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Items: 35


The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration.

Drewry LL, Jones NG, Wang Q, Onken MD, Miller MJ, Sibley LD.

Nat Microbiol. 2019 Nov;4(11):1951-1963. doi: 10.1038/s41564-019-0504-8. Epub 2019 Jul 22.


Transposase mapping identifies the genomic targets of BAP1 in uveal melanoma.

Yen M, Qi Z, Chen X, Cooper JA, Mitra RD, Onken MD.

BMC Med Genomics. 2018 Nov 6;11(1):97. doi: 10.1186/s12920-018-0424-0.


Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells.

Onken MD, Makepeace CM, Kaltenbronn KM, Kanai SM, Todd TD, Wang S, Broekelmann TJ, Rao PK, Cooper JA, Blumer KJ.

Sci Signal. 2018 Sep 4;11(546). pii: eaao6852. doi: 10.1126/scisignal.aao6852.


Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate.

Stewart-Hutchinson PJ, Szasz TP, Jaeger ER, Onken MD, Cooper JA, Morley SC.

J Leukoc Biol. 2017 Sep;102(3):941-948. doi: 10.1189/jlb.1TA0117-008R. Epub 2017 Jun 21.


Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen.

Santiago-Tirado FH, Onken MD, Cooper JA, Klein RS, Doering TL.

mBio. 2017 Jan 31;8(1). pii: e02183-16. doi: 10.1128/mBio.02183-16.


L-Plastin promotes podosome longevity and supports macrophage motility.

Zhou JY, Szasz TP, Stewart-Hutchinson PJ, Sivapalan J, Todd EM, Deady LE, Cooper JA, Onken MD, Morley SC.

Mol Immunol. 2016 Oct;78:79-88. doi: 10.1016/j.molimm.2016.08.012. Epub 2016 Sep 7.


Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis.

Vermeer DW, Coppock JD, Zeng E, Lee KM, Spanos WC, Onken MD, Uppaluri R, Lee JH, Vermeer PD.

Oncotarget. 2016 Apr 26;7(17):24194-207. doi: 10.18632/oncotarget.8254.


Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer.

Chalivendra V, Kanchi KL, Onken MD, Winkler AE, Mardis E, Uppaluri R.

Genom Data. 2015 Mar 1;3:61-62.


Endothelial monolayers and transendothelial migration depend on mechanical properties of the substrate.

Onken MD, Mooren OL, Mukherjee S, Shahan ST, Li J, Cooper JA.

Cytoskeleton (Hoboken). 2014 Dec;71(12):695-706. doi: 10.1002/cm.21203. Epub 2015 Jan 31.


Uveal melanoma cells utilize a novel route for transendothelial migration.

Onken MD, Li J, Cooper JA.

PLoS One. 2014 Dec 15;9(12):e115472. doi: 10.1371/journal.pone.0115472. eCollection 2014.


A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease.

Onken MD, Winkler AE, Kanchi KL, Chalivendra V, Law JH, Rickert CG, Kallogjeri D, Judd NP, Dunn GP, Piccirillo JF, Lewis JS Jr, Mardis ER, Uppaluri R.

Clin Cancer Res. 2014 Jun 1;20(11):2873-84. doi: 10.1158/1078-0432.CCR-14-0205. Epub 2014 Mar 25.


BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma.

Matatall KA, Agapova OA, Onken MD, Worley LA, Bowcock AM, Harbour JW.

BMC Cancer. 2013 Aug 5;13:371. doi: 10.1186/1471-2407-13-371.


Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.

Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM, Sidhu R, Onken MD, Harbour JW, Hagbi-Levi S, Chowers I, Edwards PA, Baldan A, Parks JS, Ory DS, Apte RS.

Cell Metab. 2013 Apr 2;17(4):549-61. doi: 10.1016/j.cmet.2013.03.009.


Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma.

Harbour JW, Roberson ED, Anbunathan H, Onken MD, Worley LA, Bowcock AM.

Nat Genet. 2013 Feb;45(2):133-5. doi: 10.1038/ng.2523. Epub 2013 Jan 13.


Gene expressing profiling of iris melanomas.

Harbour JW, Wilson D, Finger PT, Worley LA, Onken MD.

Ophthalmology. 2013 Jan;120(1):213, 213.e1-3. doi: 10.1016/j.ophtha.2012.08.016. No abstract available.


Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma.

Onken MD, Worley LA, Char DH, Augsburger JJ, Correa ZM, Nudleman E, Aaberg TM Jr, Altaweel MM, Bardenstein DS, Finger PT, Gallie BL, Harocopos GJ, Hovland PG, McGowan HD, Milman T, Mruthyunjaya P, Simpson ER, Smith ME, Wilson DJ, Wirostko WJ, Harbour JW.

Ophthalmology. 2012 Aug;119(8):1596-603. doi: 10.1016/j.ophtha.2012.02.017. Epub 2012 Apr 21.


Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.

Landreville S, Agapova OA, Matatall KA, Kneass ZT, Onken MD, Lee RS, Bowcock AM, Harbour JW.

Clin Cancer Res. 2012 Jan 15;18(2):408-16. doi: 10.1158/1078-0432.CCR-11-0946. Epub 2011 Oct 28.


Frequent mutation of BAP1 in metastasizing uveal melanomas.

Harbour JW, Onken MD, Roberson ED, Duan S, Cao L, Worley LA, Council ML, Matatall KA, Helms C, Bowcock AM.

Science. 2010 Dec 3;330(6009):1410-3. doi: 10.1126/science.1194472. Epub 2010 Nov 4.


p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis.

Delston RB, Matatall KA, Sun Y, Onken MD, Harbour JW.

Oncogene. 2011 Feb 3;30(5):588-99. doi: 10.1038/onc.2010.442. Epub 2010 Sep 27.


Association between gene expression profile, proliferation and metastasis in uveal melanoma.

Onken MD, Worley LA, Harbour JW.

Curr Eye Res. 2010 Sep;35(9):857-63. doi: 10.3109/02713683.2010.493265.


An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma.

Onken MD, Worley LA, Tuscan MD, Harbour JW.

J Mol Diagn. 2010 Jul;12(4):461-8. doi: 10.2353/jmoldx.2010.090220. Epub 2010 Apr 22.


Oncogenic mutations in GNAQ occur early in uveal melanoma.

Onken MD, Worley LA, Long MD, Duan S, Council ML, Bowcock AM, Harbour JW.

Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5230-4. doi: 10.1167/iovs.08-2145. Epub 2008 Aug 21.


A metastasis modifier locus on human chromosome 8p in uveal melanoma identified by integrative genomic analysis.

Onken MD, Worley LA, Harbour JW.

Clin Cancer Res. 2008 Jun 15;14(12):3737-45. doi: 10.1158/1078-0432.CCR-07-5144.


Prognostic biomarkers in uveal melanoma: evidence for a stem cell-like phenotype associated with metastasis.

Chang SH, Worley LA, Onken MD, Harbour JW.

Melanoma Res. 2008 Jun;18(3):191-200. doi: 10.1097/CMR.0b013e3283005270.


Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling.

Worley LA, Long MD, Onken MD, Harbour JW.

Melanoma Res. 2008 Jun;18(3):184-90. doi: 10.1097/CMR.0b013e3282feeac6.


Integrative genomic analysis of aneuploidy in uveal melanoma.

Ehlers JP, Worley L, Onken MD, Harbour JW.

Clin Cancer Res. 2008 Jan 1;14(1):115-22. doi: 10.1158/1078-0432.CCR-07-1825.


Loss of heterozygosity of chromosome 3 detected with single nucleotide polymorphisms is superior to monosomy 3 for predicting metastasis in uveal melanoma.

Onken MD, Worley LA, Person E, Char DH, Bowcock AM, Harbour JW.

Clin Cancer Res. 2007 May 15;13(10):2923-7.


Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma.

Worley LA, Onken MD, Person E, Robirds D, Branson J, Char DH, Perry A, Harbour JW.

Clin Cancer Res. 2007 Mar 1;13(5):1466-71.


Prognostic testing in uveal melanoma by transcriptomic profiling of fine needle biopsy specimens.

Onken MD, Worley LA, Dávila RM, Char DH, Harbour JW.

J Mol Diagn. 2006 Nov;8(5):567-73.


Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas.

Onken MD, Ehlers JP, Worley LA, Makita J, Yokota Y, Harbour JW.

Cancer Res. 2006 May 1;66(9):4602-9.


Association between microarray gene expression signature and extravascular matrix patterns in primary uveal melanomas.

Onken MD, Lin AY, Worley LA, Folberg R, Harbour JW.

Am J Ophthalmol. 2005 Oct;140(4):748-9.


DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma.

Ehlers JP, Worley L, Onken MD, Harbour JW.

Clin Cancer Res. 2005 May 15;11(10):3609-13.


Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death.

Onken MD, Worley LA, Ehlers JP, Harbour JW.

Cancer Res. 2004 Oct 15;64(20):7205-9.


Expanding roles for alpha 4 integrin and its ligands in development.

Sheppard AM, Onken MD, Rosen GD, Noakes PG, Dean DC.

Cell Adhes Commun. 1994 Apr;2(1):27-43.


Genomic organization of mouse Fc gamma receptor genes.

Kulczycki A Jr, Webber J, Soares HA, Onken MD, Thompson JA, Chaplin DD, Loh DY, Tillinghast JP.

Proc Natl Acad Sci U S A. 1990 Apr;87(7):2856-60.

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