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Items: 46

1.

PD-L1 and calcitriol dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease.

Galea R, Nel H, Talekar M, Liu X, Ooi JD, Huynh M, Hadjigol S, Robson KJ, Ting YT, Cole S, Cochlin K, Hitchcock S, Zeng B, Yekollu S, Boks M, Goh N, Roberts H, Rossjohn J, Reid HH, Boyd BJ, Malaviya R, Shealy DJ, Baker DG, Madakamutil L, Kitching AR, O'Sullivan BJ, Thomas R.

JCI Insight. 2019 Sep 5. pii: 126025. doi: 10.1172/jci.insight.126025. [Epub ahead of print]

2.

Biologicals targeting T helper cell subset differentiating cytokines are effective in the treatment of murine anti-myeloperoxidase glomerulonephritis.

Gan PY, Chan A, Ooi JD, Dick J, Nagai K, O'Sullivan KM, Oudin V, Shim R, Kitching AR, Holdsworth SR.

Kidney Int. 2019 May 27. pii: S0085-2538(19)30531-9. doi: 10.1016/j.kint.2019.05.012. [Epub ahead of print]

PMID:
31443998
3.

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity.

Ooi JD, Jiang JH, Eggenhuizen PJ, Chua LL, van Timmeren M, Loh KL, O'Sullivan KM, Gan PY, Zhong Y, Tsyganov K, Shochet LR, Ryan J, Stegeman CA, Fugger L, Reid HH, Rossjohn J, Heeringa P, Holdsworth SR, Peleg AY, Kitching AR.

Nat Commun. 2019 Jul 29;10(1):3392. doi: 10.1038/s41467-019-11255-0.

4.

Apoptotic Cell-Induced, Antigen-Specific Immunoregulation to Treat Experimental Antimyeloperoxidase GN.

Gan PY, Godfrey AS, Ooi JD, O'Sullivan KM, Oudin V, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2019 Aug;30(8):1365-1374. doi: 10.1681/ASN.2018090955. Epub 2019 Jul 23.

PMID:
31337690
5.

HLA-DR15-specific inhibition attenuates autoreactivity to the Goodpasture antigen.

Huynh M, Eggenhuizen PJ, Olson GL, Rao NB, Self CR, Sun Y, Holdsworth SR, Kitching AR, Ooi JD.

J Autoimmun. 2019 Sep;103:102276. doi: 10.1016/j.jaut.2019.05.004. Epub 2019 May 16.

PMID:
31104947
6.

HLA and kidney disease: from associations to mechanisms.

Robson KJ, Ooi JD, Holdsworth SR, Rossjohn J, Kitching AR.

Nat Rev Nephrol. 2018 Oct;14(10):636-655. doi: 10.1038/s41581-018-0057-8. Review.

PMID:
30206339
7.

Regulatory T cells in renal disease.

Alikhan MA, Huynh M, Kitching AR, Ooi JD.

Clin Transl Immunology. 2018 Jan 30;7(1):e1004. doi: 10.1002/cti2.1004. eCollection 2018. Review.

8.

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis.

Dick J, Gan PY, Ford SL, Odobasic D, Alikhan MA, Loosen SH, Hall P, Westhorpe CL, Li A, Ooi JD, Woodruff TM, Mackay CR, Kitching AR, Hickey MJ, Holdsworth SR.

Kidney Int. 2018 Mar;93(3):615-625. doi: 10.1016/j.kint.2017.09.018. Epub 2017 Dec 12.

PMID:
29241626
9.

Renal Dendritic Cells: The Long and Winding Road.

Kitching AR, Ooi JD.

J Am Soc Nephrol. 2018 Jan;29(1):4-7. doi: 10.1681/ASN.2017101145. Epub 2017 Dec 11. No abstract available.

10.

Pathogenic Role for γδ T Cells in Autoimmune Anti-Myeloperoxidase Glomerulonephritis.

Gan PY, Fujita T, Ooi JD, Alikhan MA, Dick J, Shim R, Odobasic D, O'Sullivan KM, Kitching AR, Holdsworth SR.

J Immunol. 2017 Nov 1;199(9):3042-3050. doi: 10.4049/jimmunol.1602025. Epub 2017 Sep 27.

11.

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR.

Nature. 2017 May 11;545(7653):243-247. doi: 10.1038/nature22329. Epub 2017 May 3.

12.

From bench to pet shop to bedside? The environment and immune function in mice.

Kitching AR, Ooi JD.

Kidney Int. 2016 Dec;90(6):1142-1143. doi: 10.1016/j.kint.2016.08.017. Epub 2016 Sep 28.

PMID:
27692816
13.

CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN.

Chang J, Eggenhuizen P, O'Sullivan KM, Alikhan MA, Holdsworth SR, Ooi JD, Kitching AR.

J Am Soc Nephrol. 2017 Jan;28(1):47-55. doi: 10.1681/ASN.2015121356. Epub 2016 Jun 10.

14.

Corrigendum: Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus.

Devi S, Li A, Westhorpe CL, Lo CY, Abeynaike LD, Snelgrove SL, Hall P, Ooi JD, Sobey CG, Kitching AR, Hickey MJ.

Nat Med. 2016 Apr;22(4):446. doi: 10.1038/nm0416-446a. No abstract available.

PMID:
27050593
15.

The NLRP3 inflammasome in kidney disease and autoimmunity.

Hutton HL, Ooi JD, Holdsworth SR, Kitching AR.

Nephrology (Carlton). 2016 Sep;21(9):736-44. doi: 10.1111/nep.12785. Review.

PMID:
27011059
16.

Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis.

Gan PY, O'Sullivan KM, Ooi JD, Alikhan MA, Odobasic D, Summers SA, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2016 May;27(5):1321-33. doi: 10.1681/ASN.2014090906. Epub 2015 Sep 15.

17.

Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell Recruitment.

Alikhan MA, Summers SA, Gan PY, Chan AJ, Khouri MB, Ooi JD, Ghali JR, Odobasic D, Hickey MJ, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2016 Mar;27(3):706-14. doi: 10.1681/ASN.2014090927. Epub 2015 Jun 26.

18.

Myeloperoxidase Peptide-Based Nasal Tolerance in Experimental ANCA-Associated GN.

Gan PY, Tan DS, Ooi JD, Alikhan MA, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2016 Feb;27(2):385-91. doi: 10.1681/ASN.2015010089. Epub 2015 Jun 5.

19.

Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis.

Ooi JD, Li M, Kourkoutzelos K, Yagita H, Azuma M, Holdsworth SR, Kitching AR.

Nephrology (Carlton). 2015 Dec;20(12):892-8. doi: 10.1111/nep.12532.

PMID:
26043977
20.

Mouse models of anti-neutrophil cytoplasmic antibody-associated vasculitis.

Gan PY, Ooi JD, Kitching AR, Holdsworth SR.

Curr Pharm Des. 2015;21(18):2380-90. Review.

PMID:
25777754
21.

T cell mediated autoimmune glomerular disease in mice.

Ooi JD, Gan PY, Odobasic D, Holdsworth SR, Kitching AR.

Curr Protoc Immunol. 2014 Nov 3;107:15.27.1-19. doi: 10.1002/0471142735.im1527s107. Review.

PMID:
25367126
22.

FcγRIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis.

Ooi JD, Gan PY, Chen T, Eggenhuizen PJ, Chang J, Alikhan MA, Odobasic D, Holdsworth SR, Kitching AR.

Kidney Int. 2014 Dec;86(6):1140-9. doi: 10.1038/ki.2014.189. Epub 2014 May 28.

23.

Myeloperoxidase (MPO)-specific CD4+ T cells contribute to MPO-anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis.

Gan PY, Holdsworth SR, Kitching AR, Ooi JD.

Cell Immunol. 2013 Mar;282(1):21-7. doi: 10.1016/j.cellimm.2013.04.007. Epub 2013 Apr 25.

PMID:
23665205
24.

Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis.

Roth AJ, Ooi JD, Hess JJ, van Timmeren MM, Berg EA, Poulton CE, McGregor J, Burkart M, Hogan SL, Hu Y, Winnik W, Nachman PH, Stegeman CA, Niles J, Heeringa P, Kitching AR, Holdsworth S, Jennette JC, Preston GA, Falk RJ.

J Clin Invest. 2013 Apr;123(4):1773-83. doi: 10.1172/JCI65292. Epub 2013 Mar 15.

25.

The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN.

Ooi JD, Chang J, O'Sullivan KM, Pedchenko V, Hudson BG, Vandenbark AA, Fugger L, Holdsworth SR, Kitching AR.

J Am Soc Nephrol. 2013 Feb;24(3):419-31. doi: 10.1681/ASN.2012070705. Epub 2013 Feb 14.

26.

Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN.

Tan DS, Gan PY, O'Sullivan KM, Hammett MV, Summers SA, Ooi JD, Lundgren BA, Boyd RL, Scott HS, Kitching AR, Chidgey AP, Holdsworth SR.

J Am Soc Nephrol. 2013 Mar;24(4):573-85. doi: 10.1681/ASN.2012090898. Epub 2013 Feb 7.

27.

Deficiency of annexin A1 in CD4+ T cells exacerbates T cell-dependent inflammation.

Yang YH, Song W, Deane JA, Kao W, Ooi JD, Ngo D, Kitching AR, Morand EF, Hickey MJ.

J Immunol. 2013 Feb 1;190(3):997-1007. doi: 10.4049/jimmunol.1202236. Epub 2012 Dec 24.

28.

Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus.

Devi S, Li A, Westhorpe CL, Lo CY, Abeynaike LD, Snelgrove SL, Hall P, Ooi JD, Sobey CG, Kitching AR, Hickey MJ.

Nat Med. 2013 Jan;19(1):107-12. doi: 10.1038/nm.3024. Epub 2012 Dec 16. Erratum in: Nat Med. 2016 Apr;22(4):446. Dosage error in article text.

PMID:
23242472
29.

Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis.

Gan PY, Summers SA, Ooi JD, O'Sullivan KM, Tan DS, Muljadi RC, Odobasic D, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2012 Dec;23(12):1955-66. doi: 10.1681/ASN.2012060572. Epub 2012 Nov 8.

30.

CD4+ Th1 cells are effectors in lupus nephritis--but what are their targets?

Ooi JD, Kitching AR.

Kidney Int. 2012 Nov;82(9):947-9. doi: 10.1038/ki.2012.254.

31.

The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis.

Ooi JD, Chang J, Hickey MJ, Borza DB, Fugger L, Holdsworth SR, Kitching AR.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2615-24. Epub 2012 Sep 5.

32.

Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction.

Summers SA, Gan PY, Dewage L, Ma FT, Ooi JD, O'Sullivan KM, Nikolic-Paterson DJ, Kitching AR, Holdsworth SR.

Kidney Int. 2012 Sep;82(6):676-85. doi: 10.1038/ki.2012.211. Epub 2012 Jun 6.

33.

Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis.

Snelgrove SL, Kausman JY, Lo C, Lo C, Ooi JD, Coates PT, Hickey MJ, Holdsworth SR, Kurts C, Engel DR, Kitching AR.

Am J Pathol. 2012 Jan;180(1):91-103. doi: 10.1016/j.ajpath.2011.09.039. Epub 2011 Nov 8.

PMID:
22079432
34.

The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses.

Summers SA, Phoon RK, Ooi JD, Holdsworth SR, Kitching AR.

Am J Pathol. 2011 Feb;178(2):580-90. doi: 10.1016/j.ajpath.2010.10.013.

35.

Endogenous foxp3(+) T-regulatory cells suppress anti-glomerular basement membrane nephritis.

Ooi JD, Snelgrove SL, Engel DR, Hochheiser K, Ludwig-Portugall I, Nozaki Y, O'Sullivan KM, Hickey MJ, Holdsworth SR, Kurts C, Kitching AR.

Kidney Int. 2011 May;79(9):977-86. doi: 10.1038/ki.2010.541. Epub 2011 Jan 19.

36.

Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis.

Summers SA, Steinmetz OM, Gan PY, Ooi JD, Odobasic D, Kitching AR, Holdsworth SR.

Arthritis Rheum. 2011 Apr;63(4):1124-35. doi: 10.1002/art.30208.

37.

Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis.

Summers SA, Steinmetz OM, Ooi JD, Gan PY, O'Sullivan KM, Visvanathan K, Akira S, Kitching AR, Holdsworth SR.

Am J Pathol. 2010 Nov;177(5):2234-44. doi: 10.2353/ajpath.2010.100153. Epub 2010 Sep 16.

38.

Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis.

Summers SA, van der Veen BS, O'Sullivan KM, Gan PY, Ooi JD, Heeringa P, Satchell SC, Mathieson PW, Saleem MA, Visvanathan K, Holdsworth SR, Kitching AR.

Kidney Int. 2010 Dec;78(12):1263-74. doi: 10.1038/ki.2010.327. Epub 2010 Sep 15.

39.

TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy.

Summers SA, Hoi A, Steinmetz OM, O'Sullivan KM, Ooi JD, Odobasic D, Akira S, Kitching AR, Holdsworth SR.

J Autoimmun. 2010 Dec;35(4):291-8. doi: 10.1016/j.jaut.2010.05.004.

PMID:
20810248
40.

Review: T helper 17 cells: their role in glomerulonephritis.

Ooi JD, Kitching AR, Holdsworth SR.

Nephrology (Carlton). 2010 Aug;15(5):513-21. doi: 10.1111/j.1440-1797.2010.01343.x. Review.

PMID:
20649870
41.

Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis.

Gan PY, Steinmetz OM, Tan DS, O'Sullivan KM, Ooi JD, Iwakura Y, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2010 Jun;21(6):925-31. doi: 10.1681/ASN.2009070763. Epub 2010 Mar 18.

42.

Antimyeloperoxidase antibodies rapidly induce alpha-4-integrin-dependent glomerular neutrophil adhesion.

Kuligowski MP, Kwan RY, Lo C, Wong C, James WG, Bourges D, Ooi JD, Abeynaike LD, Hall P, Kitching AR, Hickey MJ.

Blood. 2009 Jun 18;113(25):6485-94. doi: 10.1182/blood-2008-12-192617. Epub 2009 Apr 21.

43.

IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen.

Ooi JD, Phoon RK, Holdsworth SR, Kitching AR.

J Am Soc Nephrol. 2009 May;20(5):980-9. doi: 10.1681/ASN.2008080891. Epub 2009 Apr 8.

44.

Advances in the pathogenesis of Goodpasture's disease: from epitopes to autoantibodies to effector T cells.

Ooi JD, Holdsworth SR, Kitching AR.

J Autoimmun. 2008 Nov;31(3):295-300. doi: 10.1016/j.jaut.2008.04.005. Epub 2008 May 27. Review.

PMID:
18502098
45.

Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis.

Ruth AJ, Kitching AR, Kwan RY, Odobasic D, Ooi JD, Timoshanko JR, Hickey MJ, Holdsworth SR.

J Am Soc Nephrol. 2006 Jul;17(7):1940-9. Epub 2006 Jun 12.

46.

The isolation and purification of biologically active recombinant and native autoantigens for the study of autoimmune disease.

Apostolopoulos J, Ooi JD, Odobasic D, Holdsworth SR, Kitching AR.

J Immunol Methods. 2006 Jan 20;308(1-2):167-78. Epub 2005 Dec 9.

PMID:
16388818

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