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Items: 5


Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814.

Walweel K, Gomez-Hurtado N, Rebbeck RT, Oo YW, Beard NA, Molenaar P, Dos Remedios C, van Helden DF, Cornea RL, Knollmann BC, Laver DR.

J Mol Cell Cardiol. 2019 May;130:96-106. doi: 10.1016/j.yjmcc.2019.03.018. Epub 2019 Mar 27.


Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels.

Walweel K, Gomez-Hurtado N, Oo YW, Beard NA, Dos Remedios C, Johnson CN, Chazin WJ, van Helden DF, Knollmann BC, Laver DR.

J Am Coll Cardiol. 2017 Jul 4;70(1):115-117. doi: 10.1016/j.jacc.2017.04.055. No abstract available.


The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.

Walweel K, Oo YW, Laver DR.

Clin Exp Pharmacol Physiol. 2017 Jan;44(1):135-142. doi: 10.1111/1440-1681.12669. Review.


Essential Role of Calmodulin in RyR Inhibition by Dantrolene.

Oo YW, Gomez-Hurtado N, Walweel K, van Helden DF, Imtiaz MS, Knollmann BC, Laver DR.

Mol Pharmacol. 2015 Jul;88(1):57-63. doi: 10.1124/mol.115.097691. Epub 2015 Apr 28.


Increased myocardial stiffness with maintenance of length-dependent calcium activation by female sex hormones in diabetic rats.

Bupha-Intr T, Oo YW, Wattanapermpool J.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1661-8. doi: 10.1152/ajpheart.00411.2010. Epub 2011 Feb 18.

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