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Genetic heterogeneity of the Spy1336/R28-Spy1337 virulence axis in Streptococcus pyogenes and effect on gene transcript levels and pathogenesis.

Eraso JM, Kachroo P, Olsen RJ, Beres SB, Zhu L, Badu T, Shannon S, Cantu CC, Saavedra MO, Kubiak SL, Porter AR, DeLeo FR, Musser JM.

PLoS One. 2020 Mar 26;15(3):e0229064. doi: 10.1371/journal.pone.0229064. eCollection 2020.


Genome-Wide Screens Identify Group A Streptococcus Surface Proteins Promoting Female Genital Tract Colonization and Virulence.

Zhu L, Olsen RJ, Beres SB, Ojeda Saavedra M, Kubiak SL, Cantu CC, Jenkins L, Yerramilli P, Pruitt L, Charbonneau ARL, Waller AS, Musser JM.

Am J Pathol. 2020 Mar 17. pii: S0002-9440(20)30018-3. doi: 10.1016/j.ajpath.2019.12.003. [Epub ahead of print]


New Pathogenesis Mechanisms and Translational Leads Identified by Multidimensional Analysis of Necrotizing Myositis in Primates.

Kachroo P, Eraso JM, Olsen RJ, Zhu L, Kubiak SL, Pruitt L, Yerramilli P, Cantu CC, Ojeda Saavedra M, Pensar J, Corander J, Jenkins L, Kao L, Granillo A, Porter AR, DeLeo FR, Musser JM.

mBio. 2020 Feb 18;11(1). pii: e03363-19. doi: 10.1128/mBio.03363-19.


Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread.

Musser JM, Beres SB, Zhu L, Olsen RJ, Vuopio J, Hyyryläinen HL, Gröndahl-Yli-Hannuksela K, Kristinsson KG, Darenberg J, Henriques-Normark B, Hoffmann S, Caugant DA, Smith AJ, Lindsay DSJ, Boragine DM, Palzkill T.

J Clin Microbiol. 2020 Mar 25;58(4). pii: e01993-19. doi: 10.1128/JCM.01993-19. Print 2020 Mar 25.


Polymorphisms in Regulator of Cov Contribute to the Molecular Pathogenesis of Serotype M28 Group A Streptococcus.

Bernard PE, Kachroo P, Eraso JM, Zhu L, Madry JE, Linson SE, Ojeda Saavedra M, Cantu C, Musser JM, Olsen RJ.

Am J Pathol. 2019 Oct;189(10):2002-2018. doi: 10.1016/j.ajpath.2019.06.009. Epub 2019 Jul 29.


Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence.

Do H, Makthal N, Chandrangsu P, Olsen RJ, Helmann JD, Musser JM, Kumaraswami M.

Nucleic Acids Res. 2019 Sep 5;47(15):8333-8334. doi: 10.1093/nar/gkz641. No abstract available.


Draft Genome Sequence of Candida auris Strain LOM, a Human Clinical Isolate from Greater Metropolitan Houston, Texas.

Long SW, Olsen RJ, Nguyen HAT, Ojeda Saavedra M, Musser JM.

Microbiol Resour Announc. 2019 Jun 20;8(25). pii: e00532-19. doi: 10.1128/MRA.00532-19.


Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway.

Do H, Makthal N, VanderWal AR, Saavedra MO, Olsen RJ, Musser JM, Kumaraswami M.

Nat Commun. 2019 Jun 13;10(1):2586. doi: 10.1038/s41467-019-10556-8.


Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence.

Do H, Makthal N, Chandrangsu P, Olsen RJ, Helmann JD, Musser JM, Kumaraswami M.

Nucleic Acids Res. 2019 Aug 22;47(14):7476-7493. doi: 10.1093/nar/gkz524. Erratum in: Nucleic Acids Res. 2019 Sep 5;47(15):8333-8334.


HPV status in women with high-grade dysplasia on cervical biopsy and preceding negative HPV tests.

Ge Y, Mody RR, Olsen RJ, Zhou H, Luna E, Armylagos D, Puntachart N, Hendrickson H, Schwartz MR, Mody DR.

J Am Soc Cytopathol. 2019 May - Jun;8(3):149-156. doi: 10.1016/j.jasc.2019.01.001. Epub 2019 Jan 14.


From Bench to Bedside: Evaluation of AHCC Supplementation to Modulate the Host Immunity to Clear High-Risk Human Papillomavirus Infections.

Smith JA, Mathew L, Gaikwad A, Rech B, Burney MN, Faro JP, Lucci JA 3rd, Bai Y, Olsen RJ, Byrd TT.

Front Oncol. 2019 Mar 20;9:173. doi: 10.3389/fonc.2019.00173. eCollection 2019.


Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis.

Kachroo P, Eraso JM, Beres SB, Olsen RJ, Zhu L, Nasser W, Bernard PE, Cantu CC, Saavedra MO, Arredondo MJ, Strope B, Do H, Kumaraswami M, Vuopio J, Gröndahl-Yli-Hannuksela K, Kristinsson KG, Gottfredsson M, Pesonen M, Pensar J, Davenport ER, Clark AG, Corander J, Caugant DA, Gaini S, Magnussen MD, Kubiak SL, Nguyen HAT, Long SW, Porter AR, DeLeo FR, Musser JM.

Nat Genet. 2019 Mar;51(3):548-559. doi: 10.1038/s41588-018-0343-1. Epub 2019 Feb 18.


Gene fitness landscape of group A streptococcus during necrotizing myositis.

Zhu L, Olsen RJ, Beres SB, Eraso JM, Saavedra MO, Kubiak SL, Cantu CC, Jenkins L, Charbonneau ARL, Waller AS, Musser JM.

J Clin Invest. 2019 Feb 1;129(2):887-901. doi: 10.1172/JCI124994. Epub 2019 Jan 22.


Real-time Communication With Health Care Providers Through an Online Respiratory Pathogen Laboratory Report.

Christensen PA, Olsen RJ, Perez KK, Cernoch PL, Long SW.

Open Forum Infect Dis. 2018 Nov 30;5(12):ofy322. doi: 10.1093/ofid/ofy322. eCollection 2018 Dec.


Using Machine Learning To Predict Antimicrobial MICs and Associated Genomic Features for Nontyphoidal Salmonella.

Nguyen M, Long SW, McDermott PF, Olsen RJ, Olson R, Stevens RL, Tyson GH, Zhao S, Davis JJ.

J Clin Microbiol. 2019 Jan 30;57(2). pii: e01260-18. doi: 10.1128/JCM.01260-18. Print 2019 Feb.


RocA Has Serotype-Specific Gene Regulatory and Pathogenesis Activities in Serotype M28 Group A Streptococcus.

Bernard PE, Kachroo P, Zhu L, Beres SB, Eraso JM, Kajani Z, Long SW, Musser JM, Olsen RJ.

Infect Immun. 2018 Oct 25;86(11). pii: e00467-18. doi: 10.1128/IAI.00467-18. Print 2018 Nov.


Postpartum Group A Streptococcus Case Series: Reach Out to Infection Prevention!

Alexander AJ, Myers C, Beres SB, Olsen RJ, Musser JM, Mangino JE.

Open Forum Infect Dis. 2018 Jul 2;5(7):ofy159. doi: 10.1093/ofid/ofy159. eCollection 2018 Jul.


Chlorhexidine bathing and Clostridium difficile infection in a surgical intensive care unit.

Bui LN, Swan JT, Shirkey BA, Olsen RJ, Long SW, Graviss EA.

J Surg Res. 2018 Aug;228:107-111. doi: 10.1016/j.jss.2018.02.063. Epub 2018 Apr 3.


Human Papillomavirus-Driven Squamous Lesions: High-Risk Genotype Found in Conjunctival Papillomas, Dysplasia, and Carcinoma.

Moyer AB, Roberts J, Olsen RJ, Chévez-Barrios P.

Am J Dermatopathol. 2018 Jul;40(7):486-490. doi: 10.1097/DAD.0000000000001139.


Signaling by a Conserved Quorum Sensing Pathway Contributes to Growth Ex Vivo and Oropharyngeal Colonization of Human Pathogen Group A Streptococcus.

Makthal N, Do H, VanderWal AR, Olsen RJ, Musser JM, Kumaraswami M.

Infect Immun. 2018 Apr 23;86(5). pii: e00169-18. doi: 10.1128/IAI.00169-18. Print 2018 May.


Developing an in silico minimum inhibitory concentration panel test for Klebsiella pneumoniae.

Nguyen M, Brettin T, Long SW, Musser JM, Olsen RJ, Olson R, Shukla M, Stevens RL, Xia F, Yoo H, Davis JJ.

Sci Rep. 2018 Jan 11;8(1):421. doi: 10.1038/s41598-017-18972-w.


Houston Methodist Variant Viewer: An Application to Support Clinical Laboratory Interpretation of Next-generation Sequencing Data for Cancer.

Christensen PA, Ni Y, Bao F, Hendrickson HL, Greenwood M, Thomas JS, Long SW, Olsen RJ.

J Pathol Inform. 2017 Nov 23;8:44. doi: 10.4103/jpi.jpi_48_17. eCollection 2017.



Davidson M, Olsen RJ, Ewton AA, Robbins RJ.

Endocr Pract. 2017 Dec;23(12):1425-1429. doi: 10.4158/EP-2017-0001. Epub 2017 Nov 16. Review.


Whole-Genome Sequencing of a Human Clinical Isolate of emm28 Streptococcus pyogenes Causing Necrotizing Fasciitis Acquired Contemporaneously with Hurricane Harvey.

Long SW, Kachroo P, Musser JM, Olsen RJ.

Genome Announc. 2017 Nov 9;5(45). pii: e01269-17. doi: 10.1128/genomeA.01269-17.


Novel Genes Required for the Fitness of Streptococcus pyogenes in Human Saliva.

Zhu L, Charbonneau ARL, Waller AS, Olsen RJ, Beres SB, Musser JM.

mSphere. 2017 Nov 1;2(6). pii: e00460-17. doi: 10.1128/mSphereDirect.00460-17. eCollection 2017 Nov-Dec.


Genome sequence analysis of emm89 Streptococcus pyogenes strains causing infections in Scotland, 2010-2016.

Beres SB, Olsen RJ, Ojeda Saavedra M, Ure R, Reynolds A, Lindsay DSJ, Smith AJ, Musser JM.

J Med Microbiol. 2017 Dec;66(12):1765-1773. doi: 10.1099/jmm.0.000622. Epub 2017 Nov 3.


Phase Transition of H2 in Subnanometer Pores Observed at 75 K.

Olsen RJ, Gillespie AK, Contescu CI, Taylor JW, Pfeifer P, Morris JR.

ACS Nano. 2017 Nov 28;11(11):11617-11631. doi: 10.1021/acsnano.7b06640. Epub 2017 Nov 7.


Whole-Genome Sequencing of a Human Clinical Isolate of the Novel Species Klebsiella quasivariicola sp. nov.

Long SW, Linson SE, Ojeda Saavedra M, Cantu C, Davis JJ, Brettin T, Olsen RJ.

Genome Announc. 2017 Oct 19;5(42). pii: e01057-17. doi: 10.1128/genomeA.01057-17.


Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen.

Do H, Makthal N, VanderWal AR, Rettel M, Savitski MM, Peschek N, Papenfort K, Olsen RJ, Musser JM, Kumaraswami M.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8498-E8507. doi: 10.1073/pnas.1705972114. Epub 2017 Sep 18.


Emerging multidrug resistance in community-associated Staphylococcus aureus involved in skin and soft tissue infections and nasal colonization.

Lee GC, Dallas SD, Wang Y, Olsen RJ, Lawson KA, Wilson J, Frei CR.

J Antimicrob Chemother. 2017 Sep 1;72(9):2461-2468. doi: 10.1093/jac/dkx200.


The Case for Laboratory Developed Procedures: Quality and Positive Impact on Patient Care.

Kaul KL, Sabatini LM, Tsongalis GJ, Caliendo AM, Olsen RJ, Ashwood ER, Bale S, Benirschke R, Carlow D, Funke BH, Grody WW, Hayden RT, Hegde M, Lyon E, Murata K, Pessin M, Press RD, Thomson RB.

Acad Pathol. 2017 Jul 16;4:2374289517708309. doi: 10.1177/2374289517708309. eCollection 2017 Jan-Dec.


Whole-Genome Sequencing of Human Clinical Klebsiella pneumoniae Isolates Reveals Misidentification and Misunderstandings of Klebsiella pneumoniae, Klebsiella variicola, and Klebsiella quasipneumoniae.

Long SW, Linson SE, Ojeda Saavedra M, Cantu C, Davis JJ, Brettin T, Olsen RJ.

mSphere. 2017 Aug 2;2(4). pii: e00290-17. doi: 10.1128/mSphereDirect.00290-17. eCollection 2017 Jul-Aug.


A Critical Role of Zinc Importer AdcABC in Group A Streptococcus-Host Interactions During Infection and Its Implications for Vaccine Development.

Makthal N, Nguyen K, Do H, Gavagan M, Chandrangsu P, Helmann JD, Olsen RJ, Kumaraswami M.

EBioMedicine. 2017 Jul;21:131-141. doi: 10.1016/j.ebiom.2017.05.030. Epub 2017 Jun 2.


Population Genomic Analysis of 1,777 Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Isolates, Houston, Texas: Unexpected Abundance of Clonal Group 307.

Long SW, Olsen RJ, Eagar TN, Beres SB, Zhao P, Davis JJ, Brettin T, Xia F, Musser JM.

mBio. 2017 May 16;8(3). pii: e00489-17. doi: 10.1128/mBio.00489-17.


Rapid Emergence of a New Clone Impacts the Population at Risk and Increases the Incidence of Type emm89 Group A Streptococcus Invasive Disease.

Teatero S, Coleman BL, Beres SB, Olsen RJ, Kandel C, Reynolds O, Athey TBT, Musser JM, McGeer A, Fittipaldi N.

Open Forum Infect Dis. 2017 Mar 4;4(2):ofx042. doi: 10.1093/ofid/ofx042. eCollection 2017 Spring.


Opacification Domain of Serum Opacity Factor Inhibits Beta-Hemolysis and Contributes to Virulence of Streptococcus pyogenes.

Zhu L, Olsen RJ, Musser JM.

mSphere. 2017 Apr 19;2(2). pii: e00147-17. doi: 10.1128/mSphereDirect.00147-17. eCollection 2017 Mar-Apr.


Iron Efflux by PmtA Is Critical for Oxidative Stress Resistance and Contributes Significantly to Group A Streptococcus Virulence.

VanderWal AR, Makthal N, Pinochet-Barros A, Helmann JD, Olsen RJ, Kumaraswami M.

Infect Immun. 2017 May 23;85(6). pii: e00091-17. doi: 10.1128/IAI.00091-17. Print 2017 Jun.


Increased Pilus Production Conferred by a Naturally Occurring Mutation Alters Host-Pathogen Interaction in Favor of Carriage in Streptococcus pyogenes.

Flores AR, Olsen RJ, Cantu C, Pallister KB, Guerra FE, Voyich JM, Musser JM.

Infect Immun. 2017 Apr 21;85(5). pii: e00949-16. doi: 10.1128/IAI.00949-16. Print 2017 May.


Contribution of Secreted NADase and Streptolysin O to the Pathogenesis of Epidemic Serotype M1 Streptococcus pyogenes Infections.

Zhu L, Olsen RJ, Lee JD, Porter AR, DeLeo FR, Musser JM.

Am J Pathol. 2017 Mar;187(3):605-613. doi: 10.1016/j.ajpath.2016.11.003. Epub 2016 Dec 27.


Case Series Description and Genomic Characterization of Invasive Group A Streptococcal Infections in Pediatric Patients.

Dien Bard J, Mongkolrattanothai K, Kachroo P, Beres S, Olsen RJ.

Pediatr Infect Dis J. 2017 Jun;36(6):618-620. doi: 10.1097/INF.0000000000001519.


A prospective observational cohort study in primary care practices to identify factors associated with treatment failure in Staphylococcus aureus skin and soft tissue infections.

Lee GC, Hall RG, Boyd NK, Dallas SD, Du LC, Treviño LB, Treviño SB, Retzloff C, Lawson KA, Wilson J, Olsen RJ, Wang Y, Frei CR.

Ann Clin Microbiol Antimicrob. 2016 Nov 22;15(1):58.


Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis.

Eraso JM, Olsen RJ, Beres SB, Kachroo P, Porter AR, Nasser W, Bernard PE, DeLeo FR, Musser JM.

Infect Immun. 2016 Nov 18;84(12):3268-3281. Print 2016 Dec.


Predictors of community-associated Staphylococcus aureus, methicillin-resistant and methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in primary-care settings.

Lee GC, Hall RG, Boyd NK, Dallas SD, Du LC, Treviño LB, Retzloff C, Treviño SB, Lawson KA, Wilson JP, Olsen RJ, Wang Y, Frei CR.

Epidemiol Infect. 2016 Nov;144(15):3198-3204. Epub 2016 Aug 4.


Increased use of surgical energy promotes methicillin-resistant Staphylococcus aureus colonization in rabbits following open ventral hernia mesh repair.

Fernandez-Moure JS, Van Eps JL, Peress L, Cantu C, Olsen RJ, Jenkins L, Cabrera FJ, Tasciotti E, Weiner BK, Dunkin BJ.

Surg Endosc. 2017 Feb;31(2):852-860. doi: 10.1007/s00464-016-5043-2. Epub 2016 Jul 7.


Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen Streptococcus pyogenes.

Beres SB, Kachroo P, Nasser W, Olsen RJ, Zhu L, Flores AR, de la Riva I, Paez-Mayorga J, Jimenez FE, Cantu C, Vuopio J, Jalava J, Kristinsson KG, Gottfredsson M, Corander J, Fittipaldi N, Di Luca MC, Petrelli D, Vitali LA, Raiford A, Jenkins L, Musser JM.

mBio. 2016 May 31;7(3). pii: e00403-16. doi: 10.1128/mBio.00403-16.


Intergenic Variable-Number Tandem-Repeat Polymorphism Upstream of rocA Alters Toxin Production and Enhances Virulence in Streptococcus pyogenes.

Zhu L, Olsen RJ, Horstmann N, Shelburne SA, Fan J, Hu Y, Musser JM.

Infect Immun. 2016 Jun 23;84(7):2086-2093. doi: 10.1128/IAI.00258-16. Print 2016 Jul.


Integrating Rapid Diagnostics and Antimicrobial Stewardship in Two Community Hospitals Improved Process Measures and Antibiotic Adjustment Time.

Lockwood AM, Perez KK, Musick WL, Ikwuagwu JO, Attia E, Fasoranti OO, Cernoch PL, Olsen RJ, Musser JM.

Infect Control Hosp Epidemiol. 2016 Apr;37(4):425-32. doi: 10.1017/ice.2015.313. Epub 2016 Jan 7.


Structural and functional analysis of RopB: a major virulence regulator in Streptococcus pyogenes.

Makthal N, Gavagan M, Do H, Olsen RJ, Musser JM, Kumaraswami M.

Mol Microbiol. 2016 Mar;99(6):1119-33. doi: 10.1111/mmi.13294. Epub 2016 Feb 19.


Musser et al. Reply to "Emergence of the Same Successful Clade among Distinct Populations of emm89 Streptococcus pyogenes in Multiple Geographic Regions".

Musser JM, Zhu L, Olsen RJ, Nasser W.

mBio. 2015 Dec 1;6(6):e01838-15. doi: 10.1128/mBio.01838-15. No abstract available.


Next-Generation Sequencing of Matched Primary and Metastatic Rectal Adenocarcinomas Demonstrates Minimal Mutation Gain and Concordance to Colonic Adenocarcinomas.

Crumley SM, Pepper KL, Phan AT, Olsen RJ, Schwartz MR, Portier BP.

Arch Pathol Lab Med. 2016 Jun;140(6):529-35. doi: 10.5858/arpa.2015-0261-SA. Epub 2015 Nov 4.


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