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Items: 1 to 50 of 153

1.

OMIP-062: A 14-Color, 16-Antibody Panel for Immunophenotyping Human Innate Lymphoid, Myeloid and T Cells in Small Volumes of Whole Blood and Pediatric Airway Samples.

Swieboda D, Guo Y, Sagawe S, Thwaites RS, Nadel S, Openshaw PJM, Culley FJ.

Cytometry A. 2019 Oct 21. doi: 10.1002/cyto.a.23907. [Epub ahead of print] No abstract available.

2.

The Respiratory Mucosa: Front and Center in RSV Disease.

Thwaites RS, Openshaw PJ.

Am J Respir Crit Care Med. 2019 Aug 14. doi: 10.1164/rccm.201907-1306ED. [Epub ahead of print] No abstract available.

PMID:
31412707
3.

Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza.

Jha A, Dunning J, Tunstall T, Thwaites RS, Hoang LT; MOSAIC Investigators, Kon OM, Zambon MC, Hansel TT, Openshaw PJ.

Eur Respir J. 2019 Oct 24;54(4). pii: 1900949. doi: 10.1183/13993003.00949-2019. Print 2019 Oct.

PMID:
31391224
4.

Respiratory syncytial virus (RSV): a scourge from infancy to old age.

Coultas JA, Smyth R, Openshaw PJ.

Thorax. 2019 Oct;74(10):986-993. doi: 10.1136/thoraxjnl-2018-212212. Epub 2019 Aug 5.

5.

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.

Singhania A, Graham CM, Gabryšová L, Moreira-Teixeira L, Stavropoulos E, Pitt JM, Chakravarty P, Warnatsch A, Branchett WJ, Conejero L, Lin JW, Davidson S, Wilson MS, Bancroft G, Langhorne J, Frickel E, Sesay AK, Priestnall SL, Herbert E, Ioannou M, Wang Q, Humphreys IR, Dodd J, Openshaw PJM, Mayer-Barber KD, Jankovic D, Sher A, Lloyd CM, Baldwin N, Chaussabel D, Papayannopoulos V, Wack A, Banchereau JF, Pascual VM, O'Garra A.

Nat Commun. 2019 Jun 28;10(1):2887. doi: 10.1038/s41467-019-10601-6.

6.

Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice, and humans.

Progatzky F, Jha A, Wane M, Thwaites RS, Makris S, Shattock RJ, Johansson C, Openshaw PJ, Bugeon L, Hansel TT, Dallman MJ.

J Allergy Clin Immunol. 2019 Jul;144(1):342-345.e7. doi: 10.1016/j.jaci.2019.04.003. Epub 2019 Apr 16. No abstract available.

7.

Local and Systemic Immunity against Respiratory Syncytial Virus Induced by a Novel Intranasal Vaccine. A Randomized, Double-Blind, Placebo-controlled Clinical Trial.

Ascough S, Vlachantoni I, Kalyan M, Haijema BJ, Wallin-Weber S, Dijkstra-Tiekstra M, Ahmed MS, van Roosmalen M, Grimaldi R, Zhang Q, Leenhouts K, Openshaw PJ, Chiu C.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):481-492. doi: 10.1164/rccm.201810-1921OC.

PMID:
30753101
8.

Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ; MOSAIC Investigators, Moffatt MF, O'Garra A, Openshaw PJM.

Nat Immunol. 2019 Mar;20(3):373. doi: 10.1038/s41590-019-0328-y.

9.

The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates.

Mazur NI, Higgins D, Nunes MC, Melero JA, Langedijk AC, Horsley N, Buchholz UJ, Openshaw PJ, McLellan JS, Englund JA, Mejias A, Karron RA, Simões EA, Knezevic I, Ramilo O, Piedra PA, Chu HY, Falsey AR, Nair H, Kragten-Tabatabaie L, Greenough A, Baraldi E, Papadopoulos NG, Vekemans J, Polack FP, Powell M, Satav A, Walsh EE, Stein RT, Graham BS, Bont LJ; Respiratory Syncytial Virus Network (ReSViNET) Foundation.

Lancet Infect Dis. 2018 Oct;18(10):e295-e311. doi: 10.1016/S1473-3099(18)30292-5. Epub 2018 Jun 18. Review. Erratum in: Lancet Infect Dis. 2018 Jul 25;:.

10.

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJM; MOSAIC Investigators.

Nat Immunol. 2018 Jun;19(6):625-635. doi: 10.1038/s41590-018-0111-5. Epub 2018 May 18. Erratum in: Nat Immunol. 2019 Mar;20(3):373.

11.

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples.

Thwaites RS, Jarvis HC, Singh N, Jha A, Pritchard A, Fan H, Tunstall T, Nanan J, Nadel S, Kon OM, Openshaw PJ, Hansel TT.

J Vis Exp. 2018 Jan 21;(131). doi: 10.3791/56413.

12.

Biphasic activation of complement and fibrinolysis during the human nasal allergic response.

Thwaites RS, Gunawardana NC, Broich V, Mann EH, Ahnström J, Campbell GA, Lindsley S, Singh N, Tunstall T, Lane DA, Openshaw PJ, Hawrylowicz CM, Hansel TT.

J Allergy Clin Immunol. 2018 May;141(5):1892-1895.e6. doi: 10.1016/j.jaci.2018.01.022. Epub 2018 Feb 7. No abstract available.

13.

Respiratory Syncytial Virus: Targeting the G Protein Provides a New Approach for an Old Problem.

Tripp RA, Power UF, Openshaw PJM, Kauvar LM.

J Virol. 2018 Jan 17;92(3). pii: e01302-17. doi: 10.1128/JVI.01302-17. Print 2018 Feb 1. Review.

14.

Issues in vaccinology: Present challenges and future directions.

Sheerin D, Openshaw PJ, Pollard AJ.

Eur J Immunol. 2017 Dec;47(12):2017-2025. doi: 10.1002/eji.201746942. Epub 2017 Sep 27. Review.

15.

Respiratory Syncytial Virus.

Jha A, Jarvis H, Fraser C, Openshaw PJM.

In: Hui DS, Rossi GA, Johnston SL, editors. SARS, MERS and other Viral Lung Infections. Sheffield (UK): European Respiratory Society; 2016 Jun 1. Chapter 5.

16.

Maternal immunisation: collaborating with mother nature.

Marchant A, Sadarangani M, Garand M, Dauby N, Verhasselt V, Pereira L, Bjornson G, Jones CE, Halperin SA, Edwards KM, Heath P, Openshaw PJ, Scheifele DW, Kollmann TR.

Lancet Infect Dis. 2017 Jul;17(7):e197-e208. doi: 10.1016/S1473-3099(17)30229-3. Epub 2017 Apr 19. Review.

17.

Group B streptococcus and respiratory syncytial virus immunisation during pregnancy: a landscape analysis.

Heath PT, Culley FJ, Jones CE, Kampmann B, Le Doare K, Nunes MC, Sadarangani M, Chaudhry Z, Baker CJ, Openshaw PJM.

Lancet Infect Dis. 2017 Jul;17(7):e223-e234. doi: 10.1016/S1473-3099(17)30232-3. Epub 2017 Apr 19. Review.

18.

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.

Cole SL, Dunning J, Kok WL, Benam KH, Benlahrech A, Repapi E, Martinez FO, Drumright L, Powell TJ, Bennett M, Elderfield R, Thomas C; MOSAIC investigators, Dong T, McCauley J, Liew FY, Taylor S, Zambon M, Barclay W, Cerundolo V, Openshaw PJ, McMichael AJ, Ho LP.

JCI Insight. 2017 Apr 6;2(7):e91868. doi: 10.1172/jci.insight.91868.

19.

Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis.

Thwaites RS, Ito K, Chingono JMS, Coates M, Jarvis HC, Tunstall T, Anderson-Dring L, Cass L, Rapeport G, Openshaw PJ, Nadel S, Hansel TT.

J Infect Dis. 2017 Apr 15;215(8):1240-1244. doi: 10.1093/infdis/jix150.

20.

RSV Takes Control of Neonatal Breg Cells: Two Hands on the Wheel.

Openshaw PJM.

Immunity. 2017 Feb 21;46(2):171-173. doi: 10.1016/j.immuni.2017.01.011.

21.

Protective and Harmful Immunity to RSV Infection.

Openshaw PJM, Chiu C, Culley FJ, Johansson C.

Annu Rev Immunol. 2017 Apr 26;35:501-532. doi: 10.1146/annurev-immunol-051116-052206. Epub 2017 Feb 6. Review.

PMID:
28226227
22.

Vaccines in the Prevention of Viral Pneumonia.

Fraser CS, Jha A, Openshaw PJ.

Clin Chest Med. 2017 Mar;38(1):155-169. doi: 10.1016/j.ccm.2016.11.009. Epub 2016 Dec 18. Review.

23.

The Helminth-Derived Immunomodulator AvCystatin Reduces Virus Enhanced Inflammation by Induction of Regulatory IL-10+ T Cells.

Schuijs MJ, Hartmann S, Selkirk ME, Roberts LB, Openshaw PJ, Schnoeller C.

PLoS One. 2016 Aug 25;11(8):e0161885. doi: 10.1371/journal.pone.0161885. eCollection 2016.

24.

Erratum: RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection.

Jozwik A, Habibi MS, Paras A, Zhu J, Guvenel A, Dhariwal J, Almond M, Wong EH, Sykes A, Maybeno M, Del Rosario J, Trujillo-Torralbo MB, Mallia P, Sidney J, Peters B, Kon OM, Sette A, Johnston SL, Openshaw PJ, Chiu C.

Nat Commun. 2016 Mar 9;7:11011. doi: 10.1038/ncomms11011. No abstract available.

25.

RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection.

Jozwik A, Habibi MS, Paras A, Zhu J, Guvenel A, Dhariwal J, Almond M, Wong EHC, Sykes A, Maybeno M, Del Rosario J, Trujillo-Torralbo MB, Mallia P, Sidney J, Peters B, Kon OM, Sette A, Johnston SL, Openshaw PJ, Chiu C.

Nat Commun. 2015 Dec 21;6:10224. doi: 10.1038/ncomms10224. Erratum in: Nat Commun. 2016;7:11011.

26.

Nasal Lipopolysaccharide Challenge and Cytokine Measurement Reflects Innate Mucosal Immune Responsiveness.

Dhariwal J, Kitson J, Jones RE, Nicholson G, Tunstall T, Walton RP, Francombe G, Gilbert J, Tan AJ, Murdoch R, Kon OM, Openshaw PJ, Hansel TT.

PLoS One. 2015 Sep 14;10(9):e0135363. doi: 10.1371/journal.pone.0135363. eCollection 2015.

27.

Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus.

Habibi MS, Jozwik A, Makris S, Dunning J, Paras A, DeVincenzo JP, de Haan CA, Wrammert J, Openshaw PJ, Chiu C; Mechanisms of Severe Acute Influenza Consortium Investigators.

Am J Respir Crit Care Med. 2015 May 1;191(9):1040-9. doi: 10.1164/rccm.201412-2256OC.

28.

Antiviral B cell and T cell immunity in the lungs.

Chiu C, Openshaw PJ.

Nat Immunol. 2015 Jan;16(1):18-26. doi: 10.1038/ni.3056. Review.

PMID:
25521681
29.

Immunity to RSV in Early-Life.

Lambert L, Sagfors AM, Openshaw PJ, Culley FJ.

Front Immunol. 2014 Sep 29;5:466. doi: 10.3389/fimmu.2014.00466. eCollection 2014. Review.

30.

Neuraminidase inhibitors for influenza complications--Authors' reply.

Nguyen-Van-Tam JS, Openshaw PJ, Nicholson KG.

Lancet. 2014 Oct 4;384(9950):1261-2. doi: 10.1016/S0140-6736(14)61762-1. No abstract available.

PMID:
25283566
31.

Effect of ethnicity on care pathway and outcomes in patients hospitalized with influenza A(H1N1)pdm09 in the UK.

Nyland GA, McKenzie BC, Myles PR, Semple MG, Lim WS, Openshaw PJ, Read RC, Taylor BL, Brett SJ, McMenamin J, Enstone JE, Bannister B, Nicholson KG, Nguyen-Van-Tam JS.

Epidemiol Infect. 2015 Apr;143(6):1129-38. doi: 10.1017/S0950268814001873. Epub 2014 Aug 1.

32.

Live attenuated B. pertussis BPZE1 rescues the immune functions of Respiratory Syncytial virus infected human dendritic cells by promoting Th1/Th17 responses.

Schiavoni I, Fedele G, Quattrini A, Bianco M, Schnoeller C, Openshaw PJ, Locht C, Ausiello CM.

PLoS One. 2014 Jun 26;9(6):e100166. doi: 10.1371/journal.pone.0100166. eCollection 2014.

33.

Antivirals for influenza: where now for clinical practice and pandemic preparedness?

Nguyen-Van-Tam JS, Openshaw PJ, Nicholson KG.

Lancet. 2014 Aug 2;384(9941):386-7. doi: 10.1016/S0140-6736(14)60726-1. Epub 2014 May 14. No abstract available.

PMID:
24837882
34.

Alpha/beta interferon receptor signaling amplifies early proinflammatory cytokine production in the lung during respiratory syncytial virus infection.

Goritzka M, Durant LR, Pereira C, Salek-Ardakani S, Openshaw PJ, Johansson C.

J Virol. 2014 Jun;88(11):6128-36. doi: 10.1128/JVI.00333-14. Epub 2014 Mar 19.

35.

Current concepts and progress in RSV vaccine development.

Guvenel AK, Chiu C, Openshaw PJ.

Expert Rev Vaccines. 2014 Mar;13(3):333-44. doi: 10.1586/14760584.2014.878653. Epub 2014 Jan 9. Review.

PMID:
24405366
36.

The mouse model of respiratory syncytial virus disease.

Openshaw PJ.

Curr Top Microbiol Immunol. 2013;372:359-69. doi: 10.1007/978-3-642-38919-1_18.

PMID:
24362699
37.

Open source clinical science for emerging infections.

Dunning JW, Merson L, Rohde GGU, Gao Z, Semple MG, Tran D, Gordon A, Olliaro PL, Khoo SH, Bruzzone R, Horby P, Cobb JP, Longuere KS, Kellam P, Nichol A, Brett S, Everett D, Walsh TS, Hien TT, Yu H, Zambon M, Ruiz-Palacios G, Lang T, Akhvlediani T; ISARIC Working Group 3, ISARIC Council, Hayden FG, Marshall J, Webb S, Angus DC, Shindo N, van der Werf S, Openshaw PJM, Farrar J, Carson G, Baillie JK.

Lancet Infect Dis. 2014 Jan;14(1):8-9. doi: 10.1016/S1473-3099(13)70327-X. No abstract available.

PMID:
24355025
38.

Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation.

Farhadi N, Lambert L, Triulzi C, Openshaw PJ, Guerra N, Culley FJ.

J Allergy Clin Immunol. 2014 Mar;133(3):827-35.e3. doi: 10.1016/j.jaci.2013.09.048. Epub 2013 Nov 28.

39.

A gene expression signature for RSV: clinical implications and limitations.

Openshaw PJ.

PLoS Med. 2013 Nov;10(11):e1001550. doi: 10.1371/journal.pmed.1001550. Epub 2013 Nov 12.

40.

Attenuated Bordetella pertussis vaccine protects against respiratory syncytial virus disease via an IL-17-dependent mechanism.

Schnoeller C, Roux X, Sawant D, Raze D, Olszewska W, Locht C, Openshaw PJ.

Am J Respir Crit Care Med. 2014 Jan 15;189(2):194-202. doi: 10.1164/rccm.201307-1227OC.

41.

Delayed sequelae of neonatal respiratory syncytial virus infection are dependent on cells of the innate immune system.

Harker JA, Yamaguchi Y, Culley FJ, Tregoning JS, Openshaw PJ.

J Virol. 2014 Jan;88(1):604-11. doi: 10.1128/JVI.02620-13. Epub 2013 Oct 30.

42.

An evaluation of community assessment tools (CATs) in predicting use of clinical interventions and severe outcomes during the A(H1N1)pdm09 pandemic.

Semple MG, Myles PR, Nicholson KG, Lim WS, Read RC, Taylor BL, Brett SJ, Openshaw PJ, Enstone JE, McMenamin J, Bannister B, Nguyen-Van-Tam JS.

PLoS One. 2013 Sep 19;8(9):e75384. doi: 10.1371/journal.pone.0075384. eCollection 2013.

43.

Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice.

Durant LR, Makris S, Voorburg CM, Loebbermann J, Johansson C, Openshaw PJ.

J Virol. 2013 Oct;87(20):10946-54. doi: 10.1128/JVI.01295-13. Epub 2013 Aug 7.

44.

Protective and dysregulated T cell immunity in RSV infection.

Openshaw PJ, Chiu C.

Curr Opin Virol. 2013 Aug;3(4):468-74. doi: 10.1016/j.coviro.2013.05.005. Epub 2013 Jun 25. Review.

45.

Neonatal antibody responses are attenuated by interferon-γ produced by NK and T cells during RSV infection.

Tregoning JS, Wang BL, McDonald JU, Yamaguchi Y, Harker JA, Goritzka M, Johansson C, Bukreyev A, Collins PL, Openshaw PJ.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5576-81. doi: 10.1073/pnas.1214247110. Epub 2013 Mar 18.

46.

Microbes and mucosal immune responses in asthma.

Hansel TT, Johnston SL, Openshaw PJ.

Lancet. 2013 Mar 9;381(9869):861-73. Review.

PMID:
23428115
47.

Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells.

Loebbermann J, Durant L, Thornton H, Johansson C, Openshaw PJ.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2987-92. doi: 10.1073/pnas.1217580110. Epub 2013 Feb 4.

48.

Endogenous IL-21 regulates pathogenic mucosal CD4 T-cell responses during enhanced RSV disease in mice.

Dodd JS, Clark D, Muir R, Korpis C, Openshaw PJ.

Mucosal Immunol. 2013 Jul;6(4):704-17. doi: 10.1038/mi.2012.108. Epub 2012 Nov 21.

49.

Benefit and harm from immunity to respiratory syncytial virus: implications for treatment.

Habibi MS, Openshaw PJ.

Curr Opin Infect Dis. 2012 Dec;25(6):687-94. doi: 10.1097/QCO.0b013e32835a1d92. Review.

PMID:
23086186
50.

Differences between asthmatics and nonasthmatics hospitalised with influenza A infection.

Myles P, Nguyen-Van-Tam JS, Semple MG, Brett SJ, Bannister B, Read RC, Taylor BL, McMenamin J, Enstone JE, Nicholson KG, Openshaw PJ, Lim WS; Influenza Clinical Information Network FLU-CIN.

Eur Respir J. 2013 Apr;41(4):824-31. doi: 10.1183/09031936.00015512. Epub 2012 Aug 16.

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