Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 76

1.

Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors.

Nocentini A, Moi D, Deplano A, Osman SM, AlOthman ZA, Balboni G, Supuran CT, Onnis V.

Eur J Med Chem. 2020 Jan 15;186:111896. doi: 10.1016/j.ejmech.2019.111896. Epub 2019 Nov 21.

PMID:
31784185
2.

Synthesis and evaluation of antioxidant and antiproliferative activity of 2-arylbenzimidazoles.

Baldisserotto A, Demurtas M, Lampronti I, Tacchini M, Moi D, Balboni G, Pacifico S, Vertuani S, Manfredini S, Onnis V.

Bioorg Chem. 2020 Jan;94:103396. doi: 10.1016/j.bioorg.2019.103396. Epub 2019 Oct 24.

PMID:
31677860
3.

Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation.

Moi D, Nocentini A, Deplano A, Balboni G, Supuran CT, Onnis V.

Eur J Med Chem. 2019 Nov 15;182:111638. doi: 10.1016/j.ejmech.2019.111638. Epub 2019 Aug 22.

PMID:
31472471
4.

Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors.

Moi D, Foster PA, Rimmer LG, Jaffri A, Deplano A, Balboni G, Onnis V, Potter BVL.

Eur J Med Chem. 2019 Nov 15;182:111614. doi: 10.1016/j.ejmech.2019.111614. Epub 2019 Aug 12.

PMID:
31422224
5.

Targeting prokineticin system counteracts hypersensitivity, neuroinflammation, and tissue damage in a mouse model of bortezomib-induced peripheral neuropathy.

Moschetti G, Amodeo G, Maftei D, Lattanzi R, Procacci P, Sartori P, Balboni G, Onnis V, Conte V, Panerai A, Sacerdote P, Franchi S.

J Neuroinflammation. 2019 Apr 17;16(1):89. doi: 10.1186/s12974-019-1461-0.

6.

Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones.

Demurtas M, Baldisserotto A, Lampronti I, Moi D, Balboni G, Pacifico S, Vertuani S, Manfredini S, Onnis V.

Bioorg Chem. 2019 Apr;85:568-576. doi: 10.1016/j.bioorg.2019.02.007. Epub 2019 Feb 10.

PMID:
30825715
7.

Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors.

Deplano A, Cipriano M, Moraca F, Novellino E, Catalanotti B, Fowler CJ, Onnis V.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):562-576. doi: 10.1080/14756366.2018.1532418.

8.

Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity.

Baldisserotto A, Demurtas M, Lampronti I, Moi D, Balboni G, Vertuani S, Manfredini S, Onnis V.

Eur J Med Chem. 2018 Aug 5;156:118-125. doi: 10.1016/j.ejmech.2018.07.001. Epub 2018 Jul 2.

PMID:
30006157
9.

Synthesis and biological evaluation of novel pyrazoline-based aromatic sulfamates with potent carbonic anhydrase isoforms II, IV and IX inhibitory efficacy.

Nocentini A, Moi D, Balboni G, Salvadori S, Onnis V, Supuran CT.

Bioorg Chem. 2018 Apr;77:633-639. doi: 10.1016/j.bioorg.2018.02.021. Epub 2018 Feb 23.

PMID:
29502024
10.

Discovery of thiazolin-4-one-based aromatic sulfamates as a new class of carbonic anhydrase isoforms I, II, IV, and IX inhibitors.

Nocentini A, Moi D, Balboni G, Onnis V, Supuran CT.

Bioorg Chem. 2018 Apr;77:293-299. doi: 10.1016/j.bioorg.2018.01.023. Epub 2018 Jan 31.

PMID:
29421705
11.

Antagonism of EG-VEGF Receptors as Targeted Therapy for Choriocarcinoma Progression In Vitro and In Vivo.

Traboulsi W, Sergent F, Boufettal H, Brouillet S, Slim R, Hoffmann P, Benlahfid M, Zhou QY, Balboni G, Onnis V, Bolze PA, Salomon A, Sauthier P, Mallet F, Aboussaouira T, Feige JJ, Benharouga M, Alfaidy N.

Clin Cancer Res. 2017 Nov 15;23(22):7130-7140. doi: 10.1158/1078-0432.CCR-17-0811. Epub 2017 Sep 12.

12.

Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and RDDP functions.

Corona A, Onnis V, Deplano A, Bianco G, Demurtas M, Distinto S, Cheng YC, Alcaro S, Esposito F, Tramontano E.

Pathog Dis. 2017 Aug 31;75(6). doi: 10.1093/femspd/ftx078.

13.

Novel propanamides as fatty acid amide hydrolase inhibitors.

Deplano A, Morgillo CM, Demurtas M, Björklund E, Cipriano M, Svensson M, Hashemian S, Smaldone G, Pedone E, Luque FJ, Cabiddu MG, Novellino E, Fowler CJ, Catalanotti B, Onnis V.

Eur J Med Chem. 2017 Aug 18;136:523-542. doi: 10.1016/j.ejmech.2017.05.033. Epub 2017 May 12.

PMID:
28535469
14.

3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes.

Park B, Nam JH, Kim JH, Kim HJ, Onnis V, Balboni G, Lee KT, Park JH, Catto M, Carotti A, Lee JY.

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1179-1185. doi: 10.1016/j.bmcl.2017.01.068. Epub 2017 Jan 26.

PMID:
28189420
15.

Potent Nematicidal Activity of Maleimide Derivatives on Meloidogyne incognita.

Eloh K, Demurtas M, Mura MG, Deplano A, Onnis V, Sasanelli N, Maxia A, Caboni P.

J Agric Food Chem. 2016 Jun 22;64(24):4876-81. doi: 10.1021/acs.jafc.6b02250. Epub 2016 Jun 9.

PMID:
27249054
16.

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones.

Onnis V, Demurtas M, Deplano A, Balboni G, Baldisserotto A, Manfredini S, Pacifico S, Liekens S, Balzarini J.

Molecules. 2016 Apr 30;21(5). pii: E579. doi: 10.3390/molecules21050579.

17.

Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes.

Castelli M, Amodeo G, Negri L, Lattanzi R, Maftei D, Gotti C, Pistillo F, Onnis V, Congu C, Panerai AE, Sacerdote P, Franchi S.

PLoS One. 2016 Jan 5;11(1):e0146259. doi: 10.1371/journal.pone.0146259. eCollection 2016.

18.

Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode.

Karlsson J, Morgillo CM, Deplano A, Smaldone G, Pedone E, Luque FJ, Svensson M, Novellino E, Congiu C, Onnis V, Catalanotti B, Fowler CJ.

PLoS One. 2015 Nov 13;10(11):e0142711. doi: 10.1371/journal.pone.0142711. eCollection 2015.

19.

In vitro nematicidal activity of aryl hydrazones and comparative GC-MS metabolomics analysis.

Eloh K, Demurtas M, Deplano A, Ngoutane Mfopa A, Murgia A, Maxia A, Onnis V, Caboni P.

J Agric Food Chem. 2015 Nov 18;63(45):9970-6. doi: 10.1021/acs.jafc.5b04815. Epub 2015 Nov 10.

PMID:
26528945
20.

Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives.

Sakakibara N, Balboni G, Congiu C, Onnis V, Demizu Y, Misawa T, Kurihara M, Kato Y, Maruyama T, Toyama M, Okamoto M, Baba M.

Antivir Chem Chemother. 2015 Apr;24(2):62-71. doi: 10.1177/2040206615612208. Epub 2015 Oct 28.

21.

Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.

Gouveia-Figueira S, Karlsson J, Deplano A, Hashemian S, Svensson M, Fredriksson Sundbom M, Congiu C, Onnis V, Fowler CJ.

PLoS One. 2015 Sep 25;10(9):e0139212. doi: 10.1371/journal.pone.0139212. eCollection 2015.

22.

Effect of the T-type channel blocker KYS-05090S in mouse models of acute and neuropathic pain.

M'Dahoma S, Gadotti VM, Zhang FX, Park B, Nam JH, Onnis V, Balboni G, Lee JY, Zamponi GW.

Pflugers Arch. 2016 Feb;468(2):193-9. doi: 10.1007/s00424-015-1733-1. Epub 2015 Sep 10.

PMID:
26354962
23.

Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties.

Congiu C, Onnis V, Deplano A, Balboni G, Ceruso M, Supuran CT.

Bioorg Med Chem. 2015 Sep 1;23(17):5619-25. doi: 10.1016/j.bmc.2015.07.024. Epub 2015 Jul 21.

PMID:
26233796
24.

Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity.

Congiu C, Onnis V, Deplano A, Balboni G, Dedeoglu N, Supuran CT.

Bioorg Med Chem Lett. 2015 Sep 15;25(18):3850-3. doi: 10.1016/j.bmcl.2015.07.060. Epub 2015 Jul 26.

PMID:
26233435
25.

Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.

De Petrocellis L, Schiano Moriello A, Byun JS, Sohn JM, Lee JY, Vázquez-Romero A, Garrido M, Messeguer A, Zhang FX, Zamponi GW, Deplano A, Congiu C, Onnis V, Balboni G, Di Marzo V.

Pharmacol Res. 2015 Sep;99:362-9. doi: 10.1016/j.phrs.2015.07.009. Epub 2015 Jul 17.

PMID:
26192347
26.

PPARγ controls pregnancy outcome through activation of EG-VEGF: new insights into the mechanism of placental development.

Garnier V, Traboulsi W, Salomon A, Brouillet S, Fournier T, Winkler C, Desvergne B, Hoffmann P, Zhou QY, Congiu C, Onnis V, Benharouga M, Feige JJ, Alfaidy N.

Am J Physiol Endocrinol Metab. 2015 Aug 15;309(4):E357-69. doi: 10.1152/ajpendo.00093.2015. Epub 2015 Jun 16.

27.

TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives.

Congiu C, Onnis V, Balboni G, Schiano-Moriello A, Di Marzo V, De Petrocellis L.

Eur J Med Chem. 2015 Jul 15;100:129-38. doi: 10.1016/j.ejmech.2015.05.041. Epub 2015 Jun 6.

PMID:
26079089
28.

Critical role for prokineticin 2 in CNS autoimmunity.

Abou-Hamdan M, Costanza M, Fontana E, Di Dario M, Musio S, Congiu C, Onnis V, Lattanzi R, Radaelli M, Martinelli V, Salvadori S, Negri L, Poliani PL, Farina C, Balboni G, Steinman L, Pedotti R.

Neurol Neuroimmunol Neuroinflamm. 2015 Apr 9;2(3):e95. doi: 10.1212/NXI.0000000000000095. eCollection 2015 Jun.

29.

Nematicidal activity of acetophenones and chalcones against Meloidogyne incognita and structure-activity considerations.

Caboni P, Aissani N, Demurtas M, Ntalli N, Onnis V.

Pest Manag Sci. 2016 Jan;72(1):125-30. doi: 10.1002/ps.3978. Epub 2015 Feb 12.

PMID:
25641877
30.

Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species.

DeToma AS, Krishnamoorthy J, Nam Y, Lee HJ, Brender JR, Kochi A, Lee D, Onnis V, Congiu C, Manfredini S, Vertuani S, Balboni G, Ramamoorthy A, Lim MH.

Chem Sci. 2014 Dec 1;5(12):4851-4862.

31.

A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists.

Congiu C, Onnis V, Deplano A, Salvadori S, Marconi V, Maftei D, Negri L, Lattanzi R, Balboni G.

Eur J Med Chem. 2014 Jun 23;81:334-40. doi: 10.1016/j.ejmech.2014.05.030. Epub 2014 May 14.

PMID:
24852280
32.

Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties.

Congiu C, Onnis V, Balboni G, Supuran CT.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1776-9. doi: 10.1016/j.bmcl.2014.02.030. Epub 2014 Feb 21.

PMID:
24589511
33.

Inhibition of fatty acid amide hydrolase and cyclooxygenase by the N-(3-methylpyridin-2-yl)amide derivatives of flurbiprofen and naproxen.

Cipriano M, Björklund E, Wilson AA, Congiu C, Onnis V, Fowler CJ.

Eur J Pharmacol. 2013 Nov 15;720(1-3):383-90. doi: 10.1016/j.ejphar.2013.09.065. Epub 2013 Oct 8.

PMID:
24120370
34.

Synthesis and biological evaluation of novel acylhydrazone derivatives as potential antitumor agents.

Congiu C, Onnis V.

Bioorg Med Chem. 2013 Nov 1;21(21):6592-9. doi: 10.1016/j.bmc.2013.08.026. Epub 2013 Aug 22.

PMID:
24071449
35.

Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context.

Wall RJ, He G, Denison MS, Congiu C, Onnis V, Fernandes A, Bell DR, Rose M, Rowlands JC, Balboni G, Mellor IR.

Toxicology. 2012 Jul 16;297(1-3):26-33. doi: 10.1016/j.tox.2012.03.011. Epub 2012 Apr 7.

36.

Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.

Balboni G, Congiu C, Onnis V, Maresca A, Scozzafava A, Winum JY, Maietti A, Supuran CT.

Bioorg Med Chem Lett. 2012 May 1;22(9):3063-6. doi: 10.1016/j.bmcl.2012.03.071. Epub 2012 Mar 27.

PMID:
22487176
37.

Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide.

Fowler CJ, Björklund E, Lichtman AH, Naidu PS, Congiu C, Onnis V.

J Enzyme Inhib Med Chem. 2013 Feb;28(1):172-82. doi: 10.3109/14756366.2011.643304. Epub 2012 Jan 6.

38.

Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain.

Jacobson O, Weiss ID, Niu G, Balboni G, Congiu C, Onnis V, Kiesewetter DO, Lattanzi R, Salvadori S, Chen X.

J Nucl Med. 2011 Apr;52(4):600-7. doi: 10.2967/jnumed.110.084772. Epub 2011 Mar 18.

39.

Synthesis and in vitro antitumor activity of new 4,5-dihydropyrazole derivatives.

Congiu C, Onnis V, Vesci L, Castorina M, Pisano C.

Bioorg Med Chem. 2010 Sep 1;18(17):6238-48. doi: 10.1016/j.bmc.2010.07.037. Epub 2010 Aug 9.

PMID:
20702096
40.

Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators.

Onnis V, Kinsella GK, Carta G, Jagoe WN, Price T, Williams DC, Fayne D, Lloyd DG.

J Med Chem. 2010 Apr 22;53(8):3065-74. doi: 10.1021/jm901452y.

PMID:
20334371
41.

Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors.

Onnis V, Congiu C, Björklund E, Hempel F, Söderström E, Fowler CJ.

J Med Chem. 2010 Mar 11;53(5):2286-98. doi: 10.1021/jm901891p.

PMID:
20143779
42.

Synthesis and evaluation of anticancer activity of 2-arylamino-6-trifluoromethyl-3-(hydrazonocarbonyl)pyridines.

Onnis V, Cocco MT, Fadda R, Congiu C.

Bioorg Med Chem. 2009 Sep 1;17(17):6158-65. doi: 10.1016/j.bmc.2009.07.066. Epub 2009 Jul 30.

PMID:
19679483
43.

Rational ligand-based virtual screening and structure-activity relationship studies in the ligand-binding domain of the glucocorticoid receptor-α.

Onnis V, Kinsella GK, Carta G, Fayne D, Lloyd DG.

Future Med Chem. 2009 Jun;1(3):483-99. doi: 10.4155/fmc.09.39. Review.

PMID:
21426128
44.

Rational structure-based drug design and optimization in the ligand-binding domain of the glucocorticoid receptor-α.

Onnis V, Kinsella GK, Carta G, Fayne D, Lloyd DG.

Future Med Chem. 2009 May;1(2):345-59. doi: 10.4155/fmc.09.21. Review.

PMID:
21425972
45.

The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1.

Fowler CJ, Naidu PS, Lichtman A, Onnis V.

Br J Pharmacol. 2009 Feb;156(3):412-9. doi: 10.1111/j.1476-5381.2008.00029.x. Review.

46.

2-Acylhydrazino-5-arylpyrrole derivatives: synthesis and antifungal activity evaluation.

Onnis V, De Logu A, Cocco MT, Fadda R, Meleddu R, Congiu C.

Eur J Med Chem. 2009 Mar;44(3):1288-95. doi: 10.1016/j.ejmech.2008.08.003. Epub 2008 Aug 22.

PMID:
18809229
47.

Design, synthesis, and in vitro antitumor activity of new 1,4-diarylimidazole-2-ones and their 2-thione analogues.

Congiu C, Cocco MT, Onnis V.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):989-93. doi: 10.1016/j.bmcl.2007.12.023. Epub 2007 Dec 15.

PMID:
18164978
48.

Synthesis and evaluation of antitumoral activity of ester and amide derivatives of 2-arylamino-6-trifluoromethyl-3-pyridinecarboxylic acids.

Onnis V, Cocco MT, Lilliu V, Congiu C.

Bioorg Med Chem. 2008 Mar 1;16(5):2367-78. Epub 2007 Nov 29.

PMID:
18065230
49.

Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin.

Holt S, Paylor B, Boldrup L, Alajakku K, Vandevoorde S, Sundström A, Cocco MT, Onnis V, Fowler CJ.

Eur J Pharmacol. 2007 Jun 22;565(1-3):26-36. Epub 2007 Mar 7.

PMID:
17397826
50.

Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.

Balboni G, Onnis V, Congiu C, Zotti M, Sasaki Y, Ambo A, Bryant SD, Jinsmaa Y, Lazarus LH, Lazzari I, Trapella C, Salvadori S.

Bioorg Med Chem. 2007 May 1;15(9):3143-51. Epub 2007 Feb 22.

Supplemental Content

Support Center