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Items: 15

1.

Correction: Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities.

Fordyce EAF, Fraser Hunt S, Crepin D, Onions ST, Parra GF, Sleigh CJ, King-Underwood J, Finch H, Murray J.

Medchemcomm. 2018 Mar 26;9(4):746. doi: 10.1039/c8md90016g. eCollection 2018 Apr 1.

2.

Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities.

Fordyce EAF, Fraser Hunt S, Crepin D, Onions ST, Parra GF, Sleigh CJ, King-Underwood J, Finch H, Murray J.

Medchemcomm. 2018 Feb 20;9(3):583-589. doi: 10.1039/c8md00033f. eCollection 2018 Mar 1. Erratum in: Medchemcomm. 2018 Mar 26;9(4):746.

3.

Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.

Heightman TD, Berdini V, Braithwaite H, Buck IM, Cassidy M, Castro J, Courtin A, Day JEH, East C, Fazal L, Graham B, Griffiths-Jones CM, Lyons JF, Martins V, Muench S, Munck JM, Norton D, O'Reilly M, Palmer N, Pathuri P, Reader M, Rees DC, Rich SJ, Richardson C, Saini H, Thompson NT, Wallis NG, Walton H, Wilsher NE, Woolford AJ, Cooke M, Cousin D, Onions S, Shannon J, Watts J, Murray CW.

J Med Chem. 2018 Jun 14;61(11):4978-4992. doi: 10.1021/acs.jmedchem.8b00421. Epub 2018 May 31.

PMID:
29775310
4.

In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.

Colley T, Sehra G, Chowdhary A, Alanio A, Kelly SL, Kizawa Y, Armstrong-James D, Fisher MC, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Nishimoto Y, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, McConville M, King-Underwood J, Naylor A, Bretagne S, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01941-17. doi: 10.1128/AAC.01941-17. Print 2018 May.

5.

Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor.

Coates M, Brookes D, Kim YI, Allen H, Fordyce EAF, Meals EA, Colley T, Ciana CL, Parra GF, Sherbukhin V, Stockwell JA, Thomas JC, Hunt SF, Anderson-Dring L, Onions ST, Cass L, Murray PJ, Ito K, Strong P, DeVincenzo JP, Rapeport G.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00737-17. doi: 10.1128/AAC.00737-17. Print 2017 Sep.

6.

Discovery of novel benzothienoazepine derivatives as potent inhibitors of respiratory syncytial virus.

Fordyce EAF, Brookes DW, Lise-Ciana C, Coates MS, Hunt SF, Ito K, King-Underwood J, Onions ST, Parra GF, Rapeport G, Sherbukhin V, Stockwell JA, Strong P, Thomas JC, Murray J.

Bioorg Med Chem Lett. 2017 May 15;27(10):2201-2206. doi: 10.1016/j.bmcl.2017.03.053. Epub 2017 Mar 23.

PMID:
28372911
7.

In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection.

Colley T, Alanio A, Kelly SL, Sehra G, Kizawa Y, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Anderson-Dring L, Nakaoki T, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, Cooke M, Bretagne S, King-Underwood J, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16. doi: 10.1128/AAC.02280-16. Print 2017 May.

8.

Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.

Onions ST, Ito K, Charron CE, Brown RJ, Colucci M, Frickel F, Hardy G, Joly K, King-Underwood J, Kizawa Y, Knowles I, Murray PJ, Novak A, Rani A, Rapeport G, Smith A, Strong P, Taddei DM, Williams JG.

J Med Chem. 2016 Mar 10;59(5):1727-46. doi: 10.1021/acs.jmedchem.5b01029. Epub 2016 Feb 4.

PMID:
26800309
9.

A combinatorial biophysical approach; FTSA and SPR for identifying small molecule ligands and PAINs.

Redhead M, Satchell R, Morkūnaitė V, Swift D, Petrauskas V, Golding E, Onions S, Matulis D, Unitt J.

Anal Biochem. 2015 Jun 15;479:63-73. doi: 10.1016/j.ab.2015.03.013. Epub 2015 Mar 30.

PMID:
25837771
10.

Metal catalyzed rearrangement of a 2,2'-bipyridine Schiff-base ligand to a quaterpyridine-type complex.

Wang J, Onions S, Pilkington M, Stoeckli-Evans H, Halfpenny JC, Wallis JD.

Chem Commun (Camb). 2007 Sep 21;(35):3628-30. Epub 2007 May 30.

PMID:
17728875
11.

Mixed valence Mn(II)/Mn(III) [3 x 3] grid complexes: structural, electrochemical, spectroscopic, and magnetic properties.

Thompson LK, Kelly TL, Dawe LN, Grove H, Lemaire MT, Howard JA, Spencer EC, Matthews CJ, Onions ST, Coles SJ, Horton PN, Hursthouse MB, Light ME.

Inorg Chem. 2004 Nov 29;43(24):7605-16.

PMID:
15554625
12.

Self-assembly of a spin-coupled octanuclear copper(II) circular array from a single-stranded ligand.

Onions ST, Heath SL, Price DJ, Harrington RW, Clegg W, Matthews CJ.

Angew Chem Int Ed Engl. 2004 Mar 26;43(14):1814-7. No abstract available.

PMID:
15054782
13.

Self-assembly of a unique hexadecanuclear [4 x (2 x 2)]-Pb16 'grid of grids' type structure.

Onions ST, Frankin AM, Horton PN, Hursthouse MB, Matthews CJ.

Chem Commun (Camb). 2003 Dec 7;(23):2864-5.

PMID:
14680213
14.

A self-assembled tetracopper triple-stranded helicate: towards the controlled synthesis of finite one-dimensional magnetic chains.

Matthews CJ, Onions ST, Morata G, Davis LJ, Heath SL, Price DJ.

Angew Chem Int Ed Engl. 2003 Jul 14;42(27):3166-9. No abstract available.

PMID:
12866108
15.

Synthesis, structure and magnetism of a unique dodecanuclearcopper(II) 'picture frame' held in a 4 x 4 grid-like assembly.

Matthews CJ, Onions ST, Morata G, Salvia MB, Elsegood MR, Price DJ.

Chem Commun (Camb). 2003 Feb 7;(3):320-1.

PMID:
12613592

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