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NURR1 activation in skeletal muscle controls systemic energy homeostasis.

Amoasii L, Sanchez-Ortiz E, Fujikawa T, Elmquist JK, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11299-11308. doi: 10.1073/pnas.1902490116. Epub 2019 May 20.


Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers.

Hashimoto H, Wang Z, Garry GA, Malladi VS, Botten GA, Ye W, Zhou H, Osterwalder M, Dickel DE, Visel A, Liu N, Bassel-Duby R, Olson EN.

Cell Stem Cell. 2019 Jul 3;25(1):69-86.e5. doi: 10.1016/j.stem.2019.03.022. Epub 2019 May 9.


Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding.

Li S, Chen K, Zhang Y, Barnes SD, Jaichander P, Zheng Y, Hassan M, Malladi VS, Skapek SX, Xu L, Bassel-Duby R, Olson EN, Liu N.

Genes Dev. 2019 Jun 1;33(11-12):626-640. doi: 10.1101/gad.324467.119. Epub 2019 Apr 11.


CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells.

Min YL, Li H, Rodriguez-Caycedo C, Mireault AA, Huang J, Shelton JM, McAnally JR, Amoasii L, Mammen PPA, Bassel-Duby R, Olson EN.

Sci Adv. 2019 Mar 6;5(3):eaav4324. doi: 10.1126/sciadv.aav4324. eCollection 2019 Mar.


Trout myomaker contains 14 minisatellites and two sequence extensions but retains fusogenic function.

Landemaine A, Ramirez-Martinez A, Monestier O, Sabin N, Rescan PY, Olson EN, Gabillard JC.

J Biol Chem. 2019 Apr 19;294(16):6364-6374. doi: 10.1074/jbc.RA118.006047. Epub 2019 Feb 28.


Secreted MG53 From Striated Muscle Impairs Systemic Insulin Sensitivity.

Zhuang L, Bassel-Duby R, Olson EN.

Circulation. 2019 Feb 12;139(7):915-917. doi: 10.1161/CIRCULATIONAHA.118.038387. No abstract available.


Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease.

Cui M, Wang Z, Bassel-Duby R, Olson EN.

Development. 2018 Dec 20;145(24). pii: dev171983. doi: 10.1242/dev.171983. Review.


Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis.

Zhang QJ, Tran TAT, Wang M, Ranek MJ, Kokkonen-Simon KM, Gao J, Luo X, Tan W, Kyrychenko V, Liao L, Xu J, Hill JA, Olson EN, Kass DA, Martinez ED, Liu ZP.

Nat Commun. 2018 Dec 7;9(1):5230. doi: 10.1038/s41467-018-07173-2.


CRISPR Correction of Duchenne Muscular Dystrophy.

Min YL, Bassel-Duby R, Olson EN.

Annu Rev Med. 2019 Jan 27;70:239-255. doi: 10.1146/annurev-med-081117-010451. Epub 2018 Oct 31.


The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy.

Makarewich CA, Munir AZ, Schiattarella GG, Bezprozvannaya S, Raguimova ON, Cho EE, Vidal AH, Robia SL, Bassel-Duby R, Olson EN.

Elife. 2018 Oct 9;7. pii: e38319. doi: 10.7554/eLife.38319.


Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy.

Amoasii L, Hildyard JCW, Li H, Sanchez-Ortiz E, Mireault A, Caballero D, Harron R, Stathopoulou TR, Massey C, Shelton JM, Bassel-Duby R, Piercy RJ, Olson EN.

Science. 2018 Oct 5;362(6410):86-91. doi: 10.1126/science.aau1549. Epub 2018 Aug 30.


Identification of a multipotent Twist2-expressing cell population in the adult heart.

Min YL, Jaichander P, Sanchez-Ortiz E, Bezprozvannaya S, Malladi VS, Cui M, Wang Z, Bassel-Duby R, Olson EN, Liu N.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8430-E8439. doi: 10.1073/pnas.1800526115. Epub 2018 Aug 20.


Entrepreneurialism in the Translational Biologic Sciences: Why, How, and However.

Bristow MR, Leinwand LA, Olson EN.

JACC Basic Transl Sci. 2018 Mar 1;3(1):1-8. doi: 10.1016/j.jacbts.2017.10.004. eCollection 2018 Feb.


MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation.

Makarewich CA, Baskin KK, Munir AZ, Bezprozvannaya S, Sharma G, Khemtong C, Shah AM, McAnally JR, Malloy CR, Szweda LI, Bassel-Duby R, Olson EN.

Cell Rep. 2018 Jun 26;23(13):3701-3709. doi: 10.1016/j.celrep.2018.05.058.


Therapeutic approaches for cardiac regeneration and repair.

Hashimoto H, Olson EN, Bassel-Duby R.

Nat Rev Cardiol. 2018 Oct;15(10):585-600. doi: 10.1038/s41569-018-0036-6. Review.


Myoediting: Toward Prevention of Muscular Dystrophy by Therapeutic Genome Editing.

Zhang Y, Long C, Bassel-Duby R, Olson EN.

Physiol Rev. 2018 Jul 1;98(3):1205-1240. doi: 10.1152/physrev.00046.2017. Review.


Cullin-3-RING ubiquitin ligase activity is required for striated muscle function in mice.

Papizan JB, Vidal AH, Bezprozvannaya S, Bassel-Duby R, Olson EN.

J Biol Chem. 2018 Jun 8;293(23):8802-8811. doi: 10.1074/jbc.RA118.002104. Epub 2018 Apr 13.


Fusogenic micropeptide Myomixer is essential for satellite cell fusion and muscle regeneration.

Bi P, McAnally JR, Shelton JM, Sánchez-Ortiz E, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3864-3869. doi: 10.1073/pnas.1800052115. Epub 2018 Mar 26.


Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of CaV1.1.

Polster A, Nelson BR, Papadopoulos S, Olson EN, Beam KG.

J Gen Physiol. 2018 Apr 2;150(4):613-624. doi: 10.1085/jgp.201711917. Epub 2018 Feb 21.


Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing.

Long C, Li H, Tiburcy M, Rodriguez-Caycedo C, Kyrychenko V, Zhou H, Zhang Y, Min YL, Shelton JM, Mammen PPA, Liaw NY, Zimmermann WH, Bassel-Duby R, Schneider JW, Olson EN.

Sci Adv. 2018 Jan 31;4(1):eaap9004. doi: 10.1126/sciadv.aap9004. eCollection 2018 Jan.


Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy.

Amoasii L, Long C, Li H, Mireault AA, Shelton JM, Sanchez-Ortiz E, McAnally JR, Bhattacharyya S, Schmidt F, Grimm D, Hauschka SD, Bassel-Duby R, Olson EN.

Sci Transl Med. 2017 Nov 29;9(418). pii: eaan8081. doi: 10.1126/scitranslmed.aan8081. Erratum in: Sci Transl Med. 2018 Jan 24;10 (425):.


Requirement of the fusogenic micropeptide myomixer for muscle formation in zebrafish.

Shi J, Bi P, Pei J, Li H, Grishin NV, Bassel-Duby R, Chen EH, Olson EN.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11950-11955. doi: 10.1073/pnas.1715229114. Epub 2017 Oct 23.


Considerations for Cardiac CRISPR.

Carroll KJ, Olson EN.

Circ Res. 2017 Oct 27;121(10):1111-1112. doi: 10.1161/CIRCRESAHA.117.311974. No abstract available.


ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression.

Zhou H, Morales MG, Hashimoto H, Dickson ME, Song K, Ye W, Kim MS, Niederstrasser H, Wang Z, Chen B, Posner BA, Bassel-Duby R, Olson EN.

Genes Dev. 2017 Sep 1;31(17):1770-1783. doi: 10.1101/gad.305482.117.


Functional correction of dystrophin actin binding domain mutations by genome editing.

Kyrychenko V, Kyrychenko S, Tiburcy M, Shelton JM, Long C, Schneider JW, Zimmermann WH, Bassel-Duby R, Olson EN.

JCI Insight. 2017 Sep 21;2(18). pii: 95918. doi: 10.1172/jci.insight.95918. eCollection 2017 Sep 21.


Deficiency in Kelch protein Klhl31 causes congenital myopathy in mice.

Papizan JB, Garry GA, Brezprozvannaya S, McAnally JR, Bassel-Duby R, Liu N, Olson EN.

J Clin Invest. 2017 Oct 2;127(10):3730-3740. doi: 10.1172/JCI93445. Epub 2017 Sep 5.


KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.

Ramirez-Martinez A, Cenik BK, Bezprozvannaya S, Chen B, Bassel-Duby R, Liu N, Olson EN.

Elife. 2017 Aug 9;6. pii: e26439. doi: 10.7554/eLife.26439.


MED12 regulates a transcriptional network of calcium-handling genes in the heart.

Baskin KK, Makarewich CA, DeLeon SM, Ye W, Chen B, Beetz N, Schrewe H, Bassel-Duby R, Olson EN.

JCI Insight. 2017 Jul 20;2(14). pii: 91920. doi: 10.1172/jci.insight.91920. eCollection 2017 Jul 20.


A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome.

Di Gioia SA, Connors S, Matsunami N, Cannavino J, Rose MF, Gilette NM, Artoni P, de Macena Sobreira NL, Chan WM, Webb BD, Robson CD, Cheng L, Van Ryzin C, Ramirez-Martinez A, Mohassel P, Leppert M, Scholand MB, Grunseich C, Ferreira CR, Hartman T, Hayes IM, Morgan T, Markie DM, Fagiolini M, Swift A, Chines PS, Speck-Martins CE, Collins FS, Jabs EW, Bönnemann CG, Olson EN; Moebius Syndrome Research Consortium, Carey JC, Robertson SP, Manoli I, Engle EC.

Nat Commun. 2017 Jul 6;8:16077. doi: 10.1038/ncomms16077.


Mining for Micropeptides.

Makarewich CA, Olson EN.

Trends Cell Biol. 2017 Sep;27(9):685-696. doi: 10.1016/j.tcb.2017.04.006. Epub 2017 May 18. Review.


CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice.

Zhang Y, Long C, Li H, McAnally JR, Baskin KK, Shelton JM, Bassel-Duby R, Olson EN.

Sci Adv. 2017 Apr 12;3(4):e1602814. doi: 10.1126/sciadv.1602814. eCollection 2017 Apr.


Control of Muscle Metabolism by the Mediator Complex.

Amoasii L, Olson EN, Bassel-Duby R.

Cold Spring Harb Perspect Med. 2018 Feb 1;8(2). pii: a029843. doi: 10.1101/cshperspect.a029843. Review.


Control of muscle formation by the fusogenic micropeptide myomixer.

Bi P, Ramirez-Martinez A, Li H, Cannavino J, McAnally JR, Shelton JM, Sánchez-Ortiz E, Bassel-Duby R, Olson EN.

Science. 2017 Apr 21;356(6335):323-327. doi: 10.1126/science.aam9361. Epub 2017 Apr 6.


Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity.

Abad M, Hashimoto H, Zhou H, Morales MG, Chen B, Bassel-Duby R, Olson EN.

Stem Cell Reports. 2017 Mar 14;8(3):548-560. doi: 10.1016/j.stemcr.2017.01.025. Epub 2017 Mar 2.


A Twist2-dependent progenitor cell contributes to adult skeletal muscle.

Liu N, Garry GA, Li S, Bezprozvannaya S, Sanchez-Ortiz E, Chen B, Shelton JM, Jaichander P, Bassel-Duby R, Olson EN.

Nat Cell Biol. 2017 Mar;19(3):202-213. doi: 10.1038/ncb3477. Epub 2017 Feb 20.


Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.

Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654. doi: 10.1073/pnas.1621346114. Epub 2017 Jan 31.


Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I.

Fernandez AM, Hernandez-Garzón E, Perez-Domper P, Perez-Alvarez A, Mederos S, Matsui T, Santi A, Trueba-Saiz A, García-Guerra L, Pose-Utrilla J, Fielitz J, Olson EN, Fernandez de la Rosa R, Garcia Garcia L, Pozo MA, Iglesias T, Araque A, Soya H, Perea G, Martin ED, Torres Aleman I.

Diabetes. 2017 Jan;66(1):64-74. doi: 10.2337/db16-0861. Epub 2016 Oct 10.


Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides.

Anderson DM, Makarewich CA, Anderson KM, Shelton JM, Bezprozvannaya S, Bassel-Duby R, Olson EN.

Sci Signal. 2016 Dec 6;9(457):ra119.


Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development.

Anderson KM, Anderson DM, McAnally JR, Shelton JM, Bassel-Duby R, Olson EN.

Nature. 2016 Nov 17;539(7629):433-436. doi: 10.1038/nature20128. Epub 2016 Oct 26.


Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus.

Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A.

Am J Hum Genet. 2016 Oct 6;99(4):1000. doi: 10.1016/j.ajhg.2016.09.003. No abstract available.


Genome Editing of Monogenic Neuromuscular Diseases: A Systematic Review.

Long C, Amoasii L, Bassel-Duby R, Olson EN.

JAMA Neurol. 2016 Nov 1;73(11):1349-1355. doi: 10.1001/jamaneurol.2016.3388. Review.


Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation.

Polster A, Nelson BR, Olson EN, Beam KG.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10986-91. doi: 10.1073/pnas.1612441113. Epub 2016 Sep 12.


Muscle RING-finger 2 and 3 maintain striated-muscle structure and function.

Lodka D, Pahuja A, Geers-Knörr C, Scheibe RJ, Nowak M, Hamati J, Köhncke C, Purfürst B, Kanashova T, Schmidt S, Glass DJ, Morano I, Heuser A, Kraft T, Bassel-Duby R, Olson EN, Dittmar G, Sommer T, Fielitz J.

J Cachexia Sarcopenia Muscle. 2016 May;7(2):165-80. doi: 10.1002/jcsm.12057. Epub 2015 Sep 7.


Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106.

Anderson DM, Cannavino J, Li H, Anderson KM, Nelson BR, McAnally J, Bezprozvannaya S, Liu Y, Lin W, Liu N, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4494-503. doi: 10.1073/pnas.1608423113. Epub 2016 Jul 14.


Myocardin-related transcription factors are required for skeletal muscle development.

Cenik BK, Liu N, Chen B, Bezprozvannaya S, Olson EN, Bassel-Duby R.

Development. 2016 Aug 1;143(15):2853-61. doi: 10.1242/dev.135855. Epub 2016 Jul 6.


LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.

Lee DH, Park JO, Kim TS, Kim SK, Kim TH, Kim MC, Park GS, Kim JH, Kuninaka S, Olson EN, Saya H, Kim SY, Lee H, Lim DS.

Nat Commun. 2016 Jun 30;7:11961. doi: 10.1038/ncomms11961.


Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.

Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Richard Lu Q.

Dev Cell. 2016 Jun 20;37(6):582. doi: 10.1016/j.devcel.2016.06.004. No abstract available.


Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury.

Tao G, Kahr PC, Morikawa Y, Zhang M, Rahmani M, Heallen TR, Li L, Sun Z, Olson EN, Amendt BA, Martin JF.

Nature. 2016 Jun 2;534(7605):119-23. doi: 10.1038/nature17959. Epub 2016 May 25.


Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus.

Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A.

Am J Hum Genet. 2016 Jun 2;98(6):1082-1091. doi: 10.1016/j.ajhg.2016.03.022. Epub 2016 May 12. Erratum in: Am J Hum Genet. 2016 Oct 6;99(4):1000.


Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development.

Singh A, Ramesh S, Cibi DM, Yun LS, Li J, Li L, Manderfield LJ, Olson EN, Epstein JA, Singh MK.

Cell Rep. 2016 May 17;15(7):1384-1393. doi: 10.1016/j.celrep.2016.04.027. Epub 2016 May 5.

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