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Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7.

Hu S, Marineau JJ, Rajagopal N, Hamman KB, Choi YJ, Schmidt DR, Ke N, Johannessen L, Bradley MJ, Orlando DA, Alnemy SR, Ren Y, Ciblat S, Winter DK, Kabro A, Sprott KT, Hodgson JG, Fritz CC, Carulli JP, di Tomaso E, Olson ER.

Cancer Res. 2019 Jul 1;79(13):3479-3491. doi: 10.1158/0008-5472.CAN-19-0119. Epub 2019 May 7.


Flawed analysis and unconvincing interpretation: a comment on Chapron and Treves 2016.

Olson ER, Crimmins SM, Beyer DE Jr, MacNulty DR, Patterson BR, Rudolph BA, Wydeven AP, Van Deelen TR.

Proc Biol Sci. 2017 Nov 29;284(1867). pii: 20170273. doi: 10.1098/rspb.2017.0273. No abstract available.


Prolonged Expression of Secreted Enzymes in Dogs After Liver-Directed Delivery of Sleeping Beauty Transposons: Implications for Non-Viral Gene Therapy of Systemic Disease.

Aronovich EL, Hyland KA, Hall BC, Bell JB, Olson ER, Rusten MU, Hunter DW, Ellinwood NM, McIvor RS, Hackett PB.

Hum Gene Ther. 2017 Jul;28(7):551-564. doi: 10.1089/hum.2017.004. Epub 2017 May 19.


Arboreal camera trapping expands Hyla versicolor complex (Hylidae) canopy use to new heights.

Laughlin MM, Olson ER, Martin JG.

Ecology. 2017 Aug;98(8):2221-2223. doi: 10.1002/ecy.1843. Epub 2017 May 15. No abstract available.


Transgene Expression in Dogs After Liver-Directed Hydrodynamic Delivery of Sleeping Beauty Transposons Using Balloon Catheters.

Hyland KA, Aronovich EL, Olson ER, Bell JB, Rusten MU, Gunther R, Hunter DW, Hackett PB, McIvor RS.

Hum Gene Ther. 2017 Jul;28(7):541-550. doi: 10.1089/hum.2017.003. Epub 2017 Apr 19.


Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin.

Dickinson SE, Janda J, Criswell J, Blohm-Mangone K, Olson ER, Liu Z, Barber C, Petricoin EF 3rd, Calvert VS, Einspahr J, Dickinson JE, Stratton SP, Curiel-Lewandrowski C, Saboda K, Hu C, Bode AM, Dong Z, Alberts DS, Timothy Bowden G.

Cancer Prev Res (Phila). 2016 Mar;9(3):215-24. doi: 10.1158/1940-6207.CAPR-15-0419. Epub 2016 Jan 22.


A Broad Range of Dose Optima Achieve High-level, Long-term Gene Expression After Hydrodynamic Delivery of Sleeping Beauty Transposons Using Hyperactive SB100x Transposase.

Podetz-Pedersen KM, Olson ER, Somia NV, Russell SJ, McIvor RS.

Mol Ther Nucleic Acids. 2016 Jan 19;5:e279. doi: 10.1038/mtna.2015.54. Review.


Sleeping Beauty-Mediated Drug Resistance Gene Transfer in Human Hematopoietic Progenitor Cells.

Hyland KA, Olson ER, McIvor RS.

Hum Gene Ther. 2015 Oct;26(10):657-63. doi: 10.1089/hum.2015.058. Epub 2015 Sep 18.


Role of transgene regulation in ex vivo lentiviral correction of artemis deficiency.

Multhaup MM, Podetz-Pedersen KM, Karlen AD, Olson ER, Gunther R, Somia NV, Blazar BR, Cowan MJ, McIvor RS.

Hum Gene Ther. 2015 Apr;26(4):232-43. doi: 10.1089/hum.2014.062. Epub 2015 Apr 13.


Quantitative ChIP-Seq normalization reveals global modulation of the epigenome.

Orlando DA, Chen MW, Brown VE, Solanki S, Choi YJ, Olson ER, Fritz CC, Bradner JE, Guenther MG.

Cell Rep. 2014 Nov 6;9(3):1163-70. doi: 10.1016/j.celrep.2014.10.018. Epub 2014 Oct 30.


A novel chemopreventive mechanism for a traditional medicine: East Indian sandalwood oil induces autophagy and cell death in proliferating keratinocytes.

Dickinson SE, Olson ER, Levenson C, Janda J, Rusche JJ, Alberts DS, Bowden GT.

Arch Biochem Biophys. 2014 Sep 15;558:143-52. doi: 10.1016/ Epub 2014 Jul 5.


Simple and efficient methods for enrichment and isolation of endonuclease modified cells.

Moriarity BS, Rahrmann EP, Beckmann DA, Conboy CB, Watson AL, Carlson DF, Olson ER, Hyland KA, Fahrenkrug SC, McIvor RS, Largaespada DA.

PLoS One. 2014 May 5;9(5):e96114. doi: 10.1371/journal.pone.0096114. eCollection 2014.


Optimizing nasal potential difference analysis for CFTR modulator development: assessment of ivacaftor in CF subjects with the G551D-CFTR mutation.

Rowe SM, Liu B, Hill A, Hathorne H, Cohen M, Beamer JR, Accurso FJ, Dong Q, Ordoñez CL, Stone AJ, Olson ER, Clancy JP; VX06-770-101 Study Group.

PLoS One. 2013 Jul 26;8(7):e66955. doi: 10.1371/journal.pone.0066955. Print 2013.


The miR-310/13 cluster antagonizes β-catenin function in the regulation of germ and somatic cell differentiation in the Drosophila testis.

Pancratov R, Peng F, Smibert P, Yang S Jr, Olson ER, Guha-Gilford C, Kapoor AJ, Liang FX, Lai EC, Flaherty MS, DasgGupta R.

Development. 2013 Jul;140(14):2904-16. doi: 10.1242/dev.092817.


Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.

Van Goor F, Hadida S, Grootenhuis PD, Burton B, Stack JH, Straley KS, Decker CJ, Miller M, McCartney J, Olson ER, Wine JJ, Frizzell RA, Ashlock M, Negulescu PA.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18843-8. doi: 10.1073/pnas.1105787108. Epub 2011 Oct 5.


Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye.

Olson ER, Pancratov R, Chatterjee SS, Changkakoty B, Pervaiz Z, DasGupta R.

EMBO Rep. 2011 Sep 30;12(10):1047-54. doi: 10.1038/embor.2011.159.


Sleeping Beauty-mediated correction of Fanconi anemia type C.

Hyland KA, Olson ER, Clark KJ, Aronovich EL, Hackett PB, Blazar BR, Tolar J, Scott McIvor R.

J Gene Med. 2011 Sep;13(9):462-9. doi: 10.1002/jgm.1589.


Fat malabsorption and increased intestinal oxalate absorption are common after Roux-en-Y gastric bypass surgery.

Kumar R, Lieske JC, Collazo-Clavell ML, Sarr MG, Olson ER, Vrtiska TJ, Bergstralh EJ, Li X.

Surgery. 2011 May;149(5):654-61. doi: 10.1016/j.surg.2010.11.015. Epub 2011 Feb 5.


p38 MAP kinase plays a functional role in UVB-induced mouse skin carcinogenesis.

Dickinson SE, Olson ER, Zhang J, Cooper SJ, Melton T, Criswell PJ, Casanova A, Dong Z, Hu C, Saboda K, Jacobs ET, Alberts DS, Bowden GT.

Mol Carcinog. 2011 Jun;50(6):469-78. doi: 10.1002/mc.20734. Epub 2011 Jan 25.


Therapeutics development for cystic fibrosis: a successful model for a multisystem genetic disease.

Ashlock MA, Olson ER.

Annu Rev Med. 2011;62:107-25. doi: 10.1146/annurev-med-061509-131034. Review.


Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation.

Accurso FJ, Rowe SM, Clancy JP, Boyle MP, Dunitz JM, Durie PR, Sagel SD, Hornick DB, Konstan MW, Donaldson SH, Moss RB, Pilewski JM, Rubenstein RC, Uluer AZ, Aitken ML, Freedman SD, Rose LM, Mayer-Hamblett N, Dong Q, Zha J, Stone AJ, Olson ER, Ordoñez CL, Campbell PW, Ashlock MA, Ramsey BW.

N Engl J Med. 2010 Nov 18;363(21):1991-2003. doi: 10.1056/NEJMoa0909825.


The induction of S100p expression by the Prostaglandin E₂ (PGE₂)/EP4 receptor signaling pathway in colon cancer cells.

Chandramouli A, Mercado-Pimentel ME, Hutchinson A, Gibadulinová A, Olson ER, Dickinson S, Shañas R, Davenport J, Owens J, Bhattacharyya AK, Regan JW, Pastorekova S, Arumugam T, Logsdon CD, Nelson MA.

Cancer Biol Ther. 2010 Nov 15;10(10):1056-66. doi: 10.4161/cbt.10.10.13373. Epub 2010 Nov 15.


Quercetin potentiates UVB-Induced c-Fos expression: implications for its use as a chemopreventive agent.

Olson ER, Melton T, Dickinson SE, Dong Z, Alberts DS, Bowden GT.

Cancer Prev Res (Phila). 2010 Jul;3(7):876-84. doi: 10.1158/1940-6207.CAPR-09-0220. Epub 2010 Jun 15.


Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study.

Borg A, Haile RW, Malone KE, Capanu M, Diep A, Törngren T, Teraoka S, Begg CB, Thomas DC, Concannon P, Mellemkjaer L, Bernstein L, Tellhed L, Xue S, Olson ER, Liang X, Dolle J, Børresen-Dale AL, Bernstein JL.

Hum Mutat. 2010 Mar;31(3):E1200-40. doi: 10.1002/humu.21202.


Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.

Van Goor F, Hadida S, Grootenhuis PD, Burton B, Cao D, Neuberger T, Turnbull A, Singh A, Joubran J, Hazlewood A, Zhou J, McCartney J, Arumugam V, Decker C, Yang J, Young C, Olson ER, Wine JJ, Frizzell RA, Ashlock M, Negulescu P.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30. doi: 10.1073/pnas.0904709106. Epub 2009 Oct 21.


Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer.

Dickinson SE, Melton TF, Olson ER, Zhang J, Saboda K, Bowden GT.

Cancer Res. 2009 Sep 1;69(17):7103-10. doi: 10.1158/0008-5472.CAN-09-0770. Epub 2009 Aug 11.


Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.

Beilke LD, Aleksunes LM, Olson ER, Besselsen DG, Klaassen CD, Dvorak K, Cherrington NJ.

Toxicol Lett. 2009 Jul 10;188(1):38-44. doi: 10.1016/j.toxlet.2009.03.005. Epub 2009 Mar 20.


Stabilization of quercetin paradoxically reduces its proapoptotic effect on UVB-irradiated human keratinocytes.

Olson ER, Melton T, Dong Z, Bowden GT.

Cancer Prev Res (Phila). 2008 Oct;1(5):362-8. doi: 10.1158/1940-6207.CAPR-08-0101.


Cardiac myofibroblast differentiation is attenuated by alpha(3) integrin blockade: potential role in post-MI remodeling.

Bryant JE, Shamhart PE, Luther DJ, Olson ER, Koshy JC, Costic DJ, Mohile MV, Dockry M, Doane KJ, Meszaros JG.

J Mol Cell Cardiol. 2009 Feb;46(2):186-92. doi: 10.1016/j.yjmcc.2008.10.022. Epub 2008 Nov 7.


Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts.

Olson ER, Shamhart PE, Naugle JE, Meszaros JG.

Hypertension. 2008 Mar;51(3):704-11. doi: 10.1161/HYPERTENSIONAHA.107.098459. Epub 2008 Jan 14.


Primary cardiac lymphoma: utility of multimodality imaging in diagnosis and management.

Mato AR, Morgans AK, Roullet MR, Bagg A, Glatstein E, Litt HI, Downs LH, Chong EA, Olson ER, Andreadis C, Schuster SJ.

Cancer Biol Ther. 2007 Dec;6(12):1867-70. Epub 2007 Oct 13.


Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data.

Kalvass JC, Olson ER, Cassidy MP, Selley DE, Pollack GM.

J Pharmacol Exp Ther. 2007 Oct;323(1):346-55. Epub 2007 Jul 23.


Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds.

Grossman TH, Bartels DJ, Mullin S, Gross CH, Parsons JD, Liao Y, Grillot AL, Stamos D, Olson ER, Charifson PS, Mani N.

Antimicrob Agents Chemother. 2007 Feb;51(2):657-66. Epub 2006 Nov 20.


A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal.

Müh U, Hare BJ, Duerkop BA, Schuster M, Hanzelka BL, Heim R, Olson ER, Greenberg EP.

Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16948-52. Epub 2006 Oct 30.


Novel Pseudomonas aeruginosa quorum-sensing inhibitors identified in an ultra-high-throughput screen.

Müh U, Schuster M, Heim R, Singh A, Olson ER, Greenberg EP.

Antimicrob Agents Chemother. 2006 Nov;50(11):3674-9. Epub 2006 Sep 11.


Population-based estimates of breast cancer risks associated with ATM gene variants c.7271T>G and c.1066-6T>G (IVS10-6T>G) from the Breast Cancer Family Registry.

Bernstein JL, Teraoka S, Southey MC, Jenkins MA, Andrulis IL, Knight JA, John EM, Lapinski R, Wolitzer AL, Whittemore AS, West D, Seminara D, Olson ER, Spurdle AB, Chenevix-Trench G, Giles GG, Hopper JL, Concannon P.

Hum Mutat. 2006 Nov;27(11):1122-8.


In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation.

Bauer B, Yang X, Hartz AM, Olson ER, Zhao R, Kalvass JC, Pollack GM, Miller DS.

Mol Pharmacol. 2006 Oct;70(4):1212-9. Epub 2006 Jul 12.


Evidence that the promoter can influence assembly of antitermination complexes at downstream RNA sites.

Zhou Y, Shi T, Mozola MA, Olson ER, Henthorn K, Brown S, Gussin GN, Friedman DI.

J Bacteriol. 2006 Mar;188(6):2222-32.


The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry.

Bernstein JL, Teraoka SN, John EM, Andrulis IL, Knight JA, Lapinski R, Olson ER, Wolitzer AL, Seminara D, Whittemore AS, Concannon P.

Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):348-52.


Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling.

Naugle JE, Olson ER, Zhang X, Mase SE, Pilati CF, Maron MB, Folkesson HG, Horne WI, Doane KJ, Meszaros JG.

Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H323-30. Epub 2005 Sep 2.


ATM haplotypes and associated mutations in Iranian patients with ataxia-telangiectasia: recurring homozygosity without a founder haplotype.

Babaei M, Mitui M, Olson ER, Gatti RA.

Hum Genet. 2005 Jul;117(2-3):101-6. Epub 2005 Apr 21.


Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase.

Swaney JS, Roth DM, Olson ER, Naugle JE, Meszaros JG, Insel PA.

Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):437-42. Epub 2004 Dec 29.


Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol.

Olson ER, Naugle JE, Zhang X, Bomser JA, Meszaros JG.

Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1131-8. Epub 2004 Oct 21.


Escherichia coli requires the protease activity of FtsH for growth.

Jayasekera MM, Foltin SK, Olson ER, Holler TP.

Arch Biochem Biophys. 2000 Aug 1;380(1):103-7.


Novel streptopyrroles from Streptomyces rimosus with bacterial protein histidine kinase inhibitory and antimicrobial activities.

Trew SJ, Wrigley SK, Pairet L, Sohal J, Shanu-Wilson P, Hayes MA, Martin SM, Manohar RN, Chicarelli-Robinson MI, Kau DA, Byrne CV, Wellington EM, Moloney JM, Howard J, Hupe D, Olson ER.

J Antibiot (Tokyo). 2000 Jan;53(1):1-11.


Functional and biochemical characterization of Escherichia coli sugar efflux transporters.

Liu JY, Miller PF, Willard J, Olson ER.

J Biol Chem. 1999 Aug 13;274(33):22977-84.

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