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Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live-attenuated yellow fever infection.

Chan KR, Gan ES, Chan CYY, Liang C, Low JZH, Zhang SL, Ong EZ, Bhatta A, Wijaya L, Lee YH, Low JG, Ooi EE.

Nat Med. 2019 Jul 15. doi: 10.1038/s41591-019-0510-7. [Epub ahead of print]


MRI coupled with clinically-applicable iron oxide nanoparticles reveals choroid plexus involvement in a murine model of neuroinflammation.

Hubert V, Dumot C, Ong E, Amaz C, Canet-Soulas E, Chauveau F, Wiart M.

Sci Rep. 2019 Jul 11;9(1):10046. doi: 10.1038/s41598-019-46566-1.


OSCI: standardized stem cell ontology representation and use cases for stem cell investigation.

He Y, Duncan WD, Cooper DJ, Hansen J, Iyengar R, Ong E, Walker K, Tibi O, Smith S, Serra LM, Zheng J, Sarntivijai S, Schürer S, O'Shea KS, Diehl AD.

BMC Bioinformatics. 2019 Apr 25;20(Suppl 5):180. doi: 10.1186/s12859-019-2723-7.


Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.

Huang C, Liew SS, Lin GR, Poulsen A, Ang MJY, Chia BCS, Chew SY, Kwek ZP, Wee JLK, Ong EH, Retna P, Baburajendran N, Li R, Yu W, Koh-Stenta X, Ngo A, Manesh S, Fulwood J, Ke Z, Chung HH, Sepramaniam S, Chew XH, Dinie N, Lee MA, Chew YS, Low CB, Pendharkar V, Manoharan V, Vuddagiri S, Sangthongpitag K, Joy J, Matter A, Hill J, Keller TH, Foo K.

ACS Med Chem Lett. 2019 May 23;10(6):978-984. doi: 10.1021/acsmedchemlett.9b00170. eCollection 2019 Jun 13.


Flipped classroom as an effective approach in enhancing student learning of a pharmacy course with a historically low student pass rate.

Goh CF, Ong ET.

Curr Pharm Teach Learn. 2019 Jun;11(6):621-629. doi: 10.1016/j.cptl.2019.02.025. Epub 2019 Mar 1.


Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn's disease in Asia.

Ooi CJ, Hilmi I, Banerjee R, Chuah SW, Ng SC, Wei SC, Makharia GK, Pisespongsa P, Chen MH, Ran ZH, Ye BD, Park DI, Ling KL, Ong D, Ahuja V, Goh KL, Sollano J, Lim WC, Leung WK, Ali RAR, Wu DC, Ong E, Mustaffa N, Limsrivilai J, Hisamatsu T, Yang SK, Ouyang Q, Geary R, De Silva JH, Rerknimitr R, Simadibrata M, Abdullah M, Leong RW; Asia Pacific Association of Gastroenterology (APAGE) Working Group on Inflammatory Bowel Disease and Asian Organization for Crohn’s and Colitis.

Intest Res. 2019 May 31. doi: 10.5217/ir.2019.00026. [Epub ahead of print] Review.


Limiting the metabolic burden of recombinant protein expression during selection yields pools with higher expression levels.

Ong EC, Smidt P, McGrew JT.

Biotechnol Prog. 2019 May 15:e2839. doi: 10.1002/btpr.2839. [Epub ahead of print]


ODAE: Ontology-based systematic representation and analysis of drug adverse events and its usage in study of adverse events given different patient age and disease conditions.

Yu H, Nysak S, Garg N, Ong E, Ye X, Zhang X, He Y.

BMC Bioinformatics. 2019 May 1;20(Suppl 7):199. doi: 10.1186/s12859-019-2729-1.


Does Small Vessel Disease Burden Impact Collateral Circulation in Ischemic Stroke Treated by Mechanical Thrombectomy?

Eker OF, Rascle L, Cho TH, Mechtouff L, Derex L, Ong E, Berthezene Y, Nighoghossian N.

Stroke. 2019 Jun;50(6):1582-1585. doi: 10.1161/STROKEAHA.119.025608. Epub 2019 Apr 30.


Expression of resistance genes instead of gene abundance are correlated with trace levels of antibiotics in urban surface waters.

Yi X, Lin C, Ong EJL, Wang M, Li B, Zhou Z.

Environ Pollut. 2019 Jul;250:437-446. doi: 10.1016/j.envpol.2019.04.035. Epub 2019 Apr 10.


Genomic signature of early T-cell response is associated with lower antibody titer threshold for sterilizing immunity.

Ong EZ, Gan ES, de Alwis R, Wijaya L, Ong XM, Zhang M, Wong AW, Cheung YB, Zellweger RM, Ooi EE, Low JG.

Antiviral Res. 2019 Jun;166:35-41. doi: 10.1016/j.antiviral.2019.03.013. Epub 2019 Mar 30.


Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues.

Kwiatkowski J, Baburajendran N, Poulsen A, Liu B, Tee DHY, Wong YX, Poh ZY, Ong EH, Dinie N, Cherian J, Jansson AE, Hill J, Keller TH, Hung AW.

ACS Med Chem Lett. 2019 Feb 15;10(3):318-323. doi: 10.1021/acsmedchemlett.8b00546. eCollection 2019 Mar 14.


Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn's disease in Asia.

Ooi CJ, Hilmi I, Banerjee R, Chuah SW, Ng SC, Wei SC, Makharia GK, Pisespongsa P, Chen MH, Ran ZH, Ye BD, Park DI, Ling KL, Ong D, Ahuja V, Goh KL, Sollano J, Lim WC, Leung WK, Ali RAR, Wu DC, Ong E, Mustaffa N, Limsrivilai J, Hisamatsu T, Yang SK, Ouyang Q, Geary R, De Silva JH, Rerknimitr R, Simadibrata M, Abdullah M, Leong RWL; Asia-Pacific Association of Gastroenterology (APAGE) Working Group on Inflammatory Bowel Disease and Asian Organization for Crohn's and Colitis.

J Gastroenterol Hepatol. 2019 Mar 8. doi: 10.1111/jgh.14648. [Epub ahead of print] Review.


Clinical Imaging of Choroid Plexus in Health and in Brain Disorders: A Mini-Review.

Hubert V, Chauveau F, Dumot C, Ong E, Berner LP, Canet-Soulas E, Ghersi-Egea JF, Wiart M.

Front Mol Neurosci. 2019 Feb 12;12:34. doi: 10.3389/fnmol.2019.00034. eCollection 2019.


Probable transmission of hepatitis E virus (HEV) via transfusion in the United States.

Ticehurst JR, Pisanic N, Forman MS, Ordak C, Heaney CD, Ong E, Linnen JM, Ness PM, Guo N, Shan H, Nelson KE.

Transfusion. 2019 Mar;59(3):1024-1034. doi: 10.1111/trf.15140. Epub 2019 Jan 31.


Two cases of perniosis in a free flap and a graft site of the hands.

Semkova K, Ong ELH, Jullie M, Beteta V, Santos-Bris A, Bernardis C, Calonje E.

Clin Exp Dermatol. 2019 Jan 9. doi: 10.1111/ced.13879. [Epub ahead of print] No abstract available.


Dermatoscopic findings of penile intraepithelial neoplasia: Bowenoid papulosis, Bowen disease and erythroplasia of Queyrat.

Chan SL, Watchorn RE, Panagou E, Panou E, Ong EL, Heelan K, Haider A, Freeman A, Bunker CB.

Australas J Dermatol. 2018 Dec 25. doi: 10.1111/ajd.12981. [Epub ahead of print]


High positional freedom SOI subwavelength grating coupler (SWG) for 300 mm foundry fabrication.

Ong EW, Wallner T, Fahrenkopf NM, Coolbaugh DD.

Opt Express. 2018 Oct 29;26(22):28773-28792. doi: 10.1364/OE.26.028773.


Intra-patient and inter-patient comparisons of DNA damage response biomarkers in Nasopharynx Cancer (NPC): analysis of NCC0901 randomised controlled trial of induction chemotherapy in locally advanced NPC.

Chua KLM, Yeo ELL, Shihabudeen WA, Tan SH, Shwe TT, Ong EHW, Lam PYP, Soo KC, Soong YL, Fong KW, Tan TWK, Wee JTS, Chua MLK.

BMC Cancer. 2018 Nov 12;18(1):1095. doi: 10.1186/s12885-018-5005-2.


Clinical Validity and Reliability of the Malay Language Translations of Gastroesophageal Reflux Disease Questionnaire and Quality of Life in Reflux and Dyspepsia Questionnaire in a Primary Care Setting.

Vadivelu S, Ma ZF, Ong EW, Hassan N, Nik Hassan NFH, Syed Abdul Aziz SH, Kueh YC, Lee YY.

Dig Dis. 2019;37(2):100-107. doi: 10.1159/000494386. Epub 2018 Nov 1.


Pyogenic Spondylodiscitis: Risk Factors for Adverse Clinical Outcome in Routine Clinical Practice.

Widdrington JD, Emmerson I, Cullinan M, Narayanan M, Klejnow E, Watson A, Ong ELC, Schmid ML, Price DA, Schwab U, Duncan CJA.

Med Sci (Basel). 2018 Oct 30;6(4). pii: E96. doi: 10.3390/medsci6040096.


Occurrence and distribution of trace levels of antibiotics in surface waters and soils driven by non-point source pollution and anthropogenic pressure.

Yi X, Lin C, Ong EJL, Wang M, Zhou Z.

Chemosphere. 2019 Feb;216:213-223. doi: 10.1016/j.chemosphere.2018.10.087. Epub 2018 Oct 16.


Can high-volume teams of anesthesiologists and surgeons decrease perioperative costs for pancreatic surgery?

Uppal A, Vuong B, Dehal A, Stern SL, Mejia J, Weerasinghe R, Kapoor V, Ong E, Hansen PD, Bilchik AJ.

HPB (Oxford). 2019 May;21(5):589-595. doi: 10.1016/j.hpb.2018.09.008. Epub 2018 Oct 23.


Victors: a web-based knowledge base of virulence factors in human and animal pathogens.

Sayers S, Li L, Ong E, Deng S, Fu G, Lin Y, Yang B, Zhang S, Fa Z, Zhao B, Xiang Z, Li Y, Zhao XM, Olszewski MA, Chen L, He Y.

Nucleic Acids Res. 2019 Jan 8;47(D1):D693-D700. doi: 10.1093/nar/gky999.


Collateral circulation assessment within the 4.5 h time window in patients with and without DWI/FLAIR MRI mismatch.

Berthezène Y, Eker O, Makris N, Bettan M, Mansuy A, Chabrol A, Mikkelsenm IK, Hermier M, Mechtouff L, Ong E, Derex L, Berner LP, Ameli R, Pedraza S, Thomalla G, Østergaard L, Baron JC, Cho TH, Nighoghossian N.

J Neurol Sci. 2018 Nov 15;394:94-98. doi: 10.1016/j.jns.2018.09.013. Epub 2018 Sep 12.


Impact of the Thrombectomy Trials on the Management and Outcome of Large Vessel Stroke: Data From the Lyon Stroke Center.

Viannay L, Haesebaert J, Florin F, Riva R, Mechtouff L, Gory B, Ong E, Labeyrie PE, Derex L, Hermier M, Chamard L, Berner LP, Ameli R, Berthezène Y, Turjman F, Nighoghossian N, Cho TH.

Front Neurol. 2018 Aug 28;9:722. doi: 10.3389/fneur.2018.00722. eCollection 2018.


MRI Profile and Collateral Status in Patients with a Transient Ischemic Attack and an Intracranial Artery Occlusion.

Ong E, Eker O, Chamard L, Cho TH, Derex L, Buisson M, Mechtouff L, Berthezene Y, Nighoghossian N.

J Neuroimaging. 2019 Mar;29(2):187-189. doi: 10.1111/jon.12560. Epub 2018 Sep 12.


Designing an ultra-short antibacterial peptide with potent activity against Mupirocin-resistant MRSA.

Arfan G, Ong CYF, Ng SMS, Lau QY, Ng FM, Ong EHQ, Hill J, Chia CSB.

Chem Biol Drug Des. 2019 Jan;93(1):4-11. doi: 10.1111/cbdd.13377. Epub 2018 Sep 12.


Hepatopulmonary Syndrome in Children: A 20-Year Review of Presenting Symptoms, Clinical Progression, and Transplant Outcome.

Warner S, McKiernan PJ, Hartley J, Ong E, van Mourik ID, Gupte G, Abdel-Hady M, Muiesan P, Perera T, Mirza D, Sharif K, Kelly DA, Beath SV.

Liver Transpl. 2018 Sep;24(9):1271-1279. doi: 10.1002/lt.25296.


Pyogenic brain abscess and subdural empyema: presentation, management, and factors predicting outcome.

Widdrington JD, Bond H, Schwab U, Price DA, Schmid ML, McCarron B, Chadwick DR, Narayanan M, Williams J, Ong E.

Infection. 2018 Dec;46(6):785-792. doi: 10.1007/s15010-018-1182-9. Epub 2018 Jul 27.


You Poor Thing.

Ong EK.

J Palliat Med. 2018 Jul;21(7):1045. doi: 10.1089/jpm.2017.0682. No abstract available.


The Importance of Coping and Emotion Regulation in the Occurrence of Suicidal Behavior.

Ong E, Thompson C.

Psychol Rep. 2019 Aug;122(4):1192-1210. doi: 10.1177/0033294118781855. Epub 2018 Jun 21.


Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope.

Tharakaraman K, Watanabe S, Chan KR, Huan J, Subramanian V, Chionh YH, Raguram A, Quinlan D, McBee M, Ong EZ, Gan ES, Tan HC, Tyagi A, Bhushan S, Lescar J, Vasudevan SG, Ooi EE, Sasisekharan R.

Cell Host Microbe. 2018 May 9;23(5):618-627.e6. doi: 10.1016/j.chom.2018.04.004.


Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors.

Kwiatkowski J, Liu B, Tee DHY, Chen G, Ahmad NHB, Wong YX, Poh ZY, Ang SH, Tan ESW, Ong EH, Nurul Dinie, Poulsen A, Pendharkar V, Sangthongpitag K, Lee MA, Sepramaniam S, Ho SY, Cherian J, Hill J, Keller TH, Hung AW.

J Med Chem. 2018 May 24;61(10):4386-4396. doi: 10.1021/acs.jmedchem.8b00060. Epub 2018 May 4.


Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.

Yang H, Chennamaneni LR, Ho MWT, Ang SH, Tan ESW, Jeyaraj DA, Yeap YS, Liu B, Ong EH, Joy JK, Wee JLK, Kwek P, Retna P, Dinie N, Nguyen TTH, Tai SJ, Manoharan V, Pendharkar V, Low CB, Chew YS, Vuddagiri S, Sangthongpitag K, Choong ML, Lee MA, Kannan S, Verma CS, Poulsen A, Lim S, Chuah C, Ong TS, Hill J, Matter A, Nacro K.

J Med Chem. 2018 May 24;61(10):4348-4369. doi: 10.1021/acs.jmedchem.7b01714. Epub 2018 May 7.


Staged Percutaneous Intervention for Concurrent Chronic Total Occlusions in Patients With ST-Segment-Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis.

Villablanca PA, Olmedo W, Weinreich M, Gupta T, Mohananey D, Albuquerque FN, Kassas I, Briceño D, Sanina C, Brevik TA, Ong E, Ramakrishna H, Attubato M, Menegus M, Wiley J, Kalra A.

J Am Heart Assoc. 2018 Apr 13;7(8). pii: e008415. doi: 10.1161/JAHA.117.008415. Review.


Evidence and Function Relevance of Native DOR-MOR Heteromers.

Cahill CM, Ong E.

Handb Exp Pharmacol. 2018;247:115-127. doi: 10.1007/164_2018_112. Review.


The Association Between Suicidal Behavior, Attentional Control, and Frontal Asymmetry.

Thompson C, Ong ELC.

Front Psychiatry. 2018 Mar 14;9:79. doi: 10.3389/fpsyt.2018.00079. eCollection 2018.


What Are the Most Significant Cost and Value Drivers for Pancreatic Resection in an Integrated Healthcare System?

Vuong B, Dehal A, Uppal A, Stern SL, Mejia J, Weerasinghe R, Kapoor V, Ong E, Hansen PD, Bilchik AJ.

J Am Coll Surg. 2018 Jul;227(1):45-53. doi: 10.1016/j.jamcollsurg.2018.02.015. Epub 2018 Mar 23.


Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans.

Ng SMS, Yap JM, Lau QY, Ng FM, Ong EHQ, Barkham T, Teo JWP, Alfatah M, Kong KW, Hoon S, Arumugam P, Hill J, Brian Chia CS.

Eur J Med Chem. 2018 Apr 25;150:479-490. doi: 10.1016/j.ejmech.2018.03.027. Epub 2018 Mar 9.


A systematic approach to the development of a safe live attenuated Zika vaccine.

Kwek SS, Watanabe S, Chan KR, Ong EZ, Tan HC, Ng WC, Nguyen MTX, Gan ES, Zhang SL, Chan KWK, Tan JH, Sessions OM, Manuel M, Pompon J, Chua C, Hazirah S, Tryggvason K, Vasudevan SG, Ooi EE.

Nat Commun. 2018 Mar 12;9(1):1031. doi: 10.1038/s41467-018-03337-2.


Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein.

Budigi Y, Ong EZ, Robinson LN, Ong LC, Rowley KJ, Winnett A, Tan HC, Hobbie S, Shriver Z, Babcock GJ, Alonso S, Ooi EE.

PLoS Negl Trop Dis. 2018 Feb 9;12(2):e0006209. doi: 10.1371/journal.pntd.0006209. eCollection 2018 Feb.


Prognostic Model for Stratification of Radioresistant Nasopharynx Carcinoma to Curative Salvage Radiotherapy.

Li YQ, Tian YM, Tan SH, Liu MZ, Kusumawidjaja G, Ong EHW, Zhao C, Tan TWK, Fong KW, Sommat K, Soong YL, Wee JTS, Han F, Chua MLK.

J Clin Oncol. 2018 Mar 20;36(9):891-899. doi: 10.1200/JCO.2017.75.5165. Epub 2018 Feb 7.


The eXtensible ontology development (XOD) principles and tool implementation to support ontology interoperability.

He Y, Xiang Z, Zheng J, Lin Y, Overton JA, Ong E.

J Biomed Semantics. 2018 Jan 12;9(1):3. doi: 10.1186/s13326-017-0169-2. Review.


Ontological representation, integration, and analysis of LINCS cell line cells and their cellular responses.

Ong E, Xie J, Ni Z, Liu Q, Sarntivijai S, Lin Y, Cooper D, Terryn R, Stathias V, Chung C, Schürer S, He Y.

BMC Bioinformatics. 2017 Dec 21;18(Suppl 17):556. doi: 10.1186/s12859-017-1981-5.


Comparison, alignment, and synchronization of cell line information between CLO and EFO.

Ong E, Sarntivijai S, Jupp S, Parkinson H, He Y.

BMC Bioinformatics. 2017 Dec 21;18(Suppl 17):557. doi: 10.1186/s12859-017-1979-z.


The impact of wire caliber on ERCP outcomes: a multicenter randomized controlled trial of 0.025-inch and 0.035-inch guidewires.

Bassan MS, Sundaralingam P, Fanning SB, Lau J, Menon J, Ong E, Rerknimitr R, Seo DW, Teo EK, Wang HP, Reddy DN, Goh KL, Bourke MJ.

Gastrointest Endosc. 2018 Jun;87(6):1454-1460. doi: 10.1016/j.gie.2017.11.037. Epub 2018 Jan 6.


Selective intraoperative cholangiography during laparoscopic cholecystectomy in children is justified.

Martin B, Ong EGP.

J Pediatr Surg. 2018 Feb;53(2):270-273. doi: 10.1016/j.jpedsurg.2017.11.017. Epub 2017 Nov 13.


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