doi: 10.1111/vox.12764. Epub 2019 Mar 5.

12.

Adherence to clinical guidelines is associated with reduced inpatient mortality among children with severe anemia in Ugandan hospitals.

Opoka RO, Ssemata AS, Oyang W, Nambuya H, John CC, Karamagi C, Tumwine JK.

PLoS One. 2019 Jan 25;14(1):e0210982. doi: 10.1371/journal.pone.0210982. eCollection 2019.

13.

Case Report: Birth Outcome and Neurodevelopment in Placental Malaria Discordant Twins.

Conroy AL, Bangirana P, Muhindo MK, Kakuru A, Jagannathan P, Opoka RO, Liechty EA, Nakalembe M, Kamya MR, Dorsey G, John CC.

Am J Trop Med Hyg. 2019 Mar;100(3):552-555. doi: 10.4269/ajtmh.18-0659.

PMID:
30628574
14.

Community perceptions of paediatric severe anaemia in Uganda.

Dhabangi A, Idro R, John CC, Dzik WH, Siu GE, Opoka RO, Ayebare F, van Hensbroek MB.

PLoS One. 2019 Jan 3;14(1):e0209476. doi: 10.1371/journal.pone.0209476. eCollection 2019.

15.

Handheld Point-of-Care Lactate Measurement at Admission Predicts Mortality in Ugandan Children Hospitalized with Pneumonia: A Prospective Cohort Study.

Ma C, Gunaratnam LC, Ericson A, Conroy AL, Namasopo S, Opoka RO, Hawkes MT.

Am J Trop Med Hyg. 2019 Jan;100(1):37-42. doi: 10.4269/ajtmh.18-0344.

PMID:
30398141
16.

Whole-Blood Transcriptional Signatures Composed of Erythropoietic and NRF2-Regulated Genes Differ Between Cerebral Malaria and Severe Malarial Anemia.

Nallandhighal S, Park GS, Ho YY, Opoka RO, John CC, Tran TM.

J Infect Dis. 2019 Jan 1;219(1):154-164. doi: 10.1093/infdis/jiy468.

PMID:
30060095
17.

High rate of inappropriate blood transfusions in the management of children with severe anemia in Ugandan hospitals.

Opoka RO, Ssemata AS, Oyang W, Nambuya H, John CC, Tumwine JK, Karamagi C.

BMC Health Serv Res. 2018 Jul 18;18(1):566. doi: 10.1186/s12913-018-3382-5.

18.

Solar-Powered Oxygen Delivery in Low-Resource Settings: A Randomized Clinical Noninferiority Trial.

Hawkes MT, Conroy AL, Namasopo S, Bhargava R, Kain KC, Mian Q, Opoka RO.

JAMA Pediatr. 2018 Jul 1;172(7):694-696. doi: 10.1001/jamapediatrics.2018.0228. No abstract available.

19.

Use of pre-hospital medication in children presenting with malaria to the emergency unit of Mulago Hospital, Uganda: A descriptive study.

Tumukunde VS, Kiboneka E, John CC, Opoka RO, Idro R.

Malariaworld J. 2017 Jul;8. pii: 8. Epub 2017 Jul 28.

20.

Neuropsychological benefits of computerized cognitive rehabilitation training in Ugandan children surviving severe malaria: A randomized controlled trial.

Boivin MJ, Nakasujja N, Sikorskii A, Ruiseñor-Escudero H, Familiar-Lopez I, Walhof K, van der Lugt EM, Opoka RO, Giordani B.

Brain Res Bull. 2019 Feb;145:117-128. doi: 10.1016/j.brainresbull.2018.03.002. Epub 2018 Mar 6.

PMID:
29522863
21.

Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa.

Aramburo A, Todd J, George EC, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Gibb DM, Babiker AG, Maitland K.

BMC Med. 2018 Mar 9;16(1):37. doi: 10.1186/s12916-018-1014-x.

22.

Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria.

Conroy AL, Hawkes MT, Elphinstone R, Opoka RO, Namasopo S, Miller C, John CC, Kain KC.

Malar J. 2018 Feb 15;17(1):82. doi: 10.1186/s12936-018-2225-5.

23.

Children's Oxygen Administration Strategies Trial (COAST):  A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia.

Maitland K, Kiguli S, Opoka RO, Olupot-Olupot P, Engoru C, Njuguna P, Bandika V, Mpoya A, Bush A, Williams TN, Grieve R, Sadique Z, Harrison D, Rowan K.

Wellcome Open Res. 2017 Oct 11;2:100. doi: 10.12688/wellcomeopenres.12747.1. eCollection 2017.

24.

Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial.

Bangirana P, Conroy AL, Opoka RO, Hawkes MT, Hermann L, Miller C, Namasopo S, Liles WC, John CC, Kain KC.

PLoS One. 2018 Jan 25;13(1):e0191550. doi: 10.1371/journal.pone.0191550. eCollection 2018.

25.

Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia.

Opoka RO, Ndugwa CM, Latham TS, Lane A, Hume HA, Kasirye P, Hodges JS, Ware RE, John CC.

Blood. 2017 Dec 14;130(24):2585-2593. doi: 10.1182/blood-2017-06-788935. Epub 2017 Oct 19.

26.

Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria.

Shabani E, Hanisch B, Opoka RO, Lavstsen T, John CC.

BMC Med. 2017 Oct 13;15(1):183. doi: 10.1186/s12916-017-0945-y.

27.

Effect of Caregiver Training on the Neurodevelopment of HIV-Exposed Uninfected Children and Caregiver Mental Health: A Ugandan Cluster-Randomized Controlled Trial.

Boivin MJ, Nakasujja N, Familiar-Lopez I, Murray SM, Sikorskii A, Awadu J, Shohet C, Givon D, Ruiseñor-Escudero H, Schut EE, Opoka RO, Bass JK.

J Dev Behav Pediatr. 2017 Nov/Dec;38(9):753-764. doi: 10.1097/DBP.0000000000000510.

28.

Plasmodium falciparum Histidine-Rich Protein-2 Plasma Concentrations Are Higher in Retinopathy-Negative Cerebral Malaria Than in Severe Malarial Anemia.

Park GS, Opoka RO, Shabani E, Wypyszynski A, Hanisch B, John CC.

Open Forum Infect Dis. 2017 Jul 22;4(3):ofx151. doi: 10.1093/ofid/ofx151. eCollection 2017 Summer.

29.

Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency.

Jaramillo EG, Mupere E, Opoka RO, Hodges JS, Lund TC, Georgieff MK, John CC, Cusick SE.

PLoS One. 2017 Aug 30;12(8):e0183977. doi: 10.1371/journal.pone.0183977. eCollection 2017.

30.

Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia.

Opoka RO, Bangirana P, Idro R, Shabani E, Namazzi R, John CC.

Pediatr Blood Cancer. 2018 Jan;65(1). doi: 10.1002/pbc.26745. Epub 2017 Aug 17.

31.

Obligations under global health partnerships in LMICs should be contractual.

Olusanya BO, Opoka RO.

Lancet Glob Health. 2017 Sep;5(9):e869. doi: 10.1016/S2214-109X(17)30260-7. No abstract available.

32.

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria.

Holmberg D, Franzén-Röhl E, Idro R, Opoka RO, Bangirana P, Sellgren CM, Wickström R, Färnert A, Schwieler L, Engberg G, John CC.

Malar J. 2017 Jul 28;16(1):303. doi: 10.1186/s12936-017-1954-1.

33.

Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria.

Shabani E, Ouma BJ, Idro R, Bangirana P, Opoka RO, Park GS, Conroy AL, John CC.

Parasite Immunol. 2017 Jul;39(7). doi: 10.1111/pim.12438. Epub 2017 May 28.

34.

High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda.

Olupot-Olupot P, Engoru C, Uyoga S, Muhindo R, Macharia A, Kiguli S, Opoka RO, Akech S, Ndila C, Nyeko R, Mtove G, Nteziyaremye J, Chebet M, George EC, Babiker AG, Gibb DM, Williams TN, Maitland K.

Clin Infect Dis. 2017 Apr 1;64(7):939-946. doi: 10.1093/cid/cix003.

35.

Clinical Comparison of Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria.

Villaverde C, Namazzi R, Shabani E, Opoka RO, John CC.

Am J Trop Med Hyg. 2017 May;96(5):1176-1184. doi: 10.4269/ajtmh.16-0315. Epub 2017 Jan 30.

36.

Long-term Behavioral Problems in Children With Severe Malaria.

Ssenkusu JM, Hodges JS, Opoka RO, Idro R, Shapiro E, John CC, Bangirana P.

Pediatrics. 2016 Nov;138(5). pii: e20161965. Epub 2016 Oct 5. Erratum in: Pediatrics. 2017 Nov;140(5):null.

37.

Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content.

Tiberti N, Latham SL, Bush S, Cohen A, Opoka RO, John CC, Juillard A, Grau GE, Combes V.

Sci Rep. 2016 Dec 5;6:37871. doi: 10.1038/srep37871.

38.

Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial.

Conroy AL, Hawkes M, Hayford K, Hermann L, McDonald CR, Sharma S, Namasopo S, Opoka RO, John CC, Liles WC, Miller C, Kain KC.

BMC Pediatr. 2016 Nov 4;16(1):177.

39.

Brain-derived Neurotrophic Factor Is Associated With Disease Severity and Clinical Outcome in Ugandan Children Admitted to Hospital With Severe Malaria.

McDonald CR, Conroy AL, Hawkes M, Elphinstone RE, Gamble JL, Hayford K, Namasopo S, Opoka RO, Liles WC, Kain KC.

Pediatr Infect Dis J. 2017 Feb;36(2):146-150. doi: 10.1097/INF.0000000000001382.

PMID:
27798544
40.

Host Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria.

Conroy AL, Hawkes M, McDonald CR, Kim H, Higgins SJ, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC.

Open Forum Infect Dis. 2016 Jun 20;3(3):ofw134. eCollection 2016 Sep.

41.

Differing Causes of Lactic Acidosis and Deep Breathing in Cerebral Malaria and Severe Malarial Anemia May Explain Differences in Acidosis-Related Mortality.

Brand NR, Opoka RO, Hamre KE, John CC.

PLoS One. 2016 Sep 29;11(9):e0163728. doi: 10.1371/journal.pone.0163728. eCollection 2016.

42.

Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria.

Higgins SJ, Purcell LA, Silver KL, Tran V, Crowley V, Hawkes M, Conroy AL, Opoka RO, Hay JG, Quaggin SE, Thurston G, Liles WC, Kain KC.

Sci Transl Med. 2016 Sep 28;8(358):358ra128. doi: 10.1126/scitranslmed.aaf6812.

43.

Delaying Iron Therapy until 28 Days after Antimalarial Treatment Is Associated with Greater Iron Incorporation and Equivalent Hematologic Recovery after 56 Days in Children: A Randomized Controlled Trial.

Cusick SE, Opoka RO, Abrams SA, John CC, Georgieff MK, Mupere E.

J Nutr. 2016 Sep;146(9):1769-74. doi: 10.3945/jn.116.233239. Epub 2016 Jun 29.

44.

Novel Use of Hydroxyurea in an African Region With Malaria: Protocol for a Randomized Controlled Clinical Trial.

Anyanwu JN, Williams O, Sautter CL, Kasirye P, Hume H, Opoka RO, Latham T, Ndugwa C, Ware RE, John CC.

JMIR Res Protoc. 2016 Jun 23;5(2):e110. doi: 10.2196/resprot.5599.

45.

The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria.

Shabani E, Opoka RO, Bangirana P, Park GS, Vercellotti GM, Guan W, Hodges JS, Lavstsen T, John CC.

Sci Rep. 2016 Jun 3;6:27084. doi: 10.1038/srep27084.

46.

Neurocognitive domains affected by cerebral malaria and severe malarial anemia in children.

Bangirana P, Opoka RO, Boivin MJ, Idro R, Hodges JS, John CC.

Learn Individ Differ. 2016 Feb;46:38-44. Epub 2015 Jan 16.

47.

Acute Kidney Injury Is Common in Pediatric Severe Malaria and Is Associated With Increased Mortality.

Conroy AL, Hawkes M, Elphinstone RE, Morgan C, Hermann L, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC.

Open Forum Infect Dis. 2016 Feb 26;3(2):ofw046. doi: 10.1093/ofid/ofw046. eCollection 2016 Mar.

48.

Solar-powered oxygen delivery: proof of concept.

Turnbull H, Conroy A, Opoka RO, Namasopo S, Kain KC, Hawkes M.

Int J Tuberc Lung Dis. 2016 May;20(5):696-703. doi: 10.5588/ijtld.15.0796.

PMID:
27084827
49.

Malaria illness mediated by anaemia lessens cognitive development in younger Ugandan children.

Boivin MJ, Sikorskii A, Familiar-Lopez I, Ruiseñor-Escudero H, Muhindo M, Kapisi J, Bigira V, Bass JK, Opoka RO, Nakasujja N, Kamya M, Dorsey G.

Malar J. 2016 Apr 14;15:210. doi: 10.1186/s12936-016-1266-x.

50.

A Randomized Controlled Trial to Evaluate if Computerized Cognitive Rehabilitation Improves Neurocognition in Ugandan Children with HIV.

Boivin MJ, Nakasujja N, Sikorskii A, Opoka RO, Giordani B.

AIDS Res Hum Retroviruses. 2016 Aug;32(8):743-55. doi: 10.1089/AID.2016.0026. Epub 2016 May 2.

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