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Tyrosine Kinase Inhibitors in the Treatment of Hepatocellular Carcinoma.

Wai Ling Khoo TS, Rehman A, Olynyk JK.

In: Tirnitz-Parker JEE, editor. Hepatocellular Carcinoma [Internet]. Brisbane (AU): Codon Publications; 2019 Oct 24. Chapter 7.


Mouse Models of Hepatocellular Carcinoma.

Carlessi R, Köhn-Gaone J, Olynyk JK, Tirnitz-Parker JEE.

In: Tirnitz-Parker JEE, editor. Hepatocellular Carcinoma [Internet]. Brisbane (AU): Codon Publications; 2019 Oct 24. Chapter 4.


Decreased Physical Working Capacity in Adolescents With Nonalcoholic Fatty Liver Disease Associates With Reduced Iron Availability.

Mitchell T, McKinnon E, Ayonrinde O, Adams LA, Trinder D, Chua ACG, Newton RU, Straker L, Olynyk JK.

Clin Gastroenterol Hepatol. 2019 Oct 16. pii: S1542-3565(19)31116-4. doi: 10.1016/j.cgh.2019.10.017. [Epub ahead of print]


Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-β-induced collagen expression in hepatic stellate cells.

Genz B, Coleman MA, Irvine KM, Kutasovic JR, Miranda M, Gratte FD, Tirnitz-Parker JEE, Olynyk JK, Calvopina DA, Weis A, Cloonan N, Robinson H, Hill MM, Al-Ejeh F, Ramm GA.

Sci Rep. 2019 Jun 12;9(1):8541. doi: 10.1038/s41598-019-44865-1.


Bowel patterns, gastrointestinal symptoms, and emotional well-being in adolescents: A cohort study.

Ayonrinde OT, Sanfilippo FM, O'Sullivan TA, Adams LA, Ayonrinde OA, Robinson M, Oddy WH, Olynyk JK.

J Gastroenterol Hepatol. 2019 May 6. doi: 10.1111/jgh.14699. [Epub ahead of print]


Features of the metabolic syndrome in late adolescence are associated with impaired testicular function at 20 years of age.

Hart RJ, Doherty DA, Mori TA, Adams LA, Huang RC, Minaee N, Handelsman DJ, McLachlan R, Norman RJ, Dickinson JE, Olynyk JK, Beilin LJ.

Hum Reprod. 2019 Mar 1;34(3):389-402. doi: 10.1093/humrep/dey371.


Cellular Plasticity in Liver Regeneration: Spotlight on Cholangiocytes.

Tirnitz-Parker JEE, Forbes SJ, Olynyk JK, Ramm GA.

Hepatology. 2019 May;69(5):2286-2289. doi: 10.1002/hep.30340. Epub 2019 Feb 19. No abstract available.


Detection of HFE Haemochromatosis in the clinic and community using standard erythrocyte tests.

Adris N, Hazeldine S, Bentley P, Trinder D, Chua ACG, Powell LW, Ramm LE, Ramm GA, Olynyk JK.

Blood Cells Mol Dis. 2019 Feb;74:18-24. doi: 10.1016/j.bcmd.2018.10.003. Epub 2018 Oct 10.


Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study.

Litton E, Baker S, Erber W, Farmer S, Ferrier J, French C, Gummer J, Hawkins D, Higgins A, Hofmann A, De Keulenaer B, McMorrow J, Olynyk JK, Richards T, Towler S, Trengove R, Webb S; IRONMAN Study investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group.

J Intensive Care. 2018 Sep 10;6:60. doi: 10.1186/s40560-018-0328-2. eCollection 2018.


Range of Normal Liver Stiffness and Factors Associated With Increased Stiffness Measurements in Apparently Healthy Individuals.

Bazerbachi F, Haffar S, Wang Z, Cabezas J, Arias-Loste MT, Crespo J, Darwish-Murad S, Ikram MA, Olynyk JK, Gan E, Petta S, Berzuini A, Prati D, de Lédinghen V, Wong VW, Del Poggio P, Chávez-Tapia NC, Chen YP, Cheng PN, Yuen MF, Das K, Chowdhury A, Caballeria L, Fabrellas N, Ginès P, Kumar M, Sarin SK, Conti F, Andreone P, Sirli R, Cortez-Pinto H, Carvalhana S, Sugihara T, Kim SU, Parikh P, Chayama K, Corpechot C, Kim KM, Papatheodoridis G, Alsebaey A, Kamath PS, Murad MH, Watt KD.

Clin Gastroenterol Hepatol. 2019 Jan;17(1):54-64.e1. doi: 10.1016/j.cgh.2018.08.069. Epub 2018 Sep 7. Review.


A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study.

Adris N, Chua ACG, Knuiman MW, Divitini ML, Trinder D, Olynyk JK.

BMC Cancer. 2018 Sep 3;18(1):863. doi: 10.1186/s12885-018-4775-x.


Transdifferentiation of pancreatic progenitor cells to hepatocyte-like cells is not serum-dependent when facilitated by extracellular matrix proteins.

Gratte FD, Pasic S, Olynyk JK, Yeoh GCT, Tosh D, Coombe DR, Tirnitz-Parker JEE.

Sci Rep. 2018 Mar 12;8(1):4385. doi: 10.1038/s41598-018-22596-z.


Immune checkpoint inhibition: prospects for prevention and therapy of hepatocellular carcinoma.

Elsegood CL, Tirnitz-Parker JE, Olynyk JK, Yeoh GC.

Clin Transl Immunology. 2017 Nov 10;6(11):e161. doi: 10.1038/cti.2017.47. eCollection 2017 Nov. Review.


Reduction of body iron in HFE-related haemochromatosis and moderate iron overload (Mi-Iron): a multicentre, participant-blinded, randomised controlled trial.

Ong SY, Gurrin LC, Dolling L, Dixon J, Nicoll AJ, Wolthuizen M, Wood EM, Anderson GJ, Ramm GA, Allen KJ, Olynyk JK, Crawford D, Ramm LE, Gow P, Durrant S, Powell LW, Delatycki MB.

Lancet Haematol. 2017 Dec;4(12):e607-e614. doi: 10.1016/S2352-3026(17)30214-4.


The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury.

Gogoi-Tiwari J, Köhn-Gaone J, Giles C, Schmidt-Arras D, Gratte FD, Elsegood CL, McCaughan GW, Ramm GA, Olynyk JK, Tirnitz-Parker JEE.

J Vis Exp. 2017 Oct 21;(128). doi: 10.3791/56138.


Taurocholate Induces Biliary Differentiation of Liver Progenitor Cells Causing Hepatic Stellate Cell Chemotaxis in the Ductular Reaction: Role in Pediatric Cystic Fibrosis Liver Disease.

Pozniak KN, Pearen MA, Pereira TN, Kramer CSM, Kalita-De Croft P, Nawaratna SK, Fernandez-Rojo MA, Gobert GN, Tirnitz-Parker JEE, Olynyk JK, Shepherd RW, Lewindon PJ, Ramm GA.

Am J Pathol. 2017 Dec;187(12):2744-2757. doi: 10.1016/j.ajpath.2017.08.024. Epub 2017 Sep 19.


Sex differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents.

Ayonrinde OT, Adams LA, Mori TA, Beilin LJ, de Klerk N, Pennell CE, White S, Olynyk JK.

Hepatology. 2018 Jan;67(1):108-122. doi: 10.1002/hep.29347. Epub 2017 Nov 13.


Association of Transferrin Saturation With the Arthropathy of Hereditary Hemochromatosis.

Whalen NL, Olynyk JK.

Clin Gastroenterol Hepatol. 2017 Oct;15(10):1507-1508. doi: 10.1016/j.cgh.2017.06.018. Epub 2017 Jun 15. No abstract available.


Infant nutrition and maternal obesity influence the risk of non-alcoholic fatty liver disease in adolescents.

Ayonrinde OT, Oddy WH, Adams LA, Mori TA, Beilin LJ, de Klerk N, Olynyk JK.

J Hepatol. 2017 Sep;67(3):568-576. doi: 10.1016/j.jhep.2017.03.029. Epub 2017 Jun 12.


Diagnosing and preventing iron overload.

Ramanathan G, Olynyk JK, Ferrari P.

Hemodial Int. 2017 Jun;21 Suppl 1:S58-S67. doi: 10.1111/hdi.12555. Epub 2017 Mar 22. Review.


Dysregulated Erythropoietin, Hepcidin, and Bone Marrow Iron Metabolism Contribute to Interferon-Induced Anemia in Hepatitis C.

van Rijnsoever M, Galhenage S, Mollison L, Gummer J, Trengove R, Olynyk JK.

J Interferon Cytokine Res. 2016 Nov;36(11):630-634. Epub 2016 Sep 12.


HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype-stratified cohort study of hemochromatosis in Australian women.

Warne CD, Zaloumis SG, Bertalli NA, Delatycki MB, Nicoll AJ, McLaren CE, Hopper JL, Giles GG, Anderson GJ, Olynyk JK, Powell LW, Allen KJ, Gurrin LC; HealthIron Study Investigators.

J Gastroenterol Hepatol. 2017 Apr;32(4):797-802. doi: 10.1111/jgh.13621.


Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial : A randomized trial of IV iron in critical illness.

IRONMAN Investigators, Litton E, Baker S, Erber WN, Farmer S, Ferrier J, French C, Gummer J, Hawkins D, Higgins A, Hofmann A, De Keulenaer B, McMorrow J, Olynyk JK, Richards T, Towler S, Trengove R, Webb S; Australian and New Zealand Intensive Care Society Clinical Trials Group.

Intensive Care Med. 2016 Nov;42(11):1715-1722. Epub 2016 Sep 30.


Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features.

Heidari M, Johnstone DM, Bassett B, Graham RM, Chua AC, House MJ, Collingwood JF, Bettencourt C, Houlden H, Ryten M, Olynyk JK, Trinder D, Milward EA.

Mol Psychiatry. 2016 Nov;21(11):1599-1607. doi: 10.1038/mp.2015.192. Epub 2016 Jan 5.


Stereological Analysis of Liver Biopsy Histology Sections as a Reference Standard for Validating Non-Invasive Liver Fat Fraction Measurements by MRI.

St Pierre TG, House MJ, Bangma SJ, Pang W, Bathgate A, Gan EK, Ayonrinde OT, Bhathal PS, Clouston A, Olynyk JK, Adams LA.

PLoS One. 2016 Aug 8;11(8):e0160789. doi: 10.1371/journal.pone.0160789. eCollection 2016.


Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases.

Heidari M, Gerami SH, Bassett B, Graham RM, Chua AC, Aryal R, House MJ, Collingwood JF, Bettencourt C, Houlden H, Ryten M; UK Brain Expression Consortium (UKBEC), Olynyk JK, Trinder D, Johnstone DM, Milward EA.

Rare Dis. 2016 Jun 22;4(1):e1198458. doi: 10.1080/21675511.2016.1198458. eCollection 2016.


Higher concentrations of serum iron and transferrin saturation but not serum ferritin are associated with cancer outcomes.

Chua AC, Knuiman MW, Trinder D, Divitini ML, Olynyk JK.

Am J Clin Nutr. 2016 Sep;104(3):736-42. doi: 10.3945/ajcn.115.129411. Epub 2016 Aug 3.


Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib.

Woo K, Stewart SG, Kong GS, Finch-Edmondson ML, Dwyer BJ, Yeung SY, Abraham LJ, Kampmann SS, Diepeveen LA, Passman AM, Elsegood CL, Tirnitz-Parker JE, Callus BA, Olynyk JK, Yeoh GC.

Eur J Med Chem. 2016 Sep 14;120:275-83. doi: 10.1016/j.ejmech.2016.03.015. Epub 2016 Mar 9.


Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury.

Köhn-Gaone J, Dwyer BJ, Grzelak CA, Miller G, Shackel NA, Ramm GA, McCaughan GW, Elsegood CL, Olynyk JK, Tirnitz-Parker JEE.

Am J Pathol. 2016 Jul;186(7):1762-1774. doi: 10.1016/j.ajpath.2016.03.005. Epub 2016 May 13.


Association between serum hepcidin-25 and primary resistance to erythropoiesis-stimulating agents in chronic kidney disease: a secondary analysis of the HERO trial.

Gummer J, Trengove R, Pascoe EM, Badve SV, Cass A, Clarke P, McDonald SP, Morrish AT, Pedagogos E, Perkovic V, Reidlinger D, Scaria A, Walker R, Vergara LA, Hawley CM, Johnson DW, Olynyk JK, Ferrari P; HERO Study Collaborative Group.

Nephrology (Carlton). 2017 Jul;22(7):548-554. doi: 10.1111/nep.12815.


Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics.

Kalinowski DS, Stefani C, Toyokuni S, Ganz T, Anderson GJ, Subramaniam NV, Trinder D, Olynyk JK, Chua A, Jansson PJ, Sahni S, Lane DJ, Merlot AM, Kovacevic Z, Huang ML, Lee CS, Richardson DR.

Biochim Biophys Acta. 2016 Apr;1863(4):727-48. doi: 10.1016/j.bbamcr.2016.01.026. Epub 2016 Feb 2. Review.


Characterization of hepatic and cardiac iron deposition during standard treatment of anaemia in haemodialysis.

Holman R, Olynyk JK, Kulkarni H, Ferrari P.

Nephrology (Carlton). 2017 Feb;22(2):114-117. doi: 10.1111/nep.12735.


Red blood cell transfusion is associated with further bleeding and fresh-frozen plasma with mortality in nonvariceal upper gastrointestinal bleeding.

Subramaniam K, Spilsbury K, Ayonrinde OT, Latchmiah F, Mukhtar SA, Semmens JB, Leahy MF, Olynyk JK.

Transfusion. 2016 Apr;56(4):816-26. doi: 10.1111/trf.13446. Epub 2015 Dec 31.


The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis.

Köhn-Gaone J, Gogoi-Tiwari J, Ramm GA, Olynyk JK, Tirnitz-Parker JE.

Am J Physiol Gastrointest Liver Physiol. 2016 Feb 1;310(3):G143-54. doi: 10.1152/ajpgi.00215.2015. Epub 2015 Nov 25. Review.


Adverse metabolic phenotype of adolescent girls with non-alcoholic fatty liver disease plus polycystic ovary syndrome compared with other girls and boys.

Ayonrinde OT, Adams LA, Doherty DA, Mori TA, Beilin LJ, Oddy WH, Hickey M, Sloboda DM, Olynyk JK, Hart R.

J Gastroenterol Hepatol. 2016 May;31(5):980-7. doi: 10.1111/jgh.13241.


Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron).

Ong SY, Dolling L, Dixon JL, Nicoll AJ, Gurrin LC, Wolthuizen M, Wood EM, Anderson GJ, Ramm GA, Allen KJ, Olynyk JK, Crawford D, Kava J, Ramm LE, Gow P, Durrant S, Powell LW, Delatycki MB.

BMJ Open. 2015 Aug 12;5(8):e008938. doi: 10.1136/bmjopen-2015-008938.


Reply: To PMID 25524401.

Adams LA, Crawford DH, St Pierre TK, Olynyk JK.

Hepatology. 2015 Dec;62(6):1921-2. doi: 10.1002/hep.28030. Epub 2015 Oct 16. No abstract available.


Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration.

Elsegood CL, Chan CW, Degli-Esposti MA, Wikstrom ME, Domenichini A, Lazarus K, van Rooijen N, Ganss R, Olynyk JK, Yeoh GC.

Hepatology. 2015 Oct;62(4):1272-84. doi: 10.1002/hep.27977. Epub 2015 Jul 31.


Reduced mortality due to phlebotomy in moderately iron-loaded HFE haemochromatosis? The need for clinical trials.

Delatycki MB, Gurrin LC, Ong SY, Ramm GA, Anderson GJ, Olynyk JK, Allen KJ, Nicoll AJ, Powell LW.

J Hepatol. 2015 Jul;63(1):282-3. doi: 10.1016/j.jhep.2015.03.028. Epub 2015 Apr 1. No abstract available.


Authors' response.

Bremner AP, OʼSullivan TA, Oddy WH, Sherriff JL, Ayonrinde OT, Olynyk JK, Beilin LJ, Mori TA, Adams LA.

J Pediatr Gastroenterol Nutr. 2015 Apr;60(4):e35-6. doi: 10.1097/MPG.0000000000000705. No abstract available.


The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trial.

Adams LA, Crawford DH, Stuart K, House MJ, St Pierre TG, Webb M, Ching HL, Kava J, Bynevelt M, MacQuillan GC, Garas G, Ayonrinde OT, Mori TA, Croft KD, Niu X, Jeffrey GP, Olynyk JK.

Hepatology. 2015 May;61(5):1555-64. doi: 10.1002/hep.27662. Epub 2015 Mar 20.


Natural history of HFE simple heterozygosity for C282Y and H63D: a prospective 12-year study.

Zaloumis SG, Allen KJ, Bertalli NA, Turkovic L, Delatycki MB, Nicoll AJ, McLaren CE, English DR, Hopper JL, Giles GG, Anderson GJ, Olynyk JK, Powell LW, Gurrin LC; HealthIron Study Investigators.

J Gastroenterol Hepatol. 2015 Apr;30(4):719-25. doi: 10.1111/jgh.12804.


Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation.

Prakoso E, Tirnitz-Parker JE, Clouston AD, Kayali Z, Lee A, Gan EK, Ramm GA, Kench JG, Bowen DG, Olynyk JK, McCaughan GW, Shackel NA.

Liver Transpl. 2014 Dec;20(12):1508-19. doi: 10.1002/lt.24007.


Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents.

Ayonrinde OT, Olynyk JK, Marsh JA, Beilin LJ, Mori TA, Oddy WH, Adams LA.

J Gastroenterol Hepatol. 2015 Jan;30(1):163-71. doi: 10.1111/jgh.12666.


Higher ferritin levels, but not serum iron or transferrin saturation, are associated with Type 2 diabetes mellitus in adult men and women free of genetic haemochromatosis.

Yeap BB, Divitini ML, Gunton JE, Olynyk JK, Beilby JP, McQuillan B, Hung J, Knuiman MW.

Clin Endocrinol (Oxf). 2015 Apr;82(4):525-32. doi: 10.1111/cen.12529. Epub 2014 Jul 23.


Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity.

Black LJ, Jacoby P, She Ping-Delfos WC, Mori TA, Beilin LJ, Olynyk JK, Ayonrinde OT, Huang RC, Holt PG, Hart PH, Oddy WH, Adams LA.

J Gastroenterol Hepatol. 2014 Jun;29(6):1215-22. doi: 10.1111/jgh.12541.


TWEAK and LTβ Signaling during Chronic Liver Disease.

Dwyer BJ, Olynyk JK, Ramm GA, Tirnitz-Parker JE.

Front Immunol. 2014 Feb 13;5:39. doi: 10.3389/fimmu.2014.00039. eCollection 2014. Review.


Detection of liver injury in IBD using transient elastography.

Thin LW, Lawrance IC, Spilsbury K, Kava J, Olynyk JK.

J Crohns Colitis. 2014 Jul;8(7):671-7. doi: 10.1016/j.crohns.2013.12.006. Epub 2014 Feb 13.


Texture-based classification of liver fibrosis using MRI.

House MJ, Bangma SJ, Thomas M, Gan EK, Ayonrinde OT, Adams LA, Olynyk JK, St Pierre TG.

J Magn Reson Imaging. 2015 Feb;41(2):322-8. doi: 10.1002/jmri.24536. Epub 2013 Dec 18.


Lower fructose intake may help protect against development of nonalcoholic fatty liver in adolescents with obesity.

OʼSullivan TA, Oddy WH, Bremner AP, Sherriff JL, Ayonrinde OT, Olynyk JK, Beilin LJ, Mori TA, Adams LA.

J Pediatr Gastroenterol Nutr. 2014 May;58(5):624-31. doi: 10.1097/MPG.0000000000000267.

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