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Dengue pre-vaccination serology screening for the use of Dengvaxia®.

Hunsperger E, Peeling R, Gubler DJ, Ooi EE.

J Travel Med. 2019 Dec 23;26(8). pii: taz092. doi: 10.1093/jtm/taz092. No abstract available.


Persistent Dengue Infection in an Immunosuppressed Patient Reveals the Roles of Humoral and Cellular Immune Responses in Virus Clearance.

Ng KH, Zhang SL, Tan HC, Kwek SS, Sessions OM, Chan CY, Liu ID, Lee CK, Tambyah PA, Ooi EE, Yap HK.

Cell Host Microbe. 2019 Nov 13;26(5):601-605.e3. doi: 10.1016/j.chom.2019.10.005. Epub 2019 Oct 29.


Erratum: Author Correction: Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity.

Bidet K, Ho V, Chu CW, Naim ANM, Thazin K, Chan KR, Low JGH, Choy MM, Wong LH, de Sessions PF, Lee YH, Hibberd ML, Ooi EE, Fink K, Chen J.

NPJ Vaccines. 2019 Oct 24;4:46. doi: 10.1038/s41541-019-0140-6. eCollection 2019.


Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007-2013.

Linster M, Donato C, Mah MG, Grau ML, Low JG, Ooi EE, Su YCF, Smith GJD, Vijaykrishna D.

Influenza Other Respir Viruses. 2020 Jan;14(1):67-71. doi: 10.1111/irv.12662. Epub 2019 Sep 30.


Antibody-Dependent Dengue Virus Entry Modulates Cell Intrinsic Responses for Enhanced Infection.

Chan CYY, Low JZH, Gan ES, Ong EZ, Zhang SL, Tan HC, Chai X, Ghosh S, Ooi EE, Chan KR.

mSphere. 2019 Sep 18;4(5). pii: e00528-19. doi: 10.1128/mSphere.00528-19.


Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live-attenuated yellow fever infection.

Chan KR, Gan ES, Chan CYY, Liang C, Low JZH, Zhang SL, Ong EZ, Bhatta A, Wijaya L, Lee YH, Low JG, Ooi EE.

Nat Med. 2019 Aug;25(8):1218-1224. doi: 10.1038/s41591-019-0510-7. Epub 2019 Jul 15.


Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity.

Bidet K, Ho V, Chu CW, Naim ANH, Thazin K, Chan KR, Low JGH, Choy MM, Wong LH, Florez de Sessions P, Lee YH, Hibberd ML, Ooi EE, Fink K, Chen J.

NPJ Vaccines. 2019 Jun 25;4:27. doi: 10.1038/s41541-019-0119-3. eCollection 2019. Erratum in: NPJ Vaccines. 2019 Aug 13;4:36. NPJ Vaccines. 2019 Oct 24;4:46.


Dengue Mosaic Vaccines Enhance Cellular Immunity and Expand the Breadth of Neutralizing Antibody Against All Four Serotypes of Dengue Viruses in Mice.

Hou J, Shrivastava S, Fraser CC, Loo HL, Wong LH, Ho V, Fink K, Ooi EE, Chen J.

Front Immunol. 2019 Jun 20;10:1429. doi: 10.3389/fimmu.2019.01429. eCollection 2019.


Microneedle-based intradermal delivery of stabilized dengue virus.

Turvey ME, Uppu DSSM, Mohamed Sharif AR, Bidet K, Alonso S, Ooi EE, Hammond PT.

Bioeng Transl Med. 2019 Feb 25;4(2):e10127. doi: 10.1002/btm2.10127. eCollection 2019 May.


A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice.

Chan KWK, Watanabe S, Jin JY, Pompon J, Teng D, Alonso S, Vijaykrishna D, Halstead SB, Marzinek JK, Bond PJ, Burla B, Torta F, Wenk MR, Ooi EE, Vasudevan SG.

Sci Transl Med. 2019 Jun 26;11(498). pii: eaat7726. doi: 10.1126/scitranslmed.aat7726.


Evolution of Subgenomic RNA Shapes Dengue Virus Adaptation and Epidemiological Fitness.

Finol E, Ooi EE.

iScience. 2019 Jun 28;16:94-105. doi: 10.1016/j.isci.2019.05.019. Epub 2019 May 16.


Application of a targeted-enrichment methodology for full-genome sequencing of Dengue 1-4, Chikungunya and Zika viruses directly from patient samples.

Kamaraj US, Tan JH, Xin Mei O, Pan L, Chawla T, Uehara A, Wang LF, Ooi EE, Gubler DJ, Tissera H, Ng LC, Wilder-Smith A, de Sessions PF, Barkham T, Anderson DE, Sessions OM.

PLoS Negl Trop Dis. 2019 Apr 25;13(4):e0007184. doi: 10.1371/journal.pntd.0007184. eCollection 2019 Apr.


Genomic signature of early T-cell response is associated with lower antibody titer threshold for sterilizing immunity.

Ong EZ, Gan ES, de Alwis R, Wijaya L, Ong XM, Zhang M, Wong AW, Cheung YB, Zellweger RM, Ooi EE, Low JG.

Antiviral Res. 2019 Jun;166:35-41. doi: 10.1016/j.antiviral.2019.03.013. Epub 2019 Mar 30.


Structure mapping of dengue and Zika viruses reveals functional long-range interactions.

Huber RG, Lim XN, Ng WC, Sim AYL, Poh HX, Shen Y, Lim SY, Sundstrom KB, Sun X, Aw JG, Too HK, Boey PH, Wilm A, Chawla T, Choy MM, Jiang L, de Sessions PF, Loh XJ, Alonso S, Hibberd M, Nagarajan N, Ooi EE, Bond PJ, Sessions OM, Wan Y.

Nat Commun. 2019 Mar 29;10(1):1408. doi: 10.1038/s41467-019-09391-8.


Cell surface α2,3-linked sialic acid facilitates Zika virus internalization.

Tan CW, Huan Hor CH, Kwek SS, Tee HK, Sam IC, Goh ELK, Ooi EE, Chan YF, Wang LF.

Emerg Microbes Infect. 2019;8(1):426-437. doi: 10.1080/22221751.2019.1590130.



Wilder-Smith A, Ooi EE, Horstick O, Wills B.

Lancet. 2019 Jan 26;393(10169):350-363. doi: 10.1016/S0140-6736(18)32560-1. Review.


Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine.

Skibinski DAG, Jones LA, Zhu YO, Xue LW, Au B, Lee B, Naim ANM, Lee A, Kaliaperumal N, Low JGH, Lee LS, Poidinger M, Saudan P, Bachmann M, Ooi EE, Hanson BJ, Novotny-Diermayr V, Matter A, Fairhurst AM, Hibberd ML, Connolly JE.

Sci Rep. 2018 Dec 20;8(1):18007. doi: 10.1038/s41598-018-36703-7.


Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus.

Lim MQ, Kumaran EAP, Tan HC, Lye DC, Leo YS, Ooi EE, MacAry PA, Bertoletti A, Rivino L.

Front Immunol. 2018 Oct 1;9:2225. doi: 10.3389/fimmu.2018.02225. eCollection 2018.


Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway.

Ye W, Chew M, Hou J, Lai F, Leopold SJ, Loo HL, Ghose A, Dutta AK, Chen Q, Ooi EE, White NJ, Dondorp AM, Preiser P, Chen J.

PLoS Pathog. 2018 Oct 4;14(10):e1007298. doi: 10.1371/journal.ppat.1007298. eCollection 2018 Oct.


Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cells.

Saron WAA, Rathore APS, Ting L, Ooi EE, Low J, Abraham SN, St John AL.

Sci Adv. 2018 Jul 4;4(7):eaar4297. doi: 10.1126/sciadv.aar4297. eCollection 2018 Jul.


Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope.

Tharakaraman K, Watanabe S, Chan KR, Huan J, Subramanian V, Chionh YH, Raguram A, Quinlan D, McBee M, Ong EZ, Gan ES, Tan HC, Tyagi A, Bhushan S, Lescar J, Vasudevan SG, Ooi EE, Sasisekharan R.

Cell Host Microbe. 2018 May 9;23(5):618-627.e6. doi: 10.1016/j.chom.2018.04.004.


Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins.

Liao KC, Chuo V, Ng WC, Neo SP, Pompon J, Gunaratne J, Ooi EE, Garcia-Blanco MA.

RNA. 2018 Jun;24(6):803-814. doi: 10.1261/rna.064006.117. Epub 2018 Mar 23.


A systematic approach to the development of a safe live attenuated Zika vaccine.

Kwek SS, Watanabe S, Chan KR, Ong EZ, Tan HC, Ng WC, Nguyen MTX, Gan ES, Zhang SL, Chan KWK, Tan JH, Sessions OM, Manuel M, Pompon J, Chua C, Hazirah S, Tryggvason K, Vasudevan SG, Ooi EE.

Nat Commun. 2018 Mar 12;9(1):1031. doi: 10.1038/s41467-018-03337-2.


Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein.

Budigi Y, Ong EZ, Robinson LN, Ong LC, Rowley KJ, Winnett A, Tan HC, Hobbie S, Shriver Z, Babcock GJ, Alonso S, Ooi EE.

PLoS Negl Trop Dis. 2018 Feb 9;12(2):e0006209. doi: 10.1371/journal.pntd.0006209. eCollection 2018 Feb.


Serum metabolome changes in adult patients with severe dengue in the critical and recovery phases of dengue infection.

Cui L, Pang J, Lee YH, Ooi EE, Ong CN, Leo YS, Tannenbaum SR.

PLoS Negl Trop Dis. 2018 Jan 24;12(1):e0006217. doi: 10.1371/journal.pntd.0006217. eCollection 2018 Jan.


Dengue vaccine-induced CD8+ T cell immunity confers protection in the context of enhancing, interfering maternal antibodies.

Lam JH, Chua YL, Lee PX, Martínez Gómez JM, Ooi EE, Alonso S.

JCI Insight. 2017 Dec 21;2(24). pii: 94500. doi: 10.1172/jci.insight.94500.


Impulsiveness, postprandial blood glucose, and glucoregulation affect measures of behavioral flexibility.

Riby LM, Lai Teik Ong D, Azmie NBM, Ooi EL, Regina C, Yeo EKW, Massa J, Aquili L.

Nutr Res. 2017 Dec;48:65-75. doi: 10.1016/j.nutres.2017.10.011. Epub 2017 Oct 14.


Early molecular correlates of adverse events following yellow fever vaccination.

Chan CY, Chan KR, Chua CJ, Nur Hazirah S, Ghosh S, Ooi EE, Low JG.

JCI Insight. 2017 Oct 5;2(19). pii: 96031. doi: 10.1172/jci.insight.96031.


Dengue Virus-Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact-Dependent Mechanism Involving Adhesion Molecules.

Costa VV, Ye W, Chen Q, Teixeira MM, Preiser P, Ooi EE, Chen J.

mBio. 2017 Aug 1;8(4). pii: e00741-17. doi: 10.1128/mBio.00741-17.


Immune correlates of protection for dengue: State of the art and research agenda.

Katzelnick LC, Harris E; Participants in the Summit on Dengue Immune Correlates of Protection.

Vaccine. 2017 Aug 24;35(36):4659-4669. doi: 10.1016/j.vaccine.2017.07.045. Epub 2017 Jul 28.


Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission.

Pompon J, Manuel M, Ng GK, Wong B, Shan C, Manokaran G, Soto-Acosta R, Bradrick SS, Ooi EE, Missé D, Shi PY, Garcia-Blanco MA.

PLoS Pathog. 2017 Jul 28;13(7):e1006535. doi: 10.1371/journal.ppat.1006535. eCollection 2017 Jul.


Peridomestic Aedes malayensis and Aedes albopictus are capable vectors of arboviruses in cities.

Mendenhall IH, Manuel M, Moorthy M, Lee TTM, Low DHW, Missé D, Gubler DJ, Ellis BR, Ooi EE, Pompon J.

PLoS Negl Trop Dis. 2017 Jun 26;11(6):e0005667. doi: 10.1371/journal.pntd.0005667. eCollection 2017 Jun.


Dengue virus activates cGAS through the release of mitochondrial DNA.

Sun B, Sundström KB, Chew JJ, Bist P, Gan ES, Tan HC, Goh KC, Chawla T, Tang CK, Ooi EE.

Sci Rep. 2017 Jun 15;7(1):3594. doi: 10.1038/s41598-017-03932-1.


The 5' and 3' Untranslated Regions of the Flaviviral Genome.

Ng WC, Soto-Acosta R, Bradrick SS, Garcia-Blanco MA, Ooi EE.

Viruses. 2017 Jun 6;9(6). pii: E137. doi: 10.3390/v9060137. Review.


Serial Metabolome Changes in a Prospective Cohort of Subjects with Influenza Viral Infection and Comparison with Dengue Fever.

Cui L, Fang J, Ooi EE, Lee YH.

J Proteome Res. 2017 Jul 7;16(7):2614-2622. doi: 10.1021/acs.jproteome.7b00173. Epub 2017 Jun 12.


Preclinical evaluation of VIS513, a therapeutic antibody against dengue virus, in non-human primates.

Ong EZ, Budigi Y, Tan HC, Robinson LN, Rowley KJ, Winnett A, Hobbie S, Shriver Z, Babcock GJ, Ooi EE.

Antiviral Res. 2017 Aug;144:44-47. doi: 10.1016/j.antiviral.2017.05.007. Epub 2017 May 18.


A Report of Adult Human Adenovirus Infections in a Tertiary Hospital.

Kalimuddin S, Chan YFZ, Wu IQ, Tan QL, Murthee KG, Tan BH, Oon LLE, Yang Y, Lin RTP, Joseph U, Sessions OM, Smith GJD, Ooi EE, Low JGH.

Open Forum Infect Dis. 2017 Mar 25;4(2):ofx053. doi: 10.1093/ofid/ofx053. eCollection 2017 Spring.


Serum Metabolomics Investigation of Humanized Mouse Model of Dengue Virus Infection.

Cui L, Hou J, Fang J, Lee YH, Costa VV, Wong LH, Chen Q, Ooi EE, Tannenbaum SR, Chen J, Ong CN.

J Virol. 2017 Jun 26;91(14). pii: e00386-17. doi: 10.1128/JVI.00386-17. Print 2017 Jul 15.


Current Status of Dengue Therapeutics Research and Development.

Low JG, Ooi EE, Vasudevan SG.

J Infect Dis. 2017 Mar 1;215(suppl_2):S96-S102. doi: 10.1093/infdis/jiw423. Review.


Hypoxia enhances antibody-dependent dengue virus infection.

Gan ES, Cheong WF, Chan KR, Ong EZ, Chai X, Tan HC, Ghosh S, Wenk MR, Ooi EE.

EMBO J. 2017 May 15;36(10):1348-1363. doi: 10.15252/embj.201695642. Epub 2017 Mar 20.


Prophylactic platelet transfusion plus supportive care versus supportive care alone in adults with dengue and thrombocytopenia: a multicentre, open-label, randomised, superiority trial.

Lye DC, Archuleta S, Syed-Omar SF, Low JG, Oh HM, Wei Y, Fisher D, Ponnampalavanar SSL, Wijaya L, Lee LK, Ooi EE, Kamarulzaman A, Lum LC, Tambyah PA, Leo YS.

Lancet. 2017 Apr 22;389(10079):1611-1618. doi: 10.1016/S0140-6736(17)30269-6. Epub 2017 Mar 8.


Serological response to trivalent inactivated influenza vaccine in HIV-infected adults in Singapore.

Lau YF, Tang LH, Chien Lye D, Ooi EE, Leo YS.

Hum Vaccin Immunother. 2017 Mar 4;13(3):551-560. doi: 10.1080/21645515.2016.1246636. Epub 2017 Feb 17.


Dengue virus compartmentalization during antibody-enhanced infection.

Ong EZ, Zhang SL, Tan HC, Gan ES, Chan KR, Ooi EE.

Sci Rep. 2017 Jan 13;7:40923. doi: 10.1038/srep40923.


Prognosticating Dengue.

Low JG, Ooi EE.

Clin Infect Dis. 2017 Mar 1;64(5):664-665. doi: 10.1093/cid/ciw867. No abstract available.


Patterns of medication use and factors associated with antibiotic use among adult fever patients at Singapore primary care clinics.

Tun ZM, Moorthy M, Linster M, Su YC, Coker RJ, Ooi EE, Low JG, Smith GJ, Tam CC.

Antimicrob Resist Infect Control. 2016 Nov 24;5:47. eCollection 2016.


Characteristics of acute febrile illness and determinants of illness recovery among adults presenting to Singapore primary care clinics.

Tun ZM, Moorthy M, Linster M, Su YC, Coker RJ, Ooi EE, Low JG, Smith GJ, Tam CC.

BMC Infect Dis. 2016 Oct 28;16(1):612.


Asymptomatic dengue infection may trigger Guillain-Barré syndrome.

Umapathi T, Lim CS, Ooi EE, Zhang SL, Goh EJ, Tan HC, Chng KY, Willison H.

J Peripher Nerv Syst. 2016 Dec;21(4):375-377. doi: 10.1111/jns.12190. No abstract available.


Reply to "Use of Prediction Models for Risk Analysis and Decision-Making in Public Health-The Catch-22 Conundrum".

Kalimuddin S, Low JG, Ooi EE.

Ann Acad Med Singapore. 2016 Aug;45(8):367-8. No abstract available.


Cross-reactive antibodies enhance live attenuated virus infection for increased immunogenicity.

Chan KR, Wang X, Saron WAA, Gan ES, Tan HC, Mok DZL, Zhang SL, Lee YH, Liang C, Wijaya L, Ghosh S, Cheung YB, Tannenbaum SR, Abraham SN, St John AL, Low JGH, Ooi EE.

Nat Microbiol. 2016 Sep 19;1:16164. doi: 10.1038/nmicrobiol.2016.164.


The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.

Tay MY, Smith K, Ng IH, Chan KW, Zhao Y, Ooi EE, Lescar J, Luo D, Jans DA, Forwood JK, Vasudevan SG.

PLoS Pathog. 2016 Sep 13;12(9):e1005886. doi: 10.1371/journal.ppat.1005886. eCollection 2016 Sep.

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