Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 1189

1.

Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae.

Sakai K, Unten Y, Iwatsuki M, Matsuo H, Fukasawa W, Hirose T, Chinen T, Nonaka K, Nakashima T, Sunazuka T, Usui T, Murai M, Miyoshi H, Asami Y, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2019 Jun 17. doi: 10.1038/s41429-019-0197-5. [Epub ahead of print]

PMID:
31204387
2.

Antitumor activity of potent pyruvate dehydrogenase kinase 4 inhibitors from plants in pancreatic cancer.

Tambe Y, Terado T, Kim CJ, Mukaisho KI, Yoshida S, Sugihara H, Tanaka H, Chida J, Kido H, Yamaji K, Yamamoto T, Nakano H, Omura S, Inoue H.

Mol Carcinog. 2019 May 20. doi: 10.1002/mc.23045. [Epub ahead of print]

PMID:
31106493
3.

Neurolymphatic biomarkers of brain endothelial inflammatory activation: Implications for multiple sclerosis diagnosis.

Yun JW, Cvek U, Kilgore PCSR, Tsunoda I, Omura S, Sato F, Zivadinov R, Ramanathan M, Minagar A, Alexander JS.

Life Sci. 2019 Jul 15;229:116-123. doi: 10.1016/j.lfs.2019.05.021. Epub 2019 May 10.

PMID:
31082401
4.

Bioinformatics Analyses Determined the Distinct CNS and Peripheral Surrogate Biomarker Candidates Between Two Mouse Models for Progressive Multiple Sclerosis.

Omura S, Sato F, Martinez NE, Park AM, Fujita M, Kennett NJ, Cvek U, Minagar A, Alexander JS, Tsunoda I.

Front Immunol. 2019 Mar 19;10:516. doi: 10.3389/fimmu.2019.00516. eCollection 2019.

5.

Erythromycin acts through the ghrelin receptor to attenuate inflammatory responses in chondrocytes and maintain joint integrity.

Uchimura T, Nakamura DS, Link EM, Noguchi Y, Ōmura S, Sunazuka T, Greenblatt DJ, Zeng L.

Biochem Pharmacol. 2019 Jul;165:79-90. doi: 10.1016/j.bcp.2019.03.014. Epub 2019 Mar 9.

PMID:
30862504
6.

Regulatory T and B cells in peripheral blood of subcutaneous immunotherapy-treated Japanese cedar pollinosis patients.

Matsuda M, Terada T, Tsujimoto N, Morie Y, Ishida T, Takahashi H, Hamaguchi J, Tabuchi Y, Doi K, Noro K, Kikuoka Y, Omura S, Yoshida T, Ayani Y, Suzuki M, Ichihara T, Inaka Y, Inui T, Kawata R, Nabe T.

Immunotherapy. 2019 Apr;11(6):473-482. doi: 10.2217/imt-2018-0170.

PMID:
30860439
7.

Lactacystin: first-in-class proteasome inhibitor still excelling and an exemplar for future antibiotic research.

Ōmura S, Crump A.

J Antibiot (Tokyo). 2019 Apr;72(4):189-201. doi: 10.1038/s41429-019-0141-8. Epub 2019 Feb 12. Review.

PMID:
30755736
8.

Basic Gene Expression Characteristics of Glioma Stem Cells and Human Glioblastoma.

Sakamoto D, Takagi T, Fujita M, Omura S, Yoshida Y, Iida T, Yoshimura S.

Anticancer Res. 2019 Feb;39(2):597-607. doi: 10.21873/anticanres.13153.

PMID:
30711935
9.

Theiler's Virus-Mediated Immunopathology in the CNS and Heart: Roles of Organ-Specific Cytokine and Lymphatic Responses.

Omura S, Kawai E, Sato F, Martinez NE, Minagar A, Al-Kofahi M, Yun JW, Cvek U, Trutschl M, Alexander JS, Tsunoda I.

Front Immunol. 2018 Dec 10;9:2870. doi: 10.3389/fimmu.2018.02870. eCollection 2018.

10.
11.

Discovery of Antiamebic Compounds That Inhibit Cysteine Synthase From the Enteric Parasitic Protist Entamoeba histolytica by Screening of Microbial Secondary Metabolites.

Mori M, Tsuge S, Fukasawa W, Jeelani G, Nakada-Tsukui K, Nonaka K, Matsumoto A, Ōmura S, Nozaki T, Shiomi K.

Front Cell Infect Microbiol. 2018 Dec 5;8:409. doi: 10.3389/fcimb.2018.00409. eCollection 2018.

12.

New tetrahydroquinoline and indoline compounds containing a hydroxy cyclopentenone, virantmycin B and C, produced by Streptomyces sp. AM-2504.

Kimura T, Suga T, Kameoka M, Ueno M, Inahashi Y, Matsuo H, Iwatsuki M, Shigemura K, Shiomi K, Takahashi Y, Ōmura S, Nakashima T.

J Antibiot (Tokyo). 2019 Mar;72(3):169-173. doi: 10.1038/s41429-018-0117-0. Epub 2018 Dec 10.

PMID:
30532036
13.

Nanaomycin I and J: New nanaomycins generated by mycothiol-mediated compounds from "Streptomyces rosa subsp. notoensis" OS-3966.

Matsuo H, Noguchi Y, Také A, Nakanishi J, Shigemura K, Sunazuka T, Takahashi Y, Ōmura S, Nakashima T.

J Biosci Bioeng. 2019 May;127(5):549-553. doi: 10.1016/j.jbiosc.2018.10.013. Epub 2018 Nov 29.

PMID:
30503170
14.

Insecticidal properties of pyripyropene A, a microbial secondary metabolite, against agricultural pests.

Horikoshi R, Goto K, Mitomi M, Oyama K, Sunazuka T, Ōmura S.

J Pestic Sci. 2018 Nov 20;43(4):266-271. doi: 10.1584/jpestics.D18-030.

15.

Ceratinadins E and F, New Bromotyrosine Alkaloids from an Okinawan Marine Sponge Pseudoceratina sp.

Kurimoto SI, Ohno T, Hokari R, Ishiyama A, Iwatsuki M, Ōmura S, Kobayashi J, Kubota T.

Mar Drugs. 2018 Nov 23;16(12). pii: E463. doi: 10.3390/md16120463.

16.

Peyer's patch-immunomodulating glucans from sugar cane enhance protective immunity through stimulation of the hemopoietic system.

Sakai Y, Sato M, Funami Y, Ishiyama A, Hokari R, Iwatsuki M, Nagai T, Otoguro K, Yamada H, Ōmura S, Kiyohara H.

Int J Biol Macromol. 2019 Mar 1;124:505-514. doi: 10.1016/j.ijbiomac.2018.11.180. Epub 2018 Nov 22.

PMID:
30471397
17.

Anti-Inflammatory Effects of EM900 on Cultured Human Nasal Epithelial Cells.

Wakayama N, Matsune S, Takahara E, Sekine K, Yoshioka Y, Ishida M, Yamaguchi S, Okubo K, Sunazuka T, Ōmura S.

J Nippon Med Sch. 2018;85(5):265-270. doi: 10.1272/jnms.JNMS.2018_85-42.

18.

An Application of Photoactivatable Substrate for the Evaluation of Epithelial-mesenchymal Transition Inhibitors.

Nakanishi J, Sugiyama K, Matsuo H, Takahashi Y, Omura S, Nakashima T.

Anal Sci. 2019 Jan 10;35(1):65-69. doi: 10.2116/analsci.18SDP07. Epub 2018 Nov 2.

19.

IL-1β reduces cardiac lymphatic muscle contraction via COX-2 and PGE2 induction: Potential role in myocarditis.

Al-Kofahi M, Omura S, Tsunoda I, Sato F, Becker F, Gavins FNE, Woolard MD, Pattillo C, Zawieja D, Muthuchamy M, Gashev A, Shihab I, Ghoweba M, Von der Weid PY, Wang Y, Alexander JS.

Biomed Pharmacother. 2018 Nov;107:1591-1600. doi: 10.1016/j.biopha.2018.08.004. Epub 2018 Sep 6.

PMID:
30257377
20.

Pestiocandin, a new papulacandin class antibiotic isolated from Pestalotiopsis humus.

Sakai K, Suga T, Iwatsuki M, Chinen T, Nonaka K, Usui T, Asami Y, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2018 Nov;71(12):1031-1035. doi: 10.1038/s41429-018-0102-7. Epub 2018 Sep 19.

PMID:
30232378
21.

Pochoniolides A and B, new antioxidants from the fungal strain Pochonia chlamydosporia var. spinulospora FKI-7537.

Miyano R, Matsuo H, Nonaka K, Mokudai T, Niwano Y, Shiomi K, Takahashi Y, Ōmura S, Nakashima T.

J Biosci Bioeng. 2018 Nov;126(5):661-666. doi: 10.1016/j.jbiosc.2018.05.003. Epub 2018 Jun 23.

PMID:
29941346
22.

Staurosporine: new lease of life for parent compound of today's novel and highly successful anti-cancer drugs.

Ōmura S, Asami Y, Crump A.

J Antibiot (Tokyo). 2018 Aug;71(8):688-701. doi: 10.1038/s41429-018-0029-z. Epub 2018 Jun 22. Review.

PMID:
29934602
23.

Distribution and functional analysis of the phosphopantetheinyl transferase superfamily in Actinomycetales microorganisms.

Kim JH, Komatsu M, Shin-Ya K, Omura S, Ikeda H.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6828-6833. doi: 10.1073/pnas.1800715115. Epub 2018 Jun 14.

24.

Synthesis and insecticidal efficacy of pyripyropene derivatives focusing on the C-1, C-7, and C-11 positions' substituent groups.

Goto K, Horikoshi R, Mitomi M, Oyama K, Hirose T, Sunazuka T, Ōmura S.

J Antibiot (Tokyo). 2018 Sep;71(9):785-797. doi: 10.1038/s41429-018-0064-9. Epub 2018 May 23.

PMID:
29789612
25.

The first horse herders and the impact of early Bronze Age steppe expansions into Asia.

de Barros Damgaard P, Martiniano R, Kamm J, Moreno-Mayar JV, Kroonen G, Peyrot M, Barjamovic G, Rasmussen S, Zacho C, Baimukhanov N, Zaibert V, Merz V, Biddanda A, Merz I, Loman V, Evdokimov V, Usmanova E, Hemphill B, Seguin-Orlando A, Yediay FE, Ullah I, Sjögren KG, Iversen KH, Choin J, de la Fuente C, Ilardo M, Schroeder H, Moiseyev V, Gromov A, Polyakov A, Omura S, Senyurt SY, Ahmad H, McKenzie C, Margaryan A, Hameed A, Samad A, Gul N, Khokhar MH, Goriunova OI, Bazaliiskii VI, Novembre J, Weber AW, Orlando L, Allentoft ME, Nielsen R, Kristiansen K, Sikora M, Outram AK, Durbin R, Willerslev E.

Science. 2018 Jun 29;360(6396). pii: eaar7711. doi: 10.1126/science.aar7711. Epub 2018 May 9.

PMID:
29743352
26.

New metabolites, sarcopodinols A and B, isolated from deep-sea derived fungal strain Sarcopodium sp. FKJ-0025.

Matsuo H, Nonaka K, Nagano Y, Yabuki A, Fujikura K, Takahashi Y, Ōmura S, Nakashima T.

Biosci Biotechnol Biochem. 2018 Aug;82(8):1323-1326. doi: 10.1080/09168451.2018.1467264. Epub 2018 Apr 26.

PMID:
29699461
27.

Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794.

Suga T, Kimura T, Inahashi Y, Iwatsuki M, Nonaka K, Také A, Matsumoto A, Takahashi Y, Ōmura S, Nakashima T.

J Antibiot (Tokyo). 2018 Jul;71(7):619-625. doi: 10.1038/s41429-018-0055-x. Epub 2018 Apr 24.

PMID:
29691484
28.

Quellenin, a new anti-Saprolegnia compound isolated from the deep-sea fungus, Aspergillus sp. YK-76.

Takahashi K, Sakai K, Fukasawa W, Nagano Y, Sakaguchi SO, Lima AO, Pellizari VH, Iwatsuki M, Takishita K, Yoshida T, Nonaka K, Fujikura K, Ōmura S.

J Antibiot (Tokyo). 2018 Aug;71(8):741-744. doi: 10.1038/s41429-018-0053-z. Epub 2018 Apr 23.

PMID:
29686353
29.

Identification and heterologous expression of the actinoallolide biosynthetic gene cluster.

Inahashi Y, Shiraishi T, Také A, Matsumoto A, Takahashi Y, Ōmura S, Kuzuyama T, Nakashima T.

J Antibiot (Tokyo). 2018 Aug;71(8):749-752. doi: 10.1038/s41429-018-0057-8. Epub 2018 Apr 20.

PMID:
29679043
30.

Streptomyces boninensis sp. nov., isolated from soil from a limestone cave in the Ogasawara Islands.

Také A, Inahashi Y, Ōmura S, Takahashi Y, Matsumoto A.

Int J Syst Evol Microbiol. 2018 May;68(5):1795-1799. doi: 10.1099/ijsem.0.002753. Epub 2018 Apr 6.

PMID:
29624162
31.

Tolyprolinol, a new dipeptide from Tolypocladium sp. FKI-7981.

Fukasawa W, Mori N, Iwatsuki M, Hokari R, Ishiyama A, Nakajima M, Ouchi T, Nonaka K, Kojima H, Matsuo H, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2018 Jul;71(7):682-684. doi: 10.1038/s41429-018-0041-3. Epub 2018 Mar 22.

PMID:
29563600
32.

Oxoberkedienoic acid: a new octadienoic acid derivative isolated from Talaromyces verruculosus using a chemical screening system.

Sakai K, Asami Y, Chiba T, Suga T, Nonaka K, Iwatsuki M, Ōmura S, Shiomi K.

J Gen Appl Microbiol. 2018 Jul 23;64(3):136-138. doi: 10.2323/jgam.2017.09.001. Epub 2018 Mar 19. No abstract available.

33.

Pyrizomicin A and B: structure and bioactivity of new thiazolyl pyridines from Lechevalieria aerocolonigenes K10-0216.

Kimura T, Inahashi Y, Matsuo H, Suga T, Iwatsuki M, Shiomi K, Takahashi Y, Ōmura S, Nakashima T.

J Antibiot (Tokyo). 2018 Jun;71(6):606-608. doi: 10.1038/s41429-018-0038-y. Epub 2018 Mar 7.

PMID:
29515230
34.

Dipyrimicin A and B, microbial compounds isolated from Amycolatopsis sp. K16-0194.

Izuta S, Kosaka S, Kawai M, Miyano R, Matsuo H, Matsumoto A, Nonaka K, Takahashi Y, Ōmura S, Nakashima T.

J Antibiot (Tokyo). 2018 May;71(5):535-537. doi: 10.1038/s41429-018-0028-0. Epub 2018 Feb 20.

PMID:
29463887
35.

Orthognathic Surgery and Implant-Supported Bridge in a Class III Patient Injured in a Motor Vehicle Accident.

Honda K, Hirota M, Iwai T, Fujita K, Omura S, Ono T, Tohnai I.

J Craniofac Surg. 2018 May;29(3):e296-e298. doi: 10.1097/SCS.0000000000004339.

PMID:
29420385
36.

Mumiamicin: Structure and bioactivity of a new furan fatty acid from Mumia sp. YSP-2-79.

Kimura T, Tajima A, Inahashi Y, Iwatsuki M, Kasai H, Mokudai T, Niwano Y, Shiomi K, Takahashi Y, Ōmura S, Nakashima T.

J Gen Appl Microbiol. 2018 May 21;64(2):62-67. doi: 10.2323/jgam.2017.06.004. Epub 2018 Jan 25.

37.

Immunoregulation of Theiler's virus-induced demyelinating disease by glatiramer acetate without suppression of antiviral immune responses.

Omura S, Sato F, Martinez NE, Range T, Ekshyyan L, Minagar A, Alexander JS, Tsunoda I.

Arch Virol. 2018 May;163(5):1279-1284. doi: 10.1007/s00705-018-3729-6. Epub 2018 Jan 23.

38.

Jietacins, azoxy antibiotics with potent nematocidal activity: Design, synthesis, and biological evaluation against parasitic nematodes.

Sugawara A, Kubo M, Hirose T, Yahagi K, Tsunoda N, Noguchi Y, Nakashima T, Takahashi Y, Welz C, Mueller D, Mertens C, Koebberling J, Ōmura S, Sunazuka T.

Eur J Med Chem. 2018 Feb 10;145:524-538. doi: 10.1016/j.ejmech.2017.12.031. Epub 2017 Dec 28.

PMID:
29335213
39.

Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors.

Ohtawa M, Arima S, Ichida N, Terayama T, Ohno H, Yamazaki T, Ohshiro T, Sato N, Omura S, Tomoda H, Nagamitsu T.

ChemMedChem. 2018 Mar 6;13(5):411-421. doi: 10.1002/cmdc.201700645. Epub 2018 Jan 30.

PMID:
29323466
40.

Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca2+ pump inhibitor from marine cyanobacteria.

Sato E, Morita M, Ogawa H, Iwatsuki M, Hokari R, Ishiyama A, Ōmura S, Iwasaki A, Suenaga K.

Bioorg Med Chem Lett. 2018 Feb 1;28(3):298-301. doi: 10.1016/j.bmcl.2017.12.050. Epub 2017 Dec 24.

PMID:
29292225
41.

Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke.

Smith HK, Omura S, Vital SA, Becker F, Senchenkova EY, Kaur G, Tsunoda I, Peirce SM, Gavins FNE.

FASEB J. 2018 May;32(5):2381-2394. doi: 10.1096/fj.201700746R. Epub 2017 Dec 21.

42.

Helicobacter pylori and gut microbiota in multiple sclerosis versus Alzheimer's disease: 10 pitfalls of microbiome studies.

Park AM, Omura S, Fujita M, Sato F, Tsunoda I.

Clin Exp Neuroimmunol. 2017 Aug;8(3):215-232. doi: 10.1111/cen3.12401. Epub 2017 Jul 23.

43.

Chemotherapeutic efficacies of a clofazimine and diminazene aceturate combination against piroplasm parasites and their AT-rich DNA-binding activity on Babesia bovis.

Tuvshintulga B, AbouLaila M, Sivakumar T, Tayebwa DS, Gantuya S, Naranbaatar K, Ishiyama A, Iwatsuki M, Otoguro K, Ōmura S, Terkawi MA, Guswanto A, Rizk MA, Yokoyama N, Igarashi I.

Sci Rep. 2017 Oct 24;7(1):13888. doi: 10.1038/s41598-017-14304-0.

44.

Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters.

Tong Y, Liu M, Zhang Y, Liu X, Huang R, Song F, Dai H, Ren B, Sun N, Pei G, Bian J, Jia XM, Huang G, Zhou X, Li S, Zhang B, Fukuda T, Tomoda H, Ōmura S, Cannon RD, Calderone R, Zhang L.

Synth Syst Biotechnol. 2016 Oct 25;1(3):158-168. doi: 10.1016/j.synbio.2016.10.001. eCollection 2016 Sep.

45.

Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae.

Watanabe Y, Asami Y, Narusawa S, Hashimoto S, Iwatsuki M, Nonaka K, Shinohara Y, Shiotsuki T, Ichimaru N, Miyoshi H, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2017 Oct 11. doi: 10.1038/ja.2017.118. [Epub ahead of print]

PMID:
29018265
46.

Bisoxazolomycin A: a new natural product from 'Streptomyces subflavus subsp. irumaensis' AM-3603.

Koomsiri W, Inahashi Y, Kimura T, Shiomi K, Takahashi Y, Ōmura S, Thamchaipenet A, Nakashima T.

J Antibiot (Tokyo). 2017 Dec;70(12):1142-1145. doi: 10.1038/ja.2017.113. Epub 2017 Sep 27.

PMID:
28951599
47.

Saccharomonospora colocasiae sp. nov., an actinomycete isolated from the rhizosphere of Colocasia esculenta.

Wattanasuepsin W, Intra B, Také A, Inahashi Y, Euanorasetr J, Ōmura S, Matsumoto A, Panbangred W.

Int J Syst Evol Microbiol. 2017 Nov;67(11):4572-4577. doi: 10.1099/ijsem.0.002336. Epub 2017 Sep 25.

PMID:
28945543
48.

T-bet, but not Gata3, overexpression is detrimental in a neurotropic viral infection.

Sato F, Kawai E, Martinez NE, Omura S, Park AM, Takahashi S, Yoh K, Tsunoda I.

Sci Rep. 2017 Sep 5;7(1):10496. doi: 10.1038/s41598-017-10980-0.

49.

Corrigendum: γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Phellinus linteus and their absolute structure determination.

Shirahata T, Ino C, Mizuno F, Asada Y, Hirotani M, Petersson GA, Ōmura S, Yoshikawa T, Kobayashi Y.

J Antibiot (Tokyo). 2017 Aug;70(9):979. doi: 10.1038/ja.2017.71.

PMID:
28845046
50.

Antimalarial troponoids, puberulic acid and viticolins; divergent synthesis and structure-activity relationship studies.

Sennari G, Saito R, Hirose T, Iwatsuki M, Ishiyama A, Hokari R, Otoguro K, Ōmura S, Sunazuka T.

Sci Rep. 2017 Aug 3;7(1):7259. doi: 10.1038/s41598-017-07718-3.

Supplemental Content

Support Center