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How can individuals and the GI community reduce climate change?

Williams JA, Kao JY, Omary MB.

Gastroenterology. 2019 Oct 15. pii: S0016-5085(19)41452-2. doi: 10.1053/j.gastro.2019.10.013. [Epub ahead of print] No abstract available.


Tumor-Selective Altered Glycosylation and Functional Attenuation of CD73 in Human Hepatocellular Carcinoma.

Alcedo KP, Guerrero A, Basrur V, Fu D, Richardson ML, McLane JS, Tsou CC, Nesvizhskii AI, Welling TH, Lebrilla CB, Otey CA, Kim HJ, Omary MB, Snider NT.

Hepatol Commun. 2019 Aug 9;3(10):1400-1414. doi: 10.1002/hep4.1410. eCollection 2019 Oct.


Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice.

Shen H, Ji Y, Xiong Y, Kim H, Zhong X, Jin MG, Shah YM, Omary MB, Liu Y, Qi L, Rui L.

Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19090-19097. doi: 10.1073/pnas.1901056116. Epub 2019 Sep 3.


Porphyrin-Induced Protein Oxidation and Aggregation as a Mechanism of Porphyria-Associated Cell Injury.

Maitra D, Bragazzi Cunha J, Elenbaas JS, Bonkovsky HL, Shavit JA, Omary MB.

Cell Mol Gastroenterol Hepatol. 2019 Jun 21;8(4):535-548. doi: 10.1016/j.jcmgh.2019.06.006. [Epub ahead of print] Review.


Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells.

Maitra D, Carter EL, Richardson R, Rittié L, Basrur V, Zhang H, Nesvizhskii AI, Osawa Y, Wolf MW, Ragsdale SW, Lehnert N, Herrmann H, Omary MB.

Cell Mol Gastroenterol Hepatol. 2019 Jun 4. pii: S2352-345X(19)30072-4. doi: 10.1016/j.jcmgh.2019.05.010. [Epub ahead of print]


Constitutive release of CPS1 in bile and its role as a protective cytokine during acute liver injury.

Park MJ, D'Alecy LG, Anderson MA, Basrur V, Feng Y, Brady GF, Kim DI, Wu J, Nesvizhskii AI, Lahann J, Lukacs NW, Fontana RJ, Omary MB.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9125-9134. doi: 10.1073/pnas.1822173116. Epub 2019 Apr 12.


Enhancing career development of postdoctoral trainees: act locally and beyond.

Omary MB, Shah YM, Schnell S, Subramanian S, Swanson MS, O'Riordan MX.

J Physiol. 2019 May;597(9):2317-2322. doi: 10.1113/JP277684. Epub 2019 Mar 31. No abstract available.


Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice.

Shen H, Jiang L, Lin JD, Omary MB, Rui L.

J Clin Invest. 2019 Mar 19;129(6):2305-2317. doi: 10.1172/JCI124376.


NIH Career Development Awards: conversion to research grants and regional distribution.

Conte ML, Omary MB.

J Clin Invest. 2018 Dec 3;128(12):5187-5190. doi: 10.1172/JCI123875. Epub 2018 Oct 29. No abstract available.


Loss of hepatocyte β-catenin protects mice from experimental porphyria-associated liver injury.

Saggi H, Maitra D, Jiang A, Zhang R, Wang P, Cornuet P, Singh S, Locker J, Ma X, Dailey H, Abrams M, Omary MB, Monga SP, Nejak-Bowen K.

J Hepatol. 2019 Jan;70(1):108-117. doi: 10.1016/j.jhep.2018.09.023. Epub 2018 Oct 1.


Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases.

Xiong Y, Torsoni AS, Wu F, Shen H, Liu Y, Zhong X, Canet MJ, Shah YM, Omary MB, Liu Y, Rui L.

Elife. 2018 Aug 2;7. pii: e34152. doi: 10.7554/eLife.34152.


Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm.

Schofield HK, Tandon M, Park MJ, Halbrook CJ, Ramakrishnan SK, Kim EC, Shi J, Omary MB, Shah YM, Esni F, Pasca di Magliano M.

Cell Mol Gastroenterol Hepatol. 2017 Nov 10;5(2):169-185.e2. doi: 10.1016/j.jcmgh.2017.10.008. eCollection 2018.


Types I and II Keratin Intermediate Filaments.

Jacob JT, Coulombe PA, Kwan R, Omary MB.

Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4). pii: a018275. doi: 10.1101/cshperspect.a018275. Review.


Lamins and Lamin-Associated Proteins in Gastrointestinal Health and Disease.

Brady GF, Kwan R, Bragazzi Cunha J, Elenbaas JS, Omary MB.

Gastroenterology. 2018 May;154(6):1602-1619.e1. doi: 10.1053/j.gastro.2018.03.026. Epub 2018 Mar 13. Review.


The hepatic BMAL1/AKT/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPARα pathway.

Zhang D, Tong X, Nelson BB, Jin E, Sit J, Charney N, Yang M, Omary MB, Yin L.

Hepatology. 2018 Mar 13. doi: 10.1002/hep.29878. [Epub ahead of print]


The sweet side of vimentin.

Snider NT, Ku NO, Omary MB.

Elife. 2018 Mar 7;7. pii: e35336. doi: 10.7554/eLife.35336.


HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas.

Park MJ, Iyer S, Xue X, Bragazzi Cunha J, Gu S, Moons D, Pipe SW, Williams JA, Simeone DM, Shah YM, Omary MB.

Gastroenterology. 2018 May;154(6):1630-1634.e3. doi: 10.1053/j.gastro.2018.01.037. Epub 2018 Feb 1.


Lamin A/C Maintains Exocrine Pancreas Homeostasis by Regulating Stability of RB and Activity of E2F.

Elenbaas JS, Bragazzi Cunha J, Azuero-Dajud R, Nelson B, Oral EA, Williams JA, Stewart CL, Omary MB.

Gastroenterology. 2018 May;154(6):1625-1629.e8. doi: 10.1053/j.gastro.2018.01.024. Epub 2018 Jan 31.


An OLTAM system for analysis of brown/beige fat thermogenic activity.

Kim DI, Liao J, Emont MP, Park MJ, Jun H, Ramakrishnan SK, Lin JD, Shah YM, Omary MB, Wu J.

Int J Obes (Lond). 2018 Apr;42(4):939-945. doi: 10.1038/ijo.2017.308. Epub 2018 Jan 23.


Hepatocyte-Specific Deletion of Mouse Lamin A/C Leads to Male-Selective Steatohepatitis.

Kwan R, Brady GF, Brzozowski M, Weerasinghe SV, Martin H, Park MJ, Brunt MJ, Menon RK, Tong X, Yin L, Stewart CL, Omary MB.

Cell Mol Gastroenterol Hepatol. 2017 Jul 6;4(3):365-383. doi: 10.1016/j.jcmgh.2017.06.005. eCollection 2017 Nov.


Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.

Brady GF, Kwan R, Ulintz PJ, Nguyen P, Bassirian S, Basrur V, Nesvizhskii AI, Loomba R, Omary MB.

Hepatology. 2018 May;67(5):1710-1725. doi: 10.1002/hep.29522. Epub 2018 Mar 24.


Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity.

Zhang D, Tong X, VanDommelen K, Gupta N, Stamper K, Brady GF, Meng Z, Lin J, Rui L, Omary MB, Yin L.

J Clin Invest. 2017 Jun 30;127(7):2855-2867. doi: 10.1172/JCI89934. Epub 2017 Jun 19.


Globalization and changing trends of biomedical research output.

Conte ML, Liu J, Schnell S, Omary MB.

JCI Insight. 2017 Jun 15;2(12). pii: 95206. doi: 10.1172/jci.insight.95206. eCollection 2017 Jun 15.


Intermediate filament proteins of digestive organs: physiology and pathophysiology.

Omary MB.

Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G628-G634. doi: 10.1152/ajpgi.00455.2016. Epub 2017 Mar 30. Review.


Spectrum of disease associated with partial lipodystrophy: lessons from a trial cohort.

Ajluni N, Meral R, Neidert AH, Brady GF, Buras E, McKenna B, DiPaola F, Chenevert TL, Horowitz JF, Buggs-Saxton C, Rupani AR, Thomas PE, Tayeh MK, Innis JW, Omary MB, Conjeevaram H, Oral EA.

Clin Endocrinol (Oxf). 2017 May;86(5):698-707. doi: 10.1111/cen.13311. Epub 2017 Mar 27.


Not All Mice Are the Same: Standardization of Animal Research Data Presentation.

Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM Jr, Turner JR.

Cell Mol Gastroenterol Hepatol. 2016 May 6;2(4):391-393. doi: 10.1016/j.jcmgh.2016.04.001. eCollection 2016 Jul. No abstract available.


Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis.

Iyer S, Park MJ, Moons D, Kwan R, Liao J, Liu L, Omary MB.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1346-1352. doi: 10.1016/j.bbrc.2016.12.039. Epub 2016 Dec 7.


Mouse genetic background contributes to hepatocyte susceptibility to Fas-mediated apoptosis.

Weerasinghe SV, Park MJ, Portney DA, Omary MB.

Mol Biol Cell. 2016 Oct 15;27(20):3005-3012. Epub 2016 Aug 17.


Ethanol and Acetaminophen Synergistically Induce Hepatic Aggregation and TCH346-Insensitive Nuclear Translocation of GAPDH.

Snider NT, Portney DA, Willcockson HH, Maitra D, Martin HC, Greenson JK, Omary MB.

PLoS One. 2016 Aug 11;11(8):e0160982. doi: 10.1371/journal.pone.0160982. eCollection 2016.


Keratin impact on PKCδ- and ASMase-mediated regulation of hepatocyte lipid raft size - implication for FasR-associated apoptosis.

Gilbert S, Loranger A, Omary MB, Marceau N.

J Cell Sci. 2016 Sep 1;129(17):3262-73. doi: 10.1242/jcs.171124. Epub 2016 Jul 15.


Gastroenterology 2011-2016: Looking Back and Forward.

Omary MB, Carethers JM, Owyang C.

Gastroenterology. 2016 Jun;150(7):1496-1502. doi: 10.1053/j.gastro.2016.04.005. No abstract available.


E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis.

Tong X, Li P, Zhang D, VanDommelen K, Gupta N, Rui L, Omary MB, Yin L.

J Lipid Res. 2016 Jul;57(7):1219-30. doi: 10.1194/jlr.M067181. Epub 2016 Jun 1.


Not all mice are the same: Standardization of animal research data presentation.

Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM Jr, Turner JR.

Hepatology. 2016 Jun;63(6):1752-4. doi: 10.1002/hep.28608. No abstract available.


Not All Mice Are the Same: Standardization of Animal Research Data Presentation.

Omary MB, Cohen DE, El-Omar E, Jalan R, Low M, Nathanson M, Peek R, Turner J.

Gut. 2016 Jun;65(6):894-5. doi: 10.1136/gutjnl-2016-312041. No abstract available.


Not All Mice Are the Same: Standardization of Animal Research Data Presentation.

Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM Jr, Turner JR.

Gastroenterology. 2016 Jun;150(7):1503-1504. doi: 10.1053/j.gastro.2016.03.034. Epub 2016 Apr 8. No abstract available.


Mentoring: A Necessary But Not Sufficient Ingredient for Enhancing Success.

Omary MB.

Gastroenterology. 2016 May;150(5):1067-1070. doi: 10.1053/j.gastro.2016.03.001. Epub 2016 Mar 3. Review. No abstract available.


Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver.

Ku NO, Strnad P, Bantel H, Omary MB.

Hepatology. 2016 Sep;64(3):966-76. doi: 10.1002/hep.28493. Epub 2016 Apr 4. Review.


A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress.

Elenbaas JS, Maitra D, Liu Y, Lentz SI, Nelson B, Hoenerhoff MJ, Shavit JA, Omary MB.

FASEB J. 2016 May;30(5):1798-810. doi: 10.1096/fj.201500111R. Epub 2016 Feb 2.



Omary MB, Liem RK.

Methods Enzymol. 2016;568:xxiii-xxiv. doi: 10.1016/S0076-6879(16)00052-5. No abstract available.


High-Throughput Screening for Drugs that Modulate Intermediate Filament Proteins.

Sun J, Groppi VE, Gui H, Chen L, Xie Q, Liu L, Omary MB.

Methods Enzymol. 2016;568:163-85. doi: 10.1016/bs.mie.2015.09.029. Epub 2015 Nov 19.


Assays for Posttranslational Modifications of Intermediate Filament Proteins.

Snider NT, Omary MB.

Methods Enzymol. 2016;568:113-38. doi: 10.1016/bs.mie.2015.09.005. Epub 2015 Nov 6.


Cell biology to disease and back.

Omary MB.

Nat Rev Mol Cell Biol. 2016 Jan;17(1):4. doi: 10.1038/nrm.2015.9. Epub 2015 Dec 2. No abstract available.


Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1.

Zhang H, Ramakrishnan SK, Triner D, Centofanti B, Maitra D, Győrffy B, Sebolt-Leopold JS, Dame MK, Varani J, Brenner DE, Fearon ER, Omary MB, Shah YM.

Sci Signal. 2015 Oct 6;8(397):ra98. doi: 10.1126/scisignal.aac5418.


Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice.

Toivola DM, Habtezion A, Misiorek JO, Zhang L, Nyström JH, Sharpe O, Robinson WH, Kwan R, Omary MB.

FASEB J. 2015 Dec;29(12):5081-9. doi: 10.1096/fj.14-269795. Epub 2015 Sep 23.


Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury.

Usachov V, Urban TJ, Fontana RJ, Gross A, Iyer S, Omary MB, Strnad P; Drug-Induced Liver Injury Network.

BMC Med. 2015 Aug 19;13:196. doi: 10.1186/s12916-015-0418-0.


Ambient Light Promotes Selective Subcellular Proteotoxicity after Endogenous and Exogenous Porphyrinogenic Stress.

Maitra D, Elenbaas JS, Whitesall SE, Basrur V, D'Alecy LG, Omary MB.

J Biol Chem. 2015 Sep 25;290(39):23711-24. doi: 10.1074/jbc.M114.636001. Epub 2015 Jul 23.


PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding.

Kwan R, Chen L, Looi K, Tao GZ, Weerasinghe SV, Snider NT, Conti MA, Adelstein RS, Xie Q, Omary MB.

Hepatology. 2015 Dec;62(6):1858-69. doi: 10.1002/hep.27965. Epub 2015 Aug 25.


Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation.

Guldiken N, Zhou Q, Kucukoglu O, Rehm M, Levada K, Gross A, Kwan R, James LP, Trautwein C, Omary MB, Strnad P.

Hepatology. 2015 Sep;62(3):876-86. doi: 10.1002/hep.27891. Epub 2015 Jul 3.


Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism.

Helenius TO, Misiorek JO, Nyström JH, Fortelius LE, Habtezion A, Liao J, Asghar MN, Zhang H, Azhar S, Omary MB, Toivola DM.

Mol Biol Cell. 2015 Jun 15;26(12):2298-310. doi: 10.1091/mbc.E14-02-0736. Epub 2015 Apr 22.


Absence of keratins 8 and 18 in rodent epithelial cell lines associates with keratin gene mutation and DNA methylation: Cell line selective effects on cell invasion.

Kwan R, Looi KS, Omary MB.

Exp Cell Res. 2015 Jul 1;335(1):12-22. doi: 10.1016/j.yexcr.2015.04.003. Epub 2015 Apr 14.

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