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Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia.

Branford S, Kim DDH, Apperley JF, Eide CA, Mustjoki S, Ong ST, Nteliopoulos G, Ernst T, Chuah C, Gambacorti-Passerini C, Mauro MJ, Druker BJ, Kim DW, Mahon FX, Cortes J, Radich JP, Hochhaus A, Hughes TP; International CML Foundation Genomics Alliance.

Leukemia. 2019 Aug;33(8):1835-1850. doi: 10.1038/s41375-019-0512-y. Epub 2019 Jun 17. Review.


Poly-ε-Caprolactone/Gelatin Hybrid Electrospun Composite Nanofibrous Mats Containing Ultrasound Assisted Herbal Extract: Antimicrobial and Cell Proliferation Study.

Ramalingam R, Dhand C, Leung CM, Ezhilarasu H, Prasannan P, Ong ST, Subramanian S, Kamruddin M, Lakshminarayanan R, Ramakrishna S, Verma NK, Arunachalam KD.

Nanomaterials (Basel). 2019 Mar 20;9(3). pii: E462. doi: 10.3390/nano9030462.


Antimicrobial properties and biocompatibility of electrospun poly-ε-caprolactone fibrous mats containing Gymnema sylvestre leaf extract.

Ramalingam R, Dhand C, Leung CM, Ong ST, Annamalai SK, Kamruddin M, Verma NK, Ramakrishna S, Lakshminarayanan R, Arunachalam KD.

Mater Sci Eng C Mater Biol Appl. 2019 May;98:503-514. doi: 10.1016/j.msec.2018.12.135. Epub 2019 Jan 3.


GapmeR-Mediated Gene Silencing in Motile T-Cells.

Fazil MHUT, Ong ST, Chalasani MLS, Kizhakeyil A, Verma NK.

Methods Mol Biol. 2019;1930:67-73. doi: 10.1007/978-1-4939-9036-8_9.


Three-Dimensional Structured Illumination Microscopy (3D-SIM) to Dissect Signaling Cross-Talks in Motile T-Cells.

Ong ST, Wright GD, Verma NK.

Methods Mol Biol. 2019;1930:41-50. doi: 10.1007/978-1-4939-9036-8_6.


Live Cell Imaging and Analysis to Capture T-Cell Motility in Real-Time.

Ong ST, Verma NK.

Methods Mol Biol. 2019;1930:33-40. doi: 10.1007/978-1-4939-9036-8_5.


Quantification of T-Cell Migratory Phenotypes Using High-Content Analysis.

Ng AS, Ong ST, Kelleher D, Verma NK.

Methods Mol Biol. 2019;1930:25-32. doi: 10.1007/978-1-4939-9036-8_4.


A Laboratory Model to Study T-Cell Motility.

Verma NK, Palapetta SM, Ong ST, Fazil MHUT, Chalasani MLS, Prasannan P, Kizhakeyil A, Kelleher D.

Methods Mol Biol. 2019;1930:19-23. doi: 10.1007/978-1-4939-9036-8_3.


Isolation of Human Peripheral Blood T-Lymphocytes.

Kizhakeyil A, Ong ST, Fazil MHUT, Chalasani MLS, Prasannan P, Verma NK.

Methods Mol Biol. 2019;1930:11-17. doi: 10.1007/978-1-4939-9036-8_2.


The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target.

Ng KP, Manjeri A, Lee LM, Chan ZE, Tan CY, Tan QD, Majeed A, Lee KL, Chuah C, Suda T, Ong ST.

PLoS One. 2018 Oct 11;13(10):e0205254. doi: 10.1371/journal.pone.0205254. eCollection 2018.


Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches.

Leidy-Davis T, Cheng K, Goodwin LO, Morgan JL, Juan WC, Roca X, Ong ST, Bergstrom DE.

Sci Rep. 2018 Oct 9;8(1):15028. doi: 10.1038/s41598-018-33408-9.


Antimicrobial quaternary ammonium organosilane cross-linked nanofibrous collagen scaffolds for tissue engineering.

Dhand C, Balakrishnan Y, Ong ST, Dwivedi N, Venugopal JR, Harini S, Leung CM, Low KZW, Loh XJ, Beuerman RW, Ramakrishna S, Verma NK, Lakshminarayanan R.

Int J Nanomedicine. 2018 Aug 3;13:4473-4492. doi: 10.2147/IJN.S159770. eCollection 2018.


BIM deletion polymorphism profiling complements prognostic values of risk scores in imatinib-treated Asian chronic myeloid leukemia patients.

Than H, Lye WK, Sng C, Allen JC Jr, Ong ST, Chuah C.

Leuk Lymphoma. 2019 Jan;60(1):234-237. doi: 10.1080/10428194.2018.1461863. Epub 2018 Jun 19. No abstract available.


Centrosome- and Golgi-Localized Protein Kinase N-Associated Protein Serves As a Docking Platform for Protein Kinase A Signaling and Microtubule Nucleation in Migrating T-Cells.

Ong ST, Chalasani MLS, Fazil MHUT, Prasannan P, Kizhakeyil A, Wright GD, Kelleher D, Verma NK.

Front Immunol. 2018 Mar 1;9:397. doi: 10.3389/fimmu.2018.00397. eCollection 2018.


Overcoming imatinib resistance conferred by the BIM deletion polymorphism in chronic myeloid leukemia with splice-switching antisense oligonucleotides.

Liu J, Bhadra M, Sinnakannu JR, Yue WL, Tan CW, Rigo F, Ong ST, Roca X.

Oncotarget. 2017 Sep 6;8(44):77567-77585. doi: 10.18632/oncotarget.20658. eCollection 2017 Sep 29.


Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation.

Chu TTT, Sinha A, Malleret B, Suwanarusk R, Park JE, Naidu R, Das R, Dutta B, Ong ST, Verma NK, Chan JK, Nosten F, Rénia L, Sze SK, Russell B, Chandramohanadas R.

Br J Haematol. 2018 Jan;180(1):118-133. doi: 10.1111/bjh.14976. Epub 2017 Nov 2.


A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer.

Soh SX, Siddiqui FJ, Allen JC, Kim GW, Lee JC, Yatabe Y, Soda M, Mano H, Soo RA, Chin TM, Ebi H, Yano S, Matsuo K, Niu X, Lu S, Isobe K, Lee JH, Yang JC, Zhao M, Zhou C, Lee JK, Lee SH, Lee JY, Ahn MJ, Tan TJ, Tan DS, Tan EH, Ong ST, Lim WT.

Oncotarget. 2017 Jun 20;8(25):41474-41486. doi: 10.18632/oncotarget.17102. Review.


Utilization of Corn Cob and TiO2 Photocatalyst Thin Films for Dyes Removal.

Gan HY, Leow LE, Ong ST.

Acta Chim Slov. 2017 Mac;64(1):144-158.


The HDAC inhibitor SB939 overcomes resistance to BCR-ABL kinase Inhibitors conferred by the BIM deletion polymorphism in chronic myeloid leukemia.

Rauzan M, Chuah CT, Ko TK, Ong ST.

PLoS One. 2017 Mar 16;12(3):e0174107. doi: 10.1371/journal.pone.0174107. eCollection 2017.


Histone Deacetylase 3 Inhibition Overcomes BIM Deletion Polymorphism-Mediated Osimertinib Resistance in EGFR-Mutant Lung Cancer.

Tanimoto A, Takeuchi S, Arai S, Fukuda K, Yamada T, Roca X, Ong ST, Yano S.

Clin Cancer Res. 2017 Jun 15;23(12):3139-3149. doi: 10.1158/1078-0432.CCR-16-2271. Epub 2016 Dec 16.


Long-Term Real-Time In Vivo Drug Release Monitoring with AIE Thermogelling Polymer.

Liow SS, Dou Q, Kai D, Li Z, Sugiarto S, Yu CY, Kwok RT, Chen X, Wu YL, Ong ST, Kizhakeyil A, Verma NK, Tang BZ, Loh XJ.

Small. 2017 Feb;13(7). doi: 10.1002/smll.201603404. Epub 2016 Dec 8.


GapmeR cellular internalization by macropinocytosis induces sequence-specific gene silencing in human primary T-cells.

Fazil MH, Ong ST, Chalasani ML, Low JH, Kizhakeyil A, Mamidi A, Lim CF, Wright GD, Lakshminarayanan R, Kelleher D, Verma NK.

Sci Rep. 2016 Nov 24;6:37721. doi: 10.1038/srep37721.


Latent Oxidative Polymerization of Catecholamines as Potential Cross-linkers for Biocompatible and Multifunctional Biopolymer Scaffolds.

Dhand C, Barathi VA, Ong ST, Venkatesh M, Harini S, Dwivedi N, Goh ET, Nandhakumar M, Venugopal JR, Diaz SM, Fazil MH, Loh XJ, Ping LS, Beuerman RW, Verma NK, Ramakrishna S, Lakshminarayanan R.

ACS Appl Mater Interfaces. 2016 Nov 30;8(47):32266-32281. Epub 2016 Nov 15.


Correction: LFA-1/ICAM-1 Ligation in Human T Cells Promotes Th1 Polarization through a GSK3β Signaling-Dependent Notch Pathway.

Verma NK, Fazil MH, Ong ST, Chalasani ML, Low JH, Kottaiswamy A, P P, Kizhakeyil A, Kumar S, Panda AK, Freeley M, Smith SM, Boehm BO, Kelleher D.

J Immunol. 2016 Sep 1;197(5):2039-40. doi: 10.4049/jimmunol.1601160. No abstract available.


Bio-inspired in situ crosslinking and mineralization of electrospun collagen scaffolds for bone tissue engineering.

Dhand C, Ong ST, Dwivedi N, Diaz SM, Venugopal JR, Navaneethan B, Fazil MH, Liu S, Seitz V, Wintermantel E, Beuerman RW, Ramakrishna S, Verma NK, Lakshminarayanan R.

Biomaterials. 2016 Oct;104:323-38. doi: 10.1016/j.biomaterials.2016.07.007. Epub 2016 Jul 14.


LFA-1/ICAM-1 Ligation in Human T Cells Promotes Th1 Polarization through a GSK3β Signaling-Dependent Notch Pathway.

Verma NK, Fazil MH, Ong ST, Chalasani ML, Low JH, Kottaiswamy A, P P, Kizhakeyil A, Kumar S, Panda AK, Freeley M, Smith SM, Boehm BO, Kelleher D.

J Immunol. 2016 Jul 1;197(1):108-18. doi: 10.4049/jimmunol.1501264. Epub 2016 May 20. Erratum in: J Immunol. 2016 Sep 1;197(5):2039-40.


Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.

Cherian J, Nacro K, Poh ZY, Guo S, Jeyaraj DA, Wong YX, Ho M, Yang HY, Joy JK, Kwek ZP, Liu B, Wee JL, Ong EH, Choong ML, Poulsen A, Lee MA, Pendharkar V, Ding LJ, Manoharan V, Chew YS, Sangthongpitag K, Lim S, Ong ST, Hill J, Keller TH.

J Med Chem. 2016 Apr 14;59(7):3063-78. doi: 10.1021/acs.jmedchem.5b01712. Epub 2016 Apr 5.


The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia.

Ko TK, Chin HS, Chuah CT, Huang JW, Ng KP, Khaw SL, Huang DC, Ong ST.

Oncotarget. 2016 Jan 19;7(3):2721-33. doi: 10.18632/oncotarget.5436.


An N-terminal extension to the hepatitis B virus core protein forms a poorly ordered trimeric spike in assembled virus-like particles.

McGonigle R, Yap WB, Ong ST, Gatherer D, Bakker SE, Tan WS, Bhella D.

J Struct Biol. 2015 Feb;189(2):73-80. doi: 10.1016/j.jsb.2014.12.006. Epub 2014 Dec 31.


A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1.

Tsai BP, Jimenez J, Lim S, Fitzgerald KD, Zhang M, Chuah CT, Axelrod H, Wilson L, Ong ST, Semler BL, Waterman ML.

Open Biol. 2014 Nov;4(11):140180. doi: 10.1098/rsob.140180.


Heritable resistance to tyrosine kinase inhibitors.

Ong ST.

Clin Adv Hematol Oncol. 2014 Jul;12(7):454-7. No abstract available.


Reply: the BIM deletion polymorphism cannot account for intrinsic TKI resistance of Chinese individuals with chronic myeloid leukemia.

Ong ST, Chuah CT, Ko TK, Hillmer AM, Lim WT.

Nat Med. 2014 Oct;20(10):1090-1. doi: 10.1038/nm.3652. No abstract available.


Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia.

Soh SX, Lim JY, Huang JW, Jiang N, Yeoh AE, Ong ST.

PLoS One. 2014 Aug 4;9(8):e103435. doi: 10.1371/journal.pone.0103435. eCollection 2014.


Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration.

Ong ST, Freeley M, Skubis-Zegadło J, Fazil MH, Kelleher D, Fresser F, Baier G, Verma NK, Long A.

J Biol Chem. 2014 Jul 11;289(28):19420-34. doi: 10.1074/jbc.M113.545863. Epub 2014 May 28.


Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing.

Juan WC, Roca X, Ong ST.

PLoS One. 2014 Apr 17;9(4):e95210. doi: 10.1371/journal.pone.0095210. eCollection 2014.


Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition.

Ng KP, Manjeri A, Lee KL, Huang W, Tan SY, Chuah CT, Poellinger L, Ong ST.

Blood. 2014 May 22;123(21):3316-26. doi: 10.1182/blood-2013-07-511907. Epub 2014 Apr 4.


A novel BIM deletion polymorphism: implications and lessons for cancer targeted therapies.

Soh S, Ong ST.

Rinsho Ketsueki. 2013 Oct;54(10):1714-9. Review. No abstract available.


Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function.

Lim S, Saw TY, Zhang M, Janes MR, Nacro K, Hill J, Lim AQ, Chang CT, Fruman DA, Rizzieri DA, Tan SY, Fan H, Chuah CT, Ong ST.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2298-307. doi: 10.1073/pnas.1301838110. Epub 2013 Jun 4.


Clinical significance of incident hypokalemia and hyperkalemia in treated hypertensive patients in the antihypertensive and lipid-lowering treatment to prevent heart attack trial.

Alderman MH, Piller LB, Ford CE, Probstfield JL, Oparil S, Cushman WC, Einhorn PT, Franklin SS, Papademetriou V, Ong ST, Eckfeldt JH, Furberg CD, Calhoun DA, Davis BR; Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Collaborative Research Group.

Hypertension. 2012 May;59(5):926-33. doi: 10.1161/HYPERTENSIONAHA.111.180554. Epub 2012 Mar 19.


A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.

Ng KP, Hillmer AM, Chuah CT, Juan WC, Ko TK, Teo AS, Ariyaratne PN, Takahashi N, Sawada K, Fei Y, Soh S, Lee WH, Huang JW, Allen JC Jr, Woo XY, Nagarajan N, Kumar V, Thalamuthu A, Poh WT, Ang AL, Mya HT, How GF, Yang LY, Koh LP, Chowbay B, Chang CT, Nadarajan VS, Chng WJ, Than H, Lim LC, Goh YT, Zhang S, Poh D, Tan P, Seet JE, Ang MK, Chau NM, Ng QS, Tan DS, Soda M, Isobe K, Nöthen MM, Wong TY, Shahab A, Ruan X, Cacheux-Rataboul V, Sung WK, Tan EH, Yatabe Y, Mano H, Soo RA, Chin TM, Lim WT, Ruan Y, Ong ST.

Nat Med. 2012 Mar 18;18(4):521-8. doi: 10.1038/nm.2713.


The role of protein phosphorylation in therapy resistance and disease progression in chronic myelogenous leukemia.

Juan WC, Ong ST.

Prog Mol Biol Transl Sci. 2012;106:107-42. doi: 10.1016/B978-0-12-396456-4.00007-9. Review.


Mortality and morbidity during and after the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.

Cushman WC, Davis BR, Pressel SL, Cutler JA, Einhorn PT, Ford CE, Oparil S, Probstfield JL, Whelton PK, Wright JT Jr, Alderman MH, Basile JN, Black HR, Grimm RH Jr, Hamilton BP, Haywood LJ, Ong ST, Piller LB, Simpson LM, Stanford C, Weiss RJ; ALLHAT Collaborative Research Group.

J Clin Hypertens (Greenwich). 2012 Jan;14(1):20-31. doi: 10.1111/j.1751-7176.2011.00568.x. Epub 2011 Dec 9.


Dimensional profile of oral mucosa around combined tooth-implant-supported bridgework in macaque mandible.

Siar CH, Toh CG, Ali TB, Seiz D, Ong ST.

Clin Oral Implants Res. 2012 Apr;23(4):438-46. doi: 10.1111/j.1600-0501.2010.02145.x. Epub 2011 Mar 24.


Mite component-specific IgE repertoire and phenotypes of allergic disease in childhood: the tropical perspective.

Kidon MI, Chiang WC, Liew WK, Ong TC, Tiong YS, Wong KN, Angus AC, Ong ST, Gao YF, Reginald K, Bi XZ, Shang HS, Chew FT.

Pediatr Allergy Immunol. 2011 Mar;22(2):202-10. doi: 10.1111/j.1399-3038.2010.01094.x. Erratum in: Pediatr Allergy Immunol. 2011 Sep;22(6):648. Chin, Chiang Wen [corrected to Chiang, Wen Chin]; Kang, Liew Woei [corrected to Liew, Woei Kang]; Ching, Ong Tan [corrected to Ong, Tan Ching]; Seng, Tiong Yuen [corrected to Tiong, Yuen Seng]; Ning, Wong Kang [corrected to Wong, Kang Ning]; Theng, Ong Seo.


Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11.

Stevenson NJ, McFarlane C, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O'Farrelly C, Johnston JA.

FEBS Lett. 2010 Nov 5;584(21):4469-74. doi: 10.1016/j.febslet.2010.10.007. Epub 2010 Oct 8.


Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor.

Janes MR, Limon JJ, So L, Chen J, Lim RJ, Chavez MA, Vu C, Lilly MB, Mallya S, Ong ST, Konopleva M, Martin MB, Ren P, Liu Y, Rommel C, Fruman DA.

Nat Med. 2010 Feb;16(2):205-13. doi: 10.1038/nm.2091. Epub 2010 Jan 13.


Influence of abutment design on clinical status of peri-implant tissues.

Taiyeb-Ali TB, Toh CG, Siar CH, Seiz D, Ong ST.

Implant Dent. 2009 Oct;18(5):438-46. doi: 10.1097/ID.0b013e3181ad8e7a.


N-terminally His-tagged hepatitis B core antigens: construction, expression, purification and antigenicity.

Yap WB, Tey BT, Ng MY, Ong ST, Tan WS.

J Virol Methods. 2009 Sep;160(1-2):125-31. doi: 10.1016/j.jviromet.2009.04.038. Epub 2009 May 9.


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