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Items: 1 to 50 of 129


Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism.

Chen F, Coslo DM, Chen T, Zhang L, Tian Y, Smith PB, Patterson AD, Omiecinski CJ.

J Proteome Res. 2019 Jan 4;18(1):239-251. doi: 10.1021/acs.jproteome.8b00566. Epub 2018 Oct 30.


In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets.

Niu B, Coslo DM, Bataille AR, Albert I, Pugh BF, Omiecinski CJ.

Nucleic Acids Res. 2018 Sep 19;46(16):8385-8403. doi: 10.1093/nar/gky692.


Activation of the Constitutive Androstane Receptor by Monophthalates.

Laurenzana EM, Coslo DM, Vigilar MV, Roman AM, Omiecinski CJ.

Chem Res Toxicol. 2016 Oct 17;29(10):1651-1661. Epub 2016 Sep 13.


Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression.

Girer NG, Murray IA, Omiecinski CJ, Perdew GH.

J Biol Chem. 2016 Jul 15;291(29):15378-87. doi: 10.1074/jbc.M116.715151. Epub 2016 May 25.


Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver.

Hao R, Su S, Wan Y, Shen F, Niu B, Coslo DM, Albert I, Han X, Omiecinski CJ.

Biochim Biophys Acta. 2016 Sep;1859(9):1228-1237. doi: 10.1016/j.bbagrm.2016.04.002. Epub 2016 Apr 11.


Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells.

Takeda S, Ikeda E, Su S, Harada M, Okazaki H, Yoshioka Y, Nishimura H, Ishii H, Kakizoe K, Taniguchi A, Tokuyasu M, Himeno T, Watanabe K, Omiecinski CJ, Aramaki H.

Toxicology. 2014 Dec 4;326:18-24. doi: 10.1016/j.tox.2014.09.011. Epub 2014 Oct 5.


Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.

Wahlang B, Falkner KC, Clair HB, Al-Eryani L, Prough RA, States JC, Coslo DM, Omiecinski CJ, Cave MC.

Toxicol Sci. 2014 Aug 1;140(2):283-97. doi: 10.1093/toxsci/kfu083. Epub 2014 May 8.


Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter.

Su S, Yang X, Omiecinski CJ.

Biochim Biophys Acta. 2014 Jun;1839(6):493-505. doi: 10.1016/j.bbagrm.2014.03.014. Epub 2014 Apr 2.


Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action.

Currie RA, Peffer RC, Goetz AK, Omiecinski CJ, Goodman JI.

Toxicology. 2014 Jul 3;321:80-8. doi: 10.1016/j.tox.2014.03.003. Epub 2014 Mar 24.


Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.

Chen T, Laurenzana EM, Coslo DM, Chen F, Omiecinski CJ.

Biochem J. 2014 Feb 15;458(1):95-107. doi: 10.1042/BJ20130685.


Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.

Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG.

Crit Rev Toxicol. 2014 Jan;44(1):64-82. doi: 10.3109/10408444.2013.835786. Epub 2013 Nov 4. Review.


The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells.

Chen F, Zamule SM, Coslo DM, Chen T, Omiecinski CJ.

Dev Biol. 2013 Dec 15;384(2):155-65. doi: 10.1016/j.ydbio.2013.10.012. Epub 2013 Oct 18.


Δ(9)-Tetrahydrocannabinol disrupts estrogen-signaling through up-regulation of estrogen receptor β (ERβ).

Takeda S, Yoshida K, Nishimura H, Harada M, Okajima S, Miyoshi H, Okamoto Y, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H.

Chem Res Toxicol. 2013 Jul 15;26(7):1073-9. doi: 10.1021/tx4000446. Epub 2013 Jun 11.


Induction of the fatty acid 2-hydroxylase (FA2H) gene by Δ(9)-tetrahydrocannabinol in human breast cancer cells.

Takeda S, Harada M, Su S, Okajima S, Miyoshi H, Yoshida K, Nishimura H, Okamoto Y, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H.

J Toxicol Sci. 2013;38(2):305-8.


(-)-Xanthatin up-regulation of the GADD45γ tumor suppressor gene in MDA-MB-231 breast cancer cells: role of topoisomerase IIα inhibition and reactive oxygen species.

Takeda S, Noguchi M, Matsuo K, Yamaguchi Y, Kudo T, Nishimura H, Okamoto Y, Amamoto T, Shindo M, Omiecinski CJ, Aramaki H.

Toxicology. 2013 Mar 8;305:1-9. doi: 10.1016/j.tox.2012.12.019. Epub 2013 Jan 8.


Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.

Takeda S, Okajima S, Miyoshi H, Yoshida K, Okamoto Y, Okada T, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H.

Toxicol Lett. 2012 Nov 15;214(3):314-9. doi: 10.1016/j.toxlet.2012.08.029. Epub 2012 Sep 8.


The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).

Laurenzana EM, Chen T, Kannuswamy M, Sell BE, Strom SC, Li Y, Omiecinski CJ.

Mol Pharmacol. 2012 Nov;82(5):918-28. doi: 10.1124/mol.112.080721. Epub 2012 Aug 15.


Cannabidiol-2',6'-dimethyl ether as an effective protector of 15-lipoxygenase-mediated low-density lipoprotein oxidation in vitro.

Takeda S, Hirayama A, Urata S, Mano N, Fukagawa K, Imamura M, Irii A, Kitajima S, Masuyama T, Nomiyama M, Tatei S, Tomita S, Kudo T, Noguchi M, Yamaguchi Y, Okamoto Y, Amamoto T, Fukunishi Y, Watanabe K, Omiecinski CJ, Aramaki H.

Biol Pharm Bull. 2011;34(8):1252-6.


Multi-species analyses of direct activators of the constitutive androstane receptor.

Omiecinski CJ, Coslo DM, Chen T, Laurenzana EM, Peffer RC.

Toxicol Sci. 2011 Oct;123(2):550-62. doi: 10.1093/toxsci/kfr191. Epub 2011 Jul 21.


(--)-Xanthatin selectively induces GADD45γ and stimulates caspase-independent cell death in human breast cancer MDA-MB-231 cells.

Takeda S, Matsuo K, Yaji K, Okajima-Miyazaki S, Harada M, Miyoshi H, Okamoto Y, Amamoto T, Shindo M, Omiecinski CJ, Aramaki H.

Chem Res Toxicol. 2011 Jun 20;24(6):855-65. doi: 10.1021/tx200046s. Epub 2011 May 13.


Differentiation of human embryonic stem cells along a hepatic lineage.

Zamule SM, Coslo DM, Chen F, Omiecinski CJ.

Chem Biol Interact. 2011 Mar 15;190(1):62-72. doi: 10.1016/j.cbi.2011.01.009. Epub 2011 Jan 15.


Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor.

DeKeyser JG, Laurenzana EM, Peterson EC, Chen T, Omiecinski CJ.

Toxicol Sci. 2011 Apr;120(2):381-91. doi: 10.1093/toxsci/kfq394. Epub 2011 Jan 12.


Bioassay-directed fractionation for discovery of bioactive neutral lipids guided by relative mass defect filtering and multiplexed collision-induced dissociation.

Stagliano MC, DeKeyser JG, Omiecinski CJ, Jones AD.

Rapid Commun Mass Spectrom. 2010 Dec 30;24(24):3578-84. doi: 10.1002/rcm.4796.


Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities.

Omiecinski CJ, Vanden Heuvel JP, Perdew GH, Peters JM.

Toxicol Sci. 2011 Mar;120 Suppl 1:S49-75. doi: 10.1093/toxsci/kfq338. Epub 2010 Nov 8. Review.


Hepatocyte differentiation.

Olsavsky Goyak KM, Laurenzana EM, Omiecinski CJ.

Methods Mol Biol. 2010;640:115-38. doi: 10.1007/978-1-60761-688-7_6.


Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling.

DiNatale BC, Murray IA, Schroeder JC, Flaveny CA, Lahoti TS, Laurenzana EM, Omiecinski CJ, Perdew GH.

Toxicol Sci. 2010 May;115(1):89-97. doi: 10.1093/toxsci/kfq024. Epub 2010 Jan 27.


The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor.

Schroeder JC, Dinatale BC, Murray IA, Flaveny CA, Liu Q, Laurenzana EM, Lin JM, Strom SC, Omiecinski CJ, Amin S, Perdew GH.

Biochemistry. 2010 Jan 19;49(2):393-400. doi: 10.1021/bi901786x.


Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes.

Moody DE, Fang WB, Lin SN, Weyant DM, Strom SC, Omiecinski CJ.

Drug Metab Dispos. 2009 Dec;37(12):2323-9. doi: 10.1124/dmd.109.028605. Epub 2009 Sep 22.


The expression of human microsomal epoxide hydrolase is predominantly driven by a genetically polymorphic far upstream promoter.

Yang X, Liang SH, Weyant DM, Lazarus P, Gallagher CJ, Omiecinski CJ.

J Pharmacol Exp Ther. 2009 Jul;330(1):23-30. doi: 10.1124/jpet.109.150870. Epub 2009 Apr 13.


Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.

DeKeyser JG, Stagliano MC, Auerbach SS, Prabhu KS, Jones AD, Omiecinski CJ.

Mol Pharmacol. 2009 May;75(5):1005-13. doi: 10.1124/mol.108.053702. Epub 2009 Feb 11.


Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures.

Goyak KM, Johnson MC, Strom SC, Omiecinski CJ.

Toxicol Appl Pharmacol. 2008 Sep 1;231(2):216-24. doi: 10.1016/j.taap.2008.04.024. Epub 2008 May 10.


Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes.

Zamule SM, Strom SC, Omiecinski CJ.

Chem Biol Interact. 2008 Jun 17;173(3):179-86. doi: 10.1016/j.cbi.2008.03.015. Epub 2008 Apr 8.


Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action.

Bogen KT, Benson JM, Yost GS, Morris JB, Dahl AR, Clewell HJ 3rd, Krishnan K, Omiecinski CJ.

Regul Toxicol Pharmacol. 2008 Jul;51(2 Suppl):S27-36. doi: 10.1016/j.yrtph.2007.10.018. Epub 2007 Nov 22.


Regulation of the human cathepsin E gene by the constitutive androstane receptor.

Page JL, Strom SC, Omiecinski CJ.

Arch Biochem Biophys. 2007 Nov 1;467(1):132-8. Epub 2007 Aug 19.


Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver.

Patel RD, Hollingshead BD, Omiecinski CJ, Perdew GH.

Hepatology. 2007 Jul;46(1):209-18.


Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues.

Olsavsky KM, Page JL, Johnson MC, Zarbl H, Strom SC, Omiecinski CJ.

Toxicol Appl Pharmacol. 2007 Jul 1;222(1):42-56. Epub 2007 Apr 21.


Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites.

Stoner MA, Auerbach SS, Zamule SM, Strom SC, Omiecinski CJ.

Nucleic Acids Res. 2007;35(7):2177-90. Epub 2007 Mar 13.


Gene expression profiling of extracellular matrix as an effector of human hepatocyte phenotype in primary cell culture.

Page JL, Johnson MC, Olsavsky KM, Strom SC, Zarbl H, Omiecinski CJ.

Toxicol Sci. 2007 Jun;97(2):384-97. Epub 2007 Feb 27.


CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.

Auerbach SS, Dekeyser JG, Stoner MA, Omiecinski CJ.

Drug Metab Dispos. 2007 Mar;35(3):428-39. Epub 2006 Dec 28.


Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.

Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H.

J Pharmacol Exp Ther. 2007 Jan;320(1):72-80. Epub 2006 Oct 13.


Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region of the microsomal epoxide hydrolase gene (EPHX1).

Abdel-Rahman SZ, Ammenheuser MM, Omiecinski CJ, Wickliffe JK, Rosenblatt JI, Ward JB Jr.

Toxicol Sci. 2005 May;85(1):624-31. Epub 2005 Feb 16.


Functional analysis of human microsomal epoxide hydrolase genetic variants.

Hosagrahara VP, Rettie AE, Hassett C, Omiecinski CJ.

Chem Biol Interact. 2004 Nov 20;150(2):149-59.


Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1).

Liang SH, Hassett C, Omiecinski CJ.

Mol Pharmacol. 2005 Jan;67(1):220-30. Epub 2004 Oct 1.


Comparison of genomic and cDNA sequences of guinea pig CYP2B18 and rat CYP2B2: absence of a phenobarbital-responsive enhancer module in the upstream region of the CYP2B18 gene.

Yamamoto M, Mise M, Matsumoto S, Ito S, Gohyama N, Ishida S, Sagara Y, Omiecinski CJ, Oguri K, Yamada H.

J Biochem Mol Toxicol. 2004;18(3):124-30.


Alternatively spliced isoforms of the human constitutive androstane receptor.

Auerbach SS, Ramsden R, Stoner MA, Verlinde C, Hassett C, Omiecinski CJ.

Nucleic Acids Res. 2003 Jun 15;31(12):3194-207.


Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease.

Farin FM, Janssen P, Quigley S, Abbott D, Hassett C, Smith-Weller T, Franklin GM, Swanson PD, Longstreth WT Jr, Omiecinski CJ, Checkoway H.

Pharmacogenetics. 2001 Nov;11(8):703-8.


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