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Items: 49

1.

The whole genome landscape of Burkitt lymphoma subtypes.

Panea RI, Love CL, Shingleton JR, Reddy A, Bailey JA, Moormann AM, Otieno JA, Ong'echa JM, Oduor CI, Schroeder KMS, Masalu N, Chao NJ, Agajanian M, Major MB, Fedoriw Y, Richards KL, Rymkiewicz G, Miles RR, Alobeid B, Bhagat G, Flowers CR, Ondrejka SL, Hsi ED, Choi WWL, Au-Yeung RKH, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig MA, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus BC, Seshadri V, Kim SY, Gascoyne RD, Levy S, Mukhopadhyay M, Dunson DB, Dave SS.

Blood. 2019 Sep 26. pii: blood.2019001880. doi: 10.1182/blood.2019001880. [Epub ahead of print]

PMID:
31558468
2.

Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum.

Kisia LE, Kempaiah P, Anyona SB, Munde EO, Achieng AO, Ong'echa JM, Lambert CG, Chelimo K, Ouma C, Perkins DJ, Raballah E.

BMC Med Genet. 2019 Aug 16;20(1):140. doi: 10.1186/s12881-019-0866-z.

3.

Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan children.

Achieng AO, Hengartner NW, Raballah E, Cheng Q, Anyona SB, Lauve N, Guyah B, Foo-Hurwitz I, Ong'echa JM, McMahon BH, Ouma C, Lambert CG, Perkins DJ.

EBioMedicine. 2019 Jul;45:290-302. doi: 10.1016/j.ebiom.2019.06.043. Epub 2019 Jul 2.

4.

Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signalling.

Achieng AO, Guyah B, Cheng Q, Ong'echa JM, Ouma C, Lambert CG, Perkins DJ.

EBioMedicine. 2019 Jul;45:278-289. doi: 10.1016/j.ebiom.2019.06.040. Epub 2019 Jun 27.

5.

Antimalarials: Review of Plasmepsins as Drug Targets and HIV Protease Inhibitors Interactions.

Miller Iii WA, Teye J, Achieng AO, Mogire RM, Akala H, Ong'echa JM, Rathi B, Durvasula R, Kempaiah P, Kwofie SK.

Curr Top Med Chem. 2019;18(23):2022-2028. doi: 10.2174/1568026619666181130133548. Review.

PMID:
30499404
6.

Poorly cytotoxic terminally differentiated CD56negCD16pos NK cells accumulate in Kenyan children with Burkitt lymphomas.

Forconi CS, Cosgrove CP, Saikumar-Lakshmi P, Nixon CE, Foley J, Ong'echa JM, Otieno JA, Alter G, Münz C, Moormann AM.

Blood Adv. 2018 May 22;2(10):1101-1114. doi: 10.1182/bloodadvances.2017015404.

7.

Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma.

Oduor CI, Kaymaz Y, Chelimo K, Otieno JA, Ong'echa JM, Moormann AM, Bailey JA.

BMC Cancer. 2017 Nov 13;17(1):761. doi: 10.1186/s12885-017-3711-9.

8.

High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells.

Falanga YT, Frascoli M, Kaymaz Y, Forconi C, Ong'echa JM, Bailey JA, Berg LJ, Moormann AM.

JCI Insight. 2017 Aug 3;2(15). pii: 93814. doi: 10.1172/jci.insight.93814. eCollection 2017 Aug 3.

9.

Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences.

Kaymaz Y, Oduor CI, Yu H, Otieno JA, Ong'echa JM, Moormann AM, Bailey JA.

Mol Cancer Res. 2017 May;15(5):563-576. doi: 10.1158/1541-7786.MCR-16-0305.

10.

Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya.

Munde EO, Okeyo WA, Raballah E, Anyona SB, Were T, Ong'echa JM, Perkins DJ, Ouma C.

BMC Infect Dis. 2017 Apr 20;17(1):289. doi: 10.1186/s12879-017-2390-0.

11.

Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya.

Munde EO, Raballah E, Okeyo WA, Ong'echa JM, Perkins DJ, Ouma C.

BMC Infect Dis. 2017 Apr 20;17(1):291. doi: 10.1186/s12879-017-2404-y.

12.

CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia.

Raballah E, Kempaiah P, Karim Z, Orinda GO, Otieno MF, Perkins DJ, Ong'echa JM.

PLoS One. 2017 Apr 20;12(4):e0175864. doi: 10.1371/journal.pone.0175864. eCollection 2017.

13.

Human and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma.

Oduor CI, Movassagh M, Kaymaz Y, Chelimo K, Otieno J, Ong'echa JM, Moormann AM, Bailey JA.

Front Microbiol. 2017 Mar 28;8:501. doi: 10.3389/fmicb.2017.00501. eCollection 2017.

14.

Regulatory T Cells in Endemic Burkitt Lymphoma Patients Are Associated with Poor Outcomes: A Prospective, Longitudinal Study.

Parsons E, Otieno JA, Ong'echa JM, Nixon CE, Vulule J, Münz C, Stewart VA, Moormann AM.

PLoS One. 2016 Dec 29;11(12):e0167841. doi: 10.1371/journal.pone.0167841. eCollection 2016.

15.

Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp70 and NF-κB activation.

Kempaiah P, Dokladny K, Karim Z, Raballah E, Ong'echa JM, Moseley PL, Perkins DJ.

Mol Med. 2016 Oct;22:570-584. doi: 10.2119/molmed.2016.00130. Epub 2016 Aug 30.

16.

Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation.

Davenport GC, Hittner JB, Otieno V, Karim Z, Mukundan H, Fenimore PW, Hengartner NW, McMahon BH, Kempaiah P, Ong'echa JM, Perkins DJ.

Mediators Inflamm. 2016;2016:4286576. doi: 10.1155/2016/4286576. Epub 2016 Jun 22.

17.

Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study.

Buckle G, Maranda L, Skiles J, Ong'echa JM, Foley J, Epstein M, Vik TA, Schroeder A, Lemberger J, Rosmarin A, Remick SC, Bailey JA, Vulule J, Otieno JA, Moormann AM.

Int J Cancer. 2016 Sep 15;139(6):1231-40. doi: 10.1002/ijc.30170. Epub 2016 May 18.

18.

Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia.

Anyona SB, Kempaiah P, Davenport GC, Vulule JM, Hittner JB, Ong'echa JM, Perkins DJ.

Biochem Biophys Res Commun. 2013 Jul 12;436(4):585-90. doi: 10.1016/j.bbrc.2013.05.089. Epub 2013 Jun 3.

19.

Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels.

Okeyo WA, Munde EO, Okumu W, Raballah E, Anyona SB, Vulule JM, Ong'echa JM, Perkins DJ, Ouma C.

BMC Immunol. 2013 Mar 25;14:15. doi: 10.1186/1471-2172-14-15.

20.

Feedback-based, system-level properties of vertebrate-microbial interactions.

Rivas AL, Jankowski MD, Piccinini R, Leitner G, Schwarz D, Anderson KL, Fair JM, Hoogesteijn AL, Wolter W, Chaffer M, Blum S, Were T, Konah SN, Kempaiah P, Ong'echa JM, Diesterbeck US, Pilla R, Czerny CP, Hittner JB, Hyman JM, Perkins DJ.

PLoS One. 2013;8(2):e53984. doi: 10.1371/journal.pone.0053984. Epub 2013 Feb 20.

21.

Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia.

Anyona SB, Kempaiah P, Raballah E, Davenport GC, Were T, Konah SN, Vulule JM, Hittner JB, Gichuki CW, Ong'echa JM, Perkins DJ.

Am J Hematol. 2012 Aug;87(8):782-9. doi: 10.1002/ajh.23253. Epub 2012 Jun 23.

22.

Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria.

Davenport GC, Hittner JB, Were T, Ong'echa JM, Perkins DJ.

Am J Hematol. 2012 Jul;87(7):652-8. doi: 10.1002/ajh.23200. Epub 2012 May 8.

23.

Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.

Kempaiah P, Anyona SB, Raballah E, Davenport GC, Were T, Hittner JB, Ong'echa JM, Perkins DJ.

Hum Genet. 2012 Aug;131(8):1375-91. doi: 10.1007/s00439-012-1175-1. Epub 2012 May 9.

24.

Marked variation in MSP-119 antibody responses to malaria in western Kenyan highlands.

Badu K, Afrane YA, Larbi J, Stewart VA, Waitumbi J, Angov E, Ong'echa JM, Perkins DJ, Zhou G, Githeko A, Yan G.

BMC Infect Dis. 2012 Mar 1;12:50. doi: 10.1186/1471-2334-12-50.

25.

Severe malarial anemia: innate immunity and pathogenesis.

Perkins DJ, Were T, Davenport GC, Kempaiah P, Hittner JB, Ong'echa JM.

Int J Biol Sci. 2011;7(9):1427-42. Epub 2011 Nov 2. Review.

26.

Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.

Anyona SB, Kempaiah P, Raballah E, Ouma C, Were T, Davenport GC, Konah SN, Vulule JM, Hittner JB, Gichuki CW, Ong'echa JM, Perkins DJ.

Infect Immun. 2011 Dec;79(12):4923-32. doi: 10.1128/IAI.05601-11. Epub 2011 Oct 3.

27.

Identification of inflammatory biomarkers for pediatric malarial anemia severity using novel statistical methods.

Ong'echa JM, Davenport GC, Vulule JM, Hittner JB, Perkins DJ.

Infect Immun. 2011 Nov;79(11):4674-80. doi: 10.1128/IAI.05161-11. Epub 2011 Aug 22.

28.

Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria.

Ong'echa JM, Raballah EO, Kempaiah PM, Anyona SB, Were T, Davenport GC, Konah S, Vulule JM, Ouma C, Hittner JB, Perkins DJ.

BMC Genet. 2011 Aug 6;12:69. doi: 10.1186/1471-2156-12-69.

29.

Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children.

Ouma C, Davenport GC, Garcia S, Kempaiah P, Chaudhary A, Were T, Anyona SB, Raballah E, Konah SN, Hittner JB, Vulule JM, Ong'echa JM, Perkins DJ.

Hum Genet. 2012 Feb;131(2):289-99. doi: 10.1007/s00439-011-1076-8. Epub 2011 Aug 5.

30.

Bacteremia in Kenyan children presenting with malaria.

Were T, Davenport GC, Hittner JB, Ouma C, Vulule JM, Ong'echa JM, Perkins DJ.

J Clin Microbiol. 2011 Feb;49(2):671-6. doi: 10.1128/JCM.01864-10. Epub 2010 Nov 24.

31.

Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area.

Novelli EM, Hittner JB, Davenport GC, Ouma C, Were T, Obaro S, Kaplan S, Ong'echa JM, Perkins DJ.

Br J Haematol. 2010 Jun;149(5):711-21. doi: 10.1111/j.1365-2141.2010.08147.x. Epub 2010 Apr 16.

32.

Hematological predictors of increased severe anemia in Kenyan children coinfected with Plasmodium falciparum and HIV-1.

Davenport GC, Ouma C, Hittner JB, Were T, Ouma Y, Ong'echa JM, Perkins DJ.

Am J Hematol. 2010 Apr;85(4):227-33. doi: 10.1002/ajh.21653.

33.

A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia.

Ouma C, Keller CC, Davenport GC, Were T, Konah S, Otieno MF, Hittner JB, Vulule JM, Martinson J, Ong'echa JM, Ferrell RE, Perkins DJ.

Infect Immun. 2010 Jan;78(1):453-60. doi: 10.1128/IAI.00895-09. Epub 2009 Nov 2.

34.

MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia.

Awandare GA, Martinson JJ, Were T, Ouma C, Davenport GC, Ong'echa JM, Wang W, Leng L, Ferrell RE, Bucala R, Perkins DJ.

J Infect Dis. 2009 Aug 15;200(4):629-37. doi: 10.1086/600894.

35.

Suppression of a novel hematopoietic mediator in children with severe malarial anemia.

Keller CC, Ouma C, Ouma Y, Awandare GA, Davenport GC, Were T, Hittner JB, Vulule JM, Ong'echa JM, Perkins DJ.

Infect Immun. 2009 Sep;77(9):3864-71. doi: 10.1128/IAI.00342-09. Epub 2009 Jun 15.

36.

Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism.

Were T, Davenport GC, Yamo EO, Hittner JB, Awandare GA, Otieno MF, Ouma C, Orago AS, Vulule JM, Ong'echa JM, Perkins DJ.

Microbes Infect. 2009 Jul-Aug;11(8-9):811-9. doi: 10.1016/j.micinf.2009.04.021. Epub 2009 May 7.

37.

Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production.

Ouma C, Davenport GC, Were T, Otieno MF, Hittner JB, Vulule JM, Martinson J, Ong'echa JM, Ferrell RE, Perkins DJ.

Hum Genet. 2008 Dec;124(5):515-24. doi: 10.1007/s00439-008-0578-5. Epub 2008 Oct 30.

38.

Polymorphic variability in the interleukin (IL)-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1beta production.

Ouma C, Davenport GC, Awandare GA, Keller CC, Were T, Otieno MF, Vulule JM, Martinson J, Ong'echa JM, Ferrell RE, Perkins DJ.

J Infect Dis. 2008 Oct 15;198(8):1219-26. doi: 10.1086/592055.

39.

Increased circulating interleukin (IL)-23 in children with malarial anemia: in vivo and in vitro relationship with co-regulatory cytokines IL-12 and IL-10.

Ong'echa JM, Remo AM, Kristoff J, Hittner JB, Were T, Ouma C, Otieno RO, Vulule JM, Keller CC, Awandare GA, Perkins DJ.

Clin Immunol. 2008 Feb;126(2):211-21. Epub 2007 Oct 22.

40.

Role of monocyte-acquired hemozoin in suppression of macrophage migration inhibitory factor in children with severe malarial anemia.

Awandare GA, Ouma Y, Ouma C, Were T, Otieno R, Keller CC, Davenport GC, Hittner JB, Vulule J, Ferrell R, Ong'echa JM, Perkins DJ.

Infect Immun. 2007 Jan;75(1):201-10. Epub 2006 Oct 23.

41.

Suppression of RANTES in children with Plasmodium falciparum malaria.

Were T, Hittner JB, Ouma C, Otieno RO, Orago AS, Ong'echa JM, Vulule JM, Keller CC, Perkins DJ.

Haematologica. 2006 Oct;91(10):1396-9. Erratum in: Haematologica. 2007 Jan;92(1):136. Hittner, J B [added].

42.

A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria.

Awandare GA, Ouma C, Keller CC, Were T, Otieno R, Ouma Y, Davenport GC, Hittner JB, Ong'echa JM, Ferrell R, Perkins DJ.

Genes Immun. 2006 Oct;7(7):568-75. Epub 2006 Aug 24.

PMID:
16929348
44.

Association of FCgamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children.

Ouma C, Keller CC, Opondo DA, Were T, Otieno RO, Otieno MF, Orago AS, Ong'Echa JM, Vulule JM, Ferrell RE, Perkins DJ.

Am J Trop Med Hyg. 2006 Apr;74(4):573-7.

PMID:
16606986
45.

Parasitemia, anemia, and malarial anemia in infants and young children in a rural holoendemic Plasmodium falciparum transmission area.

Ong'echa JM, Keller CC, Were T, Ouma C, Otieno RO, Landis-Lewis Z, Ochiel D, Slingluff JL, Mogere S, Ogonji GA, Orago AS, Vulule JM, Kaplan SS, Day RD, Perkins DJ.

Am J Trop Med Hyg. 2006 Mar;74(3):376-85.

PMID:
16525094
46.

Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria.

Otieno RO, Ouma C, Ong'echa JM, Keller CC, Were T, Waindi EN, Michaels MG, Day RD, Vulule JM, Perkins DJ.

AIDS. 2006 Jan 9;20(2):275-80.

PMID:
16511422
47.

Stage-specific effects of Plasmodium falciparum-derived hemozoin on blood mononuclear cell TNF-alpha regulation and viral replication.

Nti BK, Slingluff JL, Keller CC, Hittner JB, Ong'echa JM, Murphey-Corb M, Perkins DJ.

AIDS. 2005 Nov 4;19(16):1771-80.

PMID:
16227784
48.

Association of interferon-gamma responses to pre-erythrocytic stage vaccine candidate antigens of Plasmodium falciparum in young Kenyan children with improved hemoglobin levels: XV. Asembo Bay Cohort Project.

Ong'echa JM, Lal AA, Terlouw DJ, Ter Kuile FO, Kariuki SK, Udhayakumar V, Orago AS, Hightower AW, Nahlen BL, Shi YP.

Am J Trop Med Hyg. 2003 May;68(5):590-7.

PMID:
12812352
49.

Effects of permethrin-treated bed nets on immunity to malaria in western Kenya II. Antibody responses in young children in an area of intense malaria transmission.

Kariuki SK, Lal AA, Terlouw DJ, ter Kuile FO, Ong'echa JM, Phillips-Howard PA, Orago AS, Kolczak MS, Hawley WA, Nahlen BL, Shi YP.

Am J Trop Med Hyg. 2003 Apr;68(4 Suppl):108-14.

PMID:
12749493

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