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Items: 1 to 50 of 81

1.

The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep.

Noya SB, Colameo D, Brüning F, Spinnler A, Mircsof D, Opitz L, Mann M, Tyagarajan SK, Robles MS, Brown SA.

Science. 2019 Oct 11;366(6462). pii: eaav2642. doi: 10.1126/science.aav2642.

PMID:
31601739
2.

Recurrent inflammatory disease caused by a heterozygous mutation in CD48.

Volkmer B, Planas R, Gossweiler E, Lünemann A, Opitz L, Mauracher A, Nüesch U, Gayden T, Kaiser D, Drexel B, Dumrese C, Jabado N, Vavassori S, Pachlopnik Schmid J.

J Allergy Clin Immunol. 2019 Aug 13. pii: S0091-6749(19)31038-3. doi: 10.1016/j.jaci.2019.07.038. [Epub ahead of print] No abstract available.

PMID:
31419545
3.

Transcriptome Profiling of Primary Skin Fibroblasts Reveal Distinct Molecular Features Between PLOD1- and FKBP14-Kyphoscoliotic Ehlers-Danlos Syndrome.

Lim PJ, Lindert U, Opitz L, Hausser I, Rohrbach M, Giunta C.

Genes (Basel). 2019 Jul 8;10(7). pii: E517. doi: 10.3390/genes10070517.

4.

Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.

Komuczki J, Tuzlak S, Friebel E, Hartwig T, Spath S, Rosenstiel P, Waisman A, Opitz L, Oukka M, Schreiner B, Pelczar P, Becher B.

Immunity. 2019 May 21;50(5):1289-1304.e6. doi: 10.1016/j.immuni.2019.04.006. Epub 2019 May 9.

PMID:
31079916
5.

Maternal overnutrition programs hedonic and metabolic phenotypes across generations through sperm tsRNAs.

Sarker G, Sun W, Rosenkranz D, Pelczar P, Opitz L, Efthymiou V, Wolfrum C, Peleg-Raibstein D.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10547-10556. doi: 10.1073/pnas.1820810116. Epub 2019 May 6.

6.

Engineered peptide barcodes for in-depth analyses of binding protein libraries.

Egloff P, Zimmermann I, Arnold FM, Hutter CAJ, Morger D, Opitz L, Poveda L, Keserue HA, Panse C, Roschitzki B, Seeger MA.

Nat Methods. 2019 May;16(5):421-428. doi: 10.1038/s41592-019-0389-8. Epub 2019 Apr 22.

PMID:
31011184
7.

Gene expression signatures of circulating human type 1, 2, and 3 innate lymphoid cells.

Li S, Morita H, Sokolowska M, Tan G, Boonpiyathad T, Opitz L, Orimo K, Archer SK, Jansen K, Tang MLK, Purcell D, Plebanski M, Akdis CA.

J Allergy Clin Immunol. 2019 Jun;143(6):2321-2325. doi: 10.1016/j.jaci.2019.01.047. Epub 2019 Feb 28. No abstract available.

PMID:
30825467
8.

Long fragments achieve lower base quality in Illumina paired-end sequencing.

Tan G, Opitz L, Schlapbach R, Rehrauer H.

Sci Rep. 2019 Feb 27;9(1):2856. doi: 10.1038/s41598-019-39076-7.

9.

The L cell transcriptome is unaffected by vertical sleeve gastrectomy but highly dependent upon position within the gastrointestinal tract.

Rollins KA, Opitz L, Arnold M, Simon E, Neubauer H, Wolfrum S.

Peptides. 2019 Mar;113:22-34. doi: 10.1016/j.peptides.2019.01.001. Epub 2019 Jan 17.

10.

Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation.

Balaz M, Becker AS, Balazova L, Straub L, Müller J, Gashi G, Maushart CI, Sun W, Dong H, Moser C, Horvath C, Efthymiou V, Rachamin Y, Modica S, Zellweger C, Bacanovic S, Stefanicka P, Varga L, Ukropcova B, Profant M, Opitz L, Amri EZ, Akula MK, Bergo M, Ukropec J, Falk C, Zamboni N, Betz MJ, Burger IA, Wolfrum C.

Cell Metab. 2019 Apr 2;29(4):901-916.e8. doi: 10.1016/j.cmet.2018.11.017. Epub 2018 Dec 20.

PMID:
30581121
11.

BATLAS: Deconvoluting Brown Adipose Tissue.

Perdikari A, Leparc GG, Balaz M, Pires ND, Lidell ME, Sun W, Fernandez-Albert F, Müller S, Akchiche N, Dong H, Balazova L, Opitz L, Röder E, Klein H, Stefanicka P, Varga L, Nuutila P, Virtanen KA, Niemi T, Taittonen M, Rudofsky G, Ukropec J, Enerbäck S, Stupka E, Neubauer H, Wolfrum C.

Cell Rep. 2018 Oct 16;25(3):784-797.e4. doi: 10.1016/j.celrep.2018.09.044.

12.

Phenotypical heterogeneity in RAG-deficient patients from a highly consanguineous population.

Meshaal SS, El Hawary RE, Abd Elaziz DS, Eldash A, Alkady R, Lotfy S, Mauracher AA, Opitz L, Pachlopnik Schmid J, van der Burg M, Chou J, Galal NM, Boutros JA, Geha R, Elmarsafy AM.

Clin Exp Immunol. 2019 Feb;195(2):202-212. doi: 10.1111/cei.13222. Epub 2018 Nov 4.

PMID:
30307608
13.

The miRNA biogenesis pathway prevents inappropriate expression of injury response genes in developing and adult Schwann cells.

Gökbuget D, Pereira JA, Opitz L, Christe D, Kessler T, Marchais A, Suter U.

Glia. 2018 Dec;66(12):2632-2644. doi: 10.1002/glia.23516. Epub 2018 Oct 8.

14.

Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis.

Jelcic I, Al Nimer F, Wang J, Lentsch V, Planas R, Jelcic I, Madjovski A, Ruhrmann S, Faigle W, Frauenknecht K, Pinilla C, Santos R, Hammer C, Ortiz Y, Opitz L, Grönlund H, Rogler G, Boyman O, Reynolds R, Lutterotti A, Khademi M, Olsson T, Piehl F, Sospedra M, Martin R.

Cell. 2018 Sep 20;175(1):85-100.e23. doi: 10.1016/j.cell.2018.08.011. Epub 2018 Aug 30.

15.

MHC-II Deficiency Among Egyptians: Novel Mutations and Unique Phenotypes.

El Hawary RE, Mauracher AA, Meshaal SS, Eldash A, Abd Elaziz DS, Alkady R, Lotfy S, Opitz L, Galal NM, Boutros JA, Pachlopnik Schmid J, Elmarsafy AM.

J Allergy Clin Immunol Pract. 2019 Mar;7(3):856-863. doi: 10.1016/j.jaip.2018.07.046. Epub 2018 Aug 28.

PMID:
30170160
16.

Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.

Sun W, Dong H, Becker AS, Dapito DH, Modica S, Grandl G, Opitz L, Efthymiou V, Straub LG, Sarker G, Balaz M, Balazova L, Perdikari A, Kiehlmann E, Bacanovic S, Zellweger C, Peleg-Raibstein D, Pelczar P, Reik W, Burger IA, von Meyenn F, Wolfrum C.

Nat Med. 2018 Nov;24(11):1777. doi: 10.1038/s41591-018-0163-y.

PMID:
30087436
17.

Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.

Sun W, Dong H, Becker AS, Dapito DH, Modica S, Grandl G, Opitz L, Efthymiou V, Straub LG, Sarker G, Balaz M, Balazova L, Perdikari A, Kiehlmann E, Bacanovic S, Zellweger C, Peleg-Raibstein D, Pelczar P, Reik W, Burger IA, von Meyenn F, Wolfrum C.

Nat Med. 2018 Nov;24(11):1776. doi: 10.1038/s41591-018-0162-z.

PMID:
30087435
18.

Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.

Sun W, Dong H, Becker AS, Dapito DH, Modica S, Grandl G, Opitz L, Efthymiou V, Straub LG, Sarker G, Balaz M, Balazova L, Perdikari A, Kiehlmann E, Bacanovic S, Zellweger C, Peleg-Raibstein D, Pelczar P, Reik W, Burger IA, von Meyenn F, Wolfrum C.

Nat Med. 2018 Sep;24(9):1372-1383. doi: 10.1038/s41591-018-0102-y. Epub 2018 Jul 9. Erratum in: Nat Med. 2018 Aug 7;:. Nat Med. 2018 Aug 7;:.

PMID:
29988127
19.

Correction to: Limited utility of tissue micro-arrays in detecting intra-tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer.

Kündig P, Giesen C, Jackson H, Bodenmiller B, Papassotirolopus B, Freiberger SN, Aquino C, Opitz L, Varga Z.

J Transl Med. 2018 Jul 2;16(1):180. doi: 10.1186/s12967-018-1553-0.

20.

Epithelial proliferation in inflammatory skin disease is regulated by tetratricopeptide repeat domain 7 (Ttc7) in fibroblasts and lymphocytes.

Nüesch U, Mauracher AA, Opitz L, Volkmer B, Michalak-Mićka K, Kamarashev J, Hartwig T, Reichmann E, Becher B, Vavassori S, Pachlopnik Schmid J.

J Allergy Clin Immunol. 2019 Jan;143(1):292-304.e8. doi: 10.1016/j.jaci.2018.02.057. Epub 2018 Jun 14.

PMID:
29775636
21.

Limited utility of tissue micro-arrays in detecting intra-tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer.

Kündig P, Giesen C, Jackson H, Bodenmiller B, Papassotirolopus B, Freiberger SN, Aquino C, Opitz L, Varga Z.

J Transl Med. 2018 May 8;16(1):118. doi: 10.1186/s12967-018-1495-6. Erratum in: J Transl Med. 2018 Jul 2;16(1):180.

22.

Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase.

Lasar D, Rosenwald M, Kiehlmann E, Balaz M, Tall B, Opitz L, Lidell ME, Zamboni N, Krznar P, Sun W, Varga L, Stefanicka P, Ukropec J, Nuutila P, Virtanen K, Amri EZ, Enerbäck S, Wahli W, Wolfrum C.

Cell Rep. 2018 Jan 16;22(3):760-773. doi: 10.1016/j.celrep.2017.12.067.

23.

Lymphadenopathy driven by TCR-Vγ8Vδ1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome.

Vavassori S, Galson JD, Trück J, van den Berg A, Tamminga RYJ, Magerus-Chatinet A, Pellé O, Camenisch Gross U, Marques Maggio E, Prader S, Opitz L, Nüesch U, Mauracher A, Volkmer B, Speer O, Suda L, Röthlisberger B, Zimmermann DR, Müller R, Diepstra A, Visser L, Haralambieva E, Neven B, Rieux-Laucat F, Pachlopnik Schmid J.

Blood Adv. 2017 Jun 22;1(15):1101-1106. doi: 10.1182/bloodadvances.2017006411. eCollection 2017 Jun 27.

24.

An optimised protocol for isolation of RNA from small sections of laser-capture microdissected FFPE tissue amenable for next-generation sequencing.

Amini P, Ettlin J, Opitz L, Clementi E, Malbon A, Markkanen E.

BMC Mol Biol. 2017 Aug 23;18(1):22. doi: 10.1186/s12867-017-0099-7.

25.

Lipid-body containing interstitial cells (lipofibroblasts) in the lungs of various mouse strains.

Opitz L, Kling KM, Brandenberger C, Mühlfeld C.

J Anat. 2017 Dec;231(6):970-977. doi: 10.1111/joa.12677. Epub 2017 Aug 8.

PMID:
28786110
26.

Effects of oral antibiotics and isotretinoin on the murine gut microbiota.

Becker E, Schmidt TSB, Bengs S, Poveda L, Opitz L, Atrott K, Stanzel C, Biedermann L, Rehman A, Jonas D, von Mering C, Rogler G, Frey-Wagner I.

Int J Antimicrob Agents. 2017 Sep;50(3):342-351. doi: 10.1016/j.ijantimicag.2017.03.017. Epub 2017 Jul 6.

PMID:
28689869
27.

SRF and MKL1 Independently Inhibit Brown Adipogenesis.

Rosenwald M, Efthymiou V, Opitz L, Wolfrum C.

PLoS One. 2017 Jan 26;12(1):e0170643. doi: 10.1371/journal.pone.0170643. eCollection 2017.

28.

Pre-infection transcript levels of FAM26F in peripheral blood mononuclear cells inform about overall plasma viral load in acute and post-acute phase after simian immunodeficiency virus infection.

Javed A, Leuchte N, Salinas G, Opitz L, Stahl-Hennig C, Sopper S, Sauermann U.

J Gen Virol. 2016 Dec;97(12):3400-3412. doi: 10.1099/jgv.0.000632. Epub 2016 Oct 18.

29.

Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells?

Becker E, Bengs S, Aluri S, Opitz L, Atrott K, Stanzel C, Castro PAR, Rogler G, Frey-Wagner I.

Sci Rep. 2016 Nov 17;6:37082. doi: 10.1038/srep37082.

30.

Esophageal Granular Cell Tumor: A Case Report and Review of Literature.

Thumallapally N, Ibrahim U, Kesavan M, Chang Q, Opitz L, Dhar M, Andrawes S.

Cureus. 2016 Sep 14;8(9):e782.

31.

Unusual dermatological presentation and immune phenotype in SCID due to an IL7R mutation: the value of whole-exome sequencing and the potential benefit of newborn screening.

Marquardt L, Lacour M, Hoernes M, Opitz L, Lecca R, Volkmer B, Reichenbach J, Hohl D, Ansari M, Ozsahin H, Güngör T, Pachlopnik Schmid J.

J Eur Acad Dermatol Venereol. 2017 Mar;31(3):e147-e148. doi: 10.1111/jdv.13888. Epub 2016 Sep 5. No abstract available.

PMID:
27593400
32.

Diurnal changes in the histone H3 signature H3K9ac|H3K27ac|H3S28p are associated with diurnal gene expression in Arabidopsis.

Baerenfaller K, Shu H, Hirsch-Hoffmann M, Fütterer J, Opitz L, Rehrauer H, Hennig L, Gruissem W.

Plant Cell Environ. 2016 Nov;39(11):2557-2569. doi: 10.1111/pce.12811. Epub 2016 Sep 30.

33.

SUSHI: an exquisite recipe for fully documented, reproducible and reusable NGS data analysis.

Hatakeyama M, Opitz L, Russo G, Qi W, Schlapbach R, Rehrauer H.

BMC Bioinformatics. 2016 Jun 2;17(1):228. doi: 10.1186/s12859-016-1104-8.

34.

Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response.

Deuel JW, Schaer CA, Boretti FS, Opitz L, Garcia-Rubio I, Baek JH, Spahn DR, Buehler PW, Schaer DJ.

Cell Death Dis. 2016 Jan 21;7:e2064. doi: 10.1038/cddis.2015.392.

35.

Global analysis of asymmetric RNA enrichment in oocytes reveals low conservation between closely related Xenopus species.

Claußen M, Lingner T, Pommerenke C, Opitz L, Salinas G, Pieler T.

Mol Biol Cell. 2015 Nov 1;26(21):3777-87. doi: 10.1091/mbc.E15-02-0115. Epub 2015 Sep 2.

36.

Genome-wide identification of CBX2 targets: insights in the human sex development network.

Eid W, Opitz L, Biason-Lauber A.

Mol Endocrinol. 2015 Feb;29(2):247-57. doi: 10.1210/me.2014-1339. Epub 2015 Jan 8.

37.

Integrative proteome and transcriptome analysis of extramedullary erythropoiesis and its reversal by transferrin treatment in a mouse model of beta-thalassemia.

Vallelian F, Gelderman-Fuhrmann MP, Schaer CA, Puglia M, Opitz L, Baek JH, Vostal J, Buehler PW, Schaer DJ.

J Proteome Res. 2015 Feb 6;14(2):1089-100. doi: 10.1021/pr5010778. Epub 2015 Jan 23.

PMID:
25566950
38.

Tissue-specific transcriptomics, chromosomal localization, and phylogeny of chemosensory and odorant binding proteins from the red flour beetle Tribolium castaneum reveal subgroup specificities for olfaction or more general functions.

Dippel S, Oberhofer G, Kahnt J, Gerischer L, Opitz L, Schachtner J, Stanke M, Schütz S, Wimmer EA, Angeli S.

BMC Genomics. 2014 Dec 18;15:1141. doi: 10.1186/1471-2164-15-1141.

39.

Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress.

Vallelian F, Deuel JW, Opitz L, Schaer CA, Puglia M, Lönn M, Engelsberger W, Schauer S, Karnaukhova E, Spahn DR, Stocker R, Buehler PW, Schaer DJ.

Cell Death Differ. 2015 Apr;22(4):597-611. doi: 10.1038/cdd.2014.154. Epub 2014 Oct 10.

40.

Gene expression profiling of brains from bovine spongiform encephalopathy (BSE)-infected cynomolgus macaques.

Barbisin M, Vanni S, Schmädicke AC, Montag J, Motzkus D, Opitz L, Salinas-Riester G, Legname G.

BMC Genomics. 2014 Jun 5;15:434. doi: 10.1186/1471-2164-15-434.

41.

CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance.

Schulz Y, Wehner P, Opitz L, Salinas-Riester G, Bongers EM, van Ravenswaaij-Arts CM, Wincent J, Schoumans J, Kohlhase J, Borchers A, Pauli S.

Hum Genet. 2014 Aug;133(8):997-1009. doi: 10.1007/s00439-014-1444-2. Epub 2014 Apr 13.

PMID:
24728844
42.

Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma.

Koch R, Demant M, Aung T, Diering N, Cicholas A, Chapuy B, Wenzel D, Lahmann M, Güntsch A, Kiecke C, Becker S, Hupfeld T, Venkataramani V, Ziepert M, Opitz L, Klapper W, Trümper L, Wulf GG.

Blood. 2014 Apr 3;123(14):2189-98. doi: 10.1182/blood-2013-08-523886. Epub 2014 Feb 21.

PMID:
24563408
43.

GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.

Fabian J, Lodrini M, Oehme I, Schier MC, Thole TM, Hielscher T, Kopp-Schneider A, Opitz L, Capper D, von Deimling A, Wiegand I, Milde T, Mahlknecht U, Westermann F, Popanda O, Roels F, Hero B, Berthold F, Fischer M, Kulozik AE, Witt O, Deubzer HE.

Cancer Res. 2014 May 1;74(9):2604-16. doi: 10.1158/0008-5472.CAN-13-1904. Epub 2014 Jan 13.

44.

Blind spots of quantitative RNA-seq: the limits for assessing abundance, differential expression, and isoform switching.

Rehrauer H, Opitz L, Tan G, Sieverling L, Schlapbach R.

BMC Bioinformatics. 2013 Dec 24;14:370. doi: 10.1186/1471-2105-14-370.

45.

Valproic acid inhibits the proliferation of cancer cells by re-expressing cyclin D2.

Witt D, Burfeind P, von Hardenberg S, Opitz L, Salinas-Riester G, Bremmer F, Schweyer S, Thelen P, Neesen J, Kaulfuss S.

Carcinogenesis. 2013 May;34(5):1115-24. doi: 10.1093/carcin/bgt019. Epub 2013 Jan 24.

PMID:
23349020
46.

A novel curcumin-based vaginal cream Vacurin selectively eliminates apposed human cervical cancer cells.

Debata PR, Castellanos MR, Fata JE, Baggett S, Rajupet S, Szerszen A, Begum S, Mata A, Murty VV, Opitz LM, Banerjee P.

Gynecol Oncol. 2013 Apr;129(1):145-53. doi: 10.1016/j.ygyno.2012.12.005. Epub 2012 Dec 9.

PMID:
23234806
47.

Apoptosis-related gene expression profiles of mouse ESCs and maGSCs: role of Fgf4 and Mnda in pluripotent cell responses to genotoxicity.

Khromov T, Dressel R, Siamishi I, Nolte J, Opitz L, Engel W, Pantakani DV.

PLoS One. 2012;7(11):e48869. doi: 10.1371/journal.pone.0048869. Epub 2012 Nov 7.

48.

Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.

Studencka M, Wesołowski R, Opitz L, Salinas-Riester G, Wisniewski JR, Jedrusik-Bode M.

PLoS Genet. 2012 Sep;8(9):e1002940. doi: 10.1371/journal.pgen.1002940. Epub 2012 Sep 13.

49.

Extrinsic and intrinsic regulation of DOR/TP53INP2 expression in mice: effects of dietary fat content, tissue type and sex in adipose and muscle tissues.

Fromm-Dornieden C, Lytovchenko O, von der Heyde S, Behnke N, Hogl S, Berghoff J, Köpper F, Opitz L, Renne U, Hoeflich A, Beissbarth T, Brenig B, Baumgartner BG.

Nutr Metab (Lond). 2012 Sep 21;9(1):86. doi: 10.1186/1743-7075-9-86.

50.

Oxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome.

Grosser E, Hirt U, Janc OA, Menzfeld C, Fischer M, Kempkes B, Vogelgesang S, Manzke TU, Opitz L, Salinas-Riester G, Müller M.

Neurobiol Dis. 2012 Oct;48(1):102-14. doi: 10.1016/j.nbd.2012.06.007. Epub 2012 Jun 30.

PMID:
22750529

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