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Infection Risks Among Patients With Multiple Sclerosis Treated With Fingolimod, Natalizumab, Rituximab, and Injectable Therapies.

Luna G, Alping P, Burman J, Fink K, Fogdell-Hahn A, Gunnarsson M, Hillert J, Langer-Gould A, Lycke J, Nilsson P, Salzer J, Svenningsson A, Vrethem M, Olsson T, Piehl F, Frisell T.

JAMA Neurol. 2019 Oct 7. doi: 10.1001/jamaneurol.2019.3365. [Epub ahead of print]


Retinal nerve fiber layer thickness associates with cognitive impairment and physical disability in multiple sclerosis.

Birkeldh U, Manouchehrinia A, Hietala MA, Hillert J, Olsson T, Piehl F, Kockum I, Brundin L, Zahavi O, Wahlberg-Ramsay M, Brautaset R, Nilsson M.

Mult Scler Relat Disord. 2019 Sep 26;36:101414. doi: 10.1016/j.msard.2019.101414. [Epub ahead of print]


The influence of human leukocyte antigen-DRB1*15:01 and its interaction with smoking in MS development is dependent on DQA1*01:01 status.

Hedström AK, Hössjer O, Hillert J, Stridh P, Kockum I, Olsson T, Alfredsson L.

Mult Scler. 2019 Oct 1:1352458519877685. doi: 10.1177/1352458519877685. [Epub ahead of print]


Non-parametric combination analysis of multiple data types enables detection of novel regulatory mechanisms in T cells of multiple sclerosis patients.

Fernandes SJ, Morikawa H, Ewing E, Ruhrmann S, Joshi RN, Lagani V, Karathanasis N, Khademi M, Planell N, Schmidt A, Tsamardinos I, Olsson T, Piehl F, Kockum I, Jagodic M, Tegnér J, Gomez-Cabrero D.

Sci Rep. 2019 Aug 19;9(1):11996. doi: 10.1038/s41598-019-48493-7.


Discovery and development of substituted thiadiazoles as inhibitors of Staphylococcus aureus Sortase A.

Wehrli PM, Uzelac I, Olsson T, Jacso T, Tietze D, Gottfries J.

Bioorg Med Chem. 2019 Oct 1;27(19):115043. doi: 10.1016/j.bmc.2019.115043. Epub 2019 Aug 7.


Comparative effectiveness of dimethyl fumarate as the initial and secondary treatment for MS.

Granqvist M, Burman J, Gunnarsson M, Lycke J, Nilsson P, Olsson T, Sundström P, Svenningsson A, Vrethem M, Frisell T, Piehl F.

Mult Scler. 2019 Aug 8:1352458519866600. doi: 10.1177/1352458519866600. [Epub ahead of print]


Environmental and genetic risk factors for MS: an integrated review.

Waubant E, Lucas R, Mowry E, Graves J, Olsson T, Alfredsson L, Langer-Gould A.

Ann Clin Transl Neurol. 2019 Sep;6(9):1905-1922. doi: 10.1002/acn3.50862. Epub 2019 Aug 7. Review.


Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk.

Tengvall K, Huang J, Hellström C, Kammer P, Biström M, Ayoglu B, Lima Bomfim I, Stridh P, Butt J, Brenner N, Michel A, Lundberg K, Padyukov L, Lundberg IE, Svenungsson E, Ernberg I, Olafsson S, Dilthey AT, Hillert J, Alfredsson L, Sundström P, Nilsson P, Waterboer T, Olsson T, Kockum I.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16955-16960. doi: 10.1073/pnas.1902623116. Epub 2019 Aug 2.


Sensitive detection of antigen-specific T-cells using bead-bound antigen for in vitro re-stimulation.

Bronge M, Kaiser A, Carvalho-Queiroz C, Nilsson OB, Ruhrmann S, Holmgren E, Olsson T, Gafvelin G, Grönlund H.

MethodsX. 2019 Jul 8;6:1635-1641. doi: 10.1016/j.mex.2019.07.004. eCollection 2019.


Synthesis and biological evaluation of truncated derivatives of abyssomicin C as antibacterial agents.

Monjas L, Fodran P, Kollback J, Cassani C, Olsson T, Genheden M, Larsson DGJ, Wallentin CJ.

Beilstein J Org Chem. 2019 Jul 2;15:1468-1474. doi: 10.3762/bjoc.15.147. eCollection 2019.


GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis.

Galli E, Hartmann FJ, Schreiner B, Ingelfinger F, Arvaniti E, Diebold M, Mrdjen D, van der Meer F, Krieg C, Nimer FA, Sanderson N, Stadelmann C, Khademi M, Piehl F, Claassen M, Derfuss T, Olsson T, Becher B.

Nat Med. 2019 Aug;25(8):1290-1300. doi: 10.1038/s41591-019-0521-4. Epub 2019 Jul 22.


Morning plasma cortisol as a cardiovascular risk factor: findings from prospective cohort and Mendelian randomization studies.

Crawford AA, Söderberg S, Kirschbaum C, Murphy L, Eliasson M, Ebrahim S, Davey Smith G, Olsson T, Sattar N, Lawlor DA, Timpson NJ, Reynolds RM, Walker BR.

Eur J Endocrinol. 2019 Jul 1. pii: EJE-19-0161.R1. doi: 10.1530/EJE-19-0161. [Epub ahead of print]


Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes.

Carlström KE, Ewing E, Granqvist M, Gyllenberg A, Aeinehband S, Enoksson SL, Checa A, Badam TVS, Huang J, Gomez-Cabrero D, Gustafsson M, Al Nimer F, Wheelock CE, Kockum I, Olsson T, Jagodic M, Piehl F.

Nat Commun. 2019 Jul 12;10(1):3081. doi: 10.1038/s41467-019-11139-3.


IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis.

Lindahl H, Guerreiro-Cacais AO, Bedri SK, Linnerbauer M, Lindén M, Abdelmagid N, Tandre K, Hollins C, Irving L, Glover C, Jones C, Alfredsson L, Rönnblom L, Kockum I, Khademi M, Jagodic M, Olsson T.

J Immunol. 2019 Aug 15;203(4):888-898. doi: 10.4049/jimmunol.1900400. Epub 2019 Jul 10.


Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.

Bridel C, van Wieringen WN, Zetterberg H, Tijms BM, Teunissen CE; and the NFL Group, Alvarez-Cermeño JC, Andreasson U, Axelsson M, Bäckström DC, Bartos A, Bjerke M, Blennow K, Boxer A, Brundin L, Burman J, Christensen T, Fialová L, Forsgren L, Frederiksen JL, Gisslén M, Gray E, Gunnarsson M, Hall S, Hansson O, Herbert MK, Jakobsson J, Jessen-Krut J, Janelidze S, Johannsson G, Jonsson M, Kappos L, Khademi M, Khalil M, Kuhle J, Landén M, Leinonen V, Logroscino G, Lu CH, Lycke J, Magdalinou NK, Malaspina A, Mattsson N, Meeter LH, Mehta SR, Modvig S, Olsson T, Paterson RW, Pérez-Santiago J, Piehl F, Pijnenburg YAL, Pyykkö OT, Ragnarsson O, Rojas JC, Romme Christensen J, Sandberg L, Scherling CS, Schott JM, Sellebjerg FT, Simone IL, Skillbäck T, Stilund M, Sundström P, Svenningsson A, Tortelli R, Tortorella C, Trentini A, Troiano M, Turner MR, van Swieten JC, Vågberg M, Verbeek MM, Villar LM, Visser PJ, Wallin A, Weiss A, Wikkelsø C, Wild EJ.

JAMA Neurol. 2019 Jun 17. doi: 10.1001/jamaneurol.2019.1534. [Epub ahead of print]


Long-term Cognitive Outcomes in Patients With Pediatric-Onset vs Adult-Onset Multiple Sclerosis.

McKay KA, Manouchehrinia A, Berrigan L, Fisk JD, Olsson T, Hillert J.

JAMA Neurol. 2019 Jun 17. doi: 10.1001/jamaneurol.2019.1546. [Epub ahead of print]


Adiposity Mediates the Association between the Dietary Inflammatory Index and Markers of Type 2 Diabetes Risk in Middle-Aged Black South African Women.

Mtintsilana A, Micklesfield LK, Chorell E, Olsson T, Shivappa N, Hebert JR, Kengne AP, Goedecke JH.

Nutrients. 2019 May 31;11(6). pii: E1246. doi: 10.3390/nu11061246.


Plasma protein profiling reveals candidate biomarkers for multiple sclerosis treatment.

Bedri SK, Nilsson OB, Fink K, Månberg A, Hamsten C, Ayoglu B, Manouchehrinia A, Nilsson P, Olsson T, Hillert J, Grönlund H, Glaser A.

PLoS One. 2019 May 29;14(5):e0217208. doi: 10.1371/journal.pone.0217208. eCollection 2019.


Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial.

Boxer AL, Qureshi I, Ahlijanian M, Grundman M, Golbe LI, Litvan I, Honig LS, Tuite P, McFarland NR, O'Suilleabhain P, Xie T, Tirucherai GS, Bechtold C, Bordelon Y, Geldmacher DS, Grossman M, Isaacson S, Zesiewicz T, Olsson T, Muralidharan KK, Graham DL, O'Gorman J, Haeberlein SB, Dam T.

Lancet Neurol. 2019 Jun;18(6):549-558. doi: 10.1016/S1474-4422(19)30139-5.


Myelin oligodendrocyte glycoprotein revisited-sensitive detection of MOG-specific T-cells in multiple sclerosis.

Bronge M, Ruhrmann S, Carvalho-Queiroz C, Nilsson OB, Kaiser A, Holmgren E, Macrini C, Winklmeier S, Meinl E, Brundin L, Khademi M, Olsson T, Gafvelin G, Grönlund H.

J Autoimmun. 2019 Aug;102:38-49. doi: 10.1016/j.jaut.2019.04.013. Epub 2019 May 1.


Postprandial levels of GLP-1, GIP and glucagon after 2 years of weight loss with a Paleolithic diet: a randomised controlled trial in healthy obese women.

Otten J, Ryberg M, Mellberg C, Andersson T, Chorell E, Lindahl B, Larsson C, Holst JJ, Olsson T.

Eur J Endocrinol. 2019 Jun 1;180(6):417-427. doi: 10.1530/EJE-19-0082.


MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis.

Kotelnikova E, Kiani NA, Messinis D, Pertsovskaya I, Pliaka V, Bernardo-Faura M, Rinas M, Vila G, Zubizarreta I, Pulido-Valdeolivas I, Sakellaropoulos T, Faigle W, Silberberg G, Masso M, Stridh P, Behrens J, Olsson T, Martin R, Paul F, Alexopoulos LG, Saez-Rodriguez J, Tegner J, Villoslada P.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9671-9676. doi: 10.1073/pnas.1818347116. Epub 2019 Apr 19.


Alterations in the metabolism of phospholipids, bile acids and branched-chain amino acids predicts development of type 2 diabetes in black South African women: a prospective cohort study.

Zeng Y, Mtintsilana A, Goedecke JH, Micklesfield LK, Olsson T, Chorell E.

Metabolism. 2019 Jun;95:57-64. doi: 10.1016/j.metabol.2019.04.001. Epub 2019 Apr 4.


Elevated resting-state connectivity in the medial temporal lobe and the prefrontal cortex among patients with Cushing's syndrome in remission.

Stomby A, Salami A, Dahlqvist P, Evang JA, Ryberg M, Bollerslev J, Olsson T, Johannsson G, Ragnarsson O.

Eur J Endocrinol. 2019 May 1;180(5):329-338. doi: 10.1530/EJE-19-0028.


Fat redistribution and accumulation of visceral adipose tissue predicts type 2 diabetes risk in middle-aged black South African women: a 13-year longitudinal study.

Mtintsilana A, Micklesfield LK, Chorell E, Olsson T, Goedecke JH.

Nutr Diabetes. 2019 Mar 27;9(1):12. doi: 10.1038/s41387-019-0079-8.


Lightweight data management with dtool.

Olsson TSG, Hartley M.

PeerJ. 2019 Mar 7;7:e6562. doi: 10.7717/peerj.6562. eCollection 2019.


Effects of a multicomponent physical activity promoting program on sedentary behavior, physical activity and body measures: a longitudinal study in different office types.

Wahlström V, Bergman F, Öhberg F, Eskilsson T, Olsson T, Järvholm LS.

Scand J Work Environ Health. 2019 Sep 1;45(5):493-504. doi: 10.5271/sjweh.3808. Epub 2019 Mar 12.


Factors associated with and long-term outcome of benign multiple sclerosis: a nationwide cohort study.

Crielaard L, Kavaliunas A, Ramanujam R, Olsson T, Hillert J, Stridh P, Kockum I, Manouchehrinia A.

J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):761-767. doi: 10.1136/jnnp-2018-319913. Epub 2019 Mar 1.


The incidence of Cushing's disease: a nationwide Swedish study.

Ragnarsson O, Olsson DS, Chantzichristos D, Papakokkinou E, Dahlqvist P, Segerstedt E, Olsson T, Petersson M, Berinder K, Bensing S, Höybye C, Edén Engström B, Burman P, Bonelli L, Follin C, Petranek D, Erfurth EM, Wahlberg J, Ekman B, Åkerman AK, Schwarcz E, Bryngelsson IL, Johannsson G.

Pituitary. 2019 Apr;22(2):179-186. doi: 10.1007/s11102-019-00951-1.


Cognitive function predicts work disability among multiple sclerosis patients.

Kavaliunas A, Tinghög P, Friberg E, Olsson T, Alexanderson K, Hillert J, Karrenbauer VD.

Mult Scler J Exp Transl Clin. 2019 Jan 14;5(1):2055217318822134. doi: 10.1177/2055217318822134. eCollection 2019 Jan-Mar.


Overall and Disease-Specific Mortality in Patients With Cushing Disease: A Swedish Nationwide Study.

Ragnarsson O, Olsson DS, Papakokkinou E, Chantzichristos D, Dahlqvist P, Segerstedt E, Olsson T, Petersson M, Berinder K, Bensing S, Höybye C, Edén-Engström B, Burman P, Bonelli L, Follin C, Petranek D, Erfurth EM, Wahlberg J, Ekman B, Åkerman AK, Schwarcz E, Bryngelsson IL, Johannsson G.

J Clin Endocrinol Metab. 2019 Jun 1;104(6):2375-2384. doi: 10.1210/jc.2018-02524.


Exercise Training Adds Cardiometabolic Benefits of a Paleolithic Diet in Type 2 Diabetes Mellitus.

Otten J, Andersson J, Ståhl J, Stomby A, Saleh A, Waling M, Ryberg M, Hauksson J, Svensson M, Johansson B, Olsson T.

J Am Heart Assoc. 2019 Jan 22;8(2):e010634. doi: 10.1161/JAHA.118.010634.


Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer's disease.

Mattsson N, Insel PS, Donohue M, Jögi J, Ossenkoppele R, Olsson T, Schöll M, Smith R, Hansson O.

Alzheimers Dement. 2019 Apr;15(4):570-580. doi: 10.1016/j.jalz.2018.12.001. Epub 2019 Jan 25.


Protocol for systematic review and meta-analysis of sex hormones and diabetes risk in ageing men and women of African ancestry.

Kufe NC, Masemola M, Chikowore T, Kengne AP, Olsson T, Goedecke JH, Micklesfield LK.

BMJ Open. 2019 Jan 3;9(1):e024446. doi: 10.1136/bmjopen-2018-024446.


Age at Menarche and Risk of Multiple Sclerosis: Current Progress From Epidemiological Investigations.

Jiang X, Olsson T, Alfredsson L.

Front Immunol. 2018 Nov 13;9:2600. doi: 10.3389/fimmu.2018.02600. eCollection 2018. Review.


The association between multiple sclerosis and pain medications.

Burkill S, Montgomery S, Kockum I, Piehl F, Strid P, Hillert J, Alfredsson L, Olsson T, Bahmanyar S.

Pain. 2019 Feb;160(2):424-432. doi: 10.1097/j.pain.0000000000001429. Erratum in: Pain. 2019 Apr;160(4):986.


Treadmill workstations in office workers who are overweight or obese: a randomised controlled trial.

Bergman F, Wahlström V, Stomby A, Otten J, Lanthén E, Renklint R, Waling M, Sörlin A, Boraxbekk CJ, Wennberg P, Öhberg F, Levine JA, Olsson T.

Lancet Public Health. 2018 Nov;3(11):e523-e535. doi: 10.1016/S2468-2667(18)30163-4. Epub 2018 Oct 12.


Identification of MS-specific serum miRNAs in an international multicenter study.

Regev K, Healy BC, Paul A, Diaz-Cruz C, Mazzola MA, Raheja R, Glanz BI, Kivisäkk P, Chitnis T, Jagodic M, Piehl F, Olsson T, Khademi M, Hauser S, Oksenberg J, Khoury SJ, Weiner HL, Gandhi R.

Neurol Neuroimmunol Neuroinflamm. 2018 Aug 20;5(5):e491. doi: 10.1212/NXI.0000000000000491. eCollection 2018 Sep.


Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis.

Jelcic I, Al Nimer F, Wang J, Lentsch V, Planas R, Jelcic I, Madjovski A, Ruhrmann S, Faigle W, Frauenknecht K, Pinilla C, Santos R, Hammer C, Ortiz Y, Opitz L, Grönlund H, Rogler G, Boyman O, Reynolds R, Lutterotti A, Khademi M, Olsson T, Piehl F, Sospedra M, Martin R.

Cell. 2018 Sep 20;175(1):85-100.e23. doi: 10.1016/j.cell.2018.08.011. Epub 2018 Aug 30.


Ectopic BASL Reveals Tissue Cell Polarity throughout Leaf Development in Arabidopsis thaliana.

Mansfield C, Newman JL, Olsson TSG, Hartley M, Chan J, Coen E.

Curr Biol. 2018 Aug 20;28(16):2638-2646.e4. doi: 10.1016/j.cub.2018.06.019. Epub 2018 Aug 9.


Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2-X) Inhibitors.

Knerr L, Giordanetto F, Nordberg P, Pettersen D, Selmi N, Beisel HG, de la Motte H, Olsson T, Perkins TDJ, Herslöf M, Månsson Å, Dahlström M, Starke I, Broddefalk J, Saarinen G, Klingegård F, Hurt-Camejo E, Rosengren B, Brengdahl J, Jansen F, Rohman M, Sandmark J, Hallberg K, Åkerud T, Roth RG, Ahlqvist M.

ACS Med Chem Lett. 2018 Jun 23;9(7):594-599. doi: 10.1021/acsmedchemlett.7b00505. eCollection 2018 Jul 12.


Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis.

Mowry EM, Hedström AK, Gianfrancesco MA, Shao X, Schaefer CA, Shen L, Bellesis KH, Briggs FBS, Olsson T, Alfredsson L, Barcellos LF.

Mult Scler Relat Disord. 2018 Aug;24:135-141. doi: 10.1016/j.msard.2018.06.009. Epub 2018 Jun 23.


Organic solvents and MS susceptibility: Interaction with MS risk HLA genes.

Hedström AK, Hössjer O, Katsoulis M, Kockum I, Olsson T, Alfredsson L.

Neurology. 2018 Jul 31;91(5):e455-e462. doi: 10.1212/WNL.0000000000005906. Epub 2018 Jul 3.


DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis.

Kular L, Liu Y, Ruhrmann S, Zheleznyakova G, Marabita F, Gomez-Cabrero D, James T, Ewing E, Lindén M, Górnikiewicz B, Aeinehband S, Stridh P, Link J, Andlauer TFM, Gasperi C, Wiendl H, Zipp F, Gold R, Tackenberg B, Weber F, Hemmer B, Strauch K, Heilmann-Heimbach S, Rawal R, Schminke U, Schmidt CO, Kacprowski T, Franke A, Laudes M, Dilthey AT, Celius EG, Søndergaard HB, Tegnér J, Harbo HF, Oturai AB, Olafsson S, Eggertsson HP, Halldorsson BV, Hjaltason H, Olafsson E, Jonsdottir I, Stefansson K, Olsson T, Piehl F, Ekström TJ, Kockum I, Feinberg AP, Jagodic M.

Nat Commun. 2018 Jun 19;9(1):2397. doi: 10.1038/s41467-018-04732-5.


Association of Pre-Disease Body Mass Index With Multiple Sclerosis Prognosis.

Manouchehrinia A, Hedström AK, Alfredsson L, Olsson T, Hillert J, Ramanujam R.

Front Neurol. 2018 May 11;9:232. doi: 10.3389/fneur.2018.00232. eCollection 2018.


Ancient genomes from Iceland reveal the making of a human population.

Ebenesersdóttir SS, Sandoval-Velasco M, Gunnarsdóttir ED, Jagadeesan A, Guðmundsdóttir VB, Thordardóttir EL, Einarsdóttir MS, Moore KHS, Sigurðsson Á, Magnúsdóttir DN, Jónsson H, Snorradóttir S, Hovig E, Møller P, Kockum I, Olsson T, Alfredsson L, Hansen TF, Werge T, Cavalleri GL, Gilbert E, Lalueza-Fox C, Walser JW 3rd, Kristjánsdóttir S, Gopalakrishnan S, Árnadóttir L, Magnússon ÓÞ, Gilbert MTP, Stefánsson K, Helgason A.

Science. 2018 Jun 1;360(6392):1028-1032. doi: 10.1126/science.aar2625.


The association between high-sensitivity C-reactive protein and metabolic risk factors in black and white South African women: a cross-sectional study.

George C, Evans J, Micklesfield LK, Olsson T, Goedecke JH.

BMC Obes. 2018 May 7;5:14. doi: 10.1186/s40608-018-0191-7. eCollection 2018.


Lifestyle and Environmental Factors in Multiple Sclerosis.

Alfredsson L, Olsson T.

Cold Spring Harb Perspect Med. 2019 Apr 1;9(4). pii: a028944. doi: 10.1101/cshperspect.a028944. Review.


A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes: a randomised controlled trial.

Otten J, Stomby A, Waling M, Isaksson A, Söderström I, Ryberg M, Svensson M, Hauksson J, Olsson T.

Diabetologia. 2018 Jul;61(7):1548-1559. doi: 10.1007/s00125-018-4618-y. Epub 2018 Apr 26.


An Exercise Intervention to Unravel the Mechanisms Underlying Insulin Resistance in a Cohort of Black South African Women: Protocol for a Randomized Controlled Trial and Baseline Characteristics of Participants.

Goedecke JH, Mendham AE, Clamp L, Nono Nankam PA, Fortuin-de Smidt MC, Phiri L, Micklesfield LK, Keswell D, Woudberg NJ, Lecour S, Alhamud A, Kaba M, Lutomia FM, van Jaarsveld PJ, de Villiers A, Kahn SE, Chorell E, Hauksson J, Olsson T.

JMIR Res Protoc. 2018 Apr 18;7(4):e75. doi: 10.2196/resprot.9098.

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