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Items: 1 to 50 of 87

1.

Testing of therapies in a novel nebulin nemaline myopathy model demonstrate a lack of efficacy.

Sztal TE, McKaige EA, Williams C, Oorschot V, Ramm G, Bryson-Richardson RJ.

Acta Neuropathol Commun. 2018 May 30;6(1):40. doi: 10.1186/s40478-018-0546-9.

2.

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.

McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M, Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT.

Science. 2018 Feb 23;359(6378). pii: eaao6047. doi: 10.1126/science.aao6047.

PMID:
29472455
3.

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy.

Westwood JA, Ellis S, Danne J, Johnson C, Oorschot V, Ramm G, Tscharke DC, Davenport AJ, Whisstock JC, Darcy PK, Kershaw MH, Slaney CY.

Oncotarget. 2017 Dec 14;8(70):115215-115229. doi: 10.18632/oncotarget.23215. eCollection 2017 Dec 29.

4.

Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.

Nguyen TN, Padman BS, Usher J, Oorschot V, Ramm G, Lazarou M.

J Cell Biol. 2016 Dec 19;215(6):857-874. Epub 2016 Nov 18.

5.

FLNC myofibrillar myopathy results from impaired autophagy and protein insufficiency.

Ruparelia AA, Oorschot V, Ramm G, Bryson-Richardson RJ.

Hum Mol Genet. 2016 Jun 1;25(11):2131-2142. Epub 2016 Mar 11.

PMID:
26969713
6.

Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth.

Boonen M, Staudt C, Gilis F, Oorschot V, Klumperman J, Jadot M.

J Cell Sci. 2016 Feb 1;129(3):557-68. doi: 10.1242/jcs.179374. Epub 2015 Dec 23.

7.

Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis.

Mareninova OA, Sendler M, Malla SR, Yakubov I, French SW, Tokhtaeva E, Vagin O, Oorschot V, Lüllmann-Rauch R, Blanz J, Dawson D, Klumperman J, Lerch MM, Mayerle J, Gukovsky I, Gukovskaya AS.

Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):678-694.

8.

Vps33B is required for delivery of endocytosed cargo to lysosomes.

Galmes R, ten Brink C, Oorschot V, Veenendaal T, Jonker C, van der Sluijs P, Klumperman J.

Traffic. 2015 Dec;16(12):1288-305. doi: 10.1111/tra.12334. Epub 2015 Oct 21.

9.

Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function.

Sztal TE, Zhao M, Williams C, Oorschot V, Parslow AC, Giousoh A, Yuen M, Hall TE, Costin A, Ramm G, Bird PI, Busch-Nentwich EM, Stemple DL, Currie PD, Cooper ST, Laing NG, Nowak KJ, Bryson-Richardson RJ.

Acta Neuropathol. 2015 Sep;130(3):389-406. doi: 10.1007/s00401-015-1430-3. Epub 2015 May 1.

10.

Immuno correlative light and electron microscopy on Tokuyasu cryosections.

Oorschot VM, Sztal TE, Bryson-Richardson RJ, Ramm G.

Methods Cell Biol. 2014;124:241-58. doi: 10.1016/B978-0-12-801075-4.00011-2.

PMID:
25287844
11.

Zebrafish models of BAG3 myofibrillar myopathy suggest a toxic gain of function leading to BAG3 insufficiency.

Ruparelia AA, Oorschot V, Vaz R, Ramm G, Bryson-Richardson RJ.

Acta Neuropathol. 2014 Dec;128(6):821-33. doi: 10.1007/s00401-014-1344-5. Epub 2014 Oct 2.

PMID:
25273835
12.

Lysosomal capturing of cytoplasmic injected nanoparticles by autophagy: an additional barrier to non viral gene delivery.

Remaut K, Oorschot V, Braeckmans K, Klumperman J, De Smedt SC.

J Control Release. 2014 Dec 10;195:29-36. doi: 10.1016/j.jconrel.2014.08.002. Epub 2014 Aug 11. Erratum in: J Control Release. 2015 Feb 10;199:179.

PMID:
25125327
13.

Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium.

Helm JR, Bentley M, Thorsen KD, Wang T, Foltz L, Oorschot V, Klumperman J, Hay JC.

J Biol Chem. 2014 Aug 22;289(34):23609-28. doi: 10.1074/jbc.M114.561829. Epub 2014 Jul 8.

14.

Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance.

Ellegaard AM, Groth-Pedersen L, Oorschot V, Klumperman J, Kirkegaard T, Nylandsted J, Jäättelä M.

Mol Cancer Ther. 2013 Oct;12(10):2018-30. doi: 10.1158/1535-7163.MCT-13-0084. Epub 2013 Aug 6.

15.

The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).

Lowery J, Szul T, Styers M, Holloway Z, Oorschot V, Klumperman J, Sztul E.

J Biol Chem. 2013 Apr 19;288(16):11532-45. doi: 10.1074/jbc.M112.438481. Epub 2013 Feb 5.

16.

hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins.

Pols MS, van Meel E, Oorschot V, ten Brink C, Fukuda M, Swetha MG, Mayor S, Klumperman J.

Nat Commun. 2013;4:1361. doi: 10.1038/ncomms2360.

PMID:
23322049
17.

Different characteristics and nucleotide binding properties of inosine monophosphate dehydrogenase (IMPDH) isoforms.

Thomas EC, Gunter JH, Webster JA, Schieber NL, Oorschot V, Parton RG, Whitehead JP.

PLoS One. 2012;7(12):e51096. doi: 10.1371/journal.pone.0051096. Epub 2012 Dec 7.

18.

Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport.

Hassink G, Slotman J, Oorschot V, Van Der Reijden BA, Monteferrario D, Noordermeer SM, Van Kerkhof P, Klumperman J, Strous GJ.

Biol Open. 2012 Jun 15;1(6):607-14. doi: 10.1242/bio.2012778. Epub 2012 May 9.

19.

The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion.

Pols MS, ten Brink C, Gosavi P, Oorschot V, Klumperman J.

Traffic. 2013 Feb;14(2):219-32. doi: 10.1111/tra.12027. Epub 2012 Dec 12.

20.

AP-3 and Rabip4' coordinately regulate spatial distribution of lysosomes.

Ivan V, Martinez-Sanchez E, Sima LE, Oorschot V, Klumperman J, Petrescu SM, van der Sluijs P.

PLoS One. 2012;7(10):e48142. doi: 10.1371/journal.pone.0048142. Epub 2012 Oct 29.

21.

Constitutive formation of caveolae in a bacterium.

Walser PJ, Ariotti N, Howes M, Ferguson C, Webb R, Schwudke D, Leneva N, Cho KJ, Cooper L, Rae J, Floetenmeyer M, Oorschot VM, Skoglund U, Simons K, Hancock JF, Parton RG.

Cell. 2012 Aug 17;150(4):752-63. doi: 10.1016/j.cell.2012.06.042.

22.

R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed.

Thayanidhi N, Liang Y, Hasegawa H, Nycz DC, Oorschot V, Klumperman J, Hay JC.

Biol Cell. 2012 Jul;104(7):397-417. doi: 10.1111/boc.201100048. Epub 2012 May 29.

PMID:
22443861
23.

Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells.

Swetha MG, Sriram V, Krishnan KS, Oorschot VM, ten Brink C, Klumperman J, Mayor S.

Traffic. 2011 Aug;12(8):1037-55. doi: 10.1111/j.1600-0854.2011.01214.x. Epub 2011 May 30.

24.

Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis.

van Meel E, Boonen M, Zhao H, Oorschot V, Ross FP, Kornfeld S, Klumperman J.

Traffic. 2011 Jul;12(7):912-24. doi: 10.1111/j.1600-0854.2011.01203.x. Epub 2011 May 5.

25.

Vacuolization of mucolipidosis type II mouse exocrine gland cells represents accumulation of autolysosomes.

Boonen M, van Meel E, Oorschot V, Klumperman J, Kornfeld S.

Mol Biol Cell. 2011 Apr 15;22(8):1135-47. doi: 10.1091/mbc.E10-07-0584. Epub 2011 Feb 16.

26.

Modern approaches for ultrastructural analysis of the zebrafish embryo.

Schieber NL, Nixon SJ, Webb RI, Oorschot VM, Parton RG.

Methods Cell Biol. 2010;96:425-42. doi: 10.1016/S0091-679X(10)96018-4.

PMID:
20869533
27.

Spatial regulation of Golgi phosphatidylinositol-4-phosphate is required for enzyme localization and glycosylation fidelity.

Cheong FY, Sharma V, Blagoveshchenskaya A, Oorschot VM, Brankatschk B, Klumperman J, Freeze HH, Mayinger P.

Traffic. 2010 Sep;11(9):1180-90. doi: 10.1111/j.1600-0854.2010.01092.x. Epub 2010 Jun 21.

28.

Termination of autophagy and reformation of lysosomes regulated by mTOR.

Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ.

Nature. 2010 Jun 17;465(7300):942-6. doi: 10.1038/nature09076. Epub 2010 Jun 6.

29.

A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells.

Verhulst PM, van der Velden LM, Oorschot V, van Faassen EE, Klumperman J, Houwen RH, Pomorski TG, Holthuis JC, Klomp LW.

Hepatology. 2010 Jun;51(6):2049-60. doi: 10.1002/hep.23586.

PMID:
20512993
30.

Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes.

Hoogenraad CC, Popa I, Futai K, Martinez-Sanchez E, Wulf PS, van Vlijmen T, Dortland BR, Oorschot V, Govers R, Monti M, Heck AJ, Sheng M, Klumperman J, Rehmann H, Jaarsma D, Kapitein LC, van der Sluijs P.

PLoS Biol. 2010 Jan 19;8(1):e1000283. doi: 10.1371/journal.pbio.1000283. Erratum in: PLoS Biol. 2010;8(9) doi:10.1371/annotation/b17dfb99-8809-4c5a-86c2-c2a0f7ca7f5e.. Sanchez-Martinez, Emma [corrected to Martinez-Sanchez, Emma].

31.

Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1.

van Anken E, Pena F, Hafkemeijer N, Christis C, Romijn EP, Grauschopf U, Oorschot VM, Pertel T, Engels S, Ora A, Lástun V, Glockshuber R, Klumperman J, Heck AJ, Luban J, Braakman I.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17019-24. doi: 10.1073/pnas.0903036106. Epub 2009 Sep 17.

32.

mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles.

Yamasaki A, Menon S, Yu S, Barrowman J, Meerloo T, Oorschot V, Klumperman J, Satoh A, Ferro-Novick S.

Mol Biol Cell. 2009 Oct;20(19):4205-15. doi: 10.1091/mbc.E09-05-0387. Epub 2009 Aug 5.

33.

Intracellular activation of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus by nonpeptide agonists.

Robben JH, Kortenoeven ML, Sze M, Yae C, Milligan G, Oorschot VM, Klumperman J, Knoers NV, Deen PM.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12195-200. doi: 10.1073/pnas.0900130106. Epub 2009 Jul 8.

34.

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.

ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H.

Dev Cell. 2009 Apr;16(4):551-62. doi: 10.1016/j.devcel.2009.01.016.

35.

Cripto localizes Nodal at the limiting membrane of early endosomes.

Blanchet MH, Le Good JA, Oorschot V, Baflast S, Minchiotti G, Klumperman J, Constam DB.

Sci Signal. 2008 Nov 11;1(45):ra13. doi: 10.1126/scisignal.1165027.

36.

Correlative light-electron microscopy (CLEM) combining live-cell imaging and immunolabeling of ultrathin cryosections.

van Rijnsoever C, Oorschot V, Klumperman J.

Nat Methods. 2008 Nov;5(11):973-80. doi: 10.1038/nmeth.1263. No abstract available.

PMID:
18974735
37.

Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation.

Blanchet MH, Le Good JA, Mesnard D, Oorschot V, Baflast S, Minchiotti G, Klumperman J, Constam DB.

EMBO J. 2008 Oct 8;27(19):2580-91. doi: 10.1038/emboj.2008.174. Epub 2008 Sep 4.

38.

The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions.

Dubé N, Kooistra MR, Pannekoek WJ, Vliem MJ, Oorschot V, Klumperman J, Rehmann H, Bos JL.

Cell Signal. 2008 Sep;20(9):1608-15. doi: 10.1016/j.cellsig.2008.05.006. Epub 2008 May 23.

PMID:
18585005
39.

PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function.

Hill MM, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, Walser P, Abankwa D, Oorschot VM, Martin S, Hancock JF, Parton RG.

Cell. 2008 Jan 11;132(1):113-24. doi: 10.1016/j.cell.2007.11.042.

40.

Caveolin-1 is transported to multi-vesicular bodies after albumin-induced endocytosis of caveolae in HepG2 cells.

Botos E, Klumperman J, Oorschot V, Igyártó B, Magyar A, Oláh M, Kiss AL.

J Cell Mol Med. 2008 Sep-Oct;12(5A):1632-9. Epub 2007 Dec 5.

41.

S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover.

Mieulet V, Roceri M, Espeillac C, Sotiropoulos A, Ohanna M, Oorschot V, Klumperman J, Sandri M, Pende M.

Am J Physiol Cell Physiol. 2007 Aug;293(2):C712-22. Epub 2007 May 9.

42.

Rescue of a nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutant by cell-penetrating peptides.

Oueslati M, Hermosilla R, Schönenberger E, Oorschot V, Beyermann M, Wiesner B, Schmidt A, Klumperman J, Rosenthal W, Schülein R.

J Biol Chem. 2007 Jul 13;282(28):20676-85. Epub 2007 May 8.

43.

Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure.

Li X, Kaloyanova D, van Eijk M, Eerland R, van der Goot G, Oorschot V, Klumperman J, Lottspeich F, Starkuviene V, Wieland FT, Helms JB.

Mol Biol Cell. 2007 Apr;18(4):1261-71. Epub 2007 Jan 24.

44.

Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel.

Kamsteeg EJ, Hendriks G, Boone M, Konings IB, Oorschot V, van der Sluijs P, Klumperman J, Deen PM.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18344-9. Epub 2006 Nov 13.

45.

A viral protein that blocks Arf1-mediated COP-I assembly by inhibiting the guanine nucleotide exchange factor GBF1.

Wessels E, Duijsings D, Niu TK, Neumann S, Oorschot VM, de Lange F, Lanke KH, Klumperman J, Henke A, Jackson CL, Melchers WJ, van Kuppeveld FJ.

Dev Cell. 2006 Aug;11(2):191-201.

46.

Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.

Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J.

Traffic. 2006 Mar;7(3):354-64.

47.

Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport.

Carlton JG, Bujny MV, Peter BJ, Oorschot VM, Rutherford A, Arkell RS, Klumperman J, McMahon HT, Cullen PJ.

J Cell Sci. 2005 Oct 1;118(Pt 19):4527-39.

48.

Sorting nexin 17 facilitates LRP recycling in the early endosome.

van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman J, Bu G.

EMBO J. 2005 Aug 17;24(16):2851-61. Epub 2005 Jul 28.

49.

Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.

Carlton J, Bujny M, Peter BJ, Oorschot VM, Rutherford A, Mellor H, Klumperman J, McMahon HT, Cullen PJ.

Curr Biol. 2004 Oct 26;14(20):1791-800.

50.

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.

Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W.

J Cell Biol. 2004 Sep 27;166(7):1041-54.

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