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Items: 1 to 50 of 114

1.

Secretion analysis of intracellular "difficult-to-express" immunoglobulin G (IgG) in Chinese hamster ovary (CHO) cells.

Kaneyoshi K, Kuroda K, Uchiyama K, Onitsuka M, Yamano-Adachi N, Koga Y, Omasa T.

Cytotechnology. 2019 Feb;71(1):305-316. doi: 10.1007/s10616-018-0286-5. Epub 2019 Jan 12.

PMID:
30637508
2.

Analysis of the immunoglobulin G (IgG) secretion efficiency in recombinant Chinese hamster ovary (CHO) cells by using Citrine-fusion IgG.

Kaneyoshi K, Yamano-Adachi N, Koga Y, Uchiyama K, Omasa T.

Cytotechnology. 2019 Feb;71(1):193-207. doi: 10.1007/s10616-018-0276-7. Epub 2019 Jan 4.

PMID:
30610509
3.

Secretory leakage of IgG1 aggregates from recombinant Chinese hamster ovary cells.

Onitsuka M, Kadoya Y, Omasa T.

J Biosci Bioeng. 2019 Jun;127(6):752-757. doi: 10.1016/j.jbiosc.2018.11.015. Epub 2018 Dec 21.

PMID:
30580968
4.

The Healing Effect of Human Milk Fat Globule-EGF Factor 8 Protein (MFG-E8) in A Rat Model of Parkinson's Disease.

Nakashima Y, Miyagi-Shiohira C, Noguchi H, Omasa T.

Brain Sci. 2018 Aug 31;8(9). pii: E167. doi: 10.3390/brainsci8090167.

5.

EGCG improves recombinant protein productivity in Chinese hamster ovary cell cultures via cell proliferation control.

Yamano N, Omasa T.

Cytotechnology. 2018 Dec;70(6):1697-1706. doi: 10.1007/s10616-018-0243-3. Epub 2018 Aug 1.

PMID:
30069612
6.

Analysis of intracellular IgG secretion in Chinese hamster ovary cells to improve IgG production.

Kaneyoshi K, Uchiyama K, Onitsuka M, Yamano N, Koga Y, Omasa T.

J Biosci Bioeng. 2019 Jan;127(1):107-113. doi: 10.1016/j.jbiosc.2018.06.018. Epub 2018 Jul 13.

PMID:
30017708
7.

Genome sequence comparison between Chinese hamster ovary (CHO) DG44 cells and mouse using end sequences of CHO BAC clones based on BAC-FISH results.

Kimura S, Omasa T.

Cytotechnology. 2018 Oct;70(5):1399-1407. doi: 10.1007/s10616-018-0233-5. Epub 2018 Jul 9.

PMID:
29987698
8.

Atorvastatin Inhibits the HIF1α-PPAR Axis, Which Is Essential for Maintaining the Function of Human Induced Pluripotent Stem Cells.

Nakashima Y, Miyagi-Shiohira C, Noguchi H, Omasa T.

Mol Ther. 2018 Jul 5;26(7):1715-1734. doi: 10.1016/j.ymthe.2018.06.005. Epub 2018 Jun 19.

9.

Development of hyper osmotic resistant CHO host cells for enhanced antibody production.

Kamachi Y, Omasa T.

J Biosci Bioeng. 2018 Apr;125(4):470-478. doi: 10.1016/j.jbiosc.2017.11.002. Epub 2017 Dec 8.

PMID:
29233458
10.

Enhanced IgG1 production by overexpression of nuclear factor kappa B inhibitor zeta (NFKBIZ) in Chinese hamster ovary cells.

Onitsuka M, Kinoshita Y, Nishizawa A, Tsutsui T, Omasa T.

Cytotechnology. 2018 Apr;70(2):675-685. doi: 10.1007/s10616-017-0170-8. Epub 2017 Nov 29.

11.

The enhancement of antibody concentration and achievement of high cell density CHO cell cultivation by adding nucleoside.

Takagi Y, Kikuchi T, Wada R, Omasa T.

Cytotechnology. 2017 Jun;69(3):511-521. doi: 10.1007/s10616-017-0066-7. Epub 2017 Mar 2.

12.

Improved recombinant antibody production by CHO cells using a production enhancer DNA element with repeated transgene integration at a predetermined chromosomal site.

Kawabe Y, Inao T, Komatsu S, Huang G, Ito A, Omasa T, Kamihira M.

J Biosci Bioeng. 2017 Mar;123(3):390-397. doi: 10.1016/j.jbiosc.2016.10.011. Epub 2016 Nov 14.

PMID:
27856232
13.

Lengthening of high-yield production levels of monoclonal antibody-producing Chinese hamster ovary cells by downregulation of breast cancer 1.

Matsuyama R, Yamano N, Kawamura N, Omasa T.

J Biosci Bioeng. 2017 Mar;123(3):382-389. doi: 10.1016/j.jbiosc.2016.09.006. Epub 2016 Oct 12.

PMID:
27742176
14.

Identification of regulatory motifs in the CHO genome for stable monoclonal antibody production.

Takagi Y, Yamazaki T, Masuda K, Nishii S, Kawakami B, Omasa T.

Cytotechnology. 2017 Jun;69(3):451-460. doi: 10.1007/s10616-016-0017-8. Epub 2016 Aug 20.

15.

Application of Unfolded Protein Response for Production of Biologics.

Omasa T.

Yakugaku Zasshi. 2016;136(6):831-9. doi: 10.1248/yakushi.15-00292-6. Review. Japanese.

16.

What Kind of Signaling Maintains Pluripotency and Viability in Human-Induced Pluripotent Stem Cells Cultured on Laminin-511 with Serum-Free Medium?

Nakashima Y, Omasa T.

Biores Open Access. 2016 Apr 1;5(1):84-93. doi: 10.1089/biores.2016.0001. eCollection 2016. Review.

17.

Increased recombinant protein production owing to expanded opportunities for vector integration in high chromosome number Chinese hamster ovary cells.

Yamano N, Takahashi M, Ali Haghparast SM, Onitsuka M, Kumamoto T, Frank J, Omasa T.

J Biosci Bioeng. 2016 Aug;122(2):226-31. doi: 10.1016/j.jbiosc.2016.01.002. Epub 2016 Feb 2.

PMID:
26850366
18.

Metabolic analysis of antibody producing Chinese hamster ovary cell culture under different stresses conditions.

Badsha MB, Kurata H, Onitsuka M, Oga T, Omasa T.

J Biosci Bioeng. 2016 Jul;122(1):117-24. doi: 10.1016/j.jbiosc.2015.12.013. Epub 2016 Jan 21.

PMID:
26803706
19.

Rapid Colorimetric Antibody Detection Using a Dual-function Peptide Probe for Silver Nanoparticle Aggregation and Antibody Recognition.

Okochi M, Kamiya T, Omasa T, Tanaka M, Honda H.

Anal Sci. 2016;32(1):93-7. doi: 10.2116/analsci.32.93.

20.

Improved Photobactericidal Activity of Ultraviolet-A Light in Combination with Isomerizable p-Coumaric Acid Derivatives.

Akihiro S, Kajiura M, Matsumura K, Omasa T.

Biocontrol Sci. 2015;20(4):231-8. doi: 10.4265/bio.20.231.

21.

Approaches to Quality Risk Management When Using Single-Use Systems in the Manufacture of Biologics.

Ishii-Watabe A, Hirose A, Katori N, Hashii N, Arai S, Awatsu H, Eiza A, Hara Y, Hattori H, Inoue T, Isono T, Iwakura M, Kajihara D, Kasahara N, Matsuda H, Murakami S, Nakagawa T, Okumura T, Omasa T, Takuma S, Terashima I, Tsukahara M, Tsutsui M, Yano T, Kawasaki N.

AAPS PharmSciTech. 2015 Oct;16(5):993-1001. doi: 10.1208/s12249-015-0368-z. Epub 2015 Aug 20.

22.

Synergistic Photobactericidal Activity Based on Ultraviolet-A Irradiation and Ferulic Acid Derivatives.

Shirai A, Kajiura M, Omasa T.

Photochem Photobiol. 2015 Nov;91(6):1422-8. doi: 10.1111/php.12507. Epub 2015 Sep 15.

PMID:
26268548
23.

Improved gene amplification by cell-cycle engineering combined with the Cre-loxP system in Chinese hamster ovary cells.

Matsuyama R, Tsutsui T, Lee KH, Onitsuka M, Omasa T.

J Biosci Bioeng. 2015 Dec;120(6):701-8. doi: 10.1016/j.jbiosc.2015.04.009. Epub 2015 Jun 21.

PMID:
26108159
24.
25.

Optimization of cell line development in the GS-CHO expression system using a high-throughput, single cell-based clone selection system.

Nakamura T, Omasa T.

J Biosci Bioeng. 2015 Sep;120(3):323-9. doi: 10.1016/j.jbiosc.2015.01.002. Epub 2015 Mar 17.

PMID:
25792187
26.

Efficient enrichment of high-producing recombinant Chinese hamster ovary cells for monoclonal antibody by flow cytometry.

Okumura T, Masuda K, Watanabe K, Miyadai K, Nonaka K, Yabuta M, Omasa T.

J Biosci Bioeng. 2015 Sep;120(3):340-6. doi: 10.1016/j.jbiosc.2015.01.007. Epub 2015 Feb 12.

PMID:
25683450
27.

Rapid evaluation of N-glycosylation status of antibodies with chemiluminescent lectin-binding assay.

Onitsuka M, Omasa T.

J Biosci Bioeng. 2015 Jul;120(1):107-10. doi: 10.1016/j.jbiosc.2014.11.015. Epub 2014 Dec 23.

PMID:
25548123
28.

Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics.

Asano R, Shimomura I, Konno S, Ito A, Masakari Y, Orimo R, Taki S, Arai K, Ogata H, Okada M, Furumoto S, Onitsuka M, Omasa T, Hayashi H, Katayose Y, Unno M, Kudo T, Umetsu M, Kumagai I.

MAbs. 2014;6(5):1243-54. doi: 10.4161/mabs.29445. Epub 2014 Oct 30.

29.

Neuraminidase gene homology contributes to the protective activity of influenza vaccines prepared from the influenza virus library.

Haredy AM, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Mori Y, Kida H, Okamoto S, Okuno Y, Yamanishi K.

J Gen Virol. 2014 Nov;95(Pt 11):2365-71. doi: 10.1099/vir.0.067488-0. Epub 2014 Jul 22.

PMID:
25053564
30.

Synthesis of thiazole derivatives and evaluation of their antiamoebic activity and cytotoxicity.

Shirai A, Endo T, Maseda H, Omasa T.

Biocontrol Sci. 2013;18(4):183-91.

31.

The osteoblastic differentiation ability of human dedifferentiated fat cells is higher than that of adipose stem cells from the buccal fat pad.

Kishimoto N, Momota Y, Hashimoto Y, Tatsumi S, Ando K, Omasa T, Kotani J.

Clin Oral Investig. 2014 Nov;18(8):1893-901. doi: 10.1007/s00784-013-1166-1. Epub 2013 Dec 21.

32.

Synergistic antimicrobial activity based on the combined use of a gemini-quaternary ammonium compound and ultraviolet-A light.

Shirai A, Aihara M, Takahashi A, Maseda H, Omasa T.

J Photochem Photobiol B. 2014 Jan 5;130:226-33. doi: 10.1016/j.jphotobiol.2013.11.027. Epub 2013 Dec 4.

PMID:
24362318
33.

Glycosylation analysis of an aggregated antibody produced by Chinese hamster ovary cells in bioreactor culture.

Onitsuka M, Kawaguchi A, Asano R, Kumagai I, Honda K, Ohtake H, Omasa T.

J Biosci Bioeng. 2014 May;117(5):639-44. doi: 10.1016/j.jbiosc.2013.11.001. Epub 2013 Dec 8.

PMID:
24326352
34.

Trehalose suppresses antibody aggregation during the culture of Chinese hamster ovary cells.

Onitsuka M, Tatsuzawa M, Asano R, Kumagai I, Shirai A, Maseda H, Omasa T.

J Biosci Bioeng. 2014 May;117(5):632-8. doi: 10.1016/j.jbiosc.2013.10.022. Epub 2013 Dec 4.

PMID:
24315529
35.

Overexpression of mutant cell division cycle 25 homolog B (CDC25B) enhances the efficiency of selection in Chinese hamster ovary cells.

Lee KH, Tsutsui T, Honda K, Ohtake H, Omasa T.

Cytotechnology. 2013 Dec;65(6):1017-26. doi: 10.1007/s10616-013-9662-3. Epub 2013 Nov 19.

36.

Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression.

Haredy AM, Nishizawa A, Honda K, Ohya T, Ohtake H, Omasa T.

Cytotechnology. 2013 Dec;65(6):993-1002. doi: 10.1007/s10616-013-9631-x. Epub 2013 Sep 13.

37.

Generation of high-producing cell lines by overexpression of cell division cycle 25 homolog A in Chinese hamster ovary cells.

Lee KH, Tsutsui T, Honda K, Asano R, Kumagai I, Ohtake H, Omasa T.

J Biosci Bioeng. 2013 Dec;116(6):754-60. doi: 10.1016/j.jbiosc.2013.05.032. Epub 2013 Jun 27.

PMID:
23810665
38.

Synthesis and biological activity of thiazolyl-acetic acid derivatives as possible antimicrobial agents.

Shirai A, Fumoto Y, Shouno T, Maseda H, Omasa T.

Biocontrol Sci. 2013;18(2):59-73.

39.

An MDCK cell culture-derived formalin-inactivated influenza virus whole-virion vaccine from an influenza virus library confers cross-protective immunity by intranasal administration in mice.

Haredy AM, Takenaka N, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Ohtake H, Mori Y, Kida H, Yamanishi K, Okamoto S.

Clin Vaccine Immunol. 2013 Jul;20(7):998-1007. doi: 10.1128/CVI.00024-13. Epub 2013 May 1.

40.

Rapid construction of transgene-amplified CHO cell lines by cell cycle checkpoint engineering.

Lee KH, Onitsuka M, Honda K, Ohtake H, Omasa T.

Appl Microbiol Biotechnol. 2013 Jul;97(13):5731-41. doi: 10.1007/s00253-013-4923-9. Epub 2013 Apr 25.

PMID:
23615744
41.

Two routes of MexS-MexT-mediated regulation of MexEF-OprN and MexAB-OprM efflux pump expression in Pseudomonas aeruginosa.

Uwate M, Ichise YK, Shirai A, Omasa T, Nakae T, Maseda H.

Microbiol Immunol. 2013 Apr;57(4):263-72. doi: 10.1111/1348-0421.12032.

42.

Development of a continuous bioconversion system using a thermophilic whole-cell biocatalyst.

Ninh PH, Honda K, Yokohigashi Y, Okano K, Omasa T, Ohtake H.

Appl Environ Microbiol. 2013 Mar;79(6):1996-2001. doi: 10.1128/AEM.03752-12. Epub 2013 Jan 18.

43.

Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells.

Araki N, Tsuruoka S, Hasegawa G, Yanagihara H, Omasa T, Enosawa S, Yamazoe Y, Fujimura A.

J Pharm Pharmacol. 2012 Dec;64(12):1715-21. doi: 10.1111/j.2042-7158.2012.01562.x. Epub 2012 Aug 2.

PMID:
23146034
44.
45.

Synthetic metabolic engineering-a novel, simple technology for designing a chimeric metabolic pathway.

Ye X, Honda K, Sakai T, Okano K, Omasa T, Hirota R, Kuroda A, Ohtake H.

Microb Cell Fact. 2012 Sep 6;11:120. doi: 10.1186/1475-2859-11-120.

46.

Action of reactive oxygen species in the antifungal mechanism of gemini-pyridinium salts against yeast.

Shirai A, Ueta S, Maseda H, Kourai H, Omasa T.

Biocontrol Sci. 2012 Jun;17(2):77-82.

47.

Erratum to: Preface.

Takagi M, Fujiwara M, Omasa T, Shirahata S.

Cytotechnology. 2012 May;64(3):219. doi: 10.1007/s10616-012-9478-6. No abstract available.

48.

Preface.

Takagi M, Fujiwara M, Omasa T, Shirahata S.

Cytotechnology. 2012 May;64(3):217-8. doi: 10.1007/s10616-012-9460-3. Epub 2012 Jun 6. No abstract available.

49.

Consideration of a Safe Protocol for Hepatocyte Transplantation Using Infantile Pigs.

Enosawa S, Yuan W, Douzen M, Nakazawa A, Omasa T, Fukuda A, Sakamoto S, Shigeta T, Kasahara M.

Cell Med. 2012 May 14;3(1-3):13-18. doi: 10.3727/215517912X639469. eCollection 2012 Jan.

50.

Dedifferentiated fat cells differentiate into osteoblasts in titanium fiber mesh.

Kishimoto N, Momota Y, Hashimoto Y, Ando K, Omasa T, Kotani J.

Cytotechnology. 2013 Jan;65(1):15-22. doi: 10.1007/s10616-012-9456-z. Epub 2012 Apr 22.

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