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Regional gene repression by DNA double-strand breaks in G1 phase cells.

Purman CE, Collins PL, Porter SI, Saini A, Gupta H, Sleckman BP, Oltz EM.

Mol Cell Biol. 2019 Oct 7. pii: MCB.00181-19. doi: 10.1128/MCB.00181-19. [Epub ahead of print]


Circadian rhythm-dependent and circadian rhythm-independent impacts of the molecular clock on type 3 innate lymphoid cells.

Wang Q, Robinette ML, Billon C, Collins PL, Bando JK, Fachi JL, Sécca C, Porter SI, Saini A, Gilfillan S, Solt LA, Musiek ES, Oltz EM, Burris TP, Colonna M.

Sci Immunol. 2019 Oct 4;4(40). pii: eaay7501. doi: 10.1126/sciimmunol.aay7501.


Publisher Correction: Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.

Cella M, Gamini R, Sécca C, Collins PL, Zhao S, Peng V, Robinette ML, Schettini J, Zaitsev K, Gordon W, Bando JK, Yomogida K, Cortez V, Fronick C, Fulton R, Lin LL, Gilfillan S, Flavell RA, Shan L, Artyomov MN, Bowman M, Oltz EM, Jelinsky SA, Colonna M.

Nat Immunol. 2019 Oct;20(10):1405. doi: 10.1038/s41590-019-0474-2.


Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.

Cella M, Gamini R, Sécca C, Collins PL, Zhao S, Peng V, Robinette ML, Schettini J, Zaitsev K, Gordon W, Bando JK, Yomogida K, Cortez V, Fronick C, Fulton R, Lin LL, Gilfillan S, Flavell RA, Shan L, Artyomov MN, Bowman M, Oltz EM, Jelinsky SA, Colonna M.

Nat Immunol. 2019 Aug;20(8):980-991. doi: 10.1038/s41590-019-0425-y. Epub 2019 Jun 17. Erratum in: Nat Immunol. 2019 Aug 6;:.


Immunity to Influenza: Closing in on a Moving Target.

Oltz EM.

J Immunol. 2019 Jan 15;202(2):325-326. doi: 10.4049/jimmunol.1890024. No abstract available.


Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells.

Collins PL, Cella M, Porter SI, Li S, Gurewitz GL, Hong HS, Johnson RP, Oltz EM, Colonna M.

Cell. 2019 Jan 10;176(1-2):348-360.e12. doi: 10.1016/j.cell.2018.11.045. Epub 2018 Dec 27.


A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire.

Barajas-Mora EM, Kleiman E, Xu J, Carrico NC, Lu H, Oltz EM, Murre C, Feeney AJ.

Mol Cell. 2019 Jan 3;73(1):48-60.e5. doi: 10.1016/j.molcel.2018.10.013. Epub 2018 Nov 15.


A New JI: The Home for All Immunology.

Oltz EM.

J Immunol. 2018 Jul 1;201(1):1-2. doi: 10.4049/jimmunol.1890009. No abstract available.


Activation of Mouse Tcrb: Uncoupling RUNX1 Function from Its Cooperative Binding with ETS1.

Zhao JY, Osipovich O, Koues OI, Majumder K, Oltz EM.

J Immunol. 2017 Aug 1;199(3):1131-1141. doi: 10.4049/jimmunol.1700146. Epub 2017 Jun 21.


cis-Regulatory Circuits Regulating NEK6 Kinase Overexpression in Transformed B Cells Are Super-Enhancer Independent.

Huang Y, Koues OI, Zhao JY, Liu R, Pyfrom SC, Payton JE, Oltz EM.

Cell Rep. 2017 Mar 21;18(12):2918-2931. doi: 10.1016/j.celrep.2017.02.067.


The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.

Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS.

Cell. 2016 Nov 3;167(4):1137. doi: 10.1016/j.cell.2016.10.034. No abstract available.


Targeted epigenetic repression of a lymphoma oncogene by sequence-specific histone modifiers induces apoptosis in DLBCL.

Luo H, Schmidt JA, Lee YS, Oltz EM, Payton JE.

Leuk Lymphoma. 2017 Feb;58(2):445-456. Epub 2016 Jun 7.


The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.

Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS.

Cell. 2016 Jun 16;165(7):1708-1720. doi: 10.1016/j.cell.2016.05.018. Epub 2016 Jun 2. Erratum in: Cell. 2016 Nov 3;167(4):1137.


NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo.

Raju S, Kretzmer LZ, Koues OI, Payton JE, Oltz EM, Cashen A, Polic B, Schreiber RD, Shaw AS, Markiewicz MA.

J Immunol. 2016 Jun 1;196(11):4805-13. doi: 10.4049/jimmunol.1501982. Epub 2016 May 2.


Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells.

Koues OI, Collins PL, Cella M, Robinette ML, Porter SI, Pyfrom SC, Payton JE, Colonna M, Oltz EM.

Cell. 2016 May 19;165(5):1134-1146. doi: 10.1016/j.cell.2016.04.014. Epub 2016 May 5.


Mapping of Variable DNA Methylation Across Multiple Cell Types Defines a Dynamic Regulatory Landscape of the Human Genome.

Gu J, Stevens M, Xing X, Li D, Zhang B, Payton JE, Oltz EM, Jarvis JN, Jiang K, Cicero T, Costello JF, Wang T.

G3 (Bethesda). 2016 Apr 7;6(4):973-86. doi: 10.1534/g3.115.025437.


Short-Circuiting Gene Regulatory Networks: Origins of B Cell Lymphoma.

Koues OI, Oltz EM, Payton JE.

Trends Genet. 2015 Dec;31(12):720-731. doi: 10.1016/j.tig.2015.09.006. Epub 2015 Oct 22. Review.


Regulation of Tcrb Gene Assembly by Genetic, Epigenetic, and Topological Mechanisms.

Majumder K, Bassing CH, Oltz EM.

Adv Immunol. 2015;128:273-306. doi: 10.1016/ Epub 2015 Aug 14. Review.


CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis.

Zhao Y, Ma CA, Wu L, Iwai K, Ashwell JD, Oltz EM, Ballard DW, Jain A.

J Biol Chem. 2015 Sep 4;290(36):22076-84. doi: 10.1074/jbc.M115.658096. Epub 2015 Jul 29.


Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation during Thymocyte Development.

Majumder K, Rupp LJ, Yang-Iott KS, Koues OI, Kyle KE, Bassing CH, Oltz EM.

J Immunol. 2015 Aug 1;195(3):1262-72. doi: 10.4049/jimmunol.1500692. Epub 2015 Jun 22.


The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes.

Collins PL, Kyle KE, Egawa T, Shinkai Y, Oltz EM.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8367-72. doi: 10.1073/pnas.1422187112. Epub 2015 Jun 22.


Enhancer sequence variants and transcription-factor deregulation synergize to construct pathogenic regulatory circuits in B-cell lymphoma.

Koues OI, Kowalewski RA, Chang LW, Pyfrom SC, Schmidt JA, Luo H, Sandoval LE, Hughes TB, Bednarski JJ, Cashen AF, Payton JE, Oltz EM.

Immunity. 2015 Jan 20;42(1):186-98. doi: 10.1016/j.immuni.2014.12.021. Epub 2014 Dec 25.


Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.

Majumder K, Koues OI, Chan EA, Kyle KE, Horowitz JE, Yang-Iott K, Bassing CH, Taniuchi I, Krangel MS, Oltz EM.

J Exp Med. 2015 Jan 12;212(1):107-20. doi: 10.1084/jem.20141479. Epub 2014 Dec 15.


HCoDES reveals chromosomal DNA end structures with single-nucleotide resolution.

Dorsett Y, Zhou Y, Tubbs AT, Chen BR, Purman C, Lee BS, George R, Bredemeyer AL, Zhao JY, Sodergen E, Weinstock GM, Han ND, Reyes A, Oltz EM, Dorsett D, Misulovin Z, Payton JE, Sleckman BP.

Mol Cell. 2014 Dec 18;56(6):808-18. doi: 10.1016/j.molcel.2014.10.024. Epub 2014 Nov 26.


Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain Loci.

Predeus AV, Gopalakrishnan S, Huang Y, Tang J, Feeney AJ, Oltz EM, Artyomov MN.

J Immunol. 2014 Feb 1;192(3):1064-70. doi: 10.4049/jimmunol.1302800. Epub 2013 Dec 18.


Histone methylation keeps the brakes on autophagy.

Collins PL, Oltz EM.

Mol Cell Biol. 2013 Oct;33(20):3974-5. doi: 10.1128/MCB.01033-13. Epub 2013 Aug 26. No abstract available.


Unifying model for molecular determinants of the preselection Vβ repertoire.

Gopalakrishnan S, Majumder K, Predeus A, Huang Y, Koues OI, Verma-Gaur J, Loguercio S, Su AI, Feeney AJ, Artyomov MN, Oltz EM.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3206-15. doi: 10.1073/pnas.1304048110. Epub 2013 Aug 5.


Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies.

Choi NM, Loguercio S, Verma-Gaur J, Degner SC, Torkamani A, Su AI, Oltz EM, Artyomov M, Feeney AJ.

J Immunol. 2013 Sep 1;191(5):2393-402. doi: 10.4049/jimmunol.1301279. Epub 2013 Jul 29.


Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.

Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, Sleckman BP.

Mol Cell Biol. 2013 Sep;33(18):3568-79. doi: 10.1128/MCB.00308-13. Epub 2013 Jul 8.


Control of Ig gene assembly: lessons from premature activation.

Gopalakrishnan S, Collins PL, Oltz EM.

EMBO J. 2013 May 15;32(10):1350-1. doi: 10.1038/emboj.2013.94. Epub 2013 Apr 23. No abstract available.


Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609.

Reed NP, Henderson MA, Oltz EM, Aune TM.

Genes Immun. 2013 Jan;14(1):7-12. doi: 10.1038/gene.2012.47. Epub 2012 Oct 18.


Preparing targets for V(D)J recombinase: transcription paves the way.

Sleckman BP, Oltz EM.

J Immunol. 2012 Jan 1;188(1):7-9. doi: 10.4049/jimmunol.1103195. Review. No abstract available.


Two forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus.

Guo C, Gerasimova T, Hao H, Ivanova I, Chakraborty T, Selimyan R, Oltz EM, Sen R.

Cell. 2011 Oct 14;147(2):332-43. doi: 10.1016/j.cell.2011.08.049. Epub 2011 Oct 6.


Genetic and epigenetic regulation of Tcrb gene assembly.

Sikes ML, Oltz EM.

Curr Top Microbiol Immunol. 2012;356:91-116. doi: 10.1007/82_2011_138. Review.


The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.

Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM.

Nat Immunol. 2011 Jun;12(6):536-43. doi: 10.1038/ni.2037. Epub 2011 May 15.


Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.

Ji Y, Little AJ, Banerjee JK, Hao B, Oltz EM, Krangel MS, Schatz DG.

J Exp Med. 2010 Dec 20;207(13):2809-16. doi: 10.1084/jem.20101136. Epub 2010 Nov 29.


Regulation of antigen receptor gene assembly by genetic-epigenetic crosstalk.

Osipovich O, Oltz EM.

Semin Immunol. 2010 Dec;22(6):313-22. doi: 10.1016/j.smim.2010.07.001. Epub 2010 Sep 15. Review.


Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo.

Kondilis-Mangum HD, Cobb RM, Osipovich O, Srivatsan S, Oltz EM, Krangel MS.

J Immunol. 2010 Jun 15;184(12):6970-7. doi: 10.4049/jimmunol.0903923. Epub 2010 May 17.


Dynamic regulation of antigen receptor gene assembly.

Thomas LR, Cobb RM, Oltz EM.

Adv Exp Med Biol. 2009;650:103-15. Review.


Cutting edge: SWI/SNF mediates antisense Igh transcription and locus-wide accessibility in B cell precursors.

Osipovich OA, Subrahmanyam R, Pierce S, Sen R, Oltz EM.

J Immunol. 2009 Aug 1;183(3):1509-13. doi: 10.4049/jimmunol.0900896. Epub 2009 Jul 13. Review.


Functional analysis of histone methyltransferase g9a in B and T lymphocytes.

Thomas LR, Miyashita H, Cobb RM, Pierce S, Tachibana M, Hobeika E, Reth M, Shinkai Y, Oltz EM.

J Immunol. 2008 Jul 1;181(1):485-93.


Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo.

Ni CY, Wu ZH, Florence WC, Parekh VV, Arrate MP, Pierce S, Schweitzer B, Van Kaer L, Joyce S, Miyamoto S, Ballard DW, Oltz EM.

J Immunol. 2008 Jun 1;180(11):7107-11.


Targeting V(D)J recombinase: putting a PHD to work.

Oltz EM, Osipovich O.

Immunity. 2007 Oct;27(4):539-41. Review.


Essential function for SWI-SNF chromatin-remodeling complexes in the promoter-directed assembly of Tcrb genes.

Osipovich O, Cobb RM, Oestreich KJ, Pierce S, Ferrier P, Oltz EM.

Nat Immunol. 2007 Aug;8(8):809-16. Epub 2007 Jun 24.


Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.

Bolland DJ, Wood AL, Afshar R, Featherstone K, Oltz EM, Corcoran AE.

Mol Cell Biol. 2007 Aug;27(15):5523-33. Epub 2007 May 25.


Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608.

Zhang F, Thomas LR, Oltz EM, Aune TM.

Nat Immunol. 2006 Dec;7(12):1309-16. Epub 2006 Oct 22.


Accessibility control of V(D)J recombination.

Cobb RM, Oestreich KJ, Osipovich OA, Oltz EM.

Adv Immunol. 2006;91:45-109. Review.


Regulation of TCRbeta gene assembly by a promoter/enhancer holocomplex.

Oestreich KJ, Cobb RM, Pierce S, Chen J, Ferrier P, Oltz EM.

Immunity. 2006 Apr;24(4):381-91.


Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination.

Afshar R, Pierce S, Bolland DJ, Corcoran A, Oltz EM.

J Immunol. 2006 Feb 15;176(4):2439-47.


Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation.

Carter RS, Pennington KN, Arrate P, Oltz EM, Ballard DW.

J Biol Chem. 2005 Dec 30;280(52):43272-9. Epub 2005 Nov 1.

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