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Items: 32


Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.

Wu G, Mazzitelli BA, Quek AJ, Veldman MJ, Conroy PJ, Caradoc-Davies TT, Ooms LM, Tuck KL, Schoenecker JG, Whisstock JC, Law RHP.

Blood Adv. 2019 Mar 12;3(5):729-733. doi: 10.1182/bloodadvances.2018025429. No abstract available.


β-catenin ablation exacerbates polycystic kidney disease progression.

Conduit SE, Hakim S, Feeney SJ, Ooms LM, Dyson JM, Abud HE, Mitchell CA.

Hum Mol Genet. 2019 Jan 15;28(2):230-244. doi: 10.1093/hmg/ddy309.


P-Rex1 and P-Rex2 RacGEFs and cancer.

Srijakotre N, Man J, Ooms LM, Lucato CM, Ellisdon AM, Mitchell CA.

Biochem Soc Trans. 2017 Aug 15;45(4):963-77. doi: 10.1042/BST20160269. Epub 2017 Jul 14. Review.


Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases.

Rodgers SJ, Ferguson DT, Mitchell CA, Ooms LM.

Biosci Rep. 2017 Feb 10;37(1). pii: BSR20160432. doi: 10.1042/BSR20160432. Print 2017 Feb 28. Review.


PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling.

Liu HJ, Ooms LM, Srijakotre N, Man J, Vieusseux J, Waters JE, Feng Y, Bailey CG, Rasko JE, Price JT, Mitchell CA.

J Biol Chem. 2016 Aug 12;291(33):17258-70. doi: 10.1074/jbc.M116.743401. Epub 2016 Jun 29.


The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.

Ooms LM, Binge LC, Davies EM, Rahman P, Conway JR, Gurung R, Ferguson DT, Papa A, Fedele CG, Vieusseux JL, Chai RC, Koentgen F, Price JT, Tiganis T, Timpson P, McLean CA, Mitchell CA.

Cancer Cell. 2015 Aug 10;28(2):155-69. doi: 10.1016/j.ccell.2015.07.003.


The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.

Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM.

J Biol Chem. 2015 Aug 21;290(34):20827-40. doi: 10.1074/jbc.M115.660456. Epub 2015 Jun 24.


Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML.

Rijal S, Fleming S, Cummings N, Rynkiewicz NK, Ooms LM, Nguyen NY, Teh TC, Avery S, McManus JF, Papenfuss AT, McLean C, Guthridge MA, Mitchell CA, Wei AH.

Blood. 2015 Apr 30;125(18):2815-24. doi: 10.1182/blood-2014-09-603555. Epub 2015 Mar 3.


INPP4B is highly expressed in prostate intermediate cells and its loss of expression in prostate carcinoma predicts for recurrence and poor long term survival.

Rynkiewicz NK, Fedele CG, Chiam K, Gupta R, Kench JG, Ooms LM, McLean CA, Giles GG, Horvath LG, Mitchell CA.

Prostate. 2015 Jan;75(1):92-102. doi: 10.1002/pros.22895. Epub 2014 Oct 4.


Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration.

Davies EM, Kong AM, Tan A, Gurung R, Sriratana A, Bukczynska PE, Ooms LM, McLean CA, Tiganis T, Mitchell CA.

Oncogene. 2015 Jul;34(28):3711-27. doi: 10.1038/onc.2014.303. Epub 2014 Sep 22.


Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.

Rahman P, Huysmans RD, Wiradjaja F, Gurung R, Ooms LM, Sheffield DA, Dyson JM, Layton MJ, Sriratana A, Takada H, Tiganis T, Mitchell CA.

J Biol Chem. 2011 Aug 26;286(34):29758-70. doi: 10.1074/jbc.M111.263103. Epub 2011 Jun 28.


Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation.

Astle MV, Ooms LM, Cole AR, Binge LC, Dyson JM, Layton MJ, Petratos S, Sutherland C, Mitchell CA.

J Biol Chem. 2011 Jul 1;286(26):23407-18. doi: 10.1074/jbc.M110.214247. Epub 2011 May 6.


A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart.

Manji SS, Williams LH, Miller KA, Ooms LM, Bahlo M, Mitchell CA, Dahl HH.

PLoS One. 2011 Mar 15;6(3):e17607. doi: 10.1371/journal.pone.0017607.


An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation.

Nguyen NY, Maxwell MJ, Ooms LM, Davies EM, Hilton AA, Collinge JE, Hilton DJ, Kile BT, Mitchell CA, Hibbs ML, Jane SM, Curtis DJ.

Blood. 2011 May 19;117(20):5362-71. doi: 10.1182/blood-2011-01-331041. Epub 2011 Mar 18.


Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers.

Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, Giles GG, Bailey CG, Rasko JE, Shields BJ, Price JT, Majerus PW, Sutherland RL, Tiganis T, McLean CA, Mitchell CA.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22231-6. doi: 10.1073/pnas.1015245107. Epub 2010 Dec 2.


Reactive oxygen species enhance insulin sensitivity.

Loh K, Deng H, Fukushima A, Cai X, Boivin B, Galic S, Bruce C, Shields BJ, Skiba B, Ooms LM, Stepto N, Wu B, Mitchell CA, Tonks NK, Watt MJ, Febbraio MA, Crack PJ, Andrikopoulos S, Tiganis T.

Cell Metab. 2009 Oct;10(4):260-72. doi: 10.1016/j.cmet.2009.08.009.


The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease.

Ooms LM, Horan KA, Rahman P, Seaton G, Gurung R, Kethesparan DS, Mitchell CA.

Biochem J. 2009 Apr 1;419(1):29-49. doi: 10.1042/BJ20081673. Review.


Analysis of phosphatidylinositol 3,4,5 trisphosphate 5-phosphatase activity by in vitro and in vivo assays.

Ooms LM, Dyson JM, Kong AM, Mitchell CA.

Methods Mol Biol. 2009;462:223-39. doi: 10.1007/978-1-60327-115-8_15.


P-Rex1 - a multidomain protein that regulates neurite differentiation.

Waters JE, Astle MV, Ooms LM, Balamatsias D, Gurung R, Mitchell CA.

J Cell Sci. 2008 Sep 1;121(Pt 17):2892-903. doi: 10.1242/jcs.030353. Epub 2008 Aug 12.


Inactivation of the phosphoinositide phosphatases Sac1p and Inp54p leads to accumulation of phosphatidylinositol 4,5-bisphosphate on vacuole membranes and vacuolar fusion defects.

Wiradjaja F, Ooms LM, Tahirovic S, Kuhne E, Devenish RJ, Munn AL, Piper RC, Mayinger P, Mitchell CA.

J Biol Chem. 2007 Jun 1;282(22):16295-307. Epub 2007 Mar 28.


The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?

Astle MV, Horan KA, Ooms LM, Mitchell CA.

Biochem Soc Symp. 2007;(74):161-81. Review.


The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.

Ooms LM, Fedele CG, Astle MV, Ivetac I, Cheung V, Pearson RB, Layton MJ, Forrai A, Nandurkar HH, Mitchell CA.

Mol Biol Cell. 2006 Feb;17(2):607-22. Epub 2005 Nov 9.


Inositol polyphosphate 5-phosphatases: lipid phosphatases with flair.

Mitchell CA, Gurung R, Kong AM, Dyson JM, Tan A, Ooms LM.

IUBMB Life. 2002 Jan;53(1):25-36. Review.


The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.

Dyson JM, O'Malley CJ, Becanovic J, Munday AD, Berndt MC, Coghill ID, Nandurkar HH, Ooms LM, Mitchell CA.

J Cell Biol. 2001 Dec 10;155(6):1065-79. Epub 2001 Dec 10.


The yeast inositol polyphosphate 5-phosphatase Inp54p localizes to the endoplasmic reticulum via a C-terminal hydrophobic anchoring tail: regulation of secretion from the endoplasmic reticulum.

Wiradjaja F, Ooms LM, Whisstock JC, McColl B, Helfenbaum L, Sambrook JF, Gething MJ, Mitchell CA.

J Biol Chem. 2001 Mar 9;276(10):7643-53. Epub 2000 Dec 14.


The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis.

Whisstock JC, Romero S, Gurung R, Nandurkar H, Ooms LM, Bottomley SP, Mitchell CA.

J Biol Chem. 2000 Nov 24;275(47):37055-61.


Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network.

Kong AM, Speed CJ, O'Malley CJ, Layton MJ, Meehan T, Loveland KL, Cheema S, Ooms LM, Mitchell CA.

J Biol Chem. 2000 Aug 4;275(31):24052-64.


The cardiac expression of striated muscle LIM protein 1 (SLIM1) is restricted to the outflow tract of the developing heart.

Brown S, Biben C, Ooms LM, Maimone M, McGrath MJ, Gurung R, Harvey RP, Mitchell CA.

J Mol Cell Cardiol. 1999 Apr;31(4):837-43.


Application of interphase cytogenetics to monitor bone marrow transplants.

Vrazas V, Ooms LM, Rudduck C, Szer J, Campbell LJ, Garson OM.

Am J Hematol. 1995 May;49(1):15-20.


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