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Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814.

Walweel K, Gomez-Hurtado N, Rebbeck RT, Oo YW, Beard NA, Molenaar P, Dos Remedios C, van Helden DF, Cornea RL, Knollmann BC, Laver DR.

J Mol Cell Cardiol. 2019 May;130:96-106. doi: 10.1016/j.yjmcc.2019.03.018. Epub 2019 Mar 27.


Review article: unanswered clinical and research questions in autoimmune hepatitis-conclusions of the International Autoimmune Hepatitis Group Research Workshop.

Dyson JK, De Martin E, Dalekos GN, Drenth JPH, Herkel J, Hubscher SG, Kelly D, Lenzi M, Milkiewicz P, Oo YH, Heneghan MA, Lohse AW; IAIHG Consortium.

Aliment Pharmacol Ther. 2019 Mar;49(5):528-536. doi: 10.1111/apt.15111. Epub 2019 Jan 22. Review.


Knowledge of potential risk of blood-borne viral infections and tattooing practice among adults in Mandalay Region, Myanmar.

Show KL, Le Win L, Saw S, Myint CK, Than KM, Oo YTN, Wai KT.

PLoS One. 2019 Jan 10;14(1):e0209853. doi: 10.1371/journal.pone.0209853. eCollection 2019.


Vδ2+ T Cells-Two Subsets for the Price of One.

Davey MS, Willcox CR, Hunter S, Oo YH, Willcox BE.

Front Immunol. 2018 Sep 25;9:2106. doi: 10.3389/fimmu.2018.02106. eCollection 2018. No abstract available.


Inequity of care provision and outcome disparity in autoimmune hepatitis in the United Kingdom.

Dyson JK, Wong LL, Bigirumurame T, Hirschfield GM, Kendrick S, Oo YH, Lohse AW, Heneghan MA, Jones DEJ; UK-AIH Consortium.

Aliment Pharmacol Ther. 2018 Nov;48(9):951-960. doi: 10.1111/apt.14968. Epub 2018 Sep 18.


First molecular detection of Theileria luwenshuni from goats in Myanmar.

Bawm S, Kakisaka K, Thu MJ, Chel HM, Oo YMN, Soe NC, Win SY, Htun LL, Win MM, Suzuki H, Nakao R, Katakura K.

Parasitol Res. 2018 Oct;117(10):3361-3364. doi: 10.1007/s00436-018-6073-6. Epub 2018 Sep 5.


The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation.

Knoblich K, Cruz Migoni S, Siew SM, Jinks E, Kaul B, Jeffery HC, Baker AT, Suliman M, Vrzalikova K, Mehenna H, Murray PG, Barone F, Oo YH, Newsome PN, Hirschfield G, Kelly D, Lee SP, Parekkadan B, Turley SJ, Fletcher AL.

PLoS Biol. 2018 Sep 4;16(9):e2005046. doi: 10.1371/journal.pbio.2005046. eCollection 2018 Sep.


The Reactive Oxygen Species-Mitophagy Signaling Pathway Regulates Liver Endothelial Cell Survival During Ischemia/Reperfusion Injury.

Bhogal RH, Weston CJ, Velduis S, G D Leuvenink H, Reynolds GM, Davies S, Nyguet-Thin L, Alfaifi M, Shepard EL, Boteon Y, Wallace L, Oo YH, Adams DH, Mirza DF, Mergental H, Muirhead G, Stephenson BTF, Afford SC.

Liver Transpl. 2018 Oct;24(10):1437-1452. doi: 10.1002/lt.25313.


Linking the gut and liver: crosstalk between regulatory T cells and mucosa-associated invariant T cells.

Atif M, Warner S, Oo YH.

Hepatol Int. 2018 Jul;12(4):305-314. doi: 10.1007/s12072-018-9882-x. Epub 2018 Jul 19. Review.


Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations.

Hunter S, Willcox CR, Davey MS, Kasatskaya SA, Jeffery HC, Chudakov DM, Oo YH, Willcox BE.

J Hepatol. 2018 Sep;69(3):654-665. doi: 10.1016/j.jhep.2018.05.007. Epub 2018 May 18.


The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets.

Davey MS, Willcox CR, Hunter S, Kasatskaya SA, Remmerswaal EBM, Salim M, Mohammed F, Bemelman FJ, Chudakov DM, Oo YH, Willcox BE.

Nat Commun. 2018 May 2;9(1):1760. doi: 10.1038/s41467-018-04076-0.


The Impact of Autoimmune Hepatitis and Its Treatment on Health Utility.

Wong LL, Fisher HF, Stocken DD, Rice S, Khanna A, Heneghan MA, Oo YH, Mells G, Kendrick S, Dyson JK, Jones DEJ; UK-AIH Consortium.

Hepatology. 2018 Oct;68(4):1487-1497. doi: 10.1002/hep.30031.


Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis.

Jeffery HC, Braitch MK, Bagnall C, Hodson J, Jeffery LE, Wawman RE, Wong LL, Birtwistle J, Bartlett H, Lohse AW, Hirschfield GM, Dyson J, Jones D, Hubscher SG, Klenerman P, Adams DH, Oo YH.

Hepatol Commun. 2018 Feb 26;2(4):421-436. doi: 10.1002/hep4.1163. eCollection 2018 Apr.


Regulatory T Cell Metabolism in the Hepatic Microenvironment.

Wawman RE, Bartlett H, Oo YH.

Front Immunol. 2018 Jan 8;8:1889. doi: 10.3389/fimmu.2017.01889. eCollection 2017. Review.


Human intrahepatic ILC2 are IL-13positive amphiregulinpositive and their frequency correlates with model of end stage liver disease score.

Jeffery HC, McDowell P, Lutz P, Wawman RE, Roberts S, Bagnall C, Birtwistle J, Adams DH, Oo YH.

PLoS One. 2017 Dec 19;12(12):e0188649. doi: 10.1371/journal.pone.0188649. eCollection 2017.


Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease.

Riva A, Patel V, Kurioka A, Jeffery HC, Wright G, Tarff S, Shawcross D, Ryan JM, Evans A, Azarian S, Bajaj JS, Fagan A, Patel V, Mehta K, Lopez C, Simonova M, Katzarov K, Hadzhiolova T, Pavlova S, Wendon JA, Oo YH, Klenerman P, Williams R, Chokshi S.

Gut. 2018 May;67(5):918-930. doi: 10.1136/gutjnl-2017-314458. Epub 2017 Nov 2.


Self-Directed Interactive Video-Based Instruction Versus Instructor-Led Teaching for Myanmar House Surgeons: A Randomized, Noninferiority Trial.

Lwin AT, Lwin T, Naing P, Oo Y, Kidd D, Cerullo M, Posen J, Hlaing K, Yenokyan G, Thinn KK, Soe ZW, Stevens KA.

J Surg Educ. 2018 Jan - Feb;75(1):238-246. doi: 10.1016/j.jsurg.2017.06.004. Epub 2017 Jun 29.


Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels.

Walweel K, Gomez-Hurtado N, Oo YW, Beard NA, Dos Remedios C, Johnson CN, Chazin WJ, van Helden DF, Knollmann BC, Laver DR.

J Am Coll Cardiol. 2017 Jul 4;70(1):115-117. doi: 10.1016/j.jacc.2017.04.055. No abstract available.


Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases.

Jeffery HC, Jeffery LE, Lutz P, Corrigan M, Webb GJ, Hirschfield GM, Adams DH, Oo YH.

Clin Exp Immunol. 2017 Jun;188(3):394-411. doi: 10.1111/cei.12940. Epub 2017 Mar 20.


Corrigendum to "Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy".

Than NN, Jeffery HC, Oo YH.

Can J Gastroenterol Hepatol. 2016;2016:1468106. Epub 2016 Nov 20.


HBV core promoter mutations and AKT upregulate S-phase kinase-associated protein 2 to promote postoperative hepatocellular carcinoma progression.

Chen L, Gu L, Gu Y, Wang H, Deng M, Stamataki Z, Oo YH, Huang Y.

Sci Rep. 2016 Oct 25;6:35917. doi: 10.1038/srep35917.


Clinical Potential of Regulatory T Cell Therapy in Liver Diseases: An Overview and Current Perspectives.

Jeffery HC, Braitch MK, Brown S, Oo YH.

Front Immunol. 2016 Sep 6;7:334. doi: 10.3389/fimmu.2016.00334. eCollection 2016. Review.


The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.

Walweel K, Oo YW, Laver DR.

Clin Exp Pharmacol Physiol. 2017 Jan;44(1):135-142. doi: 10.1111/1440-1681.12669. Review.


Betel Quid and Oral Potentially Malignant Disorders in a Periurban Township in Myanmar.

Zaw KK, Ohnmar M, Hlaing MM, Oo YT, Win SS, Htike MM, Aye PP, Shwe S, Htwe MT, Thein ZM.

PLoS One. 2016 Sep 9;11(9):e0162081. doi: 10.1371/journal.pone.0162081. eCollection 2016.


Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy.

Than NN, Jeffery HC, Oo YH.

Can J Gastroenterol Hepatol. 2016;2016:7181685. doi: 10.1155/2016/7181685. Epub 2016 May 18. Review. Erratum in: Can J Gastroenterol Hepatol. 2016;2016:1468106.


MAIT cells are activated during human viral infections.

van Wilgenburg B, Scherwitzl I, Hutchinson EC, Leng T, Kurioka A, Kulicke C, de Lara C, Cole S, Vasanawathana S, Limpitikul W, Malasit P, Young D, Denney L; STOP-HCV consortium, Moore MD, Fabris P, Giordani MT, Oo YH, Laidlaw SM, Dustin LB, Ho LP, Thompson FM, Ramamurthy N, Mongkolsapaya J, Willberg CB, Screaton GR, Klenerman P.

Nat Commun. 2016 Jun 23;7:11653. doi: 10.1038/ncomms11653.


Difference in clinical presentation, immunology profile and treatment response of type 1 autoimmune hepatitis between United Kingdom and Singapore patients.

Than NN, Ching DK, Hodson J, McDowell P, Mann J, Gupta R, Salazar E, Ngu JH, Oo YH.

Hepatol Int. 2016 Jul;10(4):673-9. doi: 10.1007/s12072-016-9727-4. Epub 2016 Apr 21.



Hübener S, Than NN, Oo YH, Lohse AW, Schramm C.

Clin Gastroenterol Hepatol. 2016 Jul;14(7):1063-4. doi: 10.1016/j.cgh.2016.04.015. Epub 2016 Apr 16. No abstract available.


Flares during long-term entecavir therapy in chronic hepatitis B.

Chi H, Arends P, Reijnders JG, Carey I, Brown A, Fasano M, Mutimer D, Deterding K, Oo YH, Petersen J, van Bommel F, de Knegt RJ, Santantonio TA, Berg T, Welzel TM, Wedemeyer H, Buti M, Pradat P, Zoulim F, Hansen BE, Janssen HL; VIRGIL Surveillance Study Group (European surveillance network for vigilance against viral resistance).

J Gastroenterol Hepatol. 2016 Nov;31(11):1882-1887. doi: 10.1111/jgh.13377.



Hübener S, Lohse AW, Schramm C, Than NN, Oo YH.

Clin Gastroenterol Hepatol. 2016 Mar 10. pii: S1542-3565(16)00265-2. doi: 10.1016/j.cgh.2016.03.013. [Epub ahead of print]


Human intrahepatic regulatory T cells are functional, require IL-2 from effector cells for survival, and are susceptible to Fas ligand-mediated apoptosis.

Chen YY, Jeffery HC, Hunter S, Bhogal R, Birtwistle J, Braitch MK, Roberts S, Ming M, Hannah J, Thomas C, Adali G, Hübscher SG, Syn WK, Afford S, Lalor PF, Adams DH, Oo YH.

Hepatology. 2016 Jul;64(1):138-50. doi: 10.1002/hep.28517. Epub 2016 Apr 15.


Single-gene association between GATA-2 and autoimmune hepatitis: A novel genetic insight highlighting immunologic pathways to disease.

Webb G, Chen YY, Li KK, Neil D, Oo YH, Richter A, Bigley V, Collin M, Adams DH, Hirschfield GM.

J Hepatol. 2016 May;64(5):1190-1193. doi: 10.1016/j.jhep.2016.01.017. Epub 2016 Jan 23.


Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1.

Jeffery HC, van Wilgenburg B, Kurioka A, Parekh K, Stirling K, Roberts S, Dutton EE, Hunter S, Geh D, Braitch MK, Rajanayagam J, Iqbal T, Pinkney T, Brown R, Withers DR, Adams DH, Klenerman P, Oo YH.

J Hepatol. 2016 May;64(5):1118-1127. doi: 10.1016/j.jhep.2015.12.017. Epub 2015 Dec 29.


Erratum to: The ACCURE-trial: the effect of appendectomy on the clinical course of ulcerative colitis, a randomised international multicenter trial (NTR2883) and the ACCURE-UK trial: a randomised external pilot trial (ISRCTN56523019).

Gardenbroek TJ, Pinkney TD, Sahami S, Morton DG, Buskens CJ, Ponsioen CY, Tanis PJ, Löwenberg M, van den Brink GR, Broeders IA, Pullens HJ, Seerden T, Boom MJ, Mallant-Hent RC, Pierik RE, Vecht J, Sosef MN, van Nunen AB, van Wagensveld BA, Stokkers PC, Gerhards MF, Jansen JM, Acherman Y, Depla AC, Mannaerts GH, West R, Iqbal T, Pathmakanthan S, Howard R, Magill L, Singh B, Oo YH, Negpodiev D, Dijkgraaf MG, D'Haens GR, Bemelman WA.

BMC Surg. 2016 Jan 4;16:1. doi: 10.1186/s12893-015-0113-2. No abstract available.


Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis.

Coombes JD, Choi SS, Swiderska-Syn M, Manka P, Reid DT, Palma E, Briones-Orta MA, Xie G, Younis R, Kitamura N, Della Peruta M, Bitencourt S, Dollé L, Oo YH, Mi Z, Kuo PC, Williams R, Chokshi S, Canbay A, Claridge LC, Eksteen B, Diehl AM, Syn WK.

Biochim Biophys Acta. 2016 Jan;1862(1):135-44. doi: 10.1016/j.bbadis.2015.10.028. Epub 2015 Oct 31.


Efficacy of 6-Mercaptopurine as Second-Line Treatment for Patients With Autoimmune Hepatitis and Azathioprine Intolerance.

Hübener S, Oo YH, Than NN, Hübener P, Weiler-Normann C, Lohse AW, Schramm C.

Clin Gastroenterol Hepatol. 2016 Mar;14(3):445-53. doi: 10.1016/j.cgh.2015.09.037. Epub 2015 Oct 19.


Chronic hepatitis C viral infection subverts vaccine-induced T-cell immunity in humans.

Kelly C, Swadling L, Capone S, Brown A, Richardson R, Halliday J, von Delft A, Oo Y, Mutimer D, Kurioka A, Hartnell F, Collier J, Ammendola V, Del Sorbo M, Grazioli F, Esposito ML, Di Marco S, Siani L, Traboni C, Hill AV, Colloca S, Nicosia A, Cortese R, Folgori A, Klenerman P, Barnes E.

Hepatology. 2016 May;63(5):1455-70. doi: 10.1002/hep.28294. Epub 2016 Jan 22.


Long-term follow-up of patients with difficult to treat type 1 autoimmune hepatitis on Tacrolimus therapy.

Than NN, Wiegard C, Weiler-Normann C, Füssel K, Mann J, Hodson J, Hirschfield GM, Lohse AW, Adams DH, Schramm C, Oo YH.

Scand J Gastroenterol. 2016 Mar;51(3):329-36. doi: 10.3109/00365521.2015.1095351. Epub 2015 Oct 12.


Longterm corticosteroid use after liver transplantation for autoimmune hepatitis is safe and associated with a lower incidence of recurrent disease.

Krishnamoorthy TL, Miezynska-Kurtycz J, Hodson J, Gunson BK, Neuberger J, Milkiewicz P, Oo YH.

Liver Transpl. 2016 Jan;22(1):34-41. doi: 10.1002/lt.24323. Epub 2015 Nov 23.


Hepatocellular carcinoma surveillance in hepatitis B virus-infected individuals: Who and how?

Li KK, Trivedi PJ, Von Heimendahl S, Bruns T, Ward ST, Oo Y, Mutimer D.

Hepatology. 2016 Apr;63(4):1394-5. doi: 10.1002/hep.27924. Epub 2015 Jul 28. No abstract available.


Autoimmune hepatitis: an approach to disease understanding and management.

Corrigan M, Hirschfield GM, Oo YH, Adams DH.

Br Med Bull. 2015 Jun;114(1):181-91. doi: 10.1093/bmb/ldv021. Epub 2015 May 20. Review.


Essential Role of Calmodulin in RyR Inhibition by Dantrolene.

Oo YW, Gomez-Hurtado N, Walweel K, van Helden DF, Imtiaz MS, Knollmann BC, Laver DR.

Mol Pharmacol. 2015 Jul;88(1):57-63. doi: 10.1124/mol.115.097691. Epub 2015 Apr 28.


Regulatory T cells and autoimmune hepatitis: what happens in the liver stays in the liver.

Oo YH, Adams DH.

J Hepatol. 2014 Nov;61(5):973-5. doi: 10.1016/j.jhep.2014.08.005. Epub 2014 Aug 14. No abstract available.


Ertapenem-associated psychosis and encephalopathy.

Oo Y, Packham D, Yau W, Munckhof WJ.

Intern Med J. 2014 Aug;44(8):817-9. doi: 10.1111/imj.12504. Review. No abstract available.


Entecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: limited role for risk scores in Caucasians.

Arends P, Sonneveld MJ, Zoutendijk R, Carey I, Brown A, Fasano M, Mutimer D, Deterding K, Reijnders JG, Oo Y, Petersen J, van Bömmel F, de Knegt RJ, Santantonio T, Berg T, Welzel TM, Wedemeyer H, Buti M, Pradat P, Zoulim F, Hansen B, Janssen HL; VIRGIL Surveillance Study Group.

Gut. 2015 Aug;64(8):1289-95. doi: 10.1136/gutjnl-2014-307023. Epub 2014 Jul 10.


Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice.

Coombes JD, Swiderska-Syn M, Dollé L, Reid D, Eksteen B, Claridge L, Briones-Orta MA, Shetty S, Oo YH, Riva A, Chokshi S, Papa S, Mi Z, Kuo PC, Williams R, Canbay A, Adams DH, Diehl AM, van Grunsven LA, Choi SS, Syn WK.

Gut. 2015 Jul;64(7):1120-31. doi: 10.1136/gutjnl-2013-306484. Epub 2014 Jun 5.


Largen: a molecular regulator of mammalian cell size control.

Yamamoto K, Gandin V, Sasaki M, McCracken S, Li W, Silvester JL, Elia AJ, Wang F, Wakutani Y, Alexandrova R, Oo YD, Mullen PJ, Inoue S, Itsumi M, Lapin V, Haight J, Wakeham A, Shahinian A, Ikura M, Topisirovic I, Sonenberg N, Mak TW.

Mol Cell. 2014 Mar 20;53(6):904-15. doi: 10.1016/j.molcel.2014.02.028.


Pheochromocytoma: a review.

Tsirlin A, Oo Y, Sharma R, Kansara A, Gliwa A, Banerji MA.

Maturitas. 2014 Mar;77(3):229-38. doi: 10.1016/j.maturitas.2013.12.009. Epub 2014 Jan 5. Review.


Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T-cell apoptosis.

Afford SC, Humphreys EH, Reid DT, Russell CL, Banz VM, Oo Y, Vo T, Jenne C, Adams DH, Eksteen B.

Hepatology. 2014 May;59(5):1932-43. doi: 10.1002/hep.26965. Epub 2014 Mar 27.


Regulatory T-cell directed therapies in liver diseases.

Oo YH, Sakaguchi S.

J Hepatol. 2013 Nov;59(5):1127-34. doi: 10.1016/j.jhep.2013.05.034. Epub 2013 May 29. Review. No abstract available.

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