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Items: 1 to 50 of 219

1.

Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma.

Mohapatra SR, Sadik A, Tykocinski LO, Dietze J, Poschet G, Heiland I, Opitz CA.

Front Immunol. 2019 Dec 4;10:2762. doi: 10.3389/fimmu.2019.02762. eCollection 2019.

2.

Hypoxia decreases the T helper cell-suppressive capacity of synovial fibroblasts by downregulating IDO1-mediated tryptophan metabolism.

Kaul NC, Mohapatra SR, Adam I, Tucher C, Tretter T, Opitz CA, Lorenz HM, Tykocinski LO.

Rheumatology (Oxford). 2019 Dec 17. pii: kez587. doi: 10.1093/rheumatology/kez587. [Epub ahead of print]

PMID:
31846032
3.

The therapeutic potential of targeting tryptophan catabolism in cancer.

Opitz CA, Somarribas Patterson LF, Mohapatra SR, Dewi DL, Sadik A, Platten M, Trump S.

Br J Cancer. 2020 Jan;122(1):30-44. doi: 10.1038/s41416-019-0664-6. Epub 2019 Dec 10. Review.

PMID:
31819194
4.

Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology.

Sonner JK, Keil M, Falk-Paulsen M, Mishra N, Rehman A, Kramer M, Deumelandt K, Röwe J, Sanghvi K, Wolf L, von Landenberg A, Wolff H, Bharti R, Oezen I, Lanz TV, Wanke F, Tang Y, Brandao I, Mohapatra SR, Epping L, Grill A, Röth R, Niesler B, Meuth SG, Opitz CA, Okun JG, Reinhardt C, Kurschus FC, Wick W, Bode HB, Rosenstiel P, Platten M.

Nat Commun. 2019 Oct 25;10(1):4877. doi: 10.1038/s41467-019-12776-4.

5.

Resistance Exercise Reduces Kynurenine Pathway Metabolites in Breast Cancer Patients Undergoing Radiotherapy.

Zimmer P, Schmidt ME, Prentzell MT, Berdel B, Wiskemann J, Kellner KH, Debus J, Ulrich C, Opitz CA, Steindorf K.

Front Oncol. 2019 Sep 25;9:962. doi: 10.3389/fonc.2019.00962. eCollection 2019.

6.

Apical root resorption after orthodontic treatment in patients with unilateral cleft lip and palate.

Bartzela TN, Mang de la Rosa MR, Wolf K, Schmidt A, Opitz C.

Clin Oral Investig. 2019 Aug 13. doi: 10.1007/s00784-019-03044-2. [Epub ahead of print]

PMID:
31410675
7.

Rapid determination of general cell status, cell viability, and optimal harvest time in eukaryotic cell cultures by impedance flow cytometry.

Opitz C, Schade G, Kaufmann S, Di Berardino M, Ottiger M, Grzesiek S.

Appl Microbiol Biotechnol. 2019 Oct;103(20):8619-8629. doi: 10.1007/s00253-019-10046-3. Epub 2019 Aug 9.

PMID:
31396681
8.

Pulmonary hypertension in HFpEF and HFrEF: Pathophysiology, diagnosis, treatment approaches.

Rosenkranz S, Kramer T, Gerhardt F, Opitz C, Olsson KM, Hoeper MM.

Herz. 2019 Sep;44(6):483-490. doi: 10.1007/s00059-019-4831-6.

PMID:
31317203
9.

[Hemodynamic Definition of Pulmonary Hypertension: Commentary on the Proposed Change by the 6th World Symposium on Pulmonary Hypertension].

Rosenkranz S, Diller GP, Dumitrescu D, Ewert R, Ghofrani HA, Grünig E, Halank M, Held M, Kaemmerer H, Klose H, Kovacs G, Konstantinides S, Lang IM, Lange TJ, Leuchte H, Mayer E, Olschewski A, Olschewski H, Olsson KM, Opitz C, Schermuly RT, Seeger W, Wilkens H, Hoeper MM.

Dtsch Med Wochenschr. 2019 Sep;144(19):1367-1372. doi: 10.1055/a-0918-3772. Epub 2019 Jul 5. German.

10.

The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner.

Heberle AM, Razquin Navas P, Langelaar-Makkinje M, Kasack K, Sadik A, Faessler E, Hahn U, Marx-Stoelting P, Opitz CA, Sers C, Heiland I, Schäuble S, Thedieck K.

Life Sci Alliance. 2019 Mar 28;2(2). pii: e201800257. doi: 10.26508/lsa.201800257. Print 2019 Apr.

11.

Right Heart Catheterization During Exercise in Patients with COPD-An Overview of Clinical Results and Methodological Aspects.

Ewert R, Heine A, Bollmann T, Müller-Heinrich A, Gläser S, Opitz CF.

COPD. 2018 Dec;15(6):588-599. doi: 10.1080/15412555.2018.1545832. Review.

PMID:
30894079
12.

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.

Platten M, Nollen EAA, Röhrig UF, Fallarino F, Opitz CA.

Nat Rev Drug Discov. 2019 May;18(5):379-401. doi: 10.1038/s41573-019-0016-5. Review.

PMID:
30760888
13.

Predictive Capability of Cardiopulmonary and Exercise Parameters From Day 1 to 6 Months After Acute Pulmonary Embolism.

Habedank D, Opitz C, Karhausen T, Kung T, Steinke I, Ewert R.

Clin Med Insights Circ Respir Pulm Med. 2018 Aug 16;12:1179548418794155. doi: 10.1177/1179548418794155. eCollection 2018.

14.

Deuterium induces a distinctive Escherichia coli proteome that correlates with the reduction in growth rate.

Opitz C, Ahrné E, Goldie KN, Schmidt A, Grzesiek S.

J Biol Chem. 2019 Feb 15;294(7):2279-2292. doi: 10.1074/jbc.RA118.006914. Epub 2018 Dec 13.

PMID:
30545941
15.

Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation.

Adam I, Dewi DL, Mooiweer J, Sadik A, Mohapatra SR, Berdel B, Keil M, Sonner JK, Thedieck K, Rose AJ, Platten M, Heiland I, Trump S, Opitz CA.

Oncoimmunology. 2018 Sep 5;7(12):e1486353. doi: 10.1080/2162402X.2018.1486353. eCollection 2018.

16.

Pulmonary hypertension associated with left heart disease: Updated Recommendations of the Cologne Consensus Conference 2018.

Rosenkranz S, Lang IM, Blindt R, Bonderman D, Bruch L, Diller GP, Felgendreher R, Gerges C, Hohenforst-Schmidt W, Holt S, Jung C, Kindermann I, Kramer T, Kübler WM, Mitrovic V, Riedel A, Rieth A, Schmeisser A, Wachter R, Weil J, Opitz CF.

Int J Cardiol. 2018 Dec 1;272S:53-62. doi: 10.1016/j.ijcard.2018.08.080. Epub 2018 Aug 27. Review.

PMID:
30527996
17.

Risk assessment in medically treated chronic thromboembolic pulmonary hypertension patients.

Delcroix M, Staehler G, Gall H, Grünig E, Held M, Halank M, Klose H, Vonk-Noordegraaf A, Rosenkranz S, Pepke-Zaba J, Opitz CF, Gibbs JSR, Lange TJ, Tsangaris I, Huscher D, Pittrow D, Olsson KM, Hoeper MM.

Eur Respir J. 2018 Nov 8;52(5). pii: 1800248. doi: 10.1183/13993003.00248-2018. Print 2018 Nov.

PMID:
30337446
18.

Long-term safety and outcome of intravenous treprostinil via an implanted pump in pulmonary hypertension.

Richter MJ, Harutyunova S, Bollmann T, Classen S, Gall H, Gerhardt Md F, Grimminger F, Grimminger J, Grünig E, Guth S, Halank M, Heine A, Hoeper MM, Klose H, Lange TJ, Meyer K, Neurohr C, Nickolaus K, Olsson KM, Opitz CF, Rosenkranz S, Seyfarth HJ, Warnke C, Wiedenroth C, Ghofrani HA, Ewert R.

J Heart Lung Transplant. 2018 Oct;37(10):1235-1244. doi: 10.1016/j.healun.2018.06.006. Epub 2018 Jun 21.

PMID:
30293617
19.

Production of isotope-labeled proteins in insect cells for NMR.

Franke B, Opitz C, Isogai S, Grahl A, Delgado L, Gossert AD, Grzesiek S.

J Biomol NMR. 2018 Jul;71(3):173-184. doi: 10.1007/s10858-018-0172-7. Epub 2018 Apr 23. Review.

PMID:
29687312
20.

Author Correction: Fourier Transform Infrared Microscopy Enables Guidance of Automated Mass Spectrometry Imaging to Predefined Tissue Morphologies.

Rabe JH, Sammour DA, Schulz S, Munteanu B, Ott M, Ochs K, Hohenberger P, Marx A, Platten M, Opitz CA, Ory DS, Hopf C.

Sci Rep. 2018 Apr 18;8(1):6361. doi: 10.1038/s41598-018-24807-z.

21.

Risk assessment in pulmonary arterial hypertension.

Hoeper MM, Pittrow D, Opitz C, Gibbs JSR, Rosenkranz S, Grünig E, Olsson KM, Huscher D.

Eur Respir J. 2018 Mar 29;51(3). pii: 1702606. doi: 10.1183/13993003.02606-2017. Print 2018 Mar. No abstract available.

22.

Alloantigen expression on malignant cells and healthy host tissue influences graft-versus-tumor reactions after allogeneic hematopoietic stem cell transplantation.

Robert S, Albring JC, Frebel K, Opitz C, Urh J, Wolf C, Heinrich C, Berdel WE, Stelljes M.

Bone Marrow Transplant. 2018 Jul;53(7):807-819. doi: 10.1038/s41409-017-0071-7. Epub 2018 Jan 23.

PMID:
29362503
23.

Fourier Transform Infrared Microscopy Enables Guidance of Automated Mass Spectrometry Imaging to Predefined Tissue Morphologies.

Rabe JH, A Sammour D, Schulz S, Munteanu B, Ott M, Ochs K, Hohenberger P, Marx A, Platten M, Opitz CA, Ory DS, Hopf C.

Sci Rep. 2018 Jan 10;8(1):313. doi: 10.1038/s41598-017-18477-6. Erratum in: Sci Rep. 2018 Apr 18;8(1):6361.

24.

Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation.

Kessler T, Sahm F, Sadik A, Stichel D, Hertenstein A, Reifenberger G, Zacher A, Sabel M, Tabatabai G, Steinbach J, Sure U, Krex D, Grosu AL, Bewerunge-Hudler M, Jones D, Pfister SM, Weller M, Opitz C, Bendszus M, von Deimling A, Platten M, Wick W.

Neuro Oncol. 2018 Feb 19;20(3):367-379. doi: 10.1093/neuonc/nox160.

25.

Quantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to Pulmonary Aspergillus fumigatus Infection.

Seddigh P, Bracht T, Molinier-Frenkel V, Castellano F, Kniemeyer O, Schuster M, Weski J, Hasenberg A, Kraus A, Poschet G, Hager T, Theegarten D, Opitz CA, Brakhage AA, Sitek B, Hasenberg M, Gunzer M.

Mol Cell Proteomics. 2017 Dec;16(12):2184-2198. doi: 10.1074/mcp.RA117.000072. Epub 2017 Sep 26.

26.

Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model.

Hoeper MM, Kramer T, Pan Z, Eichstaedt CA, Spiesshoefer J, Benjamin N, Olsson KM, Meyer K, Vizza CD, Vonk-Noordegraaf A, Distler O, Opitz C, Gibbs JSR, Delcroix M, Ghofrani HA, Huscher D, Pittrow D, Rosenkranz S, Grünig E.

Eur Respir J. 2017 Aug 3;50(2). pii: 1700740. doi: 10.1183/13993003.00740-2017. Print 2017 Aug.

27.

Intravenous treprostinil infusion via a fully implantable pump for pulmonary arterial hypertension.

Ewert R, Richter MJ, Steringer-Mascherbauer R, Grünig E, Lange TJ, Opitz CF, Warnke C, Ghofrani HA.

Clin Res Cardiol. 2017 Oct;106(10):776-783. doi: 10.1007/s00392-017-1114-1. Epub 2017 Apr 20.

PMID:
28429083
28.

Suppression of Th1 differentiation by tryptophan supplementation in vivo.

Lanz TV, Becker S, Mohapatra SR, Opitz CA, Wick W, Platten M.

Amino Acids. 2017 Jul;49(7):1169-1175. doi: 10.1007/s00726-017-2415-4. Epub 2017 Apr 18.

PMID:
28421297
29.

Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer.

Dewi DL, Mohapatra SR, Blanco Cabañes S, Adam I, Somarribas Patterson LF, Berdel B, Kahloon M, Thürmann L, Loth S, Heilmann K, Weichenhan D, Mücke O, Heiland I, Wimberger P, Kuhlmann JD, Kellner KH, Schott S, Plass C, Platten M, Gerhäuser C, Trump S, Opitz CA.

Oncoimmunology. 2017 Jan 3;6(2):e1274477. doi: 10.1080/2162402X.2016.1274477. eCollection 2017.

30.

Synovial Fibroblasts Selectively Suppress Th1 Cell Responses through IDO1-Mediated Tryptophan Catabolism.

Tykocinski LO, Lauffer AM, Bohnen A, Kaul NC, Krienke S, Tretter T, Adam I, Mohapatra SR, Saikali P, Löhning M, Neidhart M, Gay S, Oezen I, Platten M, Opitz CA, Lorenz HM.

J Immunol. 2017 Apr 15;198(8):3109-3117. doi: 10.4049/jimmunol.1600600. Epub 2017 Mar 6.

31.

The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.

Sonner JK, Deumelandt K, Ott M, Thomé CM, Rauschenbach KJ, Schulz S, Munteanu B, Mohapatra S, Adam I, Hofer AC, Feuerer M, Opitz CA, Hopf C, Wick W, Platten M.

Oncoimmunology. 2016 Nov 15;5(12):e1240858. doi: 10.1080/2162402X.2016.1240858. eCollection 2016.

32.

Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis.

Lanz TV, Williams SK, Stojic A, Iwantscheff S, Sonner JK, Grabitz C, Becker S, Böhler LI, Mohapatra SR, Sahm F, Küblbeck G, Nakamura T, Funakoshi H, Opitz CA, Wick W, Diem R, Platten M.

Sci Rep. 2017 Jan 24;7:41271. doi: 10.1038/srep41271.

33.

Pulmonary hypertension in heart failure with preserved ejection fraction: a plea for proper phenotyping and further research.

Hoeper MM, Lam CSP, Vachiery JL, Bauersachs J, Gerges C, Lang IM, Bonderman D, Olsson KM, Gibbs JSR, Dorfmuller P, Guazzi M, Galiè N, Manes A, Handoko ML, Vonk-Noordegraaf A, Lankeit M, Konstantinides S, Wachter R, Opitz C, Rosenkranz S.

Eur Heart J. 2017 Oct 7;38(38):2869-2873. doi: 10.1093/eurheartj/ehw597. Review. No abstract available.

PMID:
28011705
34.

[ESC guidelines 2015 pulmonary hypertension: diagnosis and treatment].

Opitz C, Rosenkranz S, Ghofrani HA, Grünig E, Klose H, Olschewski H, Hoeper M.

Dtsch Med Wochenschr. 2016 Nov;141(24):1764-1769. Epub 2016 Nov 30. German.

PMID:
27903027
35.

[Pulmonary Hypertension: Cologne Consensus Conference 2016].

Rosenkranz S, Ghofrani HA, Grünig E, Klose H, Olschewski H, Opitz C, Hoeper M.

Dtsch Med Wochenschr. 2016 Nov;141(24):1778-1782. Epub 2016 Nov 8. Review. German.

PMID:
27825176
36.

[Pulmonary hypertension associated with left heart disease: recommendations of the Cologne Consensus Conference 2016].

Rosenkranz S, Lang IM, Blindt R, Bonderman D, Bruch L, Diller GP, Felgendreher R, Gerges C, Hohenforst-Schmidt W, Holt S, Jung C, Kindermann I, Kramer T, Kübler WM, Mitrovic V, Riedel A, Rieth A, Schmeisser A, Wachter R, Weil J, Opitz C.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S48-S56. Epub 2016 Oct 19. Review. German.

PMID:
27760450
37.

Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study.

Konstantinides SV, Barco S, Rosenkranz S, Lankeit M, Held M, Gerhardt F, Bruch L, Ewert R, Faehling M, Freise J, Ghofrani HA, Grünig E, Halank M, Heydenreich N, Hoeper MM, Leuchte HH, Mayer E, Meyer FJ, Neurohr C, Opitz C, Pinto A, Seyfarth HJ, Wachter R, Zäpf B, Wilkens H, Binder H, Wild PS.

J Thromb Thrombolysis. 2016 Nov;42(4):600-9. doi: 10.1007/s11239-016-1415-7.

38.

Pre-Capillary, Combined, and Post-Capillary Pulmonary Hypertension: A Pathophysiological Continuum.

Opitz CF, Hoeper MM, Gibbs JS, Kaemmerer H, Pepke-Zaba J, Coghlan JG, Scelsi L, D'Alto M, Olsson KM, Ulrich S, Scholtz W, Schulz U, Grünig E, Vizza CD, Staehler G, Bruch L, Huscher D, Pittrow D, Rosenkranz S.

J Am Coll Cardiol. 2016 Jul 26;68(4):368-78. doi: 10.1016/j.jacc.2016.05.047.

39.

Monitoring Backbone Hydrogen-Bond Formation in β-Barrel Membrane Protein Folding.

Raschle T, Rios Flores P, Opitz C, Müller DJ, Hiller S.

Angew Chem Int Ed Engl. 2016 May 10;55(20):5952-5. doi: 10.1002/anie.201509910. Epub 2016 Apr 9.

PMID:
27062600
40.

Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor.

Isogai S, Deupi X, Opitz C, Heydenreich FM, Tsai CJ, Brueckner F, Schertler GF, Veprintsev DB, Grzesiek S.

Nature. 2016 Feb 11;530(7589):237-41. doi: 10.1038/nature16577. Epub 2016 Feb 3.

PMID:
26840483
41.

Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4.

Ochs K, Ott M, Rauschenbach KJ, Deumelandt K, Sahm F, Opitz CA, von Deimling A, Wick W, Platten M.

J Neurochem. 2016 Mar;136(6):1142-1154. doi: 10.1111/jnc.13503. Epub 2016 Jan 22.

42.

Pulmonary Hypertension in Patients with Chronic Fibrosing Idiopathic Interstitial Pneumonias.

Hoeper MM, Behr J, Held M, Grunig E, Vizza CD, Vonk-Noordegraaf A, Lange TJ, Claussen M, Grohé C, Klose H, Olsson KM, Zelniker T, Neurohr C, Distler O, Wirtz H, Opitz C, Huscher D, Pittrow D, Gibbs JS.

PLoS One. 2015 Dec 2;10(12):e0141911. doi: 10.1371/journal.pone.0141911. eCollection 2015.

43.

Dynamics of NAD-metabolism: everything but constant.

Opitz CA, Heiland I.

Biochem Soc Trans. 2015 Dec;43(6):1127-32. doi: 10.1042/BST20150133. Review.

PMID:
26614649
44.

MR-proADM Predicts Exercise Capacity and Survival Superior to Other Biomarkers in PH.

Kolditz M, Seyfarth HJ, Wilkens H, Ewert R, Bollmann T, Dinter C, Hertel S, Klose H, Opitz C, Grünig E, Höffken G, Halank M.

Lung. 2015 Dec;193(6):901-10. doi: 10.1007/s00408-015-9802-y. Epub 2015 Sep 12.

PMID:
26363916
45.

Exercise training improves peak oxygen consumption and haemodynamics in patients with severe pulmonary arterial hypertension and inoperable chronic thrombo-embolic pulmonary hypertension: a prospective, randomized, controlled trial.

Ehlken N, Lichtblau M, Klose H, Weidenhammer J, Fischer C, Nechwatal R, Uiker S, Halank M, Olsson K, Seeger W, Gall H, Rosenkranz S, Wilkens H, Mertens D, Seyfarth HJ, Opitz C, Ulrich S, Egenlauf B, Grünig E.

Eur Heart J. 2016 Jan 1;37(1):35-44. doi: 10.1093/eurheartj/ehv337. Epub 2015 Jul 31.

46.

An economic approach to efficient isotope labeling in insect cells using homemade 15N-, 13C- and 2H-labeled yeast extracts.

Opitz C, Isogai S, Grzesiek S.

J Biomol NMR. 2015 Jul;62(3):373-85. doi: 10.1007/s10858-015-9954-3. Epub 2015 Jun 13.

PMID:
26070442
47.

[Dyspnoea in Patients with Pulmonary Hypertension (PH) - a Survey in Spezialized German PH Centres].

Ewert R, Wilkens H, Skowasch D, Reppel M, Bollmann T, Halank M, Held M, Klose H, Gall H, Lange TJ, Opitz CF, Seyfarth HJ, Winkler J.

Pneumologie. 2015 Jun;69(6):361-5. doi: 10.1055/s-0034-1391893. Epub 2015 Apr 21. German.

48.

[Imatinib for pulmonary arterial hypertension].

Hoeper MM, Opitz C, Olschewski H, Ulrich S, Speich R, Behr J, Halank M, Wilkens H, Klose H, Lange TJ, Grünig E, Seeger W, Ewert R, Borst MM, Welte T, Rosenkranz S, Ghofrani HA.

Dtsch Med Wochenschr. 2014 Dec;139 Suppl 4:S151-4. doi: 10.1055/s-0034-1387457. Epub 2014 Dec 9. Review. German. No abstract available.

PMID:
25489685
49.

[Targeted therapy of pulmonary arterial hypertension (PAH)].

Klose H, Opitz C, Bremer H, Ewert R, Bonderman D, Rosenkranz S, Seeger W, Schmeißer A, Harbaum L, Buerke M, Ghofrani HA, Borst MM, Leuchte HH, Lange TJ, Behr J, Ulrich S, Lang I, Olschewski H, Gall H, Kabitz HJ, Kleber FX, Held M, Hoeper MM, Grünig E.

Dtsch Med Wochenschr. 2014 Dec;139 Suppl 4:S142-50. doi: 10.1055/s-0034-1387489. Epub 2014 Dec 9. Review. German. No abstract available.

PMID:
25489684
50.

Response to letters regarding article, "Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)".

Olsson KM, Delcroix M, Ghofrani HA, Tiede H, Huscher D, Speich R, Grünig E, Staehler G, Rosenkranz S, Halank M, Held M, Lange TJ, Behr J, Klose H, Claussen M, Ewert R, Opitz CF, Vizza CD, Scelsi L, Vonk-Noordegraaf A, Kaemmerer H, Gibbs JS, Coghlan G, Pepke-Zaba J, Schulz U, Gorenflo M, Pittrow D, Hoeper MM.

Circulation. 2014 Sep 16;130(12):e110-2. doi: 10.1161/CIRCULATIONAHA.114.010921. No abstract available.

PMID:
25223780

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