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Items: 1 to 50 of 82

1.

Cardiovascular models for personalised medicine: Where now and where next?

Hose DR, Lawford PV, Huberts W, Hellevik LR, Omholt SW, van de Vosse FN.

Med Eng Phys. 2019 Oct;72:38-48. doi: 10.1016/j.medengphy.2019.08.007.

PMID:
31554575
2.

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow.

Holter KE, Kehlet B, Devor A, Sejnowski TJ, Dale AM, Omholt SW, Ottersen OP, Nagelhus EA, Mardal KA, Pettersen KH.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9894-9899. doi: 10.1073/pnas.1706942114. Epub 2017 Aug 28.

3.

Functional Annotation of All Salmonid Genomes (FAASG): an international initiative supporting future salmonid research, conservation and aquaculture.

Macqueen DJ, Primmer CR, Houston RD, Nowak BF, Bernatchez L, Bergseth S, Davidson WS, Gallardo-Escárate C, Goldammer T, Guiguen Y, Iturra P, Kijas JW, Koop BF, Lien S, Maass A, Martin SAM, McGinnity P, Montecino M, Naish KA, Nichols KM, Ólafsson K, Omholt SW, Palti Y, Plastow GS, Rexroad CE Rd, Rise ML, Ritchie RJ, Sandve SR, Schulte PM, Tello A, Vidal R, Vik JO, Wargelius A, Yáñez JM; FAASG Consortium.

BMC Genomics. 2017 Jun 27;18(1):484. doi: 10.1186/s12864-017-3862-8.

4.

Disentangling genetic and epigenetic determinants of ultrafast adaptation.

Gjuvsland AB, Zörgö E, Samy JK, Stenberg S, Demirsoy IH, Roque F, Maciaszczyk-Dziubinska E, Migocka M, Alonso-Perez E, Zackrisson M, Wysocki R, Tamás MJ, Jonassen I, Omholt SW, Warringer J.

Mol Syst Biol. 2016 Dec 15;12(12):892. doi: 10.15252/msb.20166951.

5.

Roadmap for cardiovascular circulation model.

Safaei S, Bradley CP, Suresh V, Mithraratne K, Muller A, Ho H, Ladd D, Hellevik LR, Omholt SW, Chase JG, Müller LO, Watanabe SM, Blanco PJ, de Bono B, Hunter PJ.

J Physiol. 2016 Dec 1;594(23):6909-6928. doi: 10.1113/JP272660. Epub 2016 Sep 29.

6.

A novel role for pigment genes in the stress response in rainbow trout (Oncorhynchus mykiss).

Khan UW, Øverli Ø, Hinkle PM, Pasha FA, Johansen IB, Berget I, Silva PI, Kittilsen S, Höglund E, Omholt SW, Våge DI.

Sci Rep. 2016 Jul 4;6:28969. doi: 10.1038/srep28969.

7.

Scan-o-matic: High-Resolution Microbial Phenomics at a Massive Scale.

Zackrisson M, Hallin J, Ottosson LG, Dahl P, Fernandez-Parada E, Ländström E, Fernandez-Ricaud L, Kaferle P, Skyman A, Stenberg S, Omholt S, Petrovič U, Warringer J, Blomberg A.

G3 (Bethesda). 2016 Sep 8;6(9):3003-14. doi: 10.1534/g3.116.032342.

8.

The Atlantic salmon genome provides insights into rediploidization.

Lien S, Koop BF, Sandve SR, Miller JR, Kent MP, Nome T, Hvidsten TR, Leong JS, Minkley DR, Zimin A, Grammes F, Grove H, Gjuvsland A, Walenz B, Hermansen RA, von Schalburg K, Rondeau EB, Di Genova A, Samy JK, Olav Vik J, Vigeland MD, Caler L, Grimholt U, Jentoft S, Våge DI, de Jong P, Moen T, Baranski M, Palti Y, Smith DR, Yorke JA, Nederbragt AJ, Tooming-Klunderud A, Jakobsen KS, Jiang X, Fan D, Hu Y, Liberles DA, Vidal R, Iturra P, Jones SJ, Jonassen I, Maass A, Omholt SW, Davidson WS.

Nature. 2016 May 12;533(7602):200-5. doi: 10.1038/nature17164. Epub 2016 Apr 18.

PMID:
27088604
9.

Towards causally cohesive genotype-phenotype modelling for characterization of the soft-tissue mechanics of the heart in normal and pathological geometries.

Nordbø Ø, Gjuvsland AB, Nermoen A, Land S, Niederer S, Lamata P, Lee J, Smith NP, Omholt SW, Vik JO.

J R Soc Interface. 2015 May 6;12(106). pii: 20141166. doi: 10.1098/rsif.2014.1166.

10.

High-throughput biochemical fingerprinting of Saccharomyces cerevisiae by Fourier transform infrared spectroscopy.

Kohler A, Böcker U, Shapaval V, Forsmark A, Andersson M, Warringer J, Martens H, Omholt SW, Blomberg A.

PLoS One. 2015 Feb 23;10(2):e0118052. doi: 10.1371/journal.pone.0118052. eCollection 2015.

11.

150 years of the mass action law.

Voit EO, Martens HA, Omholt SW.

PLoS Comput Biol. 2015 Jan 8;11(1):e1004012. doi: 10.1371/journal.pcbi.1004012. eCollection 2015 Jan.

12.

Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.

Ibstedt S, Stenberg S, Bagés S, Gjuvsland AB, Salinas F, Kourtchenko O, Samy JK, Blomberg A, Omholt SW, Liti G, Beltran G, Warringer J.

Mol Biol Evol. 2015 Jan;32(1):153-61. doi: 10.1093/molbev/msu285. Epub 2014 Oct 27.

PMID:
25349282
13.

A computational pipeline for quantification of mouse myocardial stiffness parameters.

Nordbø O, Lamata P, Land S, Niederer S, Aronsen JM, Louch WE, Sjaastad I, Martens H, Gjuvsland AB, Tøndel K, Torp H, Lohezic M, Schneider JE, Remme EW, Smith N, Omholt SW, Vik JO.

Comput Biol Med. 2014 Oct;53:65-75. doi: 10.1016/j.compbiomed.2014.07.013. Epub 2014 Aug 2.

14.

Evolution evolves: physiology returns to centre stage.

Noble D, Jablonka E, Joyner MJ, Müller GB, Omholt SW.

J Physiol. 2014 Jun 1;592(11):2237-44. doi: 10.1113/jphysiol.2014.273151. No abstract available.

15.

Arterial stiffening provides sufficient explanation for primary hypertension.

Pettersen KH, Bugenhagen SM, Nauman J, Beard DA, Omholt SW.

PLoS Comput Biol. 2014 May 22;10(5):e1003634. doi: 10.1371/journal.pcbi.1003634. eCollection 2014 May.

16.

The evolution and functional divergence of the beta-carotene oxygenase gene family in teleost fish--exemplified by Atlantic salmon.

Helgeland H, Sandve SR, Torgersen JS, Halle MK, Sundvold H, Omholt S, Våge DI.

Gene. 2014 Jun 15;543(2):268-74. doi: 10.1016/j.gene.2014.02.042. Epub 2014 Feb 26.

PMID:
24583166
17.

A computational analysis of the long-term regulation of arterial pressure.

Beard DA, Pettersen KH, Carlson BE, Omholt SW, Bugenhagen SM.

Version 2. F1000Res. 2013 Oct 8 [revised 2013 Jan 1];2:208. doi: 10.12688/f1000research.2-208.v2. eCollection 2013.

18.

A vision and strategy for the virtual physiological human: 2012 update.

Hunter P, Chapman T, Coveney PV, de Bono B, Diaz V, Fenner J, Frangi AF, Harris P, Hose R, Kohl P, Lawford P, McCormack K, Mendes M, Omholt S, Quarteroni A, Shublaq N, Skår J, Stroetmann K, Tegner J, Thomas SR, Tollis I, Tsamardinos I, van Beek JH, Viceconti M.

Interface Focus. 2013 Apr 6;3(2):20130004. doi: 10.1098/rsfs.2013.0004.

19.

Electrodiffusive model for astrocytic and neuronal ion concentration dynamics.

Halnes G, Ostby I, Pettersen KH, Omholt SW, Einevoll GT.

PLoS Comput Biol. 2013;9(12):e1003386. doi: 10.1371/journal.pcbi.1003386. Epub 2013 Dec 19.

20.

Monotonicity is a key feature of genotype-phenotype maps.

Gjuvsland AB, Wang Y, Plahte E, Omholt SW.

Front Genet. 2013 Nov 7;4:216. doi: 10.3389/fgene.2013.00216. eCollection 2013.

21.

Life-history evolution and the polyphenic regulation of somatic maintenance and survival.

Flatt T, Amdam GV, Kirkwood TB, Omholt SW.

Q Rev Biol. 2013 Sep;88(3):185-218. Review.

PMID:
24053071
22.

Propagation of genetic variation in gene regulatory networks.

Plahte E, Gjuvsland AB, Omholt SW.

Physica D. 2013 Aug 1;256-257:7-20.

23.

Effect of regulatory architecture on broad versus narrow sense heritability.

Wang Y, Vik JO, Omholt SW, Gjuvsland AB.

PLoS Comput Biol. 2013;9(5):e1003053. doi: 10.1371/journal.pcbi.1003053. Epub 2013 May 9.

24.

Ancient evolutionary trade-offs between yeast ploidy states.

Zörgö E, Chwialkowska K, Gjuvsland AB, Garré E, Sunnerhagen P, Liti G, Blomberg A, Omholt SW, Warringer J.

PLoS Genet. 2013 Mar;9(3):e1003388. doi: 10.1371/journal.pgen.1003388. Epub 2013 Mar 21.

25.

Bridging the genotype-phenotype gap: what does it take?

Gjuvsland AB, Vik JO, Beard DA, Hunter PJ, Omholt SW.

J Physiol. 2013 Apr 15;591(8):2055-66. doi: 10.1113/jphysiol.2012.248864. Epub 2013 Feb 11. Review.

26.

Interpreting genetic effects through models of cardiac electromechanics.

Niederer SA, Land S, Omholt SW, Smith NP.

Am J Physiol Heart Circ Physiol. 2012 Dec 1;303(11):H1294-303. doi: 10.1152/ajpheart.00121.2012. Epub 2012 Oct 5. Review.

27.

From sequence to consequence and back.

Omholt SW.

Prog Biophys Mol Biol. 2013 Apr;111(2-3):75-82. doi: 10.1016/j.pbiomolbio.2012.09.003. Epub 2012 Sep 25.

28.

Multi-way metamodelling facilitates insight into the complex input-output maps of nonlinear dynamic models.

Tøndel K, Indahl UG, Gjuvsland AB, Omholt SW, Martens H.

BMC Syst Biol. 2012 Jul 20;6:88. doi: 10.1186/1752-0509-6-88.

29.

Understanding the melanocyte distribution in human epidermis: an agent-based computational model approach.

Thingnes J, Lavelle TJ, Hovig E, Omholt SW.

PLoS One. 2012;7(7):e40377. doi: 10.1371/journal.pone.0040377. Epub 2012 Jul 9.

30.

Parameters in dynamic models of complex traits are containers of missing heritability.

Wang Y, Gjuvsland AB, Vik JO, Smith NP, Hunter PJ, Omholt SW.

PLoS Comput Biol. 2012;8(4):e1002459. doi: 10.1371/journal.pcbi.1002459. Epub 2012 Apr 5.

31.

Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus.

Haj-Yasein NN, Jensen V, Østby I, Omholt SW, Voipio J, Kaila K, Ottersen OP, Hvalby Ø, Nagelhus EA.

Glia. 2012 May;60(6):867-74. doi: 10.1002/glia.22319. Epub 2012 Mar 14.

PMID:
22419561
32.

Life history shapes trait heredity by accumulation of loss-of-function alleles in yeast.

Zörgö E, Gjuvsland A, Cubillos FA, Louis EJ, Liti G, Blomberg A, Omholt SW, Warringer J.

Mol Biol Evol. 2012 Jul;29(7):1781-9. doi: 10.1093/molbev/mss019. Epub 2012 Jan 20.

PMID:
22319169
33.

Towards a quantitative understanding of the MITF-PIAS3-STAT3 connection.

Thingnes J, Lavelle TJ, Gjuvsland AB, Omholt SW, Hovig E.

BMC Syst Biol. 2012 Feb 8;6:11. doi: 10.1186/1752-0509-6-11.

34.

Genotype-Phenotype Map Characteristics of an In silico Heart Cell.

Vik JO, Gjuvsland AB, Li L, Tøndel K, Niederer S, Smith NP, Hunter PJ, Omholt SW.

Front Physiol. 2011 Dec 28;2:106. doi: 10.3389/fphys.2011.00106. eCollection 2011.

35.

A dense SNP-based linkage map for Atlantic salmon (Salmo salar) reveals extended chromosome homeologies and striking differences in sex-specific recombination patterns.

Lien S, Gidskehaug L, Moen T, Hayes BJ, Berg PR, Davidson WS, Omholt SW, Kent MP.

BMC Genomics. 2011 Dec 19;12:615. doi: 10.1186/1471-2164-12-615.

36.

Is the brain water channel aquaporin-4 a pathogenetic factor in idiopathic intracranial hypertension? Results from a combined clinical and genetic study in a Norwegian cohort.

Kerty E, Heuser K, Indahl UG, Berg PR, Nakken S, Lien S, Omholt SW, Ottersen OP, Nagelhus EA.

Acta Ophthalmol. 2013 Feb;91(1):88-91. doi: 10.1111/j.1755-3768.2011.02231.x. Epub 2011 Sep 13.

37.

The genome sequence of Atlantic cod reveals a unique immune system.

Star B, Nederbragt AJ, Jentoft S, Grimholt U, Malmstrøm M, Gregers TF, Rounge TB, Paulsen J, Solbakken MH, Sharma A, Wetten OF, Lanzén A, Winer R, Knight J, Vogel JH, Aken B, Andersen O, Lagesen K, Tooming-Klunderud A, Edvardsen RB, Tina KG, Espelund M, Nepal C, Previti C, Karlsen BO, Moum T, Skage M, Berg PR, Gjøen T, Kuhl H, Thorsen J, Malde K, Reinhardt R, Du L, Johansen SD, Searle S, Lien S, Nilsen F, Jonassen I, Omholt SW, Stenseth NC, Jakobsen KS.

Nature. 2011 Aug 10;477(7363):207-10. doi: 10.1038/nature10342.

38.

Order-preserving principles underlying genotype-phenotype maps ensure high additive proportions of genetic variance.

Gjuvsland AB, Vik JO, Woolliams JA, Omholt SW.

J Evol Biol. 2011 Oct;24(10):2269-79. doi: 10.1111/j.1420-9101.2011.02358.x. Epub 2011 Aug 10.

39.

OpenCMISS: a multi-physics & multi-scale computational infrastructure for the VPH/Physiome project.

Bradley C, Bowery A, Britten R, Budelmann V, Camara O, Christie R, Cookson A, Frangi AF, Gamage TB, Heidlauf T, Krittian S, Ladd D, Little C, Mithraratne K, Nash M, Nickerson D, Nielsen P, Nordbø O, Omholt S, Pashaei A, Paterson D, Rajagopal V, Reeve A, Röhrle O, Safaei S, Sebastián R, Steghöfer M, Wu T, Yu T, Zhang H, Hunter P.

Prog Biophys Mol Biol. 2011 Oct;107(1):32-47. doi: 10.1016/j.pbiomolbio.2011.06.015. Epub 2011 Jul 7.

PMID:
21762717
40.

Trait variation in yeast is defined by population history.

Warringer J, Zörgö E, Cubillos FA, Zia A, Gjuvsland A, Simpson JT, Forsmark A, Durbin R, Omholt SW, Louis EJ, Liti G, Moses A, Blomberg A.

PLoS Genet. 2011 Jun;7(6):e1002111. doi: 10.1371/journal.pgen.1002111. Epub 2011 Jun 16.

41.

Dependence of spontaneous neuronal firing and depolarisation block on astroglial membrane transport mechanisms.

Øyehaug L, Østby I, Lloyd CM, Omholt SW, Einevoll GT.

J Comput Neurosci. 2012 Feb;32(1):147-65. doi: 10.1007/s10827-011-0345-9. Epub 2011 Jun 11.

PMID:
21667153
42.

Hierarchical cluster-based partial least squares regression (HC-PLSR) is an efficient tool for metamodelling of nonlinear dynamic models.

Tøndel K, Indahl UG, Gjuvsland AB, Vik JO, Hunter P, Omholt SW, Martens H.

BMC Syst Biol. 2011 Jun 1;5:90. doi: 10.1186/1752-0509-5-90.

43.

Characterisation of a novel paralog of scavenger receptor class B member I (SCARB1) in Atlantic salmon (Salmo salar).

Sundvold H, Helgeland H, Baranski M, Omholt SW, Våge DI.

BMC Genet. 2011 May 30;12:52. doi: 10.1186/1471-2156-12-52.

44.

Methods for and results from the study of design principles in molecular systems.

Salvado B, Karathia H, Chimenos AU, Vilaprinyo E, Omholt S, Sorribas A, Alves R.

Math Biosci. 2011 May;231(1):3-18. doi: 10.1016/j.mbs.2011.02.005. Epub 2011 Feb 15. Review.

PMID:
21329702
45.

Assessing the complex architecture of polygenic traits in diverged yeast populations.

Cubillos FA, Billi E, Zörgö E, Parts L, Fargier P, Omholt S, Blomberg A, Warringer J, Louis EJ, Liti G.

Mol Ecol. 2011 Apr;20(7):1401-13. doi: 10.1111/j.1365-294X.2011.05005.x. Epub 2011 Jan 25.

PMID:
21261765
46.

Phenomics: the next challenge.

Houle D, Govindaraju DR, Omholt S.

Nat Rev Genet. 2010 Dec;11(12):855-66. doi: 10.1038/nrg2897. Review.

PMID:
21085204
47.

Sequencing the genome of the Atlantic salmon (Salmo salar).

Davidson WS, Koop BF, Jones SJ, Iturra P, Vidal R, Maass A, Jonassen I, Lien S, Omholt SW.

Genome Biol. 2010;11(9):403. doi: 10.1186/gb-2010-11-9-403. Epub 2010 Sep 30.

48.

A vision and strategy for the virtual physiological human in 2010 and beyond.

Hunter P, Coveney PV, de Bono B, Diaz V, Fenner J, Frangi AF, Harris P, Hose R, Kohl P, Lawford P, McCormack K, Mendes M, Omholt S, Quarteroni A, Skår J, Tegner J, Randall Thomas S, Tollis I, Tsamardinos I, van Beek JH, Viceconti M.

Philos Trans A Math Phys Eng Sci. 2010 Jun 13;368(1920):2595-614. doi: 10.1098/rsta.2010.0048.

49.

Allele interaction--single locus genetics meets regulatory biology.

Gjuvsland AB, Plahte E, Adnøy T, Omholt SW.

PLoS One. 2010 Feb 23;5(2):e9379. doi: 10.1371/journal.pone.0009379.

50.

BAC-based upgrading and physical integration of a genetic SNP map in Atlantic salmon.

Lorenz S, Brenna-Hansen S, Moen T, Roseth A, Davidson WS, Omholt SW, Lien S.

Anim Genet. 2010 Feb;41(1):48-54. doi: 10.1111/j.1365-2052.2009.01963.x. Epub 2009 Nov 16.

PMID:
19917045

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